Genes regulated by human cytokines

ABSTRACT

The present invention relates to purified polynucleotides and a composition comprising a plurality of polynucleotide probes that are modulated in response to cytokines and which are associated with human immune response, conditions, disorders, and diseases. The present invention presents methods for using the polynucleotides, and use of the polynucleotide probes as hybridizable elements in a microarray.

[0001] This application is a continuation of U.S. application Ser. No. 09/435,247, filed Nov. 5, 1999, which is hereby expressly incorporated by reference.

FIELD OF THE INVENTION

[0002] The present invention relates to a plurality of polynucleotides which may be used in detecting genes modulated in response to human cytokines. In particular, the present invention provides for the use of these polynucleotides in the diagnosis of conditions, disorders, and diseases associated with the immune system and immune response.

BACKGROUND OF THE INVENTION

[0003] Mammalian peripheral blood comprises cells of the erythroid, myeloid, and lymphoid lineages. (See, e.g., Rapaport (1987) Introduction to Hematology, Lipincott, Philadelphia Pa.; Jandi (1987) Blood: Textbook of Immunology, Little, Brown and Co., Boston Mass.; and Paul (1998) Fundamental Immunology (4^(th) ed.), Raven Press, New York N.Y.). Each of these lineages are derived from a pluripotent stem cell which, upon exposure to various molecules and other types of cells, differentiate into effector cells which migrate into the blood and other organs. These cells include red blood cells and platelets (erythroid), macrophages and granulocytes (myeloid), and T and B lymphocytes (lymphoid). The latter two groups of cells mediate immune responses to pathogens such as bacteria, parasites, and viruses.

[0004] Functional interaction of the cell types involved in immune responses involves transfer of signals via soluble messenger molecules known as cytokines. Both hematopoietic cells and non-hematopoietic cells produce cytokines which stimulate the activation, differentiation and proliferation of T cells, B cells, macrophages, and granulocytes during an active immune response. Cytokines bind to specific receptors expressed on cellular membranes and transduce a signal through the cell. Depending on the type of cytokine and the cell to which it binds, this signal initiates activation, differentiation, growth, and/or apoptosis (Aggarwal and Gutterman (1991) Human Cytokines: Handbook for Basic and Clinical Research, Blackwell, Oxford, UK).

[0005] T cells, which respond to and produce a variety of cytokines, are divided into two major groups, CD4⁺ T helper (Th) cells, and CD8⁺ cytotoxic T lymphocytes (CTL). Immune responses are primarily regulated by CD4⁺ Th cells which fall into two subclasses based on the kinds of cytokines they secrete. Th1 cells secrete primarily IL-2 and IFN-γ, regulate the responses of CTLs, B cells and macrophages, and orchestrate the removal of intracellular pathogens. In contrast, Th2 cells secrete primarily IL4 and IL-10 and promote the development of certain antibody responses such as IgG1, IgA, and IgE, an excess of the latter triggering allergic responses. In addition, Th2 cells remove extracellular pathogens, which include various bacteria and parasites (Morel and Oriss (1998) Crit. Rev. Immunol. 18:275-303).

[0006] Further studies have shown that the Th1 cytokine response predominates in organ-specific autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM), multiple sclerosis (MS), rheumatoid arthritis (RA), and Crohn's disease. A Th1 response also predominates in acute allograft rejection, eradication of tumors, and unexplained recurrent abortions. Th2 responses predominate in allergy and other atopic disorders, transplantation tolerance, chronic graft versus host disease (GVHD), and systemic autoimmune disease such as systemic lupus erythmatosus (Romangnani et al. (1997) Int. Arch. Allergy Immunol. 113:153-156).

[0007] Genes affected by these molecules may reasonably be expected to be markers of immune cell development, function, and activity. During immune responses, immune cells make a plethora of different cytokines that affect cellular functions. Until now, in vitro studies have focused on the effects of one or two cytokines on gene expression, but have not recreated the complex environment of multiple signals that occur in vivo by studying the effect of multiple cytokines simultaneously. This approach would provide a high throughput method of screening for a cytokine-related disease, assessing the efficacy of treatment for various disorders, conditions, and diseases, and providing information regarding novel genes up- or down-regulated by a complex mixture of cytokines that skew toward a particular immune response.

[0008] The present invention provides a method of high-throughput screening using a plurality of probes and purified polynucleotides in a diagnostic context as markers of various immune conditions, diseases, and disorders.

SUMMARY OF THE INVENTION

[0009] The present invention provides a composition comprising a plurality of polynucleotides wherein each polynucleotides comprises at least a fragment of a gene of SEQ ID NOs:1-516 as presented in the Sequence Listing. These polynucleotides are used to assess gene expression which is modulated by cytokines and is associated with an immune response or an immune system disorder. The invention also provides purified polynucleotides wherein each of the polynucleotides comprises at least a fragment of a gene selected from SEQ ID NOs:1-243 or a complement thereof whose expression is modulated by cytokines and is associated with an immune response or an immune system disorder. In one embodiment, each polynucleotide comprises at least a fragment of a gene selected from SEQ ID NOs:1-172 whose transcript level in a sample is altered in response to both pro-inflammatory cytokines such as IL-1β, IL-6, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-18, IL-12, IL-2, and IL-8, and anti-inflammatory cytokines such as IL4, IL-10, IL-13, transforming growth factor (TGF)-β, IL-7, IL-3, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), leukemia inhibitory factor (LIF), and leptin. In another embodiment, each polynucleotide comprises at least a fragment of a gene selected from SEQ ID NOs:173-218 whose transcript level in a sample is altered in response to pro-inflammatory cytokines. In another embodiment, each polynucleotide comprises at least a fragment of a gene selected from SEQ ID NOs:219-243 whose transcript level in a sample is altered in response to anti-inflammatory cytokines. In one aspect, the polynucleotides of the composition are immobilized on a substrate.

[0010] The invention also provides a high throughput method for detecting a polynucleotide in a sample, the method comprising hybridizing the polynucleotide composition with at least one polynucleotide in the sample, thereby forming a hybridization complex; and detecting the hybridization complex, wherein the presence of the hybridization complex indicates the presence of the polynucleotide in the sample.

[0011] The invention also provides a high throughput method of screening a library of molecules or compounds to identify a ligand, the method comprising combining the polynucleotide composition with a library of molecules or compounds under conditions to allow specific binding; and detecting specific binding, thereby identifying a ligand. Libraries of molecules or compounds are selected from DNA molecules, RNA molecules, peptide nucleic acids (PNAs), mimetics, peptides, and proteins. The invention additionally provides a method for purifying a ligand, the method comprising combining a polynucleotide of the invention with a sample under conditions which allow specific binding, recovering the bound polynucleotide, and separating the polynucleotide from the ligand, thereby obtaining purified ligand.

[0012] The invention provides an expression vector containing a polynucleotide, a host cell containing the expression vector, and a method for producing a protein comprising culturing the host cell under conditions for the expression of protein and recovering the protein from the host cell culture.

[0013] The invention also provides a protein and a method for screening a library of molecules or compounds to identify at least one ligand which specifically binds the protein. The method comprises combining the protein or a portion thereof with the library of molecules or compounds under conditions to allow specific binding and detecting specific binding, thereby identifying a ligand which specifically binds the protein. Libraries of molecules or compounds are selected from DNA molecules, RNA molecules, PNAs, mimetics, peptides, proteins, agonists, antagonists, antibodies or their fragments, immunoglobulins, inhibitors, drug compounds, and pharmaceutical agents. The invention further provides for using a protein to purify a ligand. The method comprises combining the protein or a portion thereof with a sample under conditions to allow specific binding, recovering the bound protein, and separating the protein from the ligand, thereby obtaining purified ligand.

[0014] The invention also encompasses a method of screening a patient for an immune response, disorder, condition, or disease comprising obtaining a sample from the patient; contacting the sample with polynucleotides immobilized on a substrate under conditions to allow formation of a hybridization complex; detecting and quantifying hybridization complex to determine hybridization complex level; and comparing hybridization complex level with a standard, wherein a change in hybridization complex level relative to the standard is indicative of the immune disorder, condition, or disease. The immune disorder, condition, or disease includes pro-inflammatory disorders such as viral infections and organ-specific autoimmune disorders, including insulin-dependent diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Crohn's disease and pemphigus vulgaris; and anti-inflammatory disorders such as bacterial and parasitic infections, allergies and other atopic disorders, transplantation tolerance, chronic graft versus host disease, and sytemic autoimmune disease including systemic lupus erythematosus.

DESCRIPTION OF THE TABLES

[0015] A portion of the disclosure of this patent document contains material which is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.

[0016] The Sequence Listing is a compilation of polynucleotides obtained by sequencing clone inserts (isolates) of different cDNAs and identified by hybrid complex formation using the cDNAs as probes on a microarray. Each sequence is identified by a sequence identification number (SEQ ID NO) and by the Incyte clone ID from which it was obtained.

[0017] Table 1 lists polynucleotides differentially expressed in peripheral blood mononuclear cells (PBMCs) in response to both pro- and anti-inflammatory cytokines. Columns 1 and 2 show the SEQ ID NO and Incyte clone ID, respectively, for each polynucleotide. Columns 3 and 4 show the differential expression of the gene in PBMCs in response to pro-inflammatory and anti-inflammatory cytokines, respectively.

[0018] Table 2 lists polynucleotides differentially expressed in PBMCs in response to pro-inflammatory cytokines. Columns 1 and 2 show the SEQ ID NO and Incyte clone ID, respectively, for each polynucleotide. Columns 3 and 4 show the differential expression of the gene in PBMCs in response to pro-inflammatory and anti-inflammatory cytokines, respectively.

[0019] Table 3 lists polynucleotides differentially expressed in PBMCs in response to anti-inflammatory cytokines. Columns 1 and 2 show the SEQ ID NO and Incyte clone ID, respectively, for each polynucleotide. Columns 3 and 4 show the differential expression of the gene in PBMCs in response to pro-inflammatory and anti-inflammatory cytokines, respectively.

[0020] Table 4 lists polynucleotides differentially regulated in response to pro-inflammatory cytokines, anti-inflammatory cytokines, or both pro- and anti-inflammatory cytokines. Columns 1 and 2 show the SEQ ID NO and Incyte clone ID, respectively, for each polynucleotide. Columns 3 and 4 show the GenBank hit ID and corresponding GenBank 113 database, respectively, for the top hit identified by BLAST analysis. Column 5 shows the gene description for the polynucleotide. Columns 7 and 8 show the differential expression of the gene in PBMCs in response to pro-inflammatory and anti-inflammatory cytokines, respectively.

DETAILED DESCRIPTION OF THE INVENTION

[0021] Before the nucleic acid sequences and methods are presented, it is to be understood that this invention is not limited to the particular machines, methods, and materials described. Although particular embodiments are described, machines, methods, and materials similar or equivalent to these embodiments may be used to practice the invention. The preferred machines, methods, and materials set forth are not intended to limit the scope of the invention which is limited only by the appended claims.

[0022] The singular forms “a”, “an”, and “the” include plural reference unless the context clearly dictates otherwise. All technical and scientific terms have the meanings commonly understood by one of ordinary skill in the art. All publications are incorporated by reference for the purpose of describing and disclosing the cell lines, vectors, and methodologies which are presented and which might be used in connection with the invention. Nothing in the specification is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention.

[0023] Definitions

[0024] “Amplification” refers to the production of additional copies of a nucleotide sequence and is carried out using polymerase chain reaction (PCR) technologies well known in the art.

[0025] “Complementary” describes the relationship between two single-stranded nucleotide sequences that anneal by base-pairing (5′-A-G-T-3′ pairs with its complement 3′-T-C-A-5′).

[0026] “Cytokine”, as used herein, refers to a cytokine, chemokine, cytokine-like molecule, or other molecule which elicits an immune response, and includes interleukin (IL)-1β, IL-2, IL-3, IL4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-18, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulatory factor (G-CSF), leukemia-inhibitory factor (LIF), and leptin. “Pro-inflammatory” cytokines include IL-1β, IL-6, IFN-γ, TNF-α, IL-18, IL-12, IL-2, and IL-8. “Anti-inflammatory” cytokines include IL4, IL-10, IL-13, TGF-β, IL-7, IL-3, IL-5, GM-CSF, G-CSF, LIF, and leptin.

[0027] “E-value” refers to the statistical probability that a match between two sequences occurred by chance.

[0028] “Fragment” refers to an Incyte clone or any part of a polynucleotide which retains a usable, functional characteristic. Useful fragments may be used in hybridization technologies, to identify or purify ligands, or in regulation of replication, transcription or translation.

[0029] “Ligand” refers to any molecule, agent, or compound which will bind specifically to a complementary site on a polynucleotide or protein. Such ligands stabilize or modulate the activity of polynucleotides or proteins of the invention and may be composed of at least one of the following: inorganic and organic substances including nucleic acids, proteins, carbohydrates, fats, and lipids.

[0030] “Microarray” refers to an ordered arrangement of hybridizable elements on a substrate. The elements are arranged so that there are a “plurality” of elements, preferably more than one element, more preferably at least 100 elements, and even more preferably at least 1,000 elements, and most preferably at least 10,000 on a 1 cm² substrate. The maximum number of elements is unlimited, but is at least 100,000 elements. Furthermore, the hybridization signal from each of the elements is individually distinguishable. In the present and preferred embodiment, the elements comprise polynucleotide probes.

[0031] “Oligonucleotide” is substantially equivalent to the terms amplimer, primer, oligomer, element, target, and probe and is preferably single stranded.

[0032] “Peptide nucleic acid” (PNA) refers to a DNA mimic in which nucleotide bases are attached to a pseudopeptide backbone to increase stability. PNAs, also designated antigene agents, can prevent gene expression by hybridizing to complementary messenger RNA.

[0033] “Polynucleotide” refers to a nucleic acid, oligonucleotide, polynucleotide, or any fragment thereof. It may be DNA or RNA of genomic or synthetic origin, and double-stranded or single-stranded.

[0034] “Portion” refers to any part of a protein used for any purpose, but especially for the screening of a library of molecules or compounds to identify those which specifically bind to that portion and for producing antibodies.

[0035] “Probe” refers to a probe polynucleotide capable of hybridizing with a target polynucleotide to form a probe/target complex. A “target” refers to a chain of nucleotides to which a probe can hybridize by base pairing. In most instances, the sequences of the probe and target will be complementary (no mismatches) when aligned. In some instances, there may be up to a 10% mismatch.

[0036] “Protein” refers to an amino acid sequence, peptide, polypeptide, or protein of either natural or synthetic origin. The protein is not limited to the complete, endogenous amino acid sequence and may be a fragment, epitope, variant, or derivative of a protein.

[0037] “Purified” refers to any molecules or compounds that are removed from their natural environment and are isolated or separated, and are at least about 60% free, preferably about 75% free, and most preferably about 90% free, from other components with which they are naturally associated.

[0038] “Sample” is used in its broadest sense. A sample may comprise a bodily fluid; an extract from a cell, chromosome, organelle, or membrane isolated from a cell; genomic DNA, RNA, or cDNA in solution or bound to a substrate; a cell; a tissue; a tissue print; and the like.

[0039] “Specific binding” refers to a specific interaction between two molecules which is dependent upon a particular structure or molecular side groups. For example, the hydrogen bonding between two single stranded nucleic acids or the binding between a protein/epitope and an agonist, antagonist, or antibody.

[0040] “Substrate” refers to any rigid or semi-rigid support to which molecules or compounds are bound and includes membranes, filters, chips, slides, wafers, fibers, magnetic or nonmagnetic beads, gels, capillaries or other tubing, plates, polymers, and microparticles with a variety of surface forms including wells, trenches, pins, channels and pores.

[0041] The Invention

[0042] The present invention provides a composition comprising a plurality of polynucleotide probes, wherein each polynucleotide comprises at least a fragment of a gene whose transcript is modulated by human cytokines. The plurality of probes comprise at least a fragment of the identified and novel polynucleotide sequences, SEQ ID NOs:1-516, as presented in the Sequence Listing. Novel polynucleotides were identified using the composition, wherein each polynucleotide comprises at least a fragment of a gene selected from SEQ ID NOs:1-243 whose transcript is modulated by human cytokines. SEQ ID NOs:1-172 comprise at least a fragment of a gene whose transcript level in a sample is modulated in response to both pro-inflammatory cytokines and anti-inflammatory cytokines as shown in Table 1. SEQ ID NOs:173-218 comprise at least a fragment of a gene whose transcript level in a sample is modulated in response to pro-inflammatory cytokines as shown in Table 2. SEQ ID NOs:219-243 comprise at least a fragment of a gene whose transcript level in a sample is modulated in response to anti-inflammatory cytokines as shown in Table 3.

[0043] In a particular embodiment, the probes are arranged on a substrate, preferably a microarray. The microarray can be used for large scale genetic or gene expression analysis of a large number of targets. The microarray can also be used in the diagnosis of diseases and in the monitoring of treatments where altered gene expression is associated with an immune response involving an allergy, a bacterial, viral, or parasitic infection, and the like. Further, the microarray can be employed to investigate an individual's predisposition to an autoimmune disorder including insulin-dependent diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Crohn's disease, systemic lupus erythematosus, and the like.

[0044] When the composition of the invention is employed as probes on a microarray, the probes are organized in an ordered fashion so that each element is present at a specified location on the substrate. Because the probes are at specified locations on the substrate, the hybridization patterns and intensities, which together create a unique expression profile, can be interpreted in terms of expression levels of particular genes and can be correlated with a particular metabolic process, condition, disorder, disease, stage of disease, or treatment.

[0045] The composition comprising a plurality of probes can also be used to identify or purify a molecule or compound which specifically binds to at least one of the probes. These molecules may be identified from a sample or in high throughput mode from a library of mRNAs, cDNAs, genomic fragments, and the like. Typically, samples or libraries will include targets of diagnostic or therapeutic interest. If nucleic acids in a particular sample enhance the hybridization background, it may be advantageous to remove these nucleic acids. One method for removing additional nucleic acids is by hybridizing the sample with immobilized probes and washing away those nucleic acids that do not form hybridization complexes. At a later point, hybridization complexes can be dissociated, thereby releasing the purified targets.

[0046] Method for Selecting Polynucleotides

[0047] The polynucleotides which represent genes modulated by cytokines were identified by the following method. Samples were prepared from peripheral blood mononuclear cells (PBMCs) treated with pro-inflammatory or anti-inflammatory cytokines over a defined time course. Gene expression patterns between cytokine-treated and untreated cell samples were compared. The comparisons allowed the identification of genes either upregulated or downregulated in response to each cytokine group and identification of genes either upregulated or downregulated in response to both cytokine groups. SEQ ID NOs:1-516 represent genes modulated by cytokines as identified by differential expression of polynucleotide probes on the substrate. Since polynucleotides are identified solely based on expression levels, it is not essential to know a priori the function of the particular gene. The overall pattern of expression is especially useful in characterizing expression patterns associated with an immune response due to an infection or an autoimmune disorder.

[0048] Polynucleotides

[0049] The polynucleotides of the invention can be genomic DNA, cDNA, mRNA, or any RNA-like or DNA-like material such as peptide nucleic acids, branched DNAs and the like. Polynucleotide probes can be sense or antisense strand. Where targets are double stranded, probes may be either sense or antisense strands. Where targets are single stranded, probes are complementary single strands.

[0050] In one embodiment, polynucleotides are cDNAs. In another embodiment, polynucleotides are plasmids. In the case of plasmids, the sequence of interest is the cDNA insert. The size of the cDNAs may vary and is preferably from 50 to 10,000 nucleotides, more preferably from 50 to 4000 nucleotides, and most preferably about 400 nucleotides in length.

[0051] Polynucleotides can be prepared by a variety of synthetic or enzymatic methods well known in the art. Polynucleotides can be synthesized, in whole or in part, using chemical methods well known in the art (Caruthers et al. (1980) Nucleic Acids Symp. Ser. (7):215-233). Alternatively, polynucleotides can be produced enzymatically or recombinantly, by in vitro or in vivo transcription.

[0052] Nucleotide analogs can be incorporated into polynucleotide probes by methods well known in the art. The only requirement is that the incorporated nucleotide analogs of the probe must base pair with, target nucleotides. For example, certain guanine nucleotides can be substituted with hypoxanthine which base pairs with cytosine residues. However, these base pairs are less stable than those between guanine and cytosine. Alternatively, adenine nucleotides can be substituted with 2,6-diaminopurine which can form stronger base pairs with thymidine than those between adenine and thymidine.

[0053] Additionally, polynucleotides can include nucleotides that have been derivatized chemically or enzymatically. Typical chemical modifications include derivatization with acyl, alkyl, aryl or amino groups.

[0054] Polynucleotides probes can be synthesized on a substrate. Synthesis on the surface of a substrate may be accomplished using a chemical coupling procedure and a piezoelectric printing apparatus as described by Baldeschweiler et al. (PCT publication WO95/251116). Alternatively, the probe can be synthesized on a substrate surface using a self-addressable electronic device that controls when reagents are added as described by Heller et al. (U.S. Pat. No. 5,605,662; incorporated herein by reference).

[0055] Complementary DNA (cDNA) can be arranged and then immobilized on a substrate. Probes can be immobilized by covalent means such as by chemical bonding procedures or UV. In one such method, a cDNA is bound to a glass surface which has been modified to contain epoxide or aldehyde groups. In another case, a cDNA probe is placed on a polylysine coated surface and then UV cross-linked as described by Shalon et al. (WO95/35505). In yet another method, a DNA is actively transported from a solution to a given position on a substrate by electrical means (Heller et al., supra). Alternatively, probes, clones, plasmids or cells can be arranged on a filter. In the latter case, cells are lysed, proteins and cellular components degraded, and the DNA is coupled to the filter by UV cross-linking.

[0056] Furthermore, probes do not have to be directly bound to the substrate, but rather can be bound to the substrate through a linker group. The linker groups are typically about 6 to 50 atoms long to provide exposure of the attached probe. Preferred linker groups include ethylene glycol oligomers, diamines, diacids and the like. Reactive groups on the substrate surface react with a terminal group of the linker to bind the linker to the substrate. The other terminus of the linker is then bound to the probe.

[0057] Probes can be attached to a substrate by sequentially dispensing reagents for probe synthesis on the substrate surface or by dispensing preformed DNA fragments to the substrate surface. Typical dispensers include a micropipette delivering solution to the substrate with a robotic system to control the position of the micropipette with respect to the substrate. There can be a multiplicity of dispensers so that reagents can be delivered to the reaction regions efficiently.

[0058] Uses of the Polynucleotides

[0059] The polynucleotide probes of the present invention may be used for a variety of purposes. For example, the composition of the invention may be used as probes on a microarray. The microarray can be used in high-throughput methods such as for detecting a related polynucleotide in a sample, screening libraries of molecules or compounds to identify a ligand, or diagnosing a particular condition, disease, or disorder associated with an immune response. Alternatively, a polynucleotide complementary to a given sequence of the sequence listing can inhibit or inactivate a therapeutically relevant gene related to the polynucleotide.

[0060] Array Analysis

[0061] I. Sample Preparation

[0062] In order to conduct sample analysis, a sample containing targets is provided. The samples can be any sample containing targets and obtained from any bodily fluid (blood, urine, saliva, phlegm, gastric juices, etc.), cultured cells, biopsies, or other tissue or forensic preparations.

[0063] DNA or RNA can be isolated from a sample according to any of a number of methods well known to those of skill in the art. For example, methods of purification of nucleic acids are described in Tijssen (1993) Laboratory Techniques in Biochemistry and Molecular Biology: Hybridization With Nucleic Acid Probes Part I. Theory and Nucleic Acid Preparation, Elsevier Science, New York N.Y.). In one case, total RNA is isolated using TRIZOL reagent (Life Technologies, Gaithersburg Md.), and mRNA is isolated using oligo d(T) column chromatography or glass beads. In one alternative, when targets are derived from an mRNA, targets can be a DNA reverse transcribed from that mRNA, an RNA transcribed from that DNA, a DNA amplified from that DNA, an RNA transcribed from the amplified DNA, and the like. When target is derived from DNA, target can be RNA reverse transcribed from that DNA, or DNA amplified from that DNA. In yet another alternative, targets are prepared by more than one method.

[0064] When targets in the sample are amplified it is desirable to maintain their relative abundances, including low abundance transcripts. Total mRNA can be amplified by reverse transcription using a reverse transcriptase and a primer consisting of oligo d(T) and a sequence encoding the phage T7 promoter to provide a single stranded DNA template. The second DNA strand is polymerized using a DNA polymerase and a RNAse which assists in breaking up the DNA/RNA hybrid. After synthesis of the double stranded DNA, T7 RNA polymerase can be added, and RNA transcribed from the second DNA strand template as described by Van Gelder et al. (U.S. Pat. No. 5,545,522; incorporated herein by reference). RNA can be amplified in vitro, in situ or in vivo (See Eberwine, U.S. Pat. No. 5,514,545; incorporated herein by reference).

[0065] It is also advantageous to include quantitation controls to assure that amplification and labeling procedures do not change the true abundance of targets in a sample. For this purpose, a sample is spiked with a known amount of a control target, and the composition of probes includes reference probes which specifically hybridize with the control targets. After hybridization and processing, the hybridization signals should reflect accurately the amounts of control target added to the sample.

[0066] Prior to hybridization, it may be desirable to fragment the targets. Fragmentation improves hybridization by minimizing secondary structure and cross-hybridization among target nucleic acids in the sample or with noncomplementary probes. Fragmentation can be performed by mechanical or chemical means.

[0067] Targets may be labeled with one or more labeling moieties to allow for detection and quantitation of hybridized probe/target complexes. The labeling moieties can include compositions that can be detected by spectroscopic, photochemical, biochemical, bioelectronic, immunochemical, electrical, optical or chemical means. The labeling moieties include radioisotopes, such as ³²P, ³³P or ³⁵S, chemiluminescent compounds, labeled binding proteins, heavy metal atoms, spectroscopic markers such as fluorescent markers and dyes, magnetic labels, linked enzymes, mass spectrometry tags, spin labels, electron transfer donors and acceptors, and the like. Exemplary dyes include quinoline dyes, triarylmethane dyes, phthaleins, azo dyes, cyanine dyes, and the like. Preferably, fluorescent markers absorb light above about 300 nm, preferably above 400 nm, and usually emit light at wavelengths at least greater than 10 nm above the wavelength of the light absorbed. Preferred fluorescent markers include fluorescein, phycoerythrin, rhodamine, lissamine, Cy3, and Cy5.

[0068] Labeling can be carried out during an amplification reaction, such as by polymerase chain reaction, nick translation, or in vitro transcription reactions. Label can also be incorporated after or without an amplification step, such as by 5′ or 3′-end-labeling reactions. In 5′-end labeling, the 5′ end of the target is dephosphorylated by alkaline phosphatase and then phosphorylated by T4 polynucleotide kinase in the presence of [γ-³²P]ATP. In 3′-end labeling, the label is incorporated by using either terminal transferase or by incubating the target with a labeled oligonucleotide in the presence of T4 RNA ligase.

[0069] Alternatively, the labeling moiety can be incorporated after hybridization once a probe/target complex has formed. In one case, biotin is first incorporated during an amplification step as described above. After the hybridization reaction, unbound nucleic acids are rinsed away so that the only biotin remaining bound to the substrate is that attached to targets that are hybridized to probes. Then, an avidin-conjugated fluorophore, such as avidin-phycoerythrin, that binds with high affinity to biotin is added. In another case, the labeling moiety is incorporated by intercalation into preformed target/probe complexes. In this case, an intercalating dye such as a psoralen-linked dye can be employed.

[0070] II. Hybridization and Detection

[0071] Hybridization allows a denatured polynucleotide probe and a denatured complementary target to form a stable duplex through base pairing. Hybridization methods are well known to those skilled in the art. (See, e.g., Ausubel, et al. (1997) Short Protocols in Molecular Biology, John Wiley & Sons, New York N.Y., Units 2.8-2.11, 3.18-3.19 and 4-6-4.9.) Conditions can be selected for hybridization where completely complementary probe and target can hybridize, i.e., each base pair must interact with its complementary base pair. Alternatively, conditions can be selected where probe and target have mismatches of up to about 10% but are still able to hybridize. Suitable conditions can be selected, for example, by varying the concentrations of salt in the prehybridization, hybridization, and wash solutions or by varying the hybridization and wash temperatures. With some substrates, the temperature can be decreased by adding formamide to the prehybridization and hybridization solutions.

[0072] Hybridization can be performed at low stringency with buffers, such as 5×SSC with 1% sodium dodecyl sulfate (SDS) at 60° C., which permits hybridization between probe and target sequences that contain some mismatches to form probe/target complexes. Subsequent washes are performed at higher stringency with buffers such as 0.2×SSC with 0.1% SDS at either 45° C. (medium stringency) or 68° C. (high stringency), to maintain hybridization of only those probe/target complexes that contain completely complementary sequences. Background signals can be reduced by the use of detergents such as SDS, Sarcosyl, or Triton X-100, or a blocking agent, such as salmon sperm DNA.

[0073] Hybridization specificity can be evaluated by comparing the hybridization of control probe to target sequences that are added to a sample in a known amount. The control probe may have one or more sequence mismatches compared with the corresponding target. In this manner, it is possible to evaluate whether only complementary targets are hybridizing to the probes or whether mismatched hybrid duplexes are forming.

[0074] Hybridization reactions can be performed in absolute or differential hybridization formats. In the absolute hybridization format, targets from one sample are hybridized to microarray elements, and signals detected after hybridization complexes form. Signal strength correlates with target levels in a sample. In the differential hybridization format, differential expression of a set of genes in two biological samples is analyzed. Targets from the two samples are prepared and labeled with different labeling moieties. A mixture of the two labeled targets is hybridized to the microarray elements, and signals are examined under conditions in which the emissions from the two different labels are individually detectable. Probes in the microarray that are hybridized to substantially equal numbers of targets derived from both biological samples give a distinct combined fluorescence (Shalon et al., PCT publication WO95/35505). In a preferred embodiment, the labels are fluorescent labels with distinguishable emission spectra, such as a lissamine conjugated nucleotide analog and a fluorescein conjugated nucleotide analog. In another embodiment Cy3 and Cy5 fluorophores (Amersham Pharmacia Biotech, Piscataway N.J.) are employed.

[0075] After hybridization, the microarray is washed to remove nonhybridized polynucleotides, and complex formation between the hybridizable array elements and the targets is examined. Methods for detecting complex formation are well known to those skilled in the art. In a preferred embodiment, the targets are labeled with a fluorescent label, and measurement of levels and patterns of fluorescence indicative of complex formation is accomplished by fluorescence microscopy, preferably confocal fluorescence microscopy. An argon ion laser excites the fluorescent label, emissions are directed to a photomultiplier, and the amount of emitted light is detected and quantitated. The detected signal should be proportional to the amount of probe/target complexes at each position of the microarray. The fluorescence microscope can be associated with a computer-driven scanner device to generate a quantitative two-dimensional image of hybridization intensity. The scanned image is examined to determine the abundance/expression level of hybridized target.

[0076] Typically, microarray fluorescence intensities can be normalized to take into account variations in hybridization intensities when more than one microarray is used under similar test conditions. In a preferred embodiment, individual polynucleotide probe/target complex hybridization intensities are normalized using the intensities derived from internal normalization controls contained on each microarray.

[0077] III. Screening Assays

[0078] Probes may be used to screen a library of molecules or compounds for specific binding affinity. The libraries may be DNA molecules, RNA molecules, PNAs, peptides, proteins such as transcription factors, enhancers, repressors, and other organic or inorganic ligands which regulate activities such as replication, transcription, or translation of polynucleotides in the biological system. The assay involves combining the probe with the library of molecules or compounds under conditions allowing specific binding, and detecting specific binding of a ligand to the probe.

[0079] IV. Purification of Ligand

[0080] Probes may be used to purify a ligand from a sample. A method for using a probe to purify a ligand would involve combining the probe with a sample under conditions to allow specific binding, detecting specific binding, recovering the bound protein, and using an appropriate agent to separate the polynucleotide from the purified ligand.

[0081] Protein Production and Uses

[0082] I. Expression of Encoded Proteins

[0083] Polynucleotides of the invention may be cloned into a vector and used to express the encoded protein or portions thereof in host cells. The polynucleotides can be engineered by such methods as DNA shuffling (Stemmer and Crameri, U.S. Pat. No. 5,830,721 incorporated by reference herein) and site-directed mutagenesis to create new restriction sites, alter glycosylation patterns, change codon preference to increase expression in a particular host, produce splice variants, extend half-life, and the like. The expression vector may contain transcriptional and translational control elements (promoters, enhancers, specific initiation signals, and 3′ polyadenylation sequence) from various sources which have been selected for their efficiency in a particular host. The vector, polynucleotide, and regulatory elements are combined using in vitro recombinant DNA techniques, synthetic techniques, and/or in vivo genetic recombination techniques well known in the art and described in Sambrook (supra, ch. 4, 8, 16 and 17).

[0084] A variety of host systems may be transformed with an expression vector. These include, but are not limited to, bacteria transformed with recombinant bacteriophage, plasmid, or cosmid DNA expression vectors; yeast transformed with yeast expression vectors; insect cell systems transformed with baculovirus expression vectors; plant cell systems transformed with expression vectors containing viral and/or bacterial elements; or animal cell systems (Ausubel supra, Unit 16). For example, an adenovirus transcription/translation complex may be utilized in mammalian cells. After sequences are ligated into the E1 or E3 region of the viral genome, infective virus are used to transform and express the protein in host cells. The Rous sarcoma virus enhancer or SV40 or EBV-based vectors may also be used for high-level protein expression.

[0085] Routine cloning, subcloning, and propagation of polynucleotides can be achieved using the multifunctional PBLUESCRIPT vector (Stratagene, La Jolla Calif.) or PSPORT1 plasmid (Life Technologies). Introduction of a nucleic acid sequence into the multiple cloning site of these vectors disrupts the lacZ gene and allows calorimetric screening for transformed bacteria. In addition, these vectors may be useful for in vitro transcription, dideoxy sequencing, single strand rescue with helper phage, and creation of nested deletions in the cloned sequence.

[0086] For long term production of recombinant proteins, the vector can be stably transformed into cell lines along with a selectable or visible marker gene on the same or on a separate vector. After transformation, cells are allowed to grow for about 1 to 2 days in enriched media and then are transferred to selective media. Selectable markers, such as antimetabolite, antibiotic, or herbicide resistance genes, confer resistance to the relevant selective agent and allow growth and recovery of cells which successfully express the introduced sequences. Resistant clones identified either by survival on selective media or by the expression of visible markers, such as anthocyanins, green fluorescent protein (GFP), βglucuronidase, luciferase, and the like, may be propagated using culture techniques. Visible markers are also used to quantify the amount of protein expressed by the introduced genes. Verification that the host cell contains the desired polynucleotide is based on DNA-DNA or DNA-RNA hybridizations or PCR amplification techniques.

[0087] The host cell may be chosen for its ability to modify a recombinant protein in a desired fashion. Such modifications include acetylation, carboxylation, glycosylation, phosphorylation, lipidation, acylation and the like. Post-translational processing which cleaves a “prepro” form may also be used to specify protein targeting, folding, and/or activity. Different host cells available from the American Type Culture Collection (Manassas Va.) which have specific cellular machinery and characteristic mechanisms for post-translational activities may be chosen to ensure the correct modification and processing of the recombinant protein.

[0088] II. Recovery of Proteins from Cell Culture

[0089] Heterologous moieties engineered into a vector for ease of purification include glutathione S-transferase (GST), calmodulin binding peptide (CBP), 6-His, FLAG, MYC, and the like. GST, CBP, and 6-His are purified using commercially available affinity matrices such as immobilized glutathione, calmodulin, and metal-chelate resins, respectively. FLAG and MYC are purified using commercially available monoclonal and polyclonal antibodies. A proteolytic cleavage site may be located between the desired protein sequence and the heterologous moiety for ease of separation following purification. Methods for recombinant protein expression and purification are discussed in Ausubel (supra, unit 16) and are commercially available.

[0090] III. Screening Assays

[0091] A protein or a portion thereof transcribed and translated from a probe may be used to screen libraries of molecules or compounds in any of a variety of screening assays. The protein or portion thereof may be free in solution, affixed to an abiotic or biotic substrate, borne on a cell surface, or located intracellularly. Specific binding between the protein and a ligand may be measured. Depending on the kind of library being screened, the assay may be used to identify DNA, RNA, PNAs, agonists, antagonists, antibodies, immunoglobulins, inhibitors, mimetics, peptides, proteins, drugs, or any other ligand, which specifically binds the protein. One method for high throughput screening using very small assay volumes and very small amounts of test compound is described by Burbaum et al. (U.S. Pat. No. 5,876,946; incorporated herein by reference) which screens large numbers of molecules for enzyme inhibition or receptor binding.

[0092] The protein may be used in screening assays of phagemid or B-lymphocyte immunoglobulin libraries to identify antibodies having the desired specificity. Numerous protocols for competitive binding or immunoassays using either polyclonal or monoclonal antibodies with established specificities are well known in the art. Such immunoassays typically involve the measurement of complex formation between the protein and its specific antibody. The method may employ a two-site, monoclonal-based immunoassay utilizing monoclonal antibodies reactive to two non-interfering epitopes or a competitive binding assay (Pound (1998) Immunochemical Protocols, Humana Press, Totowa N.J.).

[0093] IV. Purification of a Ligand

[0094] The encoded protein or a portion thereof may be used to purify a ligand from a sample. A method for using a protein or a portion thereof to purify a ligand would involve combining the protein or a portion thereof with a sample under conditions to allow specific binding, detecting specific binding between the protein and ligand, recovering the bound protein, and using an appropriate agent to separate the protein from the purified ligand.

[0095] V. Chemical Synthesis of Peptides

[0096] Proteins or portions thereof may be produced not only by recombinant methods, but also by using chemical methods well known in the art. Solid phase peptide synthesis may be carried out in a batchwise or continuous flow process which sequentially adds α-amino and side chain-protected amino acid residues to an insoluble polymeric support via a linker group. A linker group such as methylamine-derivatized polyethylene glycol is attached to poly(styrene-co-divinylbenzene) to form the support resin. The amino acid residues are N-α-protected by acid labile Boc (t-butyloxycarbonyl) or base-labile Fmoc (9-fluorenylmethoxycarbonyl). The carboxyl group of the protected amino acid is coupled to the amine of the linker group to anchor the residue to the solid phase support resin. Trifluoroacetic acid or piperidine are used to remove the protecting group in the case of Boc or Fmoc, respectively. Each additional amino acid is added to the anchored residue using a coupling agent or pre-activated amino acid derivative, and the resin is washed. The full length peptide is synthesized by sequential deprotection, coupling of derivitized amino acids, and washing with dichloromethane and/or N,N-dimethylformamide. The peptide is cleaved between the peptide carboxy terminus and the linker group to yield a peptide acid or amide. (Novabiochem 1997/98 Catalog and Peptide Synthesis Handbook, San Diego Calif., pp. S1-S20). Automated synthesis may also be carried out on machines such as the ABI 431A peptide synthesizer (PE Biosystems, Foster City Calif.). A protein or portion thereof may be substantially purified by preparative high performance liquid chromatography and its composition confirmed by amino acid analysis or by sequencing (Creighton (1984) Proteins, Structures and Molecular Properties, WH Freeman, New York N.Y.).

[0097] Preparation of Antibodies

[0098] Various hosts including goats, rabbits, rats, mice, humans, and others may be immunized by injection with protein or any portion thereof. Adjuvants such as Freund's, mineral gels, and surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemacyanin (KLH), and dinitrophenol may be used to increase immunological response. The oligopeptide, peptide, or portion of protein used to induce antibodies should consist of at least about five amino acids, more preferably ten amino acids, which are identical to a portion of the natural protein. Oligonucleotides may be fused with proteins such as KLH in order to produce antibodies to the chimeric molecule.

[0099] Monoclonal antibodies may be prepared using any technique which provides for the production of antibodies by continuous cell lines in culture. These include, but are not limited to, the hybridoma technique, the human B-cell hybridoma technique, and the EBV-hybridoma technique. (Kohler et al. (1975) Nature 256:495497; Kozbor et al. (1985) J. Immunol. Methods 81:31-42; Cote et al. (1983) Proc. Natl. Acad. Sci. 80:2026-2030; and Cole et al. (1984) Mol. Cell Biol. 62:109-120.)

[0100] Alternatively, techniques described for the production of single chain antibodies may be adapted, using methods known in the art, to produce epitope specific single chain antibodies. Antibody fragments which contain specific binding sites for epitopes of the mammalian protein may also be generated. For example, such fragments include, but are not limited to, F(ab′)2 fragments produced by pepsin digestion of the antibody molecule and Fab fragments generated by reducing the disulfide bridges of the F(ab′)2 fragments. Alternatively, Fab expression libraries may be constructed to allow rapid and easy identification of monoclonal Fab fragments with the desired specificity. (Huse et al. (1989) Science 246:1275-1281.)

[0101] Labeling of Molecules for Assay

[0102] A wide variety of labeling moieties and conjugation techniques are known by those skilled in the art and may be used in various nucleic acid, amino acid, and antibody assays. Synthesis of labeled molecules may be achieved using Promega (Madison Wis.) or Amersham Pharmacia Biotech kits for incorporation of a labeled nucleotide such as ³²P-dCTP, Cy3-dCTP or Cy5-dCTP or amino acid such as ³⁵S-methionine. Nucleotides and amino acids may be directly labeled with a variety of substances including fluorescent, chemiluminescent, or chromogenic agents, and the like, by chemical conjugation to amines, thiols and other groups present in the molecules using reagents such as BIODIPY or FITC (Molecular Probes, Eugene Oreg.).

[0103] Diagnostics

[0104] The polynucleotides, or fragments thereof, may be used to detect and quantify altered gene expression; absence, presence, or excess expression of mRNAs; or to monitor mRNA levels during therapeutic intervention. Conditions, diseases or disorders associated with altered expression include pro-inflammatory disorders such as organ-specific autoimmune disorders including insulin-dependent diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Crohn's disease and pemphigus vulgaris; and anti-inflammatory disorders including allergies and other atopic disorders, transplantation tolerance, chronic graft versus host disease, and sytemic autoimmune diseases such as systemic lupus erythematosus. In addition to disorders, the polynucleotides are useful for monitoring the progression of infectious diseases including, but not limited to, tuberculosis, leprosy, Leishmania, and viral infections such as HIV infection. These polynucleotides can also be utilized as markers of treatment efficacy against the diseases noted above and other immune disorders, conditions, and diseases over a period ranging from several days to months. The diagnostic assay may use hybridization or amplification technology to compare gene expression in a biological sample from a patient to standard samples in order to detect altered gene expression. Qualitative or quantitative methods for this comparison are well known in the art.

[0105] For example, the polynucleotide may be labeled by standard methods and added to a biological sample from a patient under conditions for the formation of hybridization complexes. After an incubation period, the sample is washed and the amount of label (or signal) associated with hybridization complexes, is quantified and compared with a standard value. If the amount of label in the patient sample is significantly altered in comparison to the standard value, then the presence of the associated condition, disease or disorder is indicated.

[0106] In order to provide a basis for the diagnosis of a condition, disease or disorder associated with gene expression, a normal or standard expression profile is established. This may be accomplished by combining a biological sample taken from normal subjects, either animal or human, with a probe under conditions for hybridization or amplification. Standard hybridization may be quantified by comparing the values obtained using normal subjects with values from an experiment in which a known amount of a substantially purified target sequence is used. Standard values obtained in this manner may be compared with values obtained from samples from patients who are symptomatic for a particular condition, disease, or disorder. Deviation from standard values toward those associated with a particular condition is used to diagnose that condition.

[0107] Such assays may also be used to evaluate the efficacy of a particular therapeutic treatment regimen in animal studies and in clinical trial or to monitor the treatment of an individual patient. Once the presence of a condition is established and a treatment protocol is initiated, diagnostic assays may be repeated on a regular basis to determine if the level of expression in the patient begins to approximate that which is observed in a normal subject. The results obtained from successive assays may be used to show the efficacy of treatment over a period ranging from several days to months.

[0108] Gene Expression Profiles

[0109] A gene expression profile comprises a plurality of probes and a plurality of detectable hybridization complexes, wherein each complex is formed by hybridization of one or more probes to one or more complementary targets in a sample. The polynucleotide composition of the invention is used as probes on a microarray to analyze gene expression profiles. In one embodiment, the microarray is used to monitor the progression of disease. Researchers can assess and catalog the differences in gene expression between healthy and diseased tissues or cells. By analyzing changes in patterns of gene expression, disease can be diagnosed at earlier stages before the patient is symptomatic. The invention can be used to formulate a prognosis and to design a treatment regimen. The invention can also be used to monitor the efficacy of treatment. For treatments with known side effects, the microarray is employed to improve the treatment regimen. A dosage is established that causes a change in genetic expression patterns indicative of successful treatment. Expression patterns associated with the onset of undesirable side effects are avoided. This approach may be more sensitive and rapid than waiting for the patient to show inadequate improvement, or to manifest side effects, before altering the course of treatment.

[0110] In another embodiment, animal models which mimic a human disease can be used to characterize expression profiles associated with a particular condition, disorder or disease or treatment of the condition, disorder or disease. Novel treatment regimens may be tested in these animal models using microarrays to establish and then follow expression profiles over time. In addition, microarrays may be used with cell cultures or tissues removed from animal models to rapidly screen large numbers of candidate drug molecules, looking for ones that produce an expression profile similar to those of known therapeutic drugs, with the expectation that molecules with the same expression profile will likely have similar therapeutic effects. Thus, the invention provides the means to rapidly determine the molecular mode of action of a drug.

[0111] Assays Using Antibodies

[0112] Antibodies directed against epitopes on a protein encoded by a polynucleotide of the invention may be used in assays to quantify the amount of protein found in a particular human cell. Such assays include methods utilizing the antibody and a label to detect expression level under normal or disease conditions. The antibodies may be used with or without modification, and labeled by joining them, either covalently or noncovalently, with a labeling moiety.

[0113] Protocols for detecting and measuring protein expression using either polyclonal or monoclonal antibodies are well known in the art. Examples include ELISA, RIA, and fluorescent activated cell sorting (FACS). Such immunoassays typically involve the formation of complexes between the protein and its specific antibody and the measurement of such complexes. These and other assays are described in Pound (supra). The method may employ a two-site, monoclonal-based immunoassay utilizing monoclonal antibodies reactive to two non-interfering epitopes, or a competitive binding assay. (See, e.g., Coligan et al. (1997) Current Protocols in Immunology, Wiley-Interscience, New York N.Y.; Pound, supra)

[0114] Therapeutics

[0115] The polynucleotides of the present invention are useful in antisense technology. Target protein expression is modulated through the specific binding of an antisense probe sequence to a target sequence which either encodes the target protein or directs its expression. The antisense probe can be DNA, RNA, or nucleic acid mimics and analogs. The target sequence can be cellular mRNA and/or genomic DNA and binding of the antisense sequence can affect translation and/or transcription, respectively. (Rossi et al. (1991) Antisense Res. Dev. 1(3):285-288; Lee et al. (1998) Biochemistry 37(3):900-1010; Pardridge et al. (1995) Proc. Nat. Acad. Sci. 92(12):5592-5596; and Nielsen and Haaima (1997) Chem. Soc. Rev. 96:73-78.)

[0116] The polynucleotides of the present invention and fragments thereof can be used as antisense sequences to modify the expression of the protein encoded by the polynucleotide. The antisense sequences can be produced ex vivo, for example by using any of the nucleic acid synthesizers or other automated systems known in the art. Antisense sequences can also be produced by in vitro transcription or amplification (Agrawal, supra). In therapeutic use, any gene delivery system suitable for introduction of the antisense sequences into appropriate target cells can be used. Antisense sequences can be delivered intracellularly in the form of an expression plasmid which, upon transcription, produces a sequence complementary to at least a portion of the cellular sequence encoding the target protein. (See, e.g., Slater et al. (1998) J. Allergy Cli. Immunol. 102(3):469-475; and Scanlon et al. (1995) 9(13): 1288-1296.) Antisense sequences can also be introduced intracellularly through the use of viral vectors, such as retrovirus and adeno-associated virus vectors. (See, e.g., Miller (1990) Blood 76:271; Ausubel, supra; Uckert and Walther (1994) Pharmacol. Ther. 63(3):323-347.) Other gene delivery mechanisms include liposome-derived systems, artificial viral envelopes, and other systems known in the art. (See, e.g., Rossi (1995) Br. Med. Bull. 51(1):217-225; Boado et al. (1998) J. Pharm. Sci. 87(11):1308-1315; and Morris et al. (1997) Nucleic Acids Res. 25(14):2730-2736.)

[0117] Molecules which modulate the expression of a polynucleotide of the invention or activity of the encoded protein are useful as therapeutics for conditions and disorders associated with an immune response. Such molecules include agonists which increase the expression or activity of the polynucleotide or encoded protein, respectively; or antagonists which decrease expression or activity of the polynucleotide or encoded protein, respectively. In one aspect, an antibody which specifically binds the protein may be used directly as an antagonist or indirectly as a targeting or delivery mechanism for bringing a pharmaceutical agent to cells or tissues which express the protein.

[0118] Additionally, any of the proteins or their ligands, or complementary nucleic acid sequences may be administered in combination with other appropriate therapeutic agents. Selection of the appropriate agents for use in combination therapy may be made by one of ordinary skill in the art, according to conventional pharmaceutical principles. The combination of therapeutic agents may act synergistically to effect the treatment or prevention of the conditions and disorders associated with an immune response. Using this approach, one may be able to achieve therapeutic efficacy with lower dosages of each agent, thus reducing the potential for adverse side effects. Further, the therapeutic agents may be combined with pharmaceutically-acceptable carriers including excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. Further details on techniques for formulation and administration may be found in the latest edition of Remington's Pharmaceutical Sciences (Maack Publishing Co., Easton Pa.).

[0119] It is understood that this invention is not limited to the particular methodology, protocols, and reagents described, as these may vary. It is also understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims. The examples below are provided to illustrate the subject invention and are not included for the purpose of limiting the invention.

EXAMPLES

[0120] I. Construction of cDNA Libraries

[0121] RNA was purchased from CLONTECH Laboratories, Inc. (Palo Alto Calif.) or isolated from various tissues. Some tissues were homogenized and lysed in guanidinium isothiocyanate, while others were homogenized and lysed in phenol or in a suitable mixture of denaturants, such as TRIZOL reagent (Life Technologies). The resulting lysates were centrifuged over CsCl cushions or extracted with chloroform. RNA was precipitated with either isopropanol or ethanol and sodium acetate, or by other routine methods.

[0122] Phenol extraction and precipitation of RNA were repeated as necessary to increase RNA purity. In most cases, RNA was treated with DNase. For most libraries, poly(A) RNA was isolated using oligo d(T)-coupled paramagnetic particles (Promega), OLIGOTEX latex particles (QIAGEN, Valencia Calif.), or an OLIGOTEX mRNA purification kit (QIAGEN). Alternatively, poly(A) RNA was isolated directly from tissue lysates using other kits, including the POLY(A)PURE mRNA purification kit (Ambion, Austin Tex.).

[0123] In some cases, Stratagene was provided with RNA and constructed the corresponding cDNA libraries. Otherwise, cDNA was synthesized and cDNA libraries were constructed with the UNIZAP vector system (Stratagene) or SUPERSCRIPT plasmid system (Life Technologies) using the recommended procedures or similar methods known in the art. (See Ausubel, supra, Units 5.1 through 6.6.) Reverse transcription was initiated using oligo d(T) or random primers. Synthetic oligonucleotide adapters were ligated to double stranded cDNA, and the cDNA was digested with the appropriate restriction enzyme or enzymes. For most libraries, the cDNA was size-selected (300-1000 bp) using SEPHACRYL S1000, SEPHAROSE CL2B, or SEPHAROSE CL4B column chromatography (Amersham Pharmacia Biotech) or preparative agarose gel electrophoresis. cDNAs were ligated into compatible restriction enzyme sites of the polylinker of the PBLUESCRIPT plasmid (Stratagene), PSPORT1 plasmid (Life Technologies), or PINCY plasmid (Incyte Pharmaceuticals, Palo Alto Calif.). Recombinant plasmids were transformed into XL1-Blue, XL1-BlueMRF, or SOLR competent E. coli cells (Stratagene) or DH5α, DH10B, or ELECTROMAX DH10B competent E. coli cells (Life Technologies).

[0124] In some cases, libraries were superinfected with a 5×excess of the helper phage, M13K07, according to the method of Vieira et al. (1987, Methods Enzymol. 153:3-11) and normalized or subtracted using a methodology adapted from Soares (ura), Swaroop et al. (1991, Nucl. Acids Res. 19:1954), and Bonaldo et al. (1996, Genome Research 6:791-806). The modified Soares normalization procedure was utilized to reduce the repetitive cloning of highly expressed high abundance cDNAs while maintaining the overall sequence complexity of the library. Modification included significantly longer hybridization times which allowed for increased gene discovery rates by biasing the normalized libraries toward those infrequently expressed low-abundance cDNAs which are poorly represented in a standard transcript image (Soares et al. (1994) Proc. Natl. Acad. Sci. 91:9228-9232).

[0125] II. Isolation and Sequencing of cDNA Clones

[0126] Plasmids were recovered from host cells by in vivo excision using the UNIZAP vector system (Stratagene) or by cell lysis. Plasmids were purified using one of the following: the Magic or WIZARD Minipreps DNA purification system (Promega); the AGTC Miniprep purification kit (Edge BioSystems, Gaithersburg Md.); the QIAWELL 8, QIAWELL 8 Plus, or QIAWELL 8 Ultra plasmid purification systems, or the R.E.A.L. PREP 96 plasmid purification kit (QIAGEN). Following precipitation, plasmids were resuspended in 0.1 ml of distilled water and stored, with or without lyophilization, at 4° C.

[0127] Alternatively, plasmid DNA was amplified from host cell lysates using direct link PCR in a high-throughput format (Rao (1994) Anal. Biochem. 216:1-14). Host cell lysis and thermal cycling steps were carried out in a single reaction mixture. Samples were processed and stored in 384-well plates, and the concentration of amplified plasmid DNA was quantified fluorometrically using PICOGREEN dye (Molecular Probes) and a FLUOROSKAN II fluorescence scanner (Labsystems Oy, Helsinki, Finland).

[0128] cDNA sequencing reactions were processed using standard methods or high-throughput instrumentation such as the ABI CATALYST 800 thermal cycler (PE Biosystems) or the DNA ENGINE thermal cycler (MJ Research, Watertown Mass.) in conjunction with the HYDRA microdispenser (Robbins Scientific, Sunnyvale Calif.) or the MICROLAB 2200 system (Hamilton). cDNA sequencing reactions were prepared using reagents provided by Amersham Pharmacia Biotech or supplied in ABI sequencing kits such as the ABI PRISM BIGDYE cycle sequencing kit (PE Biosystems). Electrophoretic separation of cDNA sequencing reactions and detection of labeled polynucleotides were carried out using the MEGABACE 1000 DNA sequencing system (Amersham Pharmacia Biotech); the ABI PRISM 373 or 377 sequencing system (PE Biosystems) in conjunction with standard ABI protocols and base calling software; or other sequence analysis systems known in the art. Reading frames within the cDNA sequences were identified using standard methods (reviewed in Ausubel, supra, Unit 7.7).

[0129] III. Extension of cDNA Sequences

[0130] Nucleic acid sequences were extended using Incyte cDNA clones and oligonucleotide primers. One primer was synthesized to initiate 5′ extension of the known fragment, and the other, to initiate 3′ extension of the known fragment. The initial primers were designed using OLIGO 4.06 software (National Biosciences), or another appropriate program, to be about 22 to 30 nucleotides in length, to have a GC content of about 50% or more, and to anneal to the target sequence at temperatures of about 68° C. to about 72° C. Any stretch of nucleotides which would result in hairpin structures and primer-primer dimerizations was avoided.

[0131] Selected human cDNA libraries were used to extend the sequence. If more than one extension was necessary or desired, additional or nested sets of primers were designed. Preferred libraries are ones that have been size-selected to include larger cDNAs. Also, random primed libraries are preferred because they will contain more sequences with the 5′ and upstream regions of genes. A randomly primed library is particularly useful if an oligo d(T) library does not yield a full-length cDNA.

[0132] High fidelity amplification was obtained by PCR using methods well known in the art. PCR was performed in 96-well plates using the DNA ENGINE thermal cycler (PTC-200; MJ Research). The reaction mix contained DNA template, 200 nmol of each primer, reaction buffer containing Mg²⁺, (NH₄)₂SO₄, and β-mercaptoethanol, Taq DNA polymerase (Amersham Pharmacia Biotech), ELONGASE enzyme (Life Technologies), and Pfu DNA polymerase (Stratagene), with the following parameters for primer pair PCI A and PCI B (Incyte Pharmaceuticals): Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 60° C., 1 min; Step 4: 68° C., 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68° C., 5 min; Step 7: storage at 4° C. In the alternative, the parameters for primer pair T7 and SK+ (Stratagene) were as follows: Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 57° C., 1 min; Step 4: 68° C., 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68° C., 5 min; Step 7: storage at 4° C.

[0133] The concentration of DNA in each well was determined by dispensing 100 μl PICOGREEN reagent (Molecular Probes; 0.25% reagent in 1×TE, v/v) and 0.5 μl of undiluted PCR product into each well of an opaque fluorimeter plate (Corning Costar, Acton MA) and allowing the DNA to bind to the reagent. The plate was scanned in a Fluoroskan II (Labsystems Oy) to measure the fluorescence of the sample and to quantify the concentration of DNA. A 5 μl to 10 μl aliquot of the reaction mixture was analyzed by electrophoresis on a 1% agarose mini-gel to determine which reactions were successful in extending the sequence.

[0134] The extended nucleic acids were desalted and concentrated, transferred to 384-well plates, digested with CviJI cholera virus endonuclease (Molecular Biology Research, Madison Wis.), and sonicated or sheared prior to religation into pUC18 vector (Amersham Pharmacia Biotech). For shotgun sequencing, the digested nucleic acids were separated on low concentration (0.6 to 0.8%) agarose gels, fragments were excised, and agar digested with AGARACE enzyme (Promega). Extended clones were religated using T4 DNA ligase (New England Biolabs, Beverly Mass.) into pUC18 vector (Amersham Pharmacia Biotech), treated with Pfu DNA polymerase (Stratagene) to fill-in restriction site overhangs, and transfected into competent E. coli cells. Transformed cells were selected on antibiotic-containing media, and individual colonies were picked and cultured overnight at 37° C. in 384-well plates in LB/2×carbenicillin liquid media.

[0135] The cells were lysed, and DNA was amplified by PCR using Taq DNA polymerase (Amersham Pharmacia Biotech) and Pfu DNA polymerase (Stratagene) with the following parameters: Step 1: 94° C., 3 min; Step 2: 94° C., 15 sec; Step 3: 60° C., 1 min; Step 4: 72° C., 2 min; Step 5: steps 2, 3, and 4 repeated 29 times; Step 6: 72° C., 5 min; Step 7: storage at 4° C. DNA was quantified using PICOGREEN reagent (Molecular Probes) as described above. Samples with low DNA recoveries were reamplified using the same conditions described above. Samples were diluted with 20% dimethylsulfoxide (DMSO; 1:2, v/v), and sequenced using DYENAMIC energy transfer sequencing primers and the DYENAMIC DIRECT cycle sequencing kit (Amersham Pharmacia Biotech) or the ABI PRISM BIGDYE terminator cycle sequencing kit (PE Biosystems).

[0136] IV. Assembly and Analysis of Sequences

[0137] Component nucleotide sequences from chromatograms were subjected to PHRED analysis (Phil's Revised Editing Program; Phil Green, University of Washington, Seattle Wash.) and assigned a quality score. The sequences having at least a required quality score were subject to various pre-processing algorithms to eliminate low quality 3′ ends, vector and linker sequences, polyA tails, Alu repeats, mitochondrial and ribosomal sequences, bacterial contamination sequences, and sequences smaller than 50 base pairs.

[0138] Sequences were screened using the BLOCK 2 program (Incyte Pharmaceuticals), a motif analysis program based on sequence information contained in the SWISS-PROT and PROSITE databases (Bairoch et al. (1997) Nucleic Acids Res. 25:217-221; Attwood et al. (1997) J. Chem. Inf. Comput. Sci. 37:417-424).

[0139] Processed sequences were subjected to assembly procedures in which the sequences were assigned to bins, one sequence per bin. Sequences in each bin were assembled to produce consensus sequences, templates. Subsequent new sequences were added to existing bins using the Basic Local Alignment Search Tool (BLAST; Altschul (1993) J. Mol. Evol. 36:290-300; Altschul et al. (1990) J. Mol. Biol. 215:403410; Karlin et al. (1988) Proc. Natl. Acad. Sci. 85:841-845), BLASTn (v.1.4, WashU), and CROSSMATCH software (Phil Green, supra). Candidate pairs were identified as all BLAST hits having a quality score greater than or equal to 150. Alignments of at least 82% local identity were accepted into the bin. The component sequences from each bin were assembled using PHRAP (Phil's Revised Alignment Program; Phil Green, supra). Bins with several overlapping component sequences were assembled using DEEP PHRAP (Phil Green, supra).

[0140] Bins were compared against each other, and those having local similarity of at least 82% were combined and reassembled. Reassembled bins having templates of insufficient overlap (less than 95% local identity) were re-split. Assembled templates were also subjected to analysis by STITCHER/EXON MAPPER algorithms which analyzed the probabilities of the presence of splice variants, alternatively spliced exons, splice junctions, differential expression of alternative spliced genes across tissue types, disease states, and the like. These resulting bins were subjected to several rounds of the above assembly procedures to generate the template sequences found in the LIFESEQ GOLD database (Incyte Pharmaceuticals).

[0141] The assembled templates were annotated using the following procedure. Template sequences were analyzed using BLASTn (v2.0, NCBI) versus GBpri (GenBank version 109). “Hits” were defined as an exact match having from 95% local identity over 200 base pairs through 100% local identity over 100 base pairs, or a homolog match having an E-value of ≦1×10⁻⁸. The hits were subjected to frameshift FASTx versus GENPEPT (GenBank version 109). In this analysis, a homolog match was defined as having an E-value of ≦1×10⁻⁸. The assembly method used above was described in “Database and System for Storing, Comparing and Displaying Related Biomolecular Sequence Information,” U.S. Ser. No. 09/276,534, filed Mar. 25, 1999, incorporated by reference herein, and the LIFESEQ GOLD user manual (Incyte Pharmaceuticals).

[0142] Following assembly, template sequences were subjected to motif, BLAST, Hidden Markov Model (HMM; Pearson and Lipman (1988) Proc. Natl. Acad. Sci. 85:2444-2448; Smith and Waterman (1981) J. Mol. Biol. 147:195-197), and functional analyses, and categorized in protein hierarchies using methods described in “Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data,” U.S. Ser. No. 08/812,290, filed Mar. 6, 1997; “Relational Database for Storing Biomolecule Information,” U.S. Ser. No. 08/947,845, filed Oct. 9, 1997; “Project-Based Full-Length Biomolecular Sequence Database,” U.S. Pat. No. 5,953,727; and “Relational Database and System for Storing Information Relating to Biomolecular Sequences,” U.S. Ser. No. 09/034,807, filed Mar. 4, 1998, all of which are incorporated by reference herein. Template sequences may be further queried against public databases such as the GenBank rodent, mammalian, vertebrate, eukaryote, prokaryote, and human EST databases.

[0143] V. Preparation of Microarrays

[0144] The polynucleotides present on the human GENEALBUM GEM series 1-6 microarrays (Incyte Pharmaceuticals) represent template sequences derived from the LIFESEQ GOLD assembled human sequence database (Incyte Pharmaceuticals). In cases where more than one clone was available for a particular template, the 5′-most clone in the template was used on the microarray. Polynucleotides were amplified from bacterial cells using primers complementary to vector sequences flanking the cDNA insert. Thirty cycles of PCR increased the initial quantity of polynucleotide from 1-2 ng to a final quantity greater than 5 μg. Amplified polynucleotides were then purified using SEPHACRYL-400 columns (Amersham Pharmacia Biotech).

[0145] Purified polynucleotides were immobilized on polymer-coated glass slides. Glass microscope slides (Corning, Corning N.Y.) were cleaned by ultrasound in 0.1% SDS and acetone, with extensive distilled water washes between and after treatments. Glass slides were etched in 4% hydrofluoric acid (VWR Scientific Products Corporation, West Chester Pa.), washed extensively in distilled water, and coated with 0.05% aminopropyl silane (Sigma, St. Louis Mo.) in 95% ethanol. Coated slides were cured in a 110° C oven. polynucleotides were applied to the coated glass substrate using a procedure described in U.S. Pat. No. 5,807,522, incorporated herein by reference. One microliter of the polynucleotide at an average concentration of 100 ng/ul was loaded into the open capillary printing element by a high-speed robotic apparatus which then deposited about 5 nl of polynucleotide per slide.

[0146] Microarrays were V-crosslinked using a STRATALINKER UV-crosslinker (Stratagene), and then washed at room temperature once in 0.2% SDS and three times in distilled water. Non-specific binding sites were blocked by incubation of microarrays in 0.2% casein in phosphate buffered saline (Tropix, Bedford Mass.) for 30 minutes at 60° C. followed by washes in 0.2% SDS and distilled water as before.

[0147] VI. Preparation of Target Polynucleotides

[0148] Cytokine Treatment of PBMCs

[0149] Peripheral blood mononuclear cells (PBMCs) were isolated from freshly obtained peripheral blood of two healthy donors by centrifugation of the lymphocyte enriched blood fraction over a HYPAQUE ficoll gradient (Sigma). The isolated PBMCs were grown in Yssel's media (Yssel (1984) J. Immunol. Methods 72:219-225) supplemented with 1% pooled type AB human serum. About 2×10⁷ .PBMCs from each donor were treated with Group A (pro-inflammatory) cytokines for two hours at 37° C., at the following concentrations: IL-1β, at 10 ng/ml (R&D Systems, Minneapolis Minn.); IL-2 at 10 ng/mil (R&D Systems); IL-6 at 10 ng/ml (R&D Systems); IL-8 at 10 ng/ml (R&D Systems); IL-12 at 1 ng/ml (R&D Systems); IL-18 at 10 ng/ml (Peprotech, Inc., Rockyhill N.J.); TNFα at 10 ng/ml (R&D Systems); and IFNγ at 50 ng/ml (R&D Systems). Similarly, 2×10⁷ PBMCs from each donor were treated with Group B (anti-inflammatory) cytokines for two hours at 37° C., using the following concentrations: IL-3 at 10 ng/ml (R&D Systems); IL-4 at 10 ng/ml (R&D Systems); IL-5 at 10 ng/ml (R&D Systems); IL-7 at 10 ng/ml (R&D Systems); IL-10 at 50 ng/ml (R&D Systems); LIF at 20 ng/ml (R&D Systems); GM-CSF at 10 ng/ml (R&D Systems); G-CSF at 100 ng/ml (R&D Systems); TGFβ at 10 ng/ml (R&D Systems); and leptin at 100 nM (Peprotech). Approximately 1×10⁸ PBMCs from each donor were untreated controls.

[0150] Isolation and Labeling of Target Polynucleotides

[0151] Cells were harvested and lysed in TRIZOL reagent (5×10⁶ cells/1 ml; Life Technologies). Cell lysates were vortexed, incubated at room temperature for 2-3 minutes, and extracted with 0.5 ml chloroform. The extract was mixed, incubated at room temperature for 5 minutes, and centrifuged at 16,000 g for 15 minutes at 4° C. The aqueous layer was collected and an equal volume of isopropanol was added. Samples were mixed, incubated at room temperature for 10 minutes, and centrifuged at 16,000 g for 20 minutes at 4° C. The supernatant was removed and the RNA pellet was washed with 70% ethanol, centrifuged at 16,000 g at 4° C., and resuspended in RNase-free water. The concentration of RNA was determined by measuring the optical density at 260 nm.

[0152] Poly(A) RNA was prepared using an OLIGOTEX mRNA kit (QIAGEN) with the following modifications: OLIGOTEX beads were washed in tubes instead of on spin columns, resuspended in elution buffer, and then loaded onto spin columns to recover mRNA. To obtain maximum yield, the mRNA was eluted twice. Each poly(A) RNA sample was reverse transcribed using MMLV reverse-transcriptase, 0.05 pg/μl oligo-dT primer (21 mer), 1×first strand buffer, 0.03 units/ul RNase inhibitor, 500 uM dATP, 500 uM dGTP, 500 uM dTTP, 40 uM dCTP, and 40 uM either dCTP-Cy3 or dCTP-Cy5 (Amersham Pharmacia Biotech). The reverse transcription reaction was performed in a 25 ml volume containing 200 ng poly(A) RNA using the GEMBRIGHT kit (Incyte Pharmaceuticals). Specific control poly(A) RNAs (YCFR06, YCFR45, YCFR67, YCFR85, YCFR43, YCFR22, YCFR23, YCFR25, YCFR44, YCFR26) were synthesized by in vitro transcription from non-coding yeast genomic DNA (W. Lei, unpublished). As quantitative controls, control mRNAs (YCFR06, YCFR45, YCFR67, and YCFR85) at 0.002 ng, 0.02 ng, 0.2 ng, and 2 ng were diluted into reverse transcription reaction at ratios of 1:100,000, 1:10,000, 1:1000, 1:100 (w/w) to sample mRNA, respectively. To sample differential expression patterns, control mRNAs (YCFR43, YCFR22, YCFR23, YCFR25, YCFR44, YCFR26) were diluted into reverse transcription reaction at ratios of 1:3, 3:1, 1:10, 10:1, 1:25, 25:1 (w/w) to sample mRNA. Reactions were incubated at 37° C. for 2 hr, treated with 2.5 ml of 0.5M sodium hydroxide, and incubated for 20 minutes at 85° C. to the stop the reaction and degrade the RNA.

[0153] Targets were purified using two successive CHROMA SPIN 30 gel filtration spin columns (CLONTECH). Cy3- and Cy5-labeled reaction samples were combined as described below and ethanol precipitated using 1 ml of glycogen (1 mg/ml), 60 ml sodium acetate, and 300 ml of 100% ethanol. The target was then dried to completion using a SpeedVAC system (Savant Instruments Inc., Holbrook N.Y.) and resuspended in 14 μL 5×SSC/0.2% SDS.

[0154] VII. Hybridization and Detection

[0155] Hybridization reactions contained 9 μl of target mixture consisting of 0.2 μg each of Cy3 and Cy5 labeled cDNA synthesis products in 5×SSC, 0.2% SDS hybridization buffer. The targets were assigned the following designations: a) a control experiment where the Cy3 and Cy5 targets were cDNA from untreated PBMCs; b) Cy3 was cDNA from untreated PBMCs and Cy5 was cDNA from Group A treated PBMCs; and c) Cy3 was cDNA from untreated PBMCs and Cy5 was cDNA from Group B treated PBMCs. The target mixture was heated to 65° C. for 5 minutes and was aliquoted onto the microarray surface and covered with an 1.8 cm² coverslip. The microarrays were transferred to a waterproof chamber having a cavity just slightly larger than a microscope slide. The chamber was kept at 100% humidity internally by the addition of 140 μl of 5×SSC in a corner of the chamber. The chamber containing the microarrays was incubated for about 6.5 hours at 60° C. The microarrays were washed for 10 min at 45° C. in low stringency wash buffer (1×SSC, 0.1% SDS), three times for 10 minutes each at 45° C. in high stringency wash buffer (0.1×SSC), and dried.

[0156] Reporter-labeled hybridization complexes were detected with a microscope equipped with an Innova 70 mixed gas 10 W laser (Coherent, Inc., Santa Clara Calif.) capable of generating spectral lines at 488 nm for excitation of Cy3 and at 632 nm for excitation of Cy5. The excitation laser light was focused on the microarray using a 20×microscope objective (Nikon, Inc., Melville N.Y.). The slide containing the microarray was placed on a computer-controlled X-Y stage on the microscope and raster-scanned past the objective. The 1.8 cm×1.8 cm microarray used in the present example was scanned with a resolution of 20 micrometers.

[0157] In two separate scans, the mixed gas multiline laser excited the two fluorophores sequentially. Emitted light was split, based on wavelength, into two photomultiplier tube detectors (PMT R1477; Hamamatsu Photonics Systems, Bridgewater N.J.) corresponding to the two fluorophores. Appropriate filters positioned between the microarray and the photomultiplier tubes were used to filter the signals. The emission maxima of the fluorophores used were 565 nm for Cy3 and 650 nm for Cy5. Each microarray was typically scanned twice, one scan per fluorophore using the appropriate filters at the laser source, although the apparatus was capable of recording the spectra from both fluorophores simultaneously.

[0158] The sensitivity of the scans was calibrated using the signal intensity generated by a cDNA control species. Samples of the calibrating cDNA were separately labeled with the two fluorophores and identical amounts of each were added to the hybridization mixture. A specific location on the microarray contained a complementary DNA sequence, allowing the intensity of the signal at that location to be correlated with a weight ratio of hybridizing species of 1:100,000.

[0159] The output of the photomultiplier tube was digitized using a 12-bit RTI-835H analog-to-digital (A/D) conversion board (Analog Devices, Inc., Norwood, Mass.) installed in an IBM-compatible PC computer. The digitized data were displayed as an image where the signal intensity was mapped using a linear 20-color transformation to a pseudocolor scale ranging from blue (low signal) to red (high signal). The data was also analyzed quantitatively. Where two different fluorophores were excited and measured simultaneously, the data were first corrected for optical crosstalk (due to overlapping emission spectra) between the fluorophores using each fluorophore's emission spectrum.

[0160] A grid was superimposed over the fluorescence signal image such that the signal from each spot was centered in each element of the grid. The fluorescence signal within each element was then integrated to obtain a numerical value corresponding to the average intensity of the signal. The software used for signal analysis was the GEMTOOLS gene expression analysis program (Incyte Pharmaceuticals).

[0161] VIII. Data Analysis and Results

[0162] Genes which exhibited a ≧2-fold change in expression in cytokine-treated vs untreated controls and displayed a signal intensity over 300 were identified using the GEMTOOLS program (Incyte Pharmaceuticals). The polynucleotides comprising SEQ ID NOs:1-516 as presented in the Sequence Listing showed at least a 2-fold change in expression in response to pro-inflammatory cytokines, anti-inflammatory cytokines, or both pro-and anti-inflammatory cytokines. Comparisons of expression between two different cytokine pools allowed the identification of genes useful in diagnosing a condition associated with pro-inflammatory response such as organ-specific autoimmune disorders including insulin-dependent diabetes mellitus, multiple sclerosis, rheumatoid arthritis, Crohn's disease and pemphigus vulgaris; anti-inflammatory response such as bacterial and parasitic infections, allergies and other atopic disorders, transplantation tolerance, chronic graft versus host disease, and sytemic autoimmune disease including systemic lupus erythematosus; or an immune response encompassing characteristics of both pro- and anti-inflammatory response.

[0163] Tables 1-4 represent various combinations of the polynucleotides of SEQ ID Nos:1-516 that were up or down regulated at least 2-fold in PBMCs in response to human cytokines. Since the polynucleotides were identified solely based on differential expression in cytokine-treated versus untreated tissue, it is not essential to know a priori the name, structure, or function of a particular gene or protein. The usefulness of the human sequences exists in their immediate value as diagnostics for immune response and immune disorders.

[0164] In tables 1-3, columns 1 and 2 list the SEQ ID NO and Incyte clone number, respectively, for the polynucleotides of the invention. Columns 3 and 4 indicate the differential expression of the gene measured at the end of the experiment for pro- and anti-inflammatory cytokine treatment, respectively. Differential expression values are reported as log_(n) [control (untreated)÷cytokine-treated]. A value of −1 indicates a 2-fold increase in expression in response to cytokine treatment.

[0165] Table 1 lists novel polynucleotides differentially regulated at least 2-fold in response to both pro- and anti-inflammatory cytokines. These genes are associated with the general response of PBMCs to signals from the immune system and the infective process.

[0166] Table 2 lists novel polynucleotides differentially regulated at least 2-fold in response to pro-inflammatory cytokines. These genes reflect the response of PBMCs to the mileau of cytokines released during inflammation and represent potentially useful markers for viral infections and autoimmune disorders.

[0167] Table 3 lists novel polynucleotides differentially regulated at least 2-fold in response to anti-inflammatory cytokines. These genes reflect the response of PBMCs to the mileau of cytokines released in opposition of an inflammatory response and represent potentially useful markers for bacterial and parasitic infections and allergic response.

[0168] Table 4 lists known polynucleotides differentially regulated at least 2-fold in response to pro-inflammatory cytokines, anti-inflammatory cytokines, or both pro- and anti-inflammatory cytokines. Some genes identified in table 4, such as the p53 binding protein 53BP2, IFN-γ accessory factor AF-1, and IL-2 receptor, were previously known to be modulated by cytokines. Other genes identified in table 4, such as thrombomodulin, the mucin-like hormone receptor EMR1, and the LIM protein ESP 1/CRP2, were not previously known to be modulated by cytokines. Columns 1 and 2 list the SEQ ID NO and Incyte clone ID, respectively, for the polynucleotides of the invention. Column 3 provides a description of the gene. Sequences not identified by BLAST are indicated as “Incyte EST”. Columns 4 and 5 show the GenBank ID and corresponding GenBank 113 database, respectively, of the closest homolog identified by BLAST. Columns 6 and 7 indicate the differential expression of the gene measured at the end of the experiment for pro- and anti-inflammatory cytokine treatment, respectively. Differential expression values are reported as logn [untreated÷cytokine-treated].

[0169] The polynucleotides of the Sequence Listing have been prepared by current, state-of-the-art, automated methods and, as such, may contain occasional sequencing errors or unidentified nucleotides. Such unidentified nucleotides are designated by an ‘n’. These infrequent unidentified bases do not represent a hindrance to practicing the invention for those skilled in the art. Several methods employing standard recombinant techniques may be used to correct errors and complete the missing sequence information. (See, e.g., those described in Ausubel et al. (1997) Short Protocols in Molecular Biology, John Wiley & Sons, New York N.Y.; and Sambrook et al. (1989) Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Press, Plainview N.Y.)

[0170] IX. Complementary Nucleic Acid Molecules

[0171] Molecules complementary to the polynucleotide or a fragment thereof are used to detect, decrease, or inhibit gene expression. Although use of oligonucleotides comprising from about 15 to about 30 base pairs is described, the same procedure is used with larger or smaller fragments or their derivatives (PNAs). Oligonucleotides are designed using vector NTI software (Informax, N. Bethesda Md.) and SEQ ID NOs:1-516. To inhibit transcription by preventing promoter binding, a complementary oligonucleotide is designed to bind to the most unique 5′ sequence, most preferably about 10 nucleotides before the initiation codon of the open reading frame. To inhibit translation, a complementary oligonucleotide is designed to prevent ribosomal binding to the mRNA encoding the protein.

[0172] X. Probe Preparation, Target Labeling, and Hybridization Analyses

[0173] Probe nucleic acid molecules are isolated and applied to a substrate for standard hybridization protocols by one of the following methods. A mixture of probes is fractionated by electrophoresis through an 0.7% agarose gel in 1×TAE [Tris-acetate-EDTA] running buffer and transferred to a nylon membrane by capillary transfer using 20×SSC. Alternatively, the probes are individually ligated to a vector and inserted into bacterial host cells to form a library. Probes are then arranged on a substrate by one of the following methods. In the first method, bacterial cells containing individual clones are robotically picked and arranged on a nylon membrane. The membrane is placed on bacterial growth medium, LB agar containing carbenicillin, and incubated at 37° C. for 16 hours. Bacterial colonies are denatured, neutralized, and digested with proteinase K. Nylon membranes are exposed to UV irradiation in a STRATALINKER UV-crosslinker (Stratagene) to cross-link probe to the membrane.

[0174] In the second method, probes are amplified from bacterial vectors by thirty cycles of PCR using primers complementary to vector sequences flanking the insert. Amplified probes are purified using SEPHACRYL400 beads (Amersham Pharmacia Biotech). Purified probes are robotically arrayed onto a glass microscope slide (Corning Science Products, Corning N.Y.). The slide was previously coated with 0.05% aminopropyl silane (Sigma-Aldrich, St. Louis Mo.) and cured at 110° C. The arrayed glass slide (microarray) was exposed to UV irradiation in a STRATALINKER UV-crosslinker (Stratagene).

[0175] cDNA targets are made from mRNA templates. Five micrograms of mRNA is mixed with 1 μg random primer (Life Technologies), incubated at 70° C. for 10 minutes, and lyophilized. The lyophilized sample is resuspended in 50 μl of 1×first strand buffer (cDNA Synthesis systems; Life Technologies) containing a dNTP mix, [α-³²P]dCTP, dithiothreitol, and MMLV reverse transcriptase (Stratagene), and incubated at 42° C. for 1-2 hours. After incubation, the target is diluted with 42 μl dH₂O, heated to 95° C. for 3 minutes, and cooled on ice. mRNA in the target is removed by alkaline degradation. The target is neutralized, and degraded mRNA and unincorporated nucleotides are removed using a PROBEQUANT G-50 microcolumn (Amersham Pharmacia Biotech). Targets can be labeled with fluorescent markers, Cy3-dCTP or Cy5-dCTP (Amersham Pharmacia Biotech), in place of the radionucleotide, [³²P]dCTP.

[0176] Hybridization is carried out at 65° C. in a hybridization buffer containing 0.5 M sodium phosphate (pH 7.2), 7% SDS, and 1 mM EDTA. After the substrate is incubated in hybridization buffer at 65° C. for at least 2 hours, the buffer is replaced with 10 ml of fresh buffer containing the targets. After incubation at 65° C. for 18 hours, the hybridization buffer is removed, and the substrate is washed sequentially under increasingly stringent conditions, up to 40 mM sodium phosphate, 1% SDS, 1 mM EDTA at 65° C. To detect signal produced by a radiolabeled target hybridized on a membrane, the substrate is exposed to a PHOSPHORIMAGER cassette (Amersham Pharmacia Biotech), and the image is analyzed using IMAGEQUANT data analysis software (Amersham Pharmacia Biotech). To detect signals produced by a fluorescent target hybridized on a microarray, the substrate is examined by confocal laser microscopy, and images are collected and analyzed using GEMTOOLS gene expression analysis software (Incyte Pharmaceuticals).

[0177] XI. Expression of the Encoded Protein

[0178] Expression and purification of a protein encoded by a polynucleotide of the invention is achieved using bacterial or virus-based expression systems. For expression in bacteria, cDNA is subcloned into a vector containing an antibiotic resistance gene and an inducible promoter that directs high levels of cDNA transcription. Examples of such promoters include, but are not limited to, the trp-lac (tac) hybrid promoter and the T5 or T7 bacteriophage promoter in conjunction with the lac operator regulatory element. Recombinant vectors are transformed into bacterial hosts, such as BL21(DE3). Antibiotic resistant bacteria express the protein upon induction with isopropyl beta-D-thiogalactopyranoside (IPTG). Expression in eukaryotic cells is achieved by infecting Spodoptera frugiperda (Sf9) insect cells with recombinant baculovirus, Autographica californica nuclear polyhedrosis virus. The polyhedrin gene of baculovirus is replaced with the polynucleotide by either homologous recombination or bacterial-mediated transposition involving transfer plasmid intermediates. Viral infectivity is maintained and the strong polyhedrin promoter drives high levels of polynucleotide transcription.

[0179] Protein is synthesized as a fusion protein with glutathione S-transferase (GST) permitting rapid, single-step, affinity-based purification of recombinant fusion protein from crude cell lysates. GST enables the purification of fusion proteins on immobilized glutathione under conditions that maintain protein activity and antigenicity (Amersham Pharmacia Biotech). Following purification, the GST moiety is proteolytically cleaved from the protein at specifically engineered sites.

[0180] XII. Production of Specific Antibodies

[0181] Protein encoded by a polynucleotide of the invention is purified using polyacrylamide gel electrophoresis and used to immunize mice or rabbits. Alternatively, the amino acid sequence of the protein is analyzed using LASERGENE software (DNASTAR) to determine regions of high immunogenicity. An immunogenic epitope near the C-terminus or in a hydrophilic region is selected, synthesized, and used to raise antibodies. Typically, epitopes of about 15 residues in length are produced using an ABI 431A peptide synthesizer (PE Biosystems) using Fmoc-chemistry and coupled to KLH (Sigma-Aldrich) by reaction with N-maleimidobenzoyl-N-hydroxysuccinimide ester to increase immunogenicity.

[0182] Rabbits are immunized with the epitope-KLH complex in complete Freund's adjuvant. Immunizations are repeated at intervals in incomplete Freund's adjuvant. After a minimum of seven weeks for mouse or twelve weeks for rabbit, antisera are drawn and tested for antipeptide activity. Testing involves binding the peptide to plastic, blocking with 1% bovine serum albumin, reacting with rabbit antisera, washing, and reacting with radio-iodinated goat anti-rabbit IgG. Antibody titer is then determined.

[0183] XIII. Purification of Naturally Occurring Protein Using Specific Antibodies

[0184] Naturally occurring or recombinant protein is substantially purified by immunoaffinity chromatography using antibodies specific for the protein. An immunoaffinity column is constructed by covalently coupling the antibody to CNBr-activated SEPHAROSE resin (Amersham Pharmacia Biotech). Media containing the protein is passed over the immunoaffinity column, and the column is washed using high ionic strength buffers in the presence of detergent to allow preferential absorbance of the protein. After coupling, the protein is eluted from the column using a buffer of pH 2-3 or a high concentration of urea or thiocyanate ion to disrupt antibody/protein binding, and the protein is collected.

[0185] XIV. Screening Molecules for Specific Binding with the Probe or Protein

[0186] The polynucleotide or fragments thereof are labeled with ³²P-dCTP, Cy3-dCTP, Cy5-dCTP (Amersham Pharmacia Biotech), or the protein or portions thereof are labeled with BIODIPY or FITC (Molecular Probes). Libraries of candidate molecules previously arranged on a substrate are incubated in the presence of labeled probe or protein. After incubation under conditions for either a nucleic acid or amino acid sequence, the substrate is washed, and any position on the substrate retaining label, which indicates specific binding or complex formation, is assayed, and the binding molecule is identified. Data obtained using different concentrations of the probe or protein are used to calculate affinity between the labeled probe or protein and the bound molecule.

[0187] All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims.

0 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 516 <210> SEQ ID NO 1 <211> LENGTH: 153 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 068454H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 41, 59, 102, 105, 142, 147 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 1 ccagcacact ttcatattcc ccatcacatt ggctgaagtc ntcctcaggc ctcattccna 60 tccatcaaag aagacaggac tcaccttgct ggctgctgcc anttntgctt acatcagccg 120 gtaagattta catggagaaa gncaacntag gct 153 <210> SEQ ID NO 2 <211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 153958T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 6, 20, 40, 42 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 2 gcagtnggaa tcttcttttn accacaaagt aaattaatgn tnatactgtt t 51 <210> SEQ ID NO 3 <211> LENGTH: 506 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 155870R6 <400> SEQUENCE: 3 ctttctttca cctatttgta caactccaag ttacagctga atctgtcgtg actttcctga 60 gatctacccg gggcttggct gtctgttctg ggcactggct ccgagttccc ctcctgggat 120 ttgcaggagg gcagtactga acctgcattc ttctccttgt aaatgtaggc cgggtgcccc 180 tgttctccgg gtttggaaca atacgaggtt ggtgctgatg ggatttactt gcgtacgtgc 240 tcttcacaaa aacaccgtgg atgctgaagt tagagcacgt cgccacagag cttgacatca 300 atgttagagg gtctcttact ccccgcccag ctgtgatgtt tcatctgctt tggttgtttt 360 ggtggtcttt tttaaaaata gagatttcac atctgcccag accccactca aaacgatttg 420 gtcaggttct ggttggacaa gtttaaaatc aagtagtgcc cggaattccc tcaaccaccc 480 aacttcatcc aggaatacag tctgca 506 <210> SEQ ID NO 4 <211> LENGTH: 407 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 182228R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 406 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 4 atctcaggcc ccaatgttta gaccggacac aactcacctc catccacagc accgtcgact 60 cttgcatcag agacagcaac agaatagaag tcagcatcgg aatctcaatg gtgcgggaga 120 tagaggaagt caccggagca gtcatcaaga tcatctccga aaggatccat atgccaatct 180 catgttgcag cgggaaaagg attgggtctc taaaatccag atgatgcaac tgcaaagcac 240 tgatccctac ctggatgatt tttattacca gaattacttt gaaaaactgg agaaactgtc 300 agctgctgaa gaaatacaag gtgatggccc taagaaggag cgcaccaagc ttatcacccc 360 tcaggtgggc caaactggag cacgcctata agccagtgca tttgang 407 <210> SEQ ID NO 5 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 259836T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 73-74, 122, 141, 154, 173, 186, 189, 205, 207, 218, 227, 233-234, 236-237, 239, 241, 248, 250, 254, 260, 268, 305, 307, 331, 359, 369, 428, 459, 486, 496 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 5 gaggagaggg gacttcttga aatgatgtgc ccaatcaatt cttggtttat tcttttccaa 60 aaagtaaaat aannaaagtc ttaaaagtac acaaaacaga ccttcatctt tgcattcctt 120 tncaaataaa cccaaaaagt ntgtacagca tgtntaatag tatgcaatat gcnaaagctt 180 tgtgtngcng ttagcaacat ctatncncac ccaccctntt tattcanaag tgnncnncng 240 ntaaccanan ttanatcacn aagcctgnta gtatgagagg gtcttaaatt tgttaaaact 300 ggaangntct ttgtataggg gctccattca nttgactcaa ggttataggc ttccaccgna 360 ttcagaaant cattgccatc gaatcctccc actgcataaa tggtgttccc tacagttgca 420 atcccagnat tgctccttgg tgaagtcata tttcccatna tcttccattc atttctagtt 480 ggatcngaca tttccncaca actgatggca tga 513 <210> SEQ ID NO 6 <211> LENGTH: 75 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 304934T6 <400> SEQUENCE: 6 tggatggccc ctcccatcac ctggcagtgg acctgcgttt aaggaaggcc tcagctgggg 60 tgggcgctgg tggag 75 <210> SEQ ID NO 7 <211> LENGTH: 428 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 308002T6 <400> SEQUENCE: 7 gtcagtcatt tcattgtgtt cacaatttgc taattcattt tttatcttct ctagtatcag 60 atcagatcag tgtacctcca aacagagatg gaagctacac tgcagttccc aatactactt 120 cagcatagag caaaaatgtg aagccaatta acagagaaat catttttggc attattaggc 180 aatcaaaggg gttaactaaa gtgaactgtg gttcagaaat tgagaaattc tttttctttt 240 tgaataaaaa aaggagatga aaaacttcca cttcttctca gtggttactg tagaagatgt 300 ctctttacta aaaaggggtt ttctacattt taaatgagat tcaggctatc ttagggaatg 360 agcatttgtc tttcatatga tagtgtctac cccaagaata gtccattgat gaagatttcc 420 atattttt 428 <210> SEQ ID NO 8 <211> LENGTH: 486 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 354516T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 153, 435, 437 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 8 caaaatagtc tttattctac atttttagta taaaaattcc acaagttaag tgcaccacag 60 tgtagagaga gacatacaac gctgaacttc cataacagtc aatggtacag tcaaacatca 120 catgtacaga acacacaatt tagatgaact ganattataa gataaaataa aataaaatcc 180 aatttcagaa aacaaaaatc aaaacattaa ggatccctga aatattctta aaccctaatg 240 agatttcact ggactcaagt cattttgtag tgagacattc acaatatgac gagtggggag 300 aagtgcgagg aaagaaggaa attagtctga ctggctttct gtcctgcacc attgattcaa 360 tggagactgg cgggaggaaa tggaagacta gggtggagat gggatgggtg gggccaagga 420 tggaaaggaa aggcngncaa ctaatgcgtt ccatttataa caagtaatat atatcaaaga 480 cttaaa 486 <210> SEQ ID NO 9 <211> LENGTH: 573 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 358832T6 <400> SEQUENCE: 9 aagagaatag gagtgaggag gcaggaataa cgctgggtca ctcccaggaa gtggggaaga 60 ggctgcagcc aagaagaatg agtcaggctg ctcttccttg gctttcttgg taacagcaat 120 gaacaaaagg aagacgaggc atggactcca ggcttaagtt aacaaggtca gtctgttcag 180 gccaagcaat ggaaaggaag tgtcagatct gtccaatcca tgttcataaa gaggaaataa 240 ggcctaggtc cgtctattga ggccttggct caggattggc tggggccctt ctctttgaag 300 gtcgaggccg ctgtccccag ggcgtatagg ggccacgggg acgatacctg ccaaaacccc 360 tatgtaccac tggggcaggc cgctgataac ggggtgtggg gaagaagggc ataggcagct 420 gaggaccaac cataaaattg tcttcgacga agaaacctgc atgggctgat gaggggacat 480 ctgaatggca atagaattga tccgactgga aagtatggtc tgaggaaaaa caggcatctg 540 ggggacctgt gggaaccggg gcattccctg gtg 573 <210> SEQ ID NO 10 <211> LENGTH: 457 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 392560T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 34, 56, 66, 69-70, 83, 92, 102, 135, 148, 201, 261, 294, 317, 323, 326, 355, 368, 371, 374-375, 381, 399, 403, 409, 439-440, 446 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 10 aaacaaaaca aaacaggcaa ttgataaagg cggnacaatg gggaaggaga ggtgangtgt 60 ctcctnagnn acccgacacc atntcaattc anttcaattg tnaaccacta ggagaaacag 120 aattaaataa ctatnaaggg gtacagantt aagagttcca gccttccctc ttggggaaaa 180 ctaaggcaaa gtaatactga naaaaagtgg aggaagccac accttcaggt cactccaatg 240 aggagactgg aggggacaga ngagagaatt ccacgcagac acagcaagta agcntggctt 300 gtaaacctgg gactttngca ggnggngctg ggagctgatg gaatttgtaa accangctgt 360 ggtcaagnga nganncagga nctgtaaaca aaggggcant ganccaggng ttgaaggaga 420 tgtgcctata aatggagtnn ggtctnggcc tcccaga 457 <210> SEQ ID NO 11 <211> LENGTH: 334 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 395368T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 77, 88, 91, 94-95, 102, 105-106, 153-154, 157, 179-180, 182, 187, 211-213, 219, 229, 255, 260, 270, 274, 279, 286, 291, 300-301, 303, 305, 311, 313, 316, 319-321, 323, 332 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 11 atatttttat gtgaaatgtg gttgtatana ttagaaataa gatttacaca tttcaaagca 60 cactactgca aaaatanatt atttttancc nccnnactct cnttnnagct ttgcctgctc 120 agatctcaat ctcaccagta gccctttatg ctnnggnttt ctcaagaccc tcttcttcnn 180 gngagtngac tcttcctttt tcctccccat nnngctgcng acaattttnc attaggttct 240 tacttaggat cactnttacn atcatcttcn gttncatcng atcttncctt ntgtttgccn 300 ntncnttgct nancangcnn ncnccaacta gnac 334 <210> SEQ ID NO 12 <211> LENGTH: 590 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 397122T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 72, 145, 179, 293, 314, 375, 425, 429, 438, 467, 484, 494, 500, 533, 559, 568, 574 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 12 taattaaaga acaaaattaa caggaatcaa aatgttgcag ctgtattttt tgttagacat 60 tatataaaaa angaaaagta taatacagta aatcatcttg tataacatga acttaaagag 120 ttttcaaatt aattatgatc agganaaaaa tgtcttttga acataatact gaatgacant 180 gtcacatgtc cctcatgtca gaggcctggg agtggtgagc ctgcacatgc acgttgcccg 240 tcctccatta cactgcagaa ctgtaaaaca aggttgaaag gcaaacaaca gtnttcttct 300 gatagagtta tgtngggtct taactgaccc caacagttca cactcctcag acaccaaaga 360 aggaaggaag tgtgncctct ggttactcct cttgaaggta agtgtggtca agattgcacc 420 tgtgngtgng atcctacnct tctcacaaac acagcaggta gggtagnctt gagctgaact 480 tcangaaagt tccntgatgn atgttcagtg ttggtatcaa aaaattagac acnaattctt 540 ctcagaagaa atctctatng cctgtggntc ttgncaagtg cttgcttgat 590 <210> SEQ ID NO 13 <211> LENGTH: 336 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 443631T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 263, 320 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 13 aagaaaaata aataaaaatt aataatatct tgtaaattat ctattttctc cttcaatatc 60 ttaaggtaca caattatcaa agctgatatt gaacacaaac aaattgatac aattcagtaa 120 tccgataata ttcatagtca aataagttac tttaaattgc atgcaataca actttatgtt 180 ccatagcatc tttaataaaa accgtttacc aaaatggctc ttcaaactta aaaagtgcaa 240 ttacagagtg caaaatagaa ganaatacat tatattacat ttaacatcat caaatttgaa 300 taacagatat ttaaatggan attactcttt ttaaaa 336 <210> SEQ ID NO 14 <211> LENGTH: 327 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 445246T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2, 14, 58, 168, 179, 203, 246, 320 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 14 antcacaaag gcanatcaat aaccacttac tatatataca gaaatatata taattaanat 60 ggatccaatt atctcataac tgccattttt tccaacaaag agtcattcaa ttcttcatgt 120 catgaaggtt aaaggcaaag tcttagtccc catcttatgc tttcccancc tcttcttgna 180 aactacattg aacctctatg ggntaatcat cgtcttctgt agccataagg tctctgcaag 240 catgcngact gcaggctcct cagattcttt ctccattccc tcaagtccag tttttaatga 300 acaggctgtt tgctttagan gtgctgt 327 <210> SEQ ID NO 15 <211> LENGTH: 334 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 460790T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 8-9, 11, 22, 24, 49, 104, 122, 141, 158, 163, 166, 169-170, 178, 180, 182, 185, 191, 199, 214, 216, 218, 221, 224, 229-230, 233-234, 240, 242, 256, 259, 267, 282, 291, 301-303 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 15 ctaattcnnt ncaaaaccat tntnaaatcc atctttaaac tagtcagana cacaggttat 60 tattttttta aatcacttac acactgaaca gaaaacgacc tctnaaaagg cagctgatct 120 anatcatgtc accattcata nccaatacaa catttttncc atnctnccnn aaaacctntn 180 cncanacact nctcatgcna cttatcagca cttncnanca nccngaccnn acnnacaccn 240 anacctctta tagagnacnc tgtgagngca taacatggac tngatatggc ntcacacttc 300 nnntaaagct aaaaaaaaag ataaagaaac gcga 334 <210> SEQ ID NO 16 <211> LENGTH: 458 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 466711T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 30, 76, 79, 108, 275, 318, 369, 376, 388, 432 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 16 tagcacggct gtgaggctca ttgttgaatn aagcatcctt aggcagcacg tgactgcatg 60 cagatatgtg tgctgnaana actttgcctt tttaactaaa ttaatggncc caggaacaga 120 acttggtctt ttacttgcca ttcattgtcc ttcataaggg atggcctccc aacacttaac 180 ttcagctctt caaatacttg tcattaaacc ttctaatact acaaacttac tacccagagt 240 atacacattc ctagcgattt gtggatctta acccncagca tgaatgccct tgttatagcc 300 cttgcattta ctctccantc tgcgccctta aaccaaggct gttactactg agggggcgca 360 agatttccna gcaacncatt ctccaggnca ctgattaaca gcacagcatg actctgggct 420 aaatgcttgc anaaacagtt gacctgctgg gcatggtg 458 <210> SEQ ID NO 17 <211> LENGTH: 403 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 474962T6 <400> SEQUENCE: 17 ttttcttacc cttctatgtc atactccttt taatacaccc aagaatcatg actatttttt 60 tcccgcaaca gcctcacagc attgacttta agtttagctg atgagtgata aaggctgcca 120 ttttttaaaa aacgatgttt cttttgtact caaccatgct attttaaatc tattcctact 180 acatttcttc tgctaatgta gaatcatttt tctgctttgt tataattgtt atgaattata 240 cttctggagt tgagatgatt ttgattccta cctaatgtgg tagcgtgcac aatagaaaaa 300 tgaaaagaga tttcatagtt ttatattgtg caaaaggcag agacaaatat atgtatgaaa 360 actctgccca actgcttaat attgagtctt cggccctcta cct 403 <210> SEQ ID NO 18 <211> LENGTH: 353 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 495945T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 177, 184, 275, 311, 346 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 18 tgtgggcaaa ctcacactgc cctgccacca ttgccacagt taccatatta acagggcttt 60 tcccctgcac atgttcacta ggacttaagc tgtgacttgc tgtggaagga ttttccacct 120 tcactgaatc cccccgtttc tcccttgagt gtattctctt atgtttaaca aggcaanaca 180 tagngaagta aggtttctca cactcatcac agccataggg tctctctccc gtgtgagttc 240 tgtgatgtac aatgagcatt gtctttgtaa ggaangcttc ccacagtcac tgcatttata 300 gggttctctc ntgagtgaat tgctgatgtc taatgagtcc tgactnctgt gaa 353 <210> SEQ ID NO 19 <211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 498549T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 16, 71, 124, 263 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 19 gcatagaatt tagggnatcc agtaaggggt gcttcagtat gctgaggctg gcaatagtgg 60 tgggtcattc ncactgctgg gcctacagag gagaggatgg aacaggtggc tggacttgga 120 gatnggagct gtttgctgag aggcttgaag gagccttcag aggggaatgc agccactcct 180 gccaccacct gccagggagg gagccctgag gacagaaacc ctgatctgac tgtctcccca 240 ccctcggctc tcctctcatg ctnccattgg ctcaaccagc cagaactgg 289 <210> SEQ ID NO 20 <211> LENGTH: 161 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 504202T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 3, 9, 11, 13 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 20 ggnaggttna ngngggtggg ggctgggact cccacaggag tgagagaggg gctggtctca 60 cttggtcctg ggctaggagg tctcccactg tgttcaatag cttgtaaaac acctcgaacc 120 aaggcaggtg gctgaggatg cagagacagc tctgggtacc c 161 <210> SEQ ID NO 21 <211> LENGTH: 308 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 510950T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 95, 110, 125, 196, 242, 246, 249, 265, 272, 275, 280, 282, 293, 301 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 21 tactccttac gcgatctttg tgtacatttt gtgtgaaaag gaaaaaaaaa taggaaaggc 60 attaagacta cctaattatt tatactgtat ttggnagaag cgtgtttcan tcaaacttta 120 acganaaata agttattctg ttttcatttg ctcccggacg tcagaaggca gagtttcaaa 180 cagagcatct tctacnacta aaccagctcg cttcagaggc cgacagtcac ccagttccag 240 angggnggnt tcaaagtggt taccntttac anctnagtan gnaaggaata gcnaatttcc 300 nattttcg 308 <210> SEQ ID NO 22 <211> LENGTH: 501 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 516616T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 486 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 22 ataaacttca gaagaagaat caattcacag tggcttctca gccagcacac accacccgct 60 gtaacaatca catccccgct gtgtgaatgg aggaagcgtc ctgaagagcc tgggactgtg 120 cccagttgta cttcagaaca tcagtccctt caaaccgaga atgggtgtgt tcctcctgac 180 ttctctagaa ttcagacatg cttggtcaaa agaaaacagc attagagggg aaacacgggg 240 aaaacttatt gttttaagtc tgaggaaaag gcaagctccc gctccccata gtgccatttg 300 ggggaaacta gagagttgtg aatgtatcac cagaaggggt tgttttacca cgtgtaacca 360 tggtcttagg gtgagaggca taatgccagt gctgtttggt gggtggccca aaagactccc 420 tccccagtga ggtcttgagc ccaggggtgc aggatacttg gaagtgatag ctcttcttca 480 cccttngttt ctgcccttcc t 501 <210> SEQ ID NO 23 <211> LENGTH: 478 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 519083T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 19, 95, 148, 162, 232, 252, 278, 336, 376, 389, 461 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 23 gcctgtntca tagaaacanc ttacatttgc caatataagg caaatggtct atgtacagat 60 acatcaggac tgcctaactg acagtgagtg ttgcnagcca ggctccaagc taatggagct 120 aatacggtgg agctctctgc tgaatggnct ttcccttcag gntacgtcgg atctgttctc 180 ccacagggcc atcgggaacc aaatgcactg gctgttcgtt ctccaagttc cnagtacttg 240 ggtctgctcc cntcctcatc aacaggcgga cagcatcnaa ttgtgtcaac cgatactgca 300 agctggcagc aacatggagg gcagtgttgc cattgnaagc ctttgcattc acaaaagaca 360 ggcaactggg cagctncaaa aagaggcgna tgagttccag atttgcttct tcagctgcca 420 aatgcagggc tgtgcggcca cttttgcgat ccttcgcttc naccgctgct cccatttg 478 <210> SEQ ID NO 24 <211> LENGTH: 389 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 567572T6 <400> SEQUENCE: 24 attttcatga gcagtaatta agatatgttg aaattttaaa tgtgaaagat ttcaaagttt 60 cagtatgtta acattactct tcaaatgttc ttaatatata tataaacact tacaaattat 120 agatacaact agttgtatat ctacaataca tatatgaaca ccattcttct tctctagcca 180 tatttatatg aggataaagt aataaatctc tgtgctattc aaggaaaaaa aatgaatgct 240 ttaaaaaata aatctttaaa gaatagtttc aaaaataaag ttcaaatatt gcacaaaata 300 atttaactgt aaatattact acatagtgta aaacaatttt aaaaaaattt ttacactcta 360 cagtaaatcc cactttctaa ttctataaa 389 <210> SEQ ID NO 25 <211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 633724T6 <400> SEQUENCE: 25 gagtgactat atgtatgaac aacaccattg aaaaacacac agctttaaag acaagaatcc 60 tgtaaaggag taaacaccat taaatcatca tcgttctctg cccacagcgg atttttctta 120 ggagaactgg ggcaggactg ctgcttcttt acgtgtcaat acacttgagg tttcttcttg 180 tttcttcagt cttgggtatc ctagttttgt taataaacct cttccatcag ctcttccaga 240 ctgtctccat tctcccagat gctacgctgc acccagttga ttacctttg 289 <210> SEQ ID NO 26 <211> LENGTH: 374 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 666761R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 198, 226, 342 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 26 ggatttttaa cttttttatg tgatgaacca cagaatgatg gttttaaatg tatgaaatac 60 atagaattgc aacagaaacc agttatgaaa taatgaagat attaaatatg acatctatat 120 tttagtaaag cattagtgag gactgtaaat gatctttaaa gaatttggct taaatttaat 180 ctaaaattgc tatcaggnat ttcacatcgc tgtaattttt gcctgnattc gtaactgaag 240 agataagtaa atgtcagagg ttaagataaa tctttttctt tttttacctg tccatattta 300 caaacattct gcgttccgta catagacgcc tggataagaa cncctgtgca agaatgactt 360 tggtgctact ttaa 374 <210> SEQ ID NO 27 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 709070T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 84, 93, 95, 97, 99, 164, 222 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 27 gagtccagtg taacatggtg gctgggagtg tgagtggatg aatggggggc ccgatatagg 60 aactggggcc tcggggatga gggnagccgt ccnancngnc cttcttccac gaccatcctt 120 accttcccac ccccaccgct cccattctgc agatgagaaa accnaggctc cgaaaggaaa 180 aaccactgcc tggattccca cgcctcttct ttaactcatt tncaggtgag ggcagggaag 240 gaaaatccta gggtcagca 259 <210> SEQ ID NO 28 <211> LENGTH: 475 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 993224T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 31, 33, 52, 56, 64, 70, 74, 80, 87, 100, 131, 141, 143, 314, 361, 374, 383, 385-386, 423, 426, 428, 442, 460, 470 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 28 tatccaataa gagaatagaa ataaacancc ntntgtttac gggttgcccc anggtnttac 60 cacngctacn agancactgn gaaccanagg tgtcctacan ttaataaacg catggaaaat 120 gtaaaagaga nactctgagt nanaaagcca tccaatcttt tcagagtccc atctctgaaa 180 catttcaaat ctttatctgt ttacaaatga aactgtctac atgcaaactt taaatgtcat 240 ttttccaccc acaatactca tacctctccc tgcttaacac tggttcccca cacccagagc 300 catagcaatt acanaacaaa acagtgattt gttgaacaca gtagctctaa agccacgacc 360 naacattatt tccntgaaga cancnntact atgttagtca tctgaacatt ttaccagatt 420 tcnacnanga cattatatct anacatattc tgaaggccgn tttaactcan ctagt 475 <210> SEQ ID NO 29 <211> LENGTH: 277 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1234795H1 <400> SEQUENCE: 29 gggaaaagag gacttattgt tgtcatggcc catgagatga ttggaactca aattgttact 60 gagaggttgg tggctctgct ggaaagtgga acggaaaaag tgctgctaat tgatagccgg 120 ccatttgtgg aatacaatac atcccacatt ttggaagcca ttaatatcaa ctgctccaag 180 cttatgaagc gaaggttgca acaggacaaa gtgttaatta cagagctcat ccagcattca 240 gcgaaaccat aaggttgacc attgattgcc agtcaga 277 <210> SEQ ID NO 30 <211> LENGTH: 437 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1274557F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 304 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 30 gtaattaatc ataaatatag aaacagtagt aatacagctg acattaccat ttaattttat 60 attatgaaag caaatcatct gcatgtgcat caaggccagt cctattcaac ctagctttcg 120 aatgctgata tctggttagt atgtcatttt gaagttggca cataactttt ctaaaaaaaa 180 gcagtctttg ttgtttgctt cttccctacg gatgacttct aaaaatatat gacgggtata 240 aaaaaattag ctatattgat catatcaaca ctgtaactgc tgaaatggca ttctaatgtt 300 tgcnttttat tcggacaggc cacatgatgc atagagcctc tttcatgtga cctgtgtcta 360 ctgcttaaat ctttatgctg tgttgatgat attatattga catatgaagc tgtatatggg 420 gatggatttt gtggaga 437 <210> SEQ ID NO 31 <211> LENGTH: 325 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1304655F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 50, 69-70, 77-78, 82, 87, 119, 121, 148, 151, 153, 163, 171, 187, 191, 210, 216, 229, 233, 254, 283, 285, 287-288, 312, 314, 316, 318 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 31 gctagcgagt gaacaanttc agaaagcagg aggcttgaaa acctccagtn tcataattgc 60 tctgacagnn ggcaagnngg anggtcnggt gccatcatat gcagagaaag aggcaaagnt 120 ntccaggtca cttggggcta gtgtttantg ngntggtgtc ctngattttg nacaagcaca 180 gcttganaga nttgctgatt ccaaggagcn agtttnccct gtcaaaggng ganttcaggc 240 tcttaaagga gtanttagtt ctgtactagc tcagtcgtgt acngnanncc tagaattgca 300 gccctcaagt gncngngngg gggag 325 <210> SEQ ID NO 32 <211> LENGTH: 528 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1318881T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 403, 449, 499-500 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 32 taaaggaagc aatcattcct ttatacttct ttaaatttag tattgacatt tttattttgg 60 gaaaggaggt cttttttttt tttaacatgg atacaggaaa agaaaactct ccaataaaaa 120 tattgtctaa aaagtttgtt ttgtctgcat gatttactaa atatgtacaa tttcaattca 180 cagcgaaggt aacaaagatt taaacagcca acatcacaaa tgtctcaagt tctaaaaaaa 240 aatcactgtg cacagtttaa caatttaatt gaaaaaacca aagctaagcc ttcagtctga 300 atcttttttt atgatgggca caagccatgt attttcttca tctttgttac acgatgcata 360 tttcagtgac taaaagcccc ttcccatttt agtatattag gtnatgtcag tacatactta 420 agagaggcat aaattgcctc ttggtacanc aatatgattt tgtgatgtgt tcacatataa 480 tggtcataat aatttaatnn atatatagga atgatcagga tgagtcac 528 <210> SEQ ID NO 33 <211> LENGTH: 382 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1404348T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 50, 75-76, 86, 95, 118, 122, 127, 133, 137, 139, 143, 146, 158, 163, 180, 185, 189, 203, 233, 276, 293, 305, 318, 325-326, 340, 346, 348, 350, 353, 356, 381 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 33 gaatagatca ttcagtaaaa acatacagta aaaacaaaat gtcttatcan gtacaacttt 60 caaactacaa taatnntgta ccttanttac ttccntggca cacaagtcta acatttgntt 120 tnttaanaaa tanaacncna ttnagncttc taggagcntt ttntaataaa gtaattcctn 180 attantttnt ccttgtcaga tanatcacgc acctccaaaa tacaaattcc tanacacagt 240 gagcacgtta cttaaaatga acacttaagt aaattnagta cgtggacagc ccnaggataa 300 gctgncatta tagatgcngc taggnnggcc acaaaccctn agtgcnancn ggnaanagta 360 tatttgcaac tgaattttaa na 382 <210> SEQ ID NO 34 <211> LENGTH: 613 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1415624T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 458 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 34 tagaaatttt tacatcaaag tgtgataacc tcacttacac attgttccat acttacctgg 60 ttttgtttgc atctttctgc aaacattaaa aggagatgga tttgattctg atttttttgc 120 tatggttcat gtaaacagtt gagactgcta cataaagtag gttgttgtca aaggtgaagt 180 ggccacagaa tcccaagaat agaataattc aatttggttt aatgaaattg gtggaggtct 240 tagcagatag ataatccaag actaaatatt gtcttctagg cattttaaaa attaagaact 300 ttgaggtttt cttcatgttg taaacataac ttagaccttg ttggcattaa gtttacaaaa 360 gaaaatatta aaccatgatt tttatcatcc tgcccatgtc agtatacact ctctttatta 420 tgagaatgaa accaaataat aagcaaaata catcaggntt tcaaattgta ctgcaaagaa 480 ggtcccagct ggtctcttct gggagtgatc taactaactt aagctgaccc tgcgactggc 540 tgaggataat cccttctgtc cactgcaccg tgcaatgcca cagggtcatg agatgggtca 600 gttcctcttg ctc 613 <210> SEQ ID NO 35 <211> LENGTH: 294 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1437809T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 28, 65, 90, 103, 108, 116, 123, 133, 139, 146-147, 180, 183, 219, 233, 259-260, 263, 280-281, 289, 291 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 35 gggagangcg agccttctgg gggacggnga caagaatacc gcaaagaata ccgcaatggc 60 gaacngcctt gcatagacac cgaggcgggn tagcggcgcg gcnggaanag gagagngatg 120 ganaaataac ttnggagang aaggtnncac catcgcctcc atgggcactg cgcggctgtn 180 atnaaggcca cagcggccct ccccgcttcg gggggtcang gtgtccactc canatatgcc 240 ttatacattc taatttgann canagtcctt gcatattccn ncatacttng ngtg 294 <210> SEQ ID NO 36 <211> LENGTH: 450 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1438157T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 40, 110, 112, 116, 119, 135, 152, 161-162, 194, 205, 222, 241, 244-245, 257, 262, 266, 289, 292, 304, 307, 327, 336, 352, 356, 362-363, 365, 381-382, 386-387, 407, 416, 429, 439 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 36 taactccatc tntgagaaac atttaataat gtaatgtgtn tgtggtacag ggtgagtaca 60 gatgcacagg aggccatagg gtttaggcaa aggggagcac aaaagttgan gntgangcnc 120 tgccatcaaa gctgnggggc ttcaggccaa gnacaggagc nnaggaagcc acaagggagg 180 acattttctg cagntgctga accantagca accaggtcct gngaaagccc tctcttgtgg 240 nagnntaaca gccaggnggg anagcntttc atcctgcaaa gctggggcng anagttcttc 300 tttnaangtg tcatctgcac ttcagcncag gaatcntctt ggctgaagtc cngagngtcc 360 tnncngattc ctgaagtaga nnaacnnccc ggccccaagg aagcgcnggg gcagcncaaa 420 gcccccgant ccactcagna tcttgctctg 450 <210> SEQ ID NO 37 <211> LENGTH: 539 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1439529T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 427, 526 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 37 aaaattgaca agtttaattc ttaactgcac caagtaaact tagccattta agtatttttt 60 taagttattc cctccaaaaa actgagggag cttttctttt ccaccaccac accatggttt 120 cccaatagtt ctctttttgg aggacttttc aattgatgag taaactgctt tagatatttc 180 agaacttcat tccccaaatg aaagctaatc tggacaaact atatattgca tagatttctc 240 tacagattct ttgctttaaa acctaaatgc aactaacata gtgtaatttt aacctatttg 300 ccccacagta aaaactatct gtcctgaaaa atatgatgga tatatcctgt gattttccag 360 ttaacagaat tgttctactt caaagataat tattatcata tatcaaaata accagctcaa 420 cataggncat tacttcagtc tttactggac tccataggca tatgaacttg tgcccagctt 480 tttacctctt cccacattct cctcctcctc cataagtggg atgggnatta tttaaccta 539 <210> SEQ ID NO 38 <211> LENGTH: 559 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1454203T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 490, 528, 535 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 38 acgtcagtca tttcattgtg ttcacaattt gctaattcat tttttatctt ctctagtatc 60 agatcagatc agtgtacctc caaacagaga tggaagctac actgcagttc ccaatactac 120 ttcagcatag agcaaaaatg tgaagccaat taacagagaa atcatttttg gcattattag 180 gcaatcaaag gggttaacta aagtgaactg tggttcagaa attgagaaat tctttttctt 240 tttgaataaa aaaaggagat gaaaaacttc cacttcttct cagtggttac tgtagaagat 300 gtctctttac taaaaagggg ttttctacat tttaaatgag attcaggcta tcttagggaa 360 tgagcatttg tcttttcata tgattagtgt ctaccccaag aatagttcca ttgatgaaga 420 ttttctatat tttttcatat ctagctatgc tatttcctca tgaaagtcca agacttttta 480 tgactgtggn aattttagaa tatacatgaa tgatctttca gagtcacnat tttgncataa 540 tcggtaaaaa aacttattt 559 <210> SEQ ID NO 39 <211> LENGTH: 456 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1479279F6 <400> SEQUENCE: 39 aaactatgaa tagactgacc cagctggaaa gattggattt gggaagtaac gaattcacgg 60 aagtgcctga agtacttgag caactaagtg gattgaaaga gttttggatg gatgctaata 120 gactgacttt tattccaggg tttattggta gtttgaaaca gctcacatat ttggatgttt 180 ctaaaaataa tattgaaatg gttgaagaag gaatttcaac atgtgaaaac cttcaagacc 240 tcctattatc aagcaattca cttcagcagc ttcctgagac tattggttcg ttgaagaata 300 taacaacgct taaaatagat gaaaaccagt taatgtatct gccagactct ataggagggt 360 taatatcagt agaagaactg gattgtagtt tcaatgaagt tgaagctttg ccttcatcta 420 ttgggcagct tactaactta agaacttttg ctgctg 456 <210> SEQ ID NO 40 <211> LENGTH: 129 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1487763T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 44, 51, 55, 57, 66, 78, 87, 89, 100-101, 104, 110, 113, 128 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 40 agtagcacat tgcatctgtt aagtgnccca gctcacctgt aatngttatg nttcnancgg 60 ttgttncatt ccaagatnat ggtgtangng ttacaccccn natnttcatn tcnacattct 120 gcaggttnc 129 <210> SEQ ID NO 41 <211> LENGTH: 100 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1508830T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 35, 42, 45, 51, 53 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 41 acctcgtgcc cacacagtgc ctgtctgant ccttntgttg cncanatgtg nancaggctg 60 gcagagactt gaagcctgtg gttttgtgcc tcctttgtgt 100 <210> SEQ ID NO 42 <211> LENGTH: 502 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1510668F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 254, 462 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 42 caggcatcct ctggggtgta tttggggcgc tcaacaaggc ttgatcgagc tttgggggta 60 gatctagcta ttccatgggg attcttttca gaattgctgt tttcggtaac taattccatg 120 accaggtcca tggcattgga tgacattgcg ctacactgtt gctcacccgg gtcacccgtc 180 ctcacaggtt ggatggcaag catgttgtgt tcggtcacgt caaagagggc atggacgtcg 240 tgaagaaaat atantctttc ggctctaaga gtgggaggac atccaagaag attgtcatca 300 cagactgtgg ccagttgagc taatctgtgg ccagggtgct ggcatggtgg cagctgcaaa 360 tgtccatgca cccaggtggc cgcgttgggc tgtcagccaa ggtgcctgaa acgatacgtg 420 tgcccactcc actgtcacag tgtgcctgag gaaggctgct anggatgtta gacctcggcc 480 aggacccacc acattgcttt cc 502 <210> SEQ ID NO 43 <211> LENGTH: 581 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1557279F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 564-565 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 43 gtttaaatca agagaagttg taatctcttg ttttaagctt gcgtttgagg gaaagtgact 60 ttttcaccaa ttaatatgca ttgttctgtt gtttttattt atgattgatc attatatgtg 120 acttgcataa actatttaaa aaaaaaacta taatgaccaa aatagccatg gctgagaaac 180 acagtggctg ggcagttcaa taggaggtga caatatgaca acttctcaag cttgggaact 240 caccagactg tttcctcctt taggtaacag attctgtccc acggctaaac ttgtctttca 300 cgtgggaatt gcttttgtca aacgtgaaag agtaaacaat agcatttccc cagaatgcca 360 gttttatgga gccccaaatg ctctgaaaac aattagtaac ctggaagttg tcagcccaaa 420 ggaaagaaaa atcaattgta tcttgaaatt ttacctatgg ctctttggcc tggctctttg 480 ttcattataa gttagtgtgt ccttcaggaa caatgccctt aataccatag aacatggggg 540 gccttaatag tgctaacatt aaanngcaac agatgattga g 581 <210> SEQ ID NO 44 <211> LENGTH: 423 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1561237T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 152, 385, 399 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 44 tgattgaaat aaaccaagca ttgttgggct gaattatgga gagacccgag gagtgactca 60 gcctaaagcg ttgacccagt tgtgagcagc tcacaggccc tgcaggagga gcaggccagc 120 gagggagaca caagcagatt gtcctgccag gnaggggcgg gagggcccac ccaggccaca 180 ggggccacca aagcaaaaaa gcagattatg aggcagcttc acccctccca gcactggggc 240 tggggcctgg cgagggtcac acctctgagt atgggggtgg tgctgggccc ccctctgggg 300 tcttcgatgg caaagacagg gttcctcgta ggacggcagg accacttctg gagcatttgg 360 agtttttttc tcctcacgag tcatnacttg taattgtana cgcacacgac ttgacatgta 420 gac 423 <210> SEQ ID NO 45 <211> LENGTH: 534 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1562722T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18-19, 511 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 45 aaaagaaagg aagaatanng ggaaaaaagg gagtaaggga gaagggaaaa ttcaaagcat 60 ggagaagcca ctgtttgttt ctcctgcacc tgctgtctgc catctgtcta ctctttctta 120 actcttctct tctggcttct gctgtcattg ctctgttgat ctgctcttct gaacttcatt 180 agtgaccttg tgaatgataa gttcaatagc ctcctctcaa tcccggtcct cctccacctc 240 tctagctctg ctctcctcct tgaaacattc atggctcttg acttctcatc ttccacctgt 300 ttgattctgc tccagcacct tgatcaatgt cttcctccta ccctttgtct ttaaatgcag 360 gtgccccgag ggctctgtcc ttggttctga actcttccct ccatgttttc acttcttgct 420 gggttccagt taatctctct acacacattc ctctccagcc ctcaacactc tggctaaccc 480 acatctctag ctatctgcta gacctctctg nctgatgatt ccaaacacac agaa 534 <210> SEQ ID NO 46 <211> LENGTH: 221 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1629481T6 <400> SEQUENCE: 46 gtaaacagac acatgaaatg gaaaagctct gcattatcag acttggtatg catctcaact 60 gaaatacaag caggactaac cagacacaca tctcataatt tccagtgtca ctgtacaatc 120 atattaacag tggtcagttt ttttcaatcc acagaaaagc aagcagacaa accaaggcac 180 ttaaatgtca cttggctaat gacactcatt tcaaccctcg a 221 <210> SEQ ID NO 47 <211> LENGTH: 423 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1638102F6 <400> SEQUENCE: 47 tctggctttg ttctccgttt gaaaaaccgt cactttatag gcttaatata tctattttac 60 acattaagac tgtaccttca aactgtgttg ttccatacag tagccctagt catgtgtggc 120 taaacttgaa ttaacaaaaa ttgaataaaa tttaaaattc agttcctgag gtgcactaat 180 aacatttcaa tggctccaga gtaacatatg gctggtggct actgtattag acaatacaga 240 atggtttcat catcacagaa agttctgctg gacagtgctg agttggaacc aggtgttctt 300 tacacacaga ccacttaaag actgaggttt tatttataca cctgagtttt ccaagcactt 360 ttatctttga ctgtggccaa cattctatag ggctaaatcc caactttagc agccggaagt 420 cgc 423 <210> SEQ ID NO 48 <211> LENGTH: 214 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1643115H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 48 aaagttctga tcgtaccagt ctttcttcag tgggagccca ggattctnaa tctacctctt 60 taacagatga agatgtctgc catgagttgg aaggacctat ctcctctcaa gagaccagtg 120 ctacttcagg gactaagaga attgatctca gccgaataag cctggaaagt tctgcatcct 180 tggaaggatc tctgtcgaag tttgccttac ctgg 214 <210> SEQ ID NO 49 <211> LENGTH: 427 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1647985T6 <400> SEQUENCE: 49 tttattacaa ccccctttca gaaacaaacc ccaaaacaac acagagttat aaagtgaaga 60 tatatataca cacacacaca catatatata tcatacatac aattattata tactttttca 120 gttttctttt tgataactga aaatatctac aatgttttcc attccattat agattaccat 180 tccatttgca ataattacaa acacatacat attctacgtt tgcaaaacaa gattccatct 240 gtactctctc ctgacacaca cattaccttt gtctctagtc tttcactaca aattaggcct 300 ttgaaatata tatccttctc cactccattt gtagatagct tatctcccat tgtatcctat 360 cattgccaac catcagaggt aggggcacct tttctttctg acccacactc ctacacttac 420 tatttct 427 <210> SEQ ID NO 50 <211> LENGTH: 520 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1648034F6 <400> SEQUENCE: 50 caaatgcaaa tagtctttat tatgagaaag cagtgttatc taggaaagtc acatgctggt 60 ttctttctaa taaaatgaca aagcaggttt cttaaataat ttacaaaggg cagaaattgc 120 tcttgaacag ggctacccct cctggcacat ccacagtgct ctgcatgagc atataaatag 180 gtacccgtga gcccagggtc gtaagcctgg aaatatctcc tatgccttcc tccgagtccc 240 tggtagggaa aggagggatg agagtggggc cctcaagagc cttggcacca gaaacacagt 300 gggtgagtga ctctgcggat gactccccaa aaaccaggca cccgggtaca gagctaagag 360 ctctcaaata tctgatgcta gcattcatgt tatagatgag gcaaatagaa ggctcaaggt 420 caagtgtacg atgagtttct aagctcaaga gtcccctagg aaagcagaag gaacaattct 480 ccccctctgc aaggtctccc caagacactc tcaggctatg 520 <210> SEQ ID NO 51 <211> LENGTH: 320 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1674289T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 31, 67, 69, 71, 75, 79-80, 83, 87, 89-91, 94, 127, 141, 166, 169, 172, 175-176, 182, 196, 200, 206, 219-220, 223, 225, 227, 243, 261, 270, 274, 276, 288, 293, 305-306 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 51 tgatatagct atttttgtaa gaacatcctc ntggactttg ggttaattaa atctaaactt 60 atttaangnt naacnaggnn aangtgnann natntgctaa aagaatcaag taataattac 120 ttagctncat tcctgagggt ngtatgactt ctagctgaac tcatcntgnt cngtnngatt 180 tnttaaatcc cttttngtan acctanttcc acgaaattnn aanancnttc acttcagaaa 240 ggnaaacagt tgttggggct nagcacttan tttncntgag caggaagnag ttncttccaa 300 acttnngcca tctggatact 320 <210> SEQ ID NO 52 <211> LENGTH: 619 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1685691T6 <400> SEQUENCE: 52 taaaaatgtg caaatcattt gtttttaatg gtatttatgt ttacctcttc tctacttttt 60 caaagccact aactttaggg cacatgtgga tttggtggtt tttcttaggc tacaaatcat 120 ttggtccata acaagattat caaatgacaa cctggccaga gcagatacaa atggttctga 180 cttaaatagg ttgttgagca aggagatctc acattttaaa gaatattttc agagggagaa 240 tttgagaagg ggggagaaaa aaacaaacag gaatgaacat aaaagtataa aattctagac 300 aacccactaa accagttagc aaaaagagga gctcttaatt gaaatagaga atttccccaa 360 aaaaaggtct gaatttattt ttaaaacatt agatttggaa aatacctaat ttgaaagttt 420 aattttcata tatacgtcaa acctgctttt agggtagttt agtcaaagct gaaacaaaac 480 aaataaaatt ctggcttata tatctgatac ttgaataagg actctgaaaa aaaatgttcc 540 cgtttttttt ctcgtcagcc taagatatat ttttgacatt acataaattt cagtgatatg 600 atctggctcc tatttaaca 619 <210> SEQ ID NO 53 <211> LENGTH: 566 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1693719T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 133, 136, 522, 560 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 53 tcttctgtcg ccaagggtcc cggaccgagt acacggtggc agctggctta gttggtggac 60 ggcttggccc actcgacgtt gaggatgagg tggtcgtagc caaagccgga caccccggca 120 atggcacgcg canatncctc gcggcggtgg aagctgatga aggcgaacct tggattggcc 180 agtggtcttg tccttagcca ggtagatgcg ggagatggag ccgaaaggcc ggaagagctc 240 ctgcaggtcg gtctcacgcg tgtcctctga caagttggtg acacggatgg tggcgttgtc 300 gtcggctctg cggttgggct gcatggactc cccgcggcgg ctggccccgt cgcgcaggct 360 cggcggcaca tacttccctg tcttgttctg cgtggcctgc accggctcta gctctgggga 420 ccaaaagaca gtcaagttca acctcactgt ggcgcaggcg tggggacaga accgccccag 480 gaagctcggg cttcagtgtt gagccagcgc aggcactgtg tncaaaccac aggcagccag 540 tttgccacga ggacaccaan gtgaca 566 <210> SEQ ID NO 54 <211> LENGTH: 527 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1695667F6 <400> SEQUENCE: 54 gtgagaagga gtttctgtga ttttaactgc tattgtaata gaaaccagtt gattctgaag 60 agtcacctct tttcctggaa atattttggc tgtgagttaa gaggaacatt attttctccc 120 atgctggtga ctttggaaag gggttgtcat cagtgcaatg aacttggtct gggacttcct 180 tccttcccca tggactgggc ccctgggtcc tctgttgctt ctgggagggg ccttgggagt 240 acagtttact ctaggccagg acattctaag acatgtggaa accattggtc acacctgcca 300 gcaacagaga ttagtttgta aatgtctgtt tcaggtgttt cacagcatct agtgaatgac 360 cgttgctccc ataccagatt ctggtgacct gatcttaggc ttgacagctg tggtggagac 420 ttgggttggc agaagcctac cttggtgtgt tggaagaatg attgcttagt gcatgaggtg 480 cctttacagc ccatttgcag tagtctggct gaagcctgct gctttga 527 <210> SEQ ID NO 55 <211> LENGTH: 497 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1704982T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 416 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 55 ttgtcagtac atgacaagaa aaataagctc cctggtccat agtggccaag acatatcatt 60 aacattgata tctaatacac aagttattgc acattgagat atcttaatag ttggataaca 120 ttcttatttt aaaacaatat gtgtggattg gagattttgc aatctaggca caaaagatat 180 cttctgatcc cttccgttat tcagaaagta attaaaatca actaaataga ttacaaagac 240 aagaagagca aaaaattgta atctcctggt gaacatatta tgaattggag ccaattactg 300 gtatgcattt ctattaccct tggcctttgt aatctggaag ctataaactt caaaatgttc 360 aattcagcat ataagtcatt atattagaaa attccattaa aaacctatag aaggtnaaat 420 gatttaaata tagacataaa atagtaagca tgaaggtgtc catatattaa tcctggtaat 480 ctaaaatatt attgggg 497 <210> SEQ ID NO 56 <211> LENGTH: 397 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1713873T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 39, 56, 63, 74, 96, 105, 154, 166, 168, 171, 180, 183, 190, 274, 280, 286-287, 296, 303, 305, 309, 314-315, 324, 343, 349-350, 364, 381, 393 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 56 agaatgcatt tgaacacaan atataataat aatactacna acatacattg tgatanacat 60 ttnaaaatga taanatgtcc acctgaaaca atgcantgtt catanacata cattggtcat 120 gcacatttgt gccattttct gtaattactg agtnacaatg tctgancntt naagcatgan 180 acntattgtn caaactgaaa ctgacatcag taagaggcct aacaagtgtt atcagaagag 240 gcctcacatt tgcgtaattt gctacatcag ttcncatttn attatnnaaa ttcacnttgt 300 ttnantggnt tctnntgtaa tganctggaa catgacattc ctncttaann gcaggcagga 360 ggcnacctct gcaaagtcag ncagttcggg agnattc 397 <210> SEQ ID NO 57 <211> LENGTH: 466 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1755881F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 359, 392, 402, 407, 409, 421 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 57 ctgagaaata agtatggtgg gggcnattcc ctgggttcag aactactata aagatcagaa 60 agggtgtctt attttaattt ctgtcaaagt cctttatcac ctggaggaca aagtaaacct 120 ggaggggtga tgtggattta tgtcttgtgt ggctgatgat ggtggatgtt ttcaggtctc 180 tctgaagagg ctatcatgga gctgaacctg ccgactggta ttcccattgt ctatgaattg 240 gacaagaact tgaagcctat caagcccatg cagtttctgg gggatgaaga gacggtgcgc 300 aaagccatgg aagctgtggc tgcccagggc aaggccaaga agtgaaggcc ggcggggang 360 atactgtccc caggagcacc ctccctgccc gncttgtccc tntggcncnt cccaactgca 420 natgtcacac tggaccacat tctgtagaca tcttgagttg tagctg 466 <210> SEQ ID NO 58 <211> LENGTH: 517 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1801605T6 <400> SEQUENCE: 58 tgcagattta acacatttct aatccaccac atacggatag cagtaggtat atttcttgac 60 atcattcagt ctatttcaaa aatagatttg attgtttaga ggcataattt ataaagcaag 120 ataaccaaat taaacaacag aattttaact aatattggct ttttgggatt tcttaagaaa 180 agattcacaa gcattgctca gctactggag aataattaaa tctcttcttt actcaggcac 240 ttttaatgca gtaacctcag gcttcatttt aaagtactgg ttaaaacgaa caattgcata 300 cccaaggaaa tcaaactcaa tagtggagta tttggcttga atcaaagccc acaatcccca 360 aaagaaatga gaagccaatg caaactgatt gacttgaatg aagagtattt ctacctcctt 420 ttcagtaact tcagtcccaa agcccttaaa ttctttgtag gcttcaaggt aagcacgcag 480 ccactgactc tgtagttctc tatctggata cagacta 517 <210> SEQ ID NO 59 <211> LENGTH: 469 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1809609T6 <400> SEQUENCE: 59 ttgatataaa aatataatta aaaaattttt tttggtggaa gacagatgat gctcaaattt 60 cttttccatt aagcagttgt ttctggtgat gaagaatgat ttggtaaagc agttaacaaa 120 acattttcca aagacaccag agggtctgta tagtactgca aagcaggact gaatcccttc 180 tgctgcaaat actggattcg accttggtca atcagcaatt tacaaagatg ccctattttc 240 ttcttttctt caacactaag aagcccaggc aaacaatcag cgccatcatc tgtgattctg 300 tatcctccat catcatgctc ttcactatca tcattctgat tatcttgcct ctttgtggta 360 ctatttgagg tttccaaaga tgttttccgc atcccacaag ttgcccaact actcattcgc 420 tggaaataat ggaattccac tgctccaagg cctagagcct gaaatattc 469 <210> SEQ ID NO 60 <211> LENGTH: 121 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1851506T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 18, 22, 30, 40, 61, 63, 71, 75, 83, 90, 96, 110, 117 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 60 tgtgaantaa acaatttncc anattgcatn aaaaacatgn aacaattttt tgaaacatct 60 ntntaaacta ntganagtca canatgtaan atatanaggc ttctctctgn taaaagnaag 120 g 121 <210> SEQ ID NO 61 <211> LENGTH: 404 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1856531T6 <400> SEQUENCE: 61 tccctactat caccattgtc atcatcacca tcaccatttc tatcataatc accaccatca 60 tcctcctcct cctcatcatg tccagtgtaa gctggagtgt agtggcgtga tctcggctta 120 ctgcaaactc cgcctcctgg attcaagcga ttctcctgct tctgcctccc gagtagctgg 180 aattacaggt gtgtgccacc acacccagct aatgttttgt atttttagta gaggcggggt 240 ttctccatgt tggccaggct gatctcgaac tcctgacctc aggtgatcca cctctctcag 300 cgtcccgaag tgctggaatt acaggtgtga gccactgtgc ttggtctatt tttaaagtag 360 tatcaaaatg tgcccacatg aaaatgtcac atactcattc ctca 404 <210> SEQ ID NO 62 <211> LENGTH: 584 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1873492T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 506, 571, 579 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 62 tcaacttatc accaacatct aacatttttt agttcaggta catttgggta agaacattag 60 ggagaaatgt aaattaaata ctatgaaact atgcttttaa tgaaacatgg tctcagtaaa 120 atatggacac aaaagtttag tggttttatt gcattgttag aaaattatat tatgaaagat 180 ataaaaaaat caatgttttt ctgcttcttt tataatcagt atgccatctt ttaccattat 240 ggctttaatt ttcattctac ccaacaagtt tcaaagaata gtttattaca tgccttaata 300 aaacatttaa aatatttaca gattcaaaat agatgtttta taactgaaaa aagttcacct 360 gagaattcac cgtaacattg ccattttttt cccaagttgt taatgtgact gagtgtccac 420 atgcaacctg tatcgtctac tgcatctaac atacttattt ccttatttaa aattagttaa 480 gcagtaagct atagcaaact gttaanaaaa attacaggat ggcgaaccaa gactggtatc 540 cacattttgg tttggaatat gacaatttaa ncgaattant ttgc 584 <210> SEQ ID NO 63 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1879193T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 3, 5, 16, 56 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 63 canangaggc aaagtntttc acatcataga cttcacttcc aactccttgg aatgtncatt 60 tctttggctt accggagaga ctagacagga aggccaggca atgcttaggc aactaaaatg 120 aggttggggg taatgctaac gtcaccctca cagggatggc cacggggact gttattcgca 180 agctggtttt ctagacctgt tagctggaag catggtgagc accatttctg gacgctcagg 240 ccgtgtcggg cttcagtcat ctccaccaca caggtacagc agcgctttct ggtagtcgcc 300 cttagtgtct tgctacaatg gcccaggaaa gaaaagaaac gtggtatcag aaaaaagccc 360 agactcctca ataacacaga agtagcctca acgcacaatg aagcttctcc catgacaaag 420 agaagactct gcaggagacc tgccctgata caaaggcctg gaaggcacac cca 473 <210> SEQ ID NO 64 <211> LENGTH: 127 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1880542T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 6, 8, 10, 15, 29, 33-34, 43, 54, 64, 66, 70, 90, 92, 119 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 64 aatatntncn catanattag gtaaatgtna agnnttgggt ctntggagta taantttttg 60 taanantagn cattatttgg taacagaatn tnaggatgat ggaatgatgc gaaggtatna 120 cacattt 127 <210> SEQ ID NO 65 <211> LENGTH: 341 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1880666F6 <400> SEQUENCE: 65 tagcccctca ctgttttcct cttatccatg attttgtagc ttcttgagag agttccctag 60 gctctggcca catacaccac tgcgttttgt tgttgtgggg acactggagt acccctggat 120 tcccctctcc catctcctga gactgatctc tggagttagg ctgtggtgtc ttaaccttgg 180 ctgtacactt cactagcagt ggagcaagtg aatagatacc aagtcctgtg agcagtgctt 240 ggcatatagc aagtacttct taaatgttaa ctgttgctac ttttaaatct cttacctcta 300 ataagccgtt ccagatgctt cctgatggga gataaacact g 341 <210> SEQ ID NO 66 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1881257T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 382, 449 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 66 ttagagatac aaaattttat ntacaattat tcagattaaa acatttaaac tttaggtttt 60 atttacaagt atttatctta tcttcctctc ctatttgacg ttttagctca agaagagtta 120 aaatggaatg catctgtaga tatatagttg ggaatgcgtg ttcagtcact tggctctgtg 180 ataataatct tatgtaccat gtcagacaga ttttcagact ccagatcctc tttgccatta 240 tctgaatttc ctgatgagat atagcaacca gagtcccttg ggcagtcatc taactgtgac 300 ttatttaagg agatgtctga gctcaaggat aggggctcag gttcattttc ttgctcttga 360 ataactgtaa atggaaaaaa anggcaggag ttaggtaaag caacacaaaa tcttattcat 420 ggtactcatt cactttcaag tattatccna ttttaactgg tctaaccatg act 473 <210> SEQ ID NO 67 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1900194T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 136, 155, 157, 160-161, 166, 168, 170-171, 173-175, 177, 179-182, 184, 186, 191, 193, 206, 216, 218, 220, 231, 239, 244, 247, 250-251 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 67 tgggtggttg tgtacaggac ccccatccct cacccctccc agaaccaaag aagacaagca 60 gcgccaccaa atggctccct ctgcccaagt gaaagccgag aggtcagcgg ctggctgggg 120 aggcaggtga gcgcanacgg cacagggcag gggcngntgn ngtganangn ngnnngncnn 180 nncngnctgg ncnggggttg atgggnagat ggcggngntn cttgggtagc ngggtaggnt 240 tggnggntgn nggttggta 259 <210> SEQ ID NO 68 <211> LENGTH: 369 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1908377F6 <400> SEQUENCE: 68 catgagtctg ctattgttaa agcaacacaa atcagccgga gaaaacacct attttctcgt 60 gataaactaa agctttttct gaagcaacac tgtgaaccac aagatggagt cattaaaata 120 aaggcatcat ctctttcaac gtataaaata gcagaacaag atttttctta tttcttccct 180 gatgatccac ccacatttat cttcagtcct gctaacagac gaagagggag acctcccaaa 240 cgaatacata ttagtcaaga ggacaatgtt gctaataaac agactcttgc aagttatagg 300 agcaaagcta ctaaagaaag agataaactt ttgaaacaag aagaaatgaa gtcactggct 360 ttttgaaaa 369 <210> SEQ ID NO 69 <211> LENGTH: 202 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1909861F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 80 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 69 ctgcccgtct cggcctccca aagtgtgtga agggaacaag gagatatatt ctgggtgaag 60 ggtgatgctg gctgcagatn gtgagccctc agactcacta gtggacatgg aagatgagga 120 aaggggcccc agcatggcag tgggaagggc tggggacctt caggttgggc ccacaggggt 180 aggagacatt accgtggggc ca 202 <210> SEQ ID NO 70 <211> LENGTH: 334 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1911715T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 187 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 70 acaaattatc aagaaaaaga caagccagta gaaaaacaga taaggatgca actaaacaat 60 tttcaaaaaa gcaaatcaaa tagccagtaa gcttaggaga agatgctgaa atgcattaat 120 attaagggag acacagacta agataatatg ctatcaactt agactcatcc aattggaaat 180 tttttanaag gtaaacatac cttttcgtga tatgaattga gggaacatgt actcttacat 240 tttgcttcta aaactgtcaa ttgttagaag tttttttgga aagcaatctg gaaaaatctg 300 ttggaattta ttaaatgcat gtacccatcg aaca 334 <210> SEQ ID NO 71 <211> LENGTH: 215 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1930135F6 <400> SEQUENCE: 71 gttacttaca gtagcacaga aatgttagca tatttattta aatagtcctg cagcagagac 60 cctgcgattg taaagtgatt taagtatttc tgggtagtgt ttgtgattta cggatttgtt 120 actgaaaaac aaaaaaaatc actactgtga atttactact atgtaacctt gtggtcgtat 180 ttcattataa ataaaataag aattgctctt ctgcc 215 <210> SEQ ID NO 72 <211> LENGTH: 533 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1943678T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 122-124, 384, 465 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 72 agggaggatc gatgccacgt gggccccagc tcacccgggt ggaggctggg agctgaaacc 60 gaacccaggc aggagatggg cgacggcgga ggtgcaaggc agggcacggc gcacaagacg 120 annncggccg ggcggggtgg attagaggtc actctcgccg tacagcgccg tggagaagga 180 catgtagtcc agagcacctg gcacggagtc ggggccggtg tagggggcca tccgcgcgat 240 gcagtactca gcctggtcgg gtggcagctc gcggcgcact cgtccatggt aatgtagttc 300 ttgtccccag ccaggatctt gaaggaagcc atgacttggt ctgctgtatc tgtgtcggct 360 gtctcgcggg acatgaagtc aatnaaggcc tggaatgtca ctacccccag gcggttgggg 420 tccacaaatg ctcatgatgc gggcaaattc tgctttctcc catgntgtaa cccatggaga 480 tcaggcaggc gcggaaatca tccgtgtcca tcatgcctgt cttctttctg ggg 533 <210> SEQ ID NO 73 <211> LENGTH: 367 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1963968T6 <400> SEQUENCE: 73 cattttcata ataaaatggt atatccacaa ataaaaatta aaaacaattg agaggtgggg 60 aaaatatcag tattatttta aaaaaataaa aatggcaatt gtaaagcagg cagtttcttg 120 ctcatgccac acgatatgcc ttcattaagg tgtactcttt ccggttggtg tgagcagccc 180 agatgaagag agcagaagcc atgaactgta agggagcaga gacacaagcc aggcagaagg 240 accatccaaa ttcaccggat acattgtcag ggagctctag tttctggtgg agtagttcca 300 ttccagcaac ataacaactt actgagccca gtgtacacag acctgcaagg agatggagaa 360 tgcccgt 367 <210> SEQ ID NO 74 <211> LENGTH: 469 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1973066T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 204 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 74 agagcaatag gaaaaattaa atcatttccc acatattgtt ttcttaaaac agagcctaca 60 aggacatatt cagcaccaaa taaaaaagga aaaaaagaga aattacaaac agccatagaa 120 tataatctat aaagcaaaca tttaatattg cactttgttt tgctaacatt ttggatttta 180 cttttcctaa ttgaaaaatc aggnatctat cttgaatact ggaatacaac tgtgaacctc 240 acatcttatg tcaggaattg accaatattt ttaaaaaagt aatgcctcta aagaaataca 300 ttttaaaggg gaaaataaaa ctttatttga taaagtttta tacatttaaa gttttatcac 360 attttgtgat ccagtgccaa ttatcagaat attggtcatt cttgcttcat gtgttatttg 420 taagagtata taatgacaag tattcccaat gctatgcata tcaacaatt 469 <210> SEQ ID NO 75 <211> LENGTH: 510 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2016488T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 499 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 75 gtagatataa cttccaggaa ataagttaca taaatataac agaataaatt cattttctta 60 agtttcaaat taaagatgat taagaaatac agctttatgt aaagtttctg ctttttctca 120 accacgccta aagaggaaag aactggcagc aggaacactt gctcctagga aacaaataca 180 acaaaattat aattaaaaag atcttcaagc tatcaaaatt tgtgagagaa ggatggtaag 240 aatgcagtag aaattaccaa atgacaaaca aaatcctatc agttttcagg ttggtcaaaa 300 gtaacttcat gaatatagcc tgtgatcagc atatgtccca tagcttatat gccctctata 360 cctccagagt tgcataataa acttttaaca ataaaacaac aacgaatatc aggttgtaaa 420 tatttatatt tctctcacat acaatgttgt atgagacact tgttttaata tgtatccata 480 ggattaatac tcatatggna gtataatgtg 510 <210> SEQ ID NO 76 <211> LENGTH: 65 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2025468T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 5, 14, 18, 37, 51, 53, 59 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 76 gatanagaag caanaaancc aggcaaatac ccatcanaga cagtgacaag ngnagctgng 60 ggcac 65 <210> SEQ ID NO 77 <211> LENGTH: 454 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2054867T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 65, 275, 301, 306, 330, 360, 377, 429, 431 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 77 aaataaaaaa gggatcaatc aacatatatc ttagaagtcc ttccaagant cttggtatgc 60 aacanccatg gaggctgtga cctttttcct tcttttctca gcctgcagtt catttaagga 120 tcaccggaga tgactcgtgc tctagttctt aaaatcaaac ttgttctgcc aaatccaaga 180 ccctgaattt gtccaaattg tagaaacatg cttttaccac ccgtccacca aaatacctcc 240 cattcaagtc aacaaccgct ttaattgctg attcnactct ctcaaattct aaaaatatcc 300 ntactncttc atcatcaggg ggcaccaggn atttcaaata tcacacattt tccaactttn 360 gccatatttt tcacatnctt ccttggtttc aacttccaag tcttcatcca cctctcccgc 420 accaaccang ntccttagta agaccacttt agta 454 <210> SEQ ID NO 78 <211> LENGTH: 153 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2073909T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 24, 56, 68, 70, 74-75, 79, 111, 116, 123, 128, 131, 136, 139, 141, 146-147, 151 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 78 agctgggaaa atcagcggtt gganttggcc acacgctcca gctcgtcctt cttctnaatg 60 gcataggngn tcgnngagnc cttggcagga ttgatgagct catctgccag ntactnagca 120 atngtctnaa ngttcnggna ngcagnntca nga 153 <210> SEQ ID NO 79 <211> LENGTH: 89 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2102771T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 54, 59, 66 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 79 aggaatagat gcttgggatg tattaatgag caaaacaata ccagtagcaa actnttacnc 60 gcaganaagg gtttcaaata ttgttggca 89 <210> SEQ ID NO 80 <211> LENGTH: 522 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2121554T6 <400> SEQUENCE: 80 gcaataaata aaaccagaca tattgacttc taaaaaacaa aaccaaacaa aaaaaaaatc 60 ccctaaacta tatacatcct acaggaatac aggcattatc aaatgtagaa atggtatcac 120 tctgaaagat ggggctattt acacaagtta caagaattgc gttgctgtct ttaagaagtc 180 tcctccttga ataactcata aactctaagg gagagagagt actggtgggg aagcggggtt 240 caaagaggag acatcctcca tctttattga tggacaagac agtctcaagg aaaaacatca 300 atatccaaac accgtattga gtcccttaac aaggctccac agatcagctg gctttcaaaa 360 agcctggaag ggtgctccac tcaggaactc ccaagagaaa ccatcttgtc cctcagccag 420 gctgggactg gcagtgaggc catgctgagc cagtggcaaa cccgtgggct gtgggtttca 480 caagacaacc tggctctgtg ctgtcacacc cagccttcaa ca 522 <210> SEQ ID NO 81 <211> LENGTH: 573 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2134473T6 <400> SEQUENCE: 81 ataaaacact aacaagttgt gatctgcaag ttaaaaattc caatatgaaa ttcctctgtc 60 ttcctattac cctaagattg ctaggtcttc gctaagacct ttgttattat gaatagcagc 120 aaacagatac atacattata gagccaacaa cagagatgaa taacatagct cagaatttca 180 ggaaatggac agaccagaac ttaatgctct tcaaaaagta aaatataaag ctatcctccc 240 acgtttagta cggagatcta attaaagtaa ccatctttaa atgatacttt caagtatttt 300 ccaaccatag taggctcaat agttgtactc ttttgtagtt gttccctttt tagttgttct 360 catagaaagg gattaattct gaacaattag ccaattaatt taaattaatt ttaatcatga 420 gcaatacagt acctagaaca catgtaagga tgaatctgaa cactttcccc ttattttact 480 ttgaggataa cagagaacaa tggaaaacac tatccttcag ttatcaaaaa ctcactgtgg 540 gcaatggtta ccaatacatt aaaggctgta ctg 573 <210> SEQ ID NO 82 <211> LENGTH: 431 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2208881T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49, 97-99, 157, 166, 225-226, 236, 242, 258, 279-280, 283, 289-290, 297, 307, 323, 368, 387, 396-398, 400, 417, 429-430 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 82 acaaaacaaa acaggcaatt gataaaggcg gcacaatggg gaaggagang tgaggtgtct 60 ccttagccac ccgacaccat ctcaattcag ttcaatnnng aaacactagg agaaacagac 120 ttaaataact atcaaggggt acagagttaa gagttcnagc cttccntctt ggggaaaact 180 aaggcaaagt aatactgaga aaaagtggag gaagccacac cttcnngtca ctccantgag 240 gncgactgga ggggacanag gagagaattc cccgcagann cancaagtnn gcgtggnttc 300 taaaccnggg actttggcag gtngggctgg gagctgatgg aatttgtaaa ccaggctgtg 360 gtcaaggnag gaggcaggag ctgtaancaa aggggnnntn acctaggcaa tgaaagncct 420 gtgcctatnn a 431 <210> SEQ ID NO 83 <211> LENGTH: 406 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2211623T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 200, 223-225, 238, 242-243, 275, 278, 289, 299-300, 312, 315, 361, 376, 387, 389, 395, 404 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 83 gtgcaaatgt tattggctat tgtaaaaatc aatctcattt cctgaggaag tgctaacaca 60 gcttatccta tgacaatgtc aaaggcatag aatgctctat gtcacccact ccctgctgct 120 gttgtttctg cttatcccca cagcttacag ggaggggagt gacccccttg gttttccagg 180 aagcatcagt tcaggggcan cttcctgctg atctgttctt tgnnngagac gggcagcntc 240 tnnggacatg gcccagcctg ccccagaaga gctanttngt agtgtttang gagcccgtnn 300 tcaggaatct tntcntccga gcagctcctc cccgagacac tgtccagatg ctccagctca 360 ntgacagcgt tctgcnacac aatgggntnt gagangggcc tctngg 406 <210> SEQ ID NO 84 <211> LENGTH: 361 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2216715F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 57, 78, 245, 264, 266, 293-294, 296, 303, 320, 352 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 84 gtaaatctga attagtcaga acatctcngc ccgggaacat tttgtattta ccgatantga 60 tggccaagtg tatcatcnca ctgttgaagg aaactcagta aaagacagtg ctcggattcc 120 accagatgga agtatgggta gtattacctg catcgcttgg aaaggtgata cattagtgct 180 tggagatatg gatggaaatt taaatttctg ggacttgaaa ggcagagtat ccagaggaat 240 acccncacac cgaagttggg tgangnagat tcgttttgct cctggtaaag ggnncnaaga 300 ttnatagcat gtacaatgan ggagctgaag tgtgggatac taaagaggtt cngatggtga 360 g 361 <210> SEQ ID NO 85 <211> LENGTH: 196 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2239116F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 122, 130 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 85 accactttta gcagcagatg aaagagtttc ttttcctgca attgagacag cactggtatg 60 acttggtttt ctgtttgcac cacttccatt ggttatacag gacatgggaa taactgctcg 120 anggcttggn tggcctttac ttgagactga ttttttcact gaggccacat gatcttcaga 180 gattgcaaga cgcctc 196 <210> SEQ ID NO 86 <211> LENGTH: 359 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2242596F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 15, 23, 129, 145 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 86 ccgcgcttgg cgcanaggaa gcngcggcga acgcggcctg aattcccggc gccggcccca 60 gctcctctgc cgctgccgcc atgctcgact tcttcaccat tttctccaag ggcgggcttg 120 tgctctggng cttccagggc gttangactc atgcaccgga cccgttaacg cgttgattcg 180 ttccgtgctg ctgcaggaac ggggaggtaa caactccttc acccatgagg cactcacact 240 caagtataaa ctggacaacc agtttgagct ggtgtttgtg gttggttttc agaagatcct 300 gacatgacat atgtagacaa attgatagat gacgtgcatc ggctgtttcg ggacaagta 359 <210> SEQ ID NO 87 <211> LENGTH: 481 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2264984T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 303, 321, 346, 351, 368, 417, 426, 459, 463 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 87 tattacatga tttgtgcaat tgcaaaggtt acatttttga tctctggttt tttaagaacg 60 cacgtcatgg tgagagtact ttggtcacca cgggaaacac aaccaaccaa gtgttttgcc 120 aagagacaca gatcggaacg ctcatcacaa cactgcatgg ctcattcagt gcaggttgcc 180 acaggtctac agtcacatgg ttaatgaaaa tccaaaacag gaccaacagg atgacacatt 240 ttctgttctt aatgctcatt gccattattg ctagtaagtc aatgggagga gaaataagct 300 gangatctga tgactgagga naagtctgac actagatttt gttccnatca ncatttatta 360 ggtcaaanga aagaacacag tttatgtggg ttttaataat gtagttttaa aaagaanttc 420 agaatnacca ttcagttttc taaaaataca gttgctctng tcngtatgta gaggaagctc 480 t 481 <210> SEQ ID NO 88 <211> LENGTH: 475 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2299164R6 <400> SEQUENCE: 88 gtatggccac tgccccacta tgttttattt tcttatgtaa gtttgcatat cagtcatgac 60 tagtgcctag aaagcaatgt gatggtcagg atctcatgac attatatttg agtttctttc 120 agatcattta ggatactctt aatctcactt catcaatcaa atattttttg agtgtatgct 180 gtagctgaaa gagtatgtac gtacgtataa gactagagag atattaagtc tcagtacact 240 tcctgtgcca tgttattcag ctcactggtt tacaaatata ggttgtcttg tggttgtagg 300 agcccactgt aacaatattg ggcagccttt tttttttttt ttttaattgc aacaatgcaa 360 aagccaagaa agtataaggg tcacaagtct aaacaatgaa ttcttcaaca gggaaaacag 420 ctagcttgaa aacttgctga aaaacacaac ttgtgtttat ggcatttagt acctt 475 <210> SEQ ID NO 89 <211> LENGTH: 435 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2299181R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 328, 361-362, 368, 371, 373, 382, 385-386, 389, 395, 397, 402, 430 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 89 caaatttggc tgcaggctcc ccgagtgcct gggcttctct acccagggtc ctgtctgtcg 60 gctgcaccat acgtccctga ccacaaggca tccacgtgca caggagtatg cgcccagcag 120 ctgggaagga ggctgacctc agacggtggc ctgtggatcc cagctctgtc atttcctggc 180 tgggtgacct caacctagtc accctttttg agtcttgttt tctcagatta tgaaatagga 240 aaaatttcct tcctcgtgag ataagcacgt gccattagct attaaggaca cgcacataaa 300 tgagctgcat gtgaatccac acatgccntt ccatgaagac atcaaagagg atcatgtgga 360 nntttggngc ntnccgggtg gnccnnccnt aaggncngtg antggtcaga cctgtcctga 420 ggcttttacn aattg 435 <210> SEQ ID NO 90 <211> LENGTH: 74 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2328025T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 60, 63, 65-66, 69-70, 73 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 90 aagaaaaagc tggatctcag cattcaccag agcaaaattc aatggcaacc tgcacntaan 60 tcncnnttnn aant 74 <210> SEQ ID NO 91 <211> LENGTH: 460 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2370487T6 <400> SEQUENCE: 91 aacttttgtc tagttttgca attctcagat attccagtgc aaaaatagat cccattacag 60 acagcgtaaa gtgcttggaa tgagggccaa tgatgaacaa agagcacaaa aacagcttca 120 tcttagggta taagaaggga taatagcata cctaaatcct tatggaaata gaaacattct 180 aagggggatg caacaatttt gaaaagaatt agagcaatat ttctacagta ttacattatt 240 actagtagat aataagggta caaattaatg tctcaatatc aaagtggttc agtattacat 300 gacacatggc tctttggaaa atattttacc tgatatatac aaccacaaga agaaaacaca 360 gacaaatggc tttagtcaat gattactata cagtgaatga atgatgtgca acatttaata 420 gtcacaaagc atttgctttc agtacagata atggaataca 460 <210> SEQ ID NO 92 <211> LENGTH: 510 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2376728T6 <400> SEQUENCE: 92 aaacttagtt atttgtagct gtcagatgag aagtatttcc taattacacc cattcataaa 60 cactcatttt atcacttcaa agagcaccag tgtatttttt caacaaacca gaaagtaaga 120 aggtaggggc ttatttcatg taacagtgct attatgataa ggcaccacta ggtatatgaa 180 aaagccaaag tatttccaaa tcatgtgttt ttgttactgg tgtcttaacc attagacagg 240 atggttagaa aaaagctgct aacattatta atgaaccaca ttatagcccc tttcccacca 300 ttctgtgctt ttagttttac ttataacaga aatgaaaaca acaacgtagt acatgacctg 360 ttaaaacaaa catcttttcc caaccttcca agaaaataac ctaaaaataa acaagaaaca 420 aaaaatttat ctgatatatt tgcaaaagcc tatccctgta gaagagtgtg aggagtggga 480 gaaggcaggg ggacctactt tctatggaat 510 <210> SEQ ID NO 93 <211> LENGTH: 500 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2478811F6 <400> SEQUENCE: 93 caactgtatg ctactgggac agactgttgc atttgaattg tgatagattt ctttggctac 60 ctgtgcataa tgtagtttgt agtatcaatg tgttacaaga gtgattgttt cttcatgcca 120 gagaaaatga attgcaatca tcaaatggtg tttcataact tggtagtagt aacttacctt 180 accttaccta gaaaaatatt aatgtaagcc atataacatg ggattttcct caatgatttt 240 agtgcctcct tttgtacttc actcagatac taaatagtag tttattcttt aatataagtt 300 acattctgct cctcaaccaa atgcaatttt ttgtgtgtgt ttgaaagcta atttgagaaa 360 atttcatagg ttacatttcc tgcagcctat ctttatccac agaaagtgtt ttcttttttt 420 taaatcaaga cttttaaaac tggatttcct cccatcactg ttttttgaag gtcctccaag 480 tccgtgttaa ggtaaatatc 500 <210> SEQ ID NO 94 <211> LENGTH: 557 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2486153T6 <400> SEQUENCE: 94 ctgttcatca agtcagttcc ctaatttcaa aaagccgaac caaagcaaag catgttgact 60 tacattgctt ctttagttct ttcagctgtt gtttaaactg tacaaatttt tcattatttt 120 gaaagtctgc atcagaattc ttgctctgta aagccaaaaa tttcttctct accaataatt 180 ttaaatctgg tattttttct ggacgttctt ctttcacatg atttattgta gattgaacag 240 cctttacata atggtttagt tgccgatcca atgtagcaaa ttcaaccatt gccttgtcca 300 tactatattc actactcact tcagtctgac tttccacaag atccaaagca acactagaag 360 ctgtgtccat accagagttg atacaggctt ggaagttttt caaggaggag agagcagact 420 ctacaccact gaaggagatg aaaccagttg aacctgaatt tgaactggaa cgtcctggca 480 tcttgaaatt agtacctggg ccaccaaaac acagctggac tcaatatatg gggaaggtaa 540 gtgtcctcag tttttgg 557 <210> SEQ ID NO 95 <211> LENGTH: 252 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2493520T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 3, 5, 8, 12, 15-16, 23, 25, 32, 50-51, 61, 63, 71, 73, 83, 85, 91, 157, 162-163, 167, 185, 195-196, 217, 221, 238, 246 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 95 aanantanca tnaannatat ctnanaacca anagtttacc atgtctatan ntatttgtaa 60 nanaacttat nanagtgtat ctnanaaaca ncccaaatta gggccaggtt acgtgtccaa 120 taagcatttt tcaaactctc cctctgggtg tgtgcgnaca cnncatnagg ctctattaca 180 cacgnatcca agccnnggcc tcacacaatg ccacaanttt nctgtttgtg cgaaatgnct 240 atatanaata ca 252 <210> SEQ ID NO 96 <211> LENGTH: 423 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2514029T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 23, 26, 29, 47, 53, 57, 60, 64, 92-93, 125, 130, 132, 134-135, 209, 226, 228, 255-256, 258, 273, 318, 337, 353, 384, 388, 390, 398, 400, 403, 417 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 96 ctcctggccc gggaganagc ggnggnggng gcgccgtatc aactgcngca ganacanaan 60 cgcncgtcgt tcagcgcagt gttcatcgac gnngcctcta ggtccctgga tcttggtctg 120 caggncgcan gngnncttgg ggcaatggtc actccagtct ccaaagtctc cccagctcag 180 cccaggcccc tgcagttcct cgccgtctna acagcggaag ctcacntngt tcgctgctgt 240 gttgtcaccg agggnngngg gtgcctccac gcnaagagca aagccactag gtaggcgccg 300 ccgcgacacc acagcggntc actccattcg ccccagnttc cagactggga ctntaccacg 360 tgcgtattgc ctaggacgtt cccncgcncn agtgcagncn tgntcccatt cagtgcngtg 420 tcg 423 <210> SEQ ID NO 97 <211> LENGTH: 342 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2518676F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 35, 271 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 97 cgacagggag ggatgcgcgc ctgggtgtag ttgtngggga ggaagtggct agctcagggc 60 ttcaggggac agacagggag agatgactga gttagatgag actagggggc gggctggggg 120 tgcgagaagg aagcttggca aggagactag gtctaggggg accacagtgg ggcaggctgc 180 atggaaaata tccgcaggtc ccccaggcag aacagccacg ctccaggcca ggctgtccct 240 actgcctggt ggagggggaa cttgacctct nggaaggcgc cgctcttgca taactgagcg 300 agcccgggtg cgctggtctg tgtggaagga ggaagcaagg ag 342 <210> SEQ ID NO 98 <211> LENGTH: 430 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2545961F7 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 124-125, 413 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 98 gcgggatctt caaccacctc gagcggctgc tggacgaaga aattagcaga gtacggaaag 60 acatgtacaa tgacacatta aatggcagta cagagaaaag gagtgcagaa ttgcctgatg 120 ctgnngggac ctattgttca gttacaagag aaactttatg tgcctgtaaa agaataccca 180 gattttaatt ttgttgggag aatccttgga cctagaggac ttacagccaa acaacttgaa 240 gcagaaaccg gatgtaaaat catggtccga ggcaaaggct caatgaggga taaaaaaaag 300 gaggagcaaa atagaggcaa gcccaattgg gagcatctaa atgaagattt acatgtacta 360 atcactgtgg aagatgctca gaacagagca gaaatcaaat tgaagagagc agntgaagaa 420 gtgaagaaat 430 <210> SEQ ID NO 99 <211> LENGTH: 505 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2547841T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 261 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 99 tgtcagtcta catccaaatt tgctactaaa aataaaataa agtcacatcc cacattagga 60 ataccgaggt ctgaaaaaca ctttttgagc caagcctatt gtataaataa atgactagtt 120 tcttttcata tcaaaattcc cataaaaaat tacattcccc cctccccagt tctacctgta 180 gccatgatga atgtaaaaat ttaaatatga cacatccttg tcaaagaaaa ggtgcaaagt 240 ctattaacag ctttaaaagt ngcatttgca gagtgtgatc atacagttat gtactcattc 300 ccaaagtgca aatattgcca taatttaaca ctgttttgat tcagttgcaa gaattaaaca 360 ttacacagga ttgaaaagta cacccagggc ctctatcagt gccctaaagc ccttcccact 420 ttggtctcct tcactaaagc agactccaaa gtgttcatca gagtttagtt tacttcacac 480 agcccagcga agtatacaac attat 505 <210> SEQ ID NO 100 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2578906T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 268, 290-291 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 100 acttttttct ttcaacttcc ataacaaaat acagagctat cagatacccc tggaaaaaat 60 atgtatatta tacatatatt tctataacat tacatcatat atatataata tatatgcaaa 120 aatttgaaga ctttatagaa agcggaacat ctaaaaggca ctgcacaatg gagttaagat 180 tacttacatt ttatgtacat atacacactt tactctgctc aagcaggtaa ctagtgaagt 240 cacctttcac atgtaaatgt ctcattcnca aatccctgca tcacaattcn nta 293 <210> SEQ ID NO 101 <211> LENGTH: 527 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2591681T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 178, 220, 231, 253, 274, 415, 421, 442 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 101 aatgtgtaag ttaatgtctg gaaagatgtt ttgaacagga tgcaggaatt agaaggcaca 60 gaaatgataa tataaaaatt tagatcatat atgaattttt tctaaatgtt caagctaatt 120 gctttcatta gtcatcctga actgctgcag gtttcatttc ccaccaggac agctgtgnct 180 tttaaagtaa aaatagtcat ttgtattaac tataaggaan aagtggcttc ngctggaaga 240 acttaccaac cgnaacactc ttgagcttat aganataact ttggtaagtg gcctctctta 300 aaaaggctgc tgaaagctct aaaatataag gataaaacat acggtttcag actgtacact 360 ttgctgctac aaactacatc ttgatgggat taagaggcta cattgattct tgggnttatt 420 ncaccaacaa tccatctctg anctacccat gggctgcatc tggaacaagg taaactccaa 480 gaataaatgg aacagtgggt ccctaaagca ctcttcccaa caagcaa 527 <210> SEQ ID NO 102 <211> LENGTH: 409 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2591814T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 271-272, 390 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 102 aacggccatc tcactgttca catatataca cgtatgtaca ggaagaacct agtgtttcta 60 gctttcccgg cagaaggccc tgccagccca gagtccttag tcggataatg tatcacagat 120 acaacagtcg agcaaccacg agagcgttag tgcgacagag gcctctgtcc tccctcttct 180 caaagtccca tgattctgtc aaggtaatat tgccaataat cattcacatt tcacgtggtt 240 ttagacacgc aggttattca gacagacaca nngccaaaac aagcctcaaa gccagaacaa 300 aacaaaacaa aacaaaatcg aacataggta taaaaggtaa aatatatgta caaagtacac 360 agtacgtgag gtatacacgg cattctcacn atgcatgtta gtagtttgc 409 <210> SEQ ID NO 103 <211> LENGTH: 397 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2601127T6 <400> SEQUENCE: 103 ttctggaatt ttcagaaaca aaacataaaa aaattatata ctttattaca aatggtaaac 60 tcagagtgct ccaaatctct tatttacaaa caacactggg caggataccc aaacaaacaa 120 acaagaaata acttacaaag gcatgaagct gtttattgac agtaatcagc tttcatcaaa 180 ttaaaaaata tatatatgta catacacagt taacgaaggc aggccagaaa gagttcatct 240 gtaggctcag cctcgctctc acaaacctcc ctcctgccgc ccctctctca caggcccatg 300 cctggttagc tctgacacca gctgaatagg aagcacggca agtttgagac tctcttgcat 360 aaaccataag cctcagtgtc agggacatgt gctgtga 397 <210> SEQ ID NO 104 <211> LENGTH: 509 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2603774T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 334, 370 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 104 acacagtaca caggaggcaa agtgtttcac atcatagact tcacttccaa ctccttggaa 60 tgttcatttc tttggcttac aggagagact agacaggaag gccaggcaat gcttaggcaa 120 ctaaaatgag gttgggggta atgctaacgt caccctcaca gggatggcca cggggactgt 180 tattcgcaag ctggttttct agacctgtta gctggaagca tggtgagcac catttctgga 240 cgctcaggcc gtgtcgggct tcagtcatct ccaccacaca ggtacagcag cgctttctgg 300 tagtcgccct tagtgtcttg ctacaatggc ccangaaaga aaagaaacgt ggtatcagaa 360 aaaagcccan actcctcaat aacacagaag tagcctcaac gcacaatgaa agcttctccc 420 atgacaaaga gaagactctg caggagacct gccctaatac aaaggcctgg aaggccagca 480 cccaaaccat tgccagggaa gccttccag 509 <210> SEQ ID NO 105 <211> LENGTH: 497 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2630834F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 8, 17, 35, 68, 195, 209, 212, 216, 224 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 105 gcgggacngg gaggtgntag atgtagaatg aaaantcata tatttatgag agaggttatt 60 ttaatggntg aattatttgt gtcacagctc agctttttgg aagacaaact caaacaccta 120 taatttcatt tatatttcta attcacttgg aacctttctg ctttatggta cctagaaaat 180 gataatttgt gtaanccaaa acttctaana tnaatngctt aatncttgaa atatgttatt 240 ggaaaatttt aagcagtgct taaacaccat taaattatta tgaacttgta attcagaatt 300 gagtaaagaa atattttttc tagtccttca tatattgaaa acttgccaca tgacattgta 360 tcgtcttcat tttccagaag atgcgttggt gtgccatagg gttctaactt ccttgaaaat 420 aggtttttaa gtcaattgta aatatacgta ttattgttaa aaagtaactt taaactgcca 480 cacatagctt tcaaaca 497 <210> SEQ ID NO 106 <211> LENGTH: 440 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2655030T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 71, 81, 88, 118, 126, 168, 203, 205-207, 211, 288, 408, 430 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 106 tttaaaaaaa gaaaacctag gcaacacaga catatattaa aaacatcagt ttcaaatttc 60 ttccaagttt ncttttaaat ncaggttnaa aaagcagatc aactctagat attgtagncc 120 aactanataa gaaatactga aactaacttt cctttaagaa atcttaanga ggcacacttt 180 ctagtggtga aacactcctc canannnaac ntagtaagaa ggtaagggta tgaacagcaa 240 agttgtgtaa cattttctta tttctataat tttacttatt ctggatantt ttagaaaata 300 aactcatgtt ttaactaaga ctgttaacca agtacaaaac tatttgttgt tgcatttgca 360 gatacagtat cctacaaata tgtgcagcaa gcccatgaag cacttccncc gtcgatactg 420 atatttcagn atttaatata 440 <210> SEQ ID NO 107 <211> LENGTH: 510 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2672695T6 <400> SEQUENCE: 107 gtgttgctac actcaattac aattaaggat gcagtatatc acctaaaaat cccattaaag 60 atgctattgc agtaacagta aaaatataca gttatattct accacaatac ccatttaaaa 120 gttagtttcc tacatgctgc ctttggccta aaaagttcaa aacgaattca aattaatttg 180 ttatttacga tttcactaat tcaagacttc atttaaaaat attgcttatt tagtgtaaaa 240 gtctgagata aactgtaaac atatttaata agttacatat ggttaacaat catatttggc 300 acctaaatat acatgtttaa ttcctaacac atcaagttta tcctgacaaa caaatttaca 360 aaaaacagta ataaagcaaa tatctgagag ataatactgc atctttaaca gtaactgtgt 420 acttctgttt aaatgtagaa tgtatagaaa atctgttgtg aatgaagtat gcacagttta 480 tcaatttttt aaaaaaccaa aaccaaaaac 510 <210> SEQ ID NO 108 <211> LENGTH: 575 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2693989T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 67, 91, 102, 114, 120, 128, 148, 159, 175, 189, 195, 204, 206, 214, 231, 236, 251, 276, 359, 369, 390, 400, 414, 428, 433, 471, 477, 487, 501-502, 516, 536-538, 546, 553, 568 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 108 catggtagaa aaaaaacctg gaaagtcatt atactataca ttgagtgaca atcttccatc 60 gcagagnttc aggggagaat tgtgagaaga ncccatgagg antacagaca tttnatcttn 120 ggggaganat cttctggagc tgtgcttntc cttcatgcnt tctggtgttt gtttnctctc 180 caggaagana gctanatcca gggnancccc agantgcatt gaaaggcatg nttcanacct 240 atgctaatga nggctgattt cgcagtggct tggcanagct gtagcacata ccatgttgga 300 ttgtaaactg acctggcact cactggcact tgggatatgt gtgttgaatg aatgtacana 360 gcagagaant acttagaaag tatggaaggn gccattcagn ttccagagac taanctccag 420 gtcatganct ctnatcacag aggtgtctaa accctcgcta gccatggtta nctcagngtc 480 tttgtgncac catttataat nntccaagag tatttntgct gtatagaaaa atggcnnnta 540 ggggtnggag gtntgcaaga agaagatntg cttat 575 <210> SEQ ID NO 109 <211> LENGTH: 237 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2718743F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 191, 213, 216, 232, 236 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 109 gataaatatt tgctgatgat aagacaaaaa tatacacgtc tattaagagg tctgcaatgt 60 ctgaacacag tgagggagaa aaatccttag agaaggtcgc ttaatctcaa ttacccaaag 120 tcattgcttg gcagaatatc tgtggtctat tatccttagt gaagtgacag gcttggagaa 180 gcagggaaat ntggggacca tgtgtgctat atnaancaag gactggtcac cntccna 237 <210> SEQ ID NO 110 <211> LENGTH: 239 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2721122H1 <400> SEQUENCE: 110 aaacgacagc cctgggggca actcttgtga cctcctgccc caggctccca gcaccatgac 60 ggtttcatac actctcaaag tggcggaggc ccgcttcgga ggtttctctg gcctgcttct 120 ccgctggagg ggaagcatct acaagctcct ctacaaggaa ttcctcctct ttggggcctt 180 gtacgctgtg cttagcatca cctaccggct gctgctgacc caggagcaga ggtacgtgt 239 <210> SEQ ID NO 111 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2735638T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 457 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 111 aaagtgcata tagagtggcc acaggtttga cacagagacc ttggtgatgt aggctatgaa 60 caaatttaaa tggcaacttc attgctgcca ctgaaccaat cctgaatttg ggctcaacag 120 gtgaaaagta acaatatcaa acgaatacta aacagcataa caaaaagatt ttcagactct 180 tggtcataaa gaccgtaatc gttcacattg aatcaatgac taaacatttt tgattaccca 240 gctacctcca agcaaactga aaactgtcta gtggatcctg aagtccatag tgcctctagc 300 cgggtctttc aagtgttgca ccacagggtg atgattgatg gtaaaaacag ggatcaaccc 360 ttgtagatcg gtggtaagta tggaaaccct ctaagaacag tgcagcgtat gtgggtattc 420 agactggttg catacagcat tcaaaaccag tgctggnata gcttgcccaa agtg 474 <210> SEQ ID NO 112 <211> LENGTH: 443 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2739124T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 403, 437 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 112 ttagatatgc aaagcaatgc agataccaaa atatgctttc caagtgtttt tggctgagtt 60 tgtctctttc agcagttctg accctaagat acatacttat atggaaaaag ctatggataa 120 aaataaataa aatacatctt aatcatcaat atatagacaa aattgaatag aaaaaagtaa 180 gaacattata aagcatgaaa atttacataa aattattcct gaatgtgagg gttgaaagac 240 tctagaggcc tgaaatctat ttgaaagaga aactttcaag aaaaggaaaa aagcattcct 300 ctacttagaa tagatatgct atgatctgat tctgaagcaa tgggattgaa ctgaatgata 360 tatgaggttc ttccatggcc cactgattta gatgatagca gtnaaaaata tattagtgaa 420 aatcatttaa tactggnaaa gaa 443 <210> SEQ ID NO 113 <211> LENGTH: 452 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2747213T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 377 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 113 ataattttaa gaggtaataa atgcatgtcc atatccattc ttacctggcc tagaacaatc 60 aattggctat aagtcctttg actcataagg ccttcagcca tagggagtcc catggaagta 120 taggatggac ccgagatggg gagccatgcc accctagcaa cgctgtggga caaaattaaa 180 atttgctggt ttttgatgtt gcctctggca aatcttggcc agaaggggaa gaacgtaaat 240 gaaaatgaaa attcgaaggc cccccacaac tatctgaatg gacttcctct tcctccaggg 300 ttcaggccat gatggaaagt gggaggtggg acatgcttca ttatacctct ctggcattaa 360 cattcacagt ctattcnctc tgaagcttgc tacctggatg tttcatctgc atgataaaat 420 cccaggtctt cagacaaact caactaattg tc 452 <210> SEQ ID NO 114 <211> LENGTH: 225 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2752482R6 <400> SEQUENCE: 114 cccaaatctg tgtaaaatct gctgcaaagg tgtcatccct cttgtgtcat cactggggtt 60 agaggtgggt ccgaaataat cttctgtgtc cttcagttgg actctcggct gccaattgat 120 ctctttttca ttgccatctc tggggtggtt ctttggtttt ttgtgtgttt tccccttcat 180 ctctacctgt gaaagtgaaa ttctattgta aaaaaaagaa aaaag 225 <210> SEQ ID NO 115 <211> LENGTH: 458 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2757678R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 134, 427 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 115 ctccagtctt cactgtggtt gtgccccaca gtggtcctca ggttggccag tggagaagga 60 agctctggtt ctcagtgtga tgcatccccc aggttggtcc tgagatgagg taaattctgg 120 tcatcactgt gaantgccct cgggggtctc cgggtcctga gtagaagcaa ggtctgtttg 180 tcactgtgga ttcccccctg ccaagggtcc ccaggtcagt cctgaggaga aggcagctca 240 gtctttactg tgatgcagcc tctagtgatc cccaggtcct gagtagaagg aaggcctggt 300 cctctgtgga ttcaacccag aggtctgtga gcagaatgca ggtactgcaa gcaggctaga 360 caaggtgtgt gcttgcaccc cttccttact acctaggcac agtgttggat ggtcagtgct 420 tcctgtntgt gatggccatg tgccccctct tgcaagtc 458 <210> SEQ ID NO 116 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2765789T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 5, 24, 55, 69, 81, 193, 195, 204, 216, 223, 233, 250, 262, 267, 294, 333, 345, 386, 395, 453 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 116 gaaancagcc tttgtgtgat attncaaaca tttataagcc ttttagagat tcttncaaag 60 aacactgtna acaactcaac nacttttgat taaaatatca cacacaaaga aacacaatag 120 gagttgaaaa aattataaat gctagaagaa aaattctaat aacatttggt ggttacttta 180 cacatttatt tancncatat aaanccaaat gggaanccat ttnccttttt ttncataaaa 240 acaaagtttn cactggttaa anctgancta aaatcatttt atgtatgagg agancaaatc 300 taaattactt ccattttgaa aaaacaaaca ccngcttatt cattnctatt cattcaagtc 360 ataggcccca ttatttggat gatacnctat ttagnctaga agccagaaaa ggaaacatct 420 ccatctaata aagaagtctg gacaatgcaa aangtaaaag t 461 <210> SEQ ID NO 117 <211> LENGTH: 509 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2784742T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57-58, 82, 91, 103-104, 114, 132, 134, 149, 161, 173-175, 181, 207, 211, 242, 259, 263, 265, 274, 321, 327, 329, 349, 354, 358, 367, 377, 452, 469, 473, 495, 504 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 117 tttgaggatg acatctagaa cgcaccttgc tctgagactc ctcaataatc aaattgnntt 60 agaccaacaa tactgctaag tnttaaaagc ngtgaagcaa agnnaacgca tcanatagta 120 caggggcatc tnanagagct tccactganc tccccaatgg nttctatgca atnnncctct 180 nttccataac tgtattaaca actaccngga naggaaagat gagattaaaa ataatgatac 240 tnaactgaat tgttttaanc cantncccca tatnttggga aaaattcatt tagttcaaca 300 gcaatacaac acaatgtgaa natattntnc ttagacacag atattccana attnaaanat 360 ttacaangca agtcaanata taaaaccata gtacactgtt aaataacctt taaacataca 420 tacattgcag ttttcaaata aagacattca tntcattgta caaggatang aanaaatcct 480 taaaattacc tactntagtt tatnatata 509 <210> SEQ ID NO 118 <211> LENGTH: 510 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2786881F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 485 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 118 gattggtcat ttagaaacta gccaaaagtg agacttttaa tgtagaacat ttttcagaaa 60 tgggtacaaa gaaaaatgca tattactgta tatttcagag tgtttatgtg aaccttgtat 120 ttaattgaga gtcccatgta cgttctgcag cctttttgct gcttctatca tctgaagttt 180 gtgtagtaca aataaggcct ttgggattct taatgacatt tatgttaaaa tgttctcttc 240 tctttaaaca ccgttttcca atccacctgt cagggagtcc aaatcgtgtc tgtgttgatg 300 atgctatact ttgtagctag aaaaacaatt ttagtgttgt gggctctgta ttcagacttc 360 ctttttacaa gaccgatggg cagtgataga ttattttatc atatttaatg catgggaaat 420 agtgtgctga ggaagctatt aaaagtataa ctcagtgaat tgggtctgag ttttaaatga 480 gatanttcaa aattggcttg ccactgtaaa 510 <210> SEQ ID NO 119 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2790863T6 <400> SEQUENCE: 119 aatacaattg cttttaaaat gtagcaaaga gtcatttact actctcagaa gtggcacata 60 catggcatag aaaacaatct atagtcagtt aactattaaa acagaaactt gaaatttaag 120 tgacaaacat ttgtagcact ccctaaagaa ataggaaata aaaatgcatt tatccatatg 180 aacttgatta ttctgaatta ctgactataa aaaggctatt gtgaaagata tcacactttg 240 aaacagcaaa tgaattttca attttacatt taattataag accacaataa aaagttgaac 300 atgcgcatat ctatgcattt cacagaagat tagtaaaact gatggcaact tcagaattat 360 ttcatgaagg gtacaaacag tctttaccac aattttccca tggtcttatc cttcaaaata 420 aaattccaca cactatcaaa ctaaatcaag atttgctagt ggataaaatt accataaata 480 taccgtactc tctctgaaac agctacaaac atcttgtttt tgcaaaatat acaatggttc 540 tcaatctttc tg 552 <210> SEQ ID NO 120 <211> LENGTH: 518 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2799276T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 422 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 120 ttggagtctg tggaatccgg gcggcggtgc tgctgagagg agtggaatgg gaaagcatgg 60 actccctttg ggcagggggt cctgacctca cacctcctcc cagagggtcc ctcacaaatc 120 ccacgagggt gttggagaaa gcaggctggg gctctagcct tttgggcagg agtctcggac 180 acaggaaggt ggtaatgggg taccccagga aacagcccca tgcctccgag atgggagagg 240 ggctggggca gagcctgtga gggccacagc agggtcagag ctgcctcctc agacctggcg 300 tcccagtggg aggaggtggc ttggggaggg gggtcaggag aagccaaccc gaagcaccgt 360 ctgggtgtgt gttccattgt gggtctctcc ggcattaggg gttagggctt gcataggaaa 420 antggctcag tgttcatgtg ttgggttctg ccagcaactg ggccactgcc agggaagccc 480 gactctgcat ccaggtgatg ccaacacatc ctctcgaa 518 <210> SEQ ID NO 121 <211> LENGTH: 536 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2801448F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 185 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 121 aaagccataa aaataagaaa ctcagcctgt ggcctttctt tcttccaagg ctgggcttct 60 ttttttaagt gacttcatgc agtttgttgc ttttaaaaat ttgtccagaa tcgttttctg 120 cagaagcatg gtctgttagg agcttactgg ccgtagcaga agcaattgtt tcctgaattc 180 ttganattta tctttgctgt attcatttag ggcttgggag agtccgaaga taattcagtc 240 actgtcagat taataattct gtcaggacaa agaataccgt tatgattatt taatccttta 300 aaattgtggt ctccagagct tgttctcaga atggcccaga ccaagcctta attgtgatag 360 tgaatattaa tggtcacttt aaggagaaat tatagtccaa gatgaaatga acataaacct 420 gtttgccctg gctttcagtg gaagatgata ttagagacca aaatctggtt ctgaaggtgt 480 gtatcagccc taaggtgaac cagacttggg aaagattgtc ttaaaaatca atgagt 536 <210> SEQ ID NO 122 <211> LENGTH: 463 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2827489F7 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 419, 425 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 122 aaagaaaaat tagataatat caatagccca tcttctaaca cattgcctag ctcattactt 60 tcaatacata ttttccaaac taaaaattaa aatctcaact ctttaagaga agtttcgtaa 120 ttttgtagta taagagatta tcctggcaat atagttttaa tgccaatata ttgaaactta 180 catgacattt cagtggtttt gcagtgtttt cccaagtatg gtacctttac cactgaaggt 240 acacagtgat ttctgggtgt taaacagatg aacatttttt attttaatag ctatacaata 300 taaccagcaa ataaaatcca tgttttcatg gatattattg cttagagtta gttaagtttt 360 aaaatgtgat ttaaaggaaa atattaagta ctagtacaag agatacccag tatgacagna 420 aatgnatagt ggaagggcaa aagacaagtt taaggaaatg ctg 463 <210> SEQ ID NO 123 <211> LENGTH: 329 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2833430F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 5-6, 15, 23, 27-28, 39, 74, 159, 198, 264, 266, 282, 319 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 123 aaggnnactg aaganactga aanagannag agtttgtanc tgaaaaagaa tagggatagc 60 aaggaaaccc aganctgcat tcccctaagt ggggccatcc catgtgattg aattgtccat 120 agcttgccta tggtgagaaa tgtgcatgct ccgtgagcng gtctcttgaa acaggactta 180 tgcttcctct atattctngt taaattttcc aaacacataa gttcactgag cacagatttc 240 ttatccagag acaagtagaa tctnancgca gactgttggc anagtttcca ggcacttagc 300 catgttccct tcctgactna aatccccaa 329 <210> SEQ ID NO 124 <211> LENGTH: 410 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2833844T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 77, 105, 116, 142, 149, 152-153, 158, 165, 178, 189, 192, 194, 197, 199, 208, 221, 256, 304, 311-313, 319, 338, 344, 383-384, 392, 400 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 124 gctgagcatt cggtccacta acctgagtca tatccggcac tggtttctct agaaagggct 60 ccgacgggga atgctgntga caggcacttt ctgcggggtg ttctngggtt attggnggag 120 ctgtgcccaa ggtggtgatg ancggtgtng anntgaanac tggtngtgca agcccagntg 180 aggctgcant gnanganang ttggcaantg ctgaaaacat ngcttttgac caggatgttc 240 attggccagg tatcantcgt tcctggattg cttgtcggtc tccaaggcca acaccaggac 300 aacnatttag nnncatgtnc ccagtcaatt cccttggngc cgangacatg cctataaatg 360 gacgagactg ctgcatgttt ctnnggccat antcctctgn ccgattccca 410 <210> SEQ ID NO 125 <211> LENGTH: 250 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2835032T6 <400> SEQUENCE: 125 cctgaagatg caggtttctc tttggtatca tttttcttca gtttaaataa cttccttcag 60 catatctcat agagcaatcc cattgctcat gaattatttt atctgagaat gtctttattt 120 caccttcacc catgaagaat attttcactg gatataaaat tctgagttga caggtctttt 180 cttccaatgt gttaaaggca ccattccact aaattcttcc aaggattgtg atgagaagtg 240 catgggtaca 250 <210> SEQ ID NO 126 <211> LENGTH: 368 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2838139F6 <400> SEQUENCE: 126 ggggagaggg gctggatggc cgaggccgga acgggccctg gggtgcgggt taggaccgac 60 gtacctagca gcactggccc tcggacggtc cctgacccca cctcggggcg ggcgcacatg 120 agctgcttcc cacccaggga aagctggggt gctggccccg gcccctcgaa gagggcttag 180 gaggacggaa gctggccaga gatgaagggg ttttggcctg ggtgtgagtg acaaggaact 240 ggtgccagcc cctccctccc cggcactgag gcgtccgtgg gggctagatt attcctcctt 300 ttcttccaag ctgtcctgaa tccccacgaa ggccctggct cagctcttcc caccacaggc 360 acaccagg 368 <210> SEQ ID NO 127 <211> LENGTH: 486 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2838241T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 179, 362, 411, 413, 428, 452 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 127 ttcatacata tccattatca gtgccttgaa aaccaaacaa ctttaaaagt tagcagcagt 60 ttctgcaagt acaaaaatac acatttatta cataacatat ggtagtaaaa tttgtcaaga 120 tatattatac aaactcaaag cattttagat aaagcatcag tctaatatat tatagattna 180 tggagtataa taaaatgaca tatagtctgt cttcaaatca tacaatataa tactttacag 240 caatattaac aaactattca cattaagaat tacaggagta tctaagggaa cacagatagt 300 aggaatggtt attaaaaaac ctcagcaact attttcttct atgcttcaaa ttgggtgaat 360 gnttttttac ctgctaacat gaaaaaaaaa aaaaggcaat ttcttccaga nanacactcc 420 aagccgtnaa gagcttcatt cacatcttgc angtctgact gaccagtagt atgccctaag 480 ggaaag 486 <210> SEQ ID NO 128 <211> LENGTH: 556 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2838993T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 128 tnttatcagg aattcttcaa tggcattctt gtaatactat ttagttcatt tttataatta 60 cttcctaaga gacaaattgt cctagaagtg gggggtttct gagtaagaca ctggcatgcc 120 tggcaacatg caagaccttg tgcttcaata cttggaagaa gcacaaatta ctaagatata 180 attgctgctt ttgtattgct tataattcaa caggggaaat aaaagtaagt caaaggtaga 240 gcatgacaaa gacttctaga gaagtacagg tgataaccct gggagttccc aagaattcat 300 aggagctctg ggtgtgaatg aatgtcctct cgtcatgtgt atgccttaca gattagagtc 360 tgttgatgtt gggtctaaag ggtactaatg gagcaaggct gtcctcttac tgatagcagg 420 gcattatggc taatatttcg gaagtgaaat aaatccttct gtcaagaagg catagaaaac 480 aaagcagcaa gtccaaggta aggtttaaac ctcctagctc ttcttccctg gggcagaata 540 cccacagtca tagttg 556 <210> SEQ ID NO 129 <211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2849791H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 116, 120, 128, 164, 179 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 129 gctgtgtggc cttttctctc ctgtgggcag gtccagtgat tgctgggatc acccaggcac 60 caacatctca gatcctggca gcaggacggc gcatgacact gagatgtacc cagggnatgn 120 ggcacaangg cccgtacggg aaaggacaga atagggcggg ggcnggctca ccataatcna 180 tacgcagtac atggcaaaga gaatccctga tggttatagt gtctccagag caaacacaga 240 tgatttcccc tcacgttggc gtctgctgta cctctcagac atctgtgta 289 <210> SEQ ID NO 130 <211> LENGTH: 505 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2858295T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 452, 501 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 130 aaaatgaaca agttcaatca aaaacatccc aatggaaaaa aatcacacta agaataaaac 60 acttacagaa cggcaagaaa actgggttaa catataaatt tgtgtctgtt gaaaccagag 120 tacatgctag aaaacattaa cacagatacg acagagtgtg gttttttttt agaaatgggt 180 aatttctctc tccagtatcc tttcacttgt atgagatatt tctcctctcc tgttttcaca 240 aaccaagaaa tccccaggta ggccaatccc agaggtgcca tttagcagta tgcagcagcc 300 cagtttcagc ataacaaaac atgccttggt agtggctctc tcatgcaaat aaaagaaagc 360 ttaagaaatt cttgttgtag gtggattagg caaggctgcc attcagctgg tataagctaa 420 aagtaaaaaa tcaaaacgct caagaaaacg gncacaattt tggaatgtta aagatgtctt 480 tataaagttt ttttcaagac ntcat 505 <210> SEQ ID NO 131 <211> LENGTH: 380 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2932975R6 <400> SEQUENCE: 131 gcagggacaa gttacaggaa tgttctccaa gcagcaatcc aaaagagtct caaggatcct 60 tcaaataact tcagggtgag tctggagaaa acatatggaa tcccagcatg aaaccgtttc 120 agagttctaa taaaaatatg catattctca cagcatgtac tttatttaat atctgaaaaa 180 attgtgatag aaatgtgtat ttgttttaaa aacgtgtaac ttcttatatt tcaaagctaa 240 tacatgttca ttgagatatt tggagactat agagaaagat aaaagaaaat aaatcaccta 300 tattccacta tccaaagaca accactgtta gtattttggt atatttcctt ctagactctt 360 ttttatgtgg gtttgcactg 380 <210> SEQ ID NO 132 <211> LENGTH: 392 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2965657T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 36, 70, 100, 127, 147, 160, 165, 177, 186, 192-193, 199, 220, 228-229, 235-236, 240, 258, 261, 267, 271, 273, 281, 283, 285, 289, 297, 300, 308, 312, 317, 322, 324, 342, 348, 361, 363, 376, 385, 391 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 132 aaagatnatc acaacaaaat atacactaac ttaaanaaca aaagattata gtgacataaa 60 atgttatatn ctctttttaa gtgggtaaaa gtattttgtn tgcgtctaca taaatttcta 120 ttcatgngag aataacaaat attaaantac agtgatagtn tgcanttctt ctatagnatg 180 aacatngaca tnnccctgna gcttttagtt tacagggagn ttccatgnng ccacnnactn 240 aactaattat ccaacacntc ngttatntcc ngnctcaaat ngntncacnt tccaccnatn 300 aactgagnaa gnagcanttc angntctcct tcattttgct anaaagcntt ttttcttttg 360 ncnaaatgcc aagtgngaaa ttgtnttttt nc 392 <210> SEQ ID NO 133 <211> LENGTH: 298 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2967286T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 35, 69, 94, 184, 201, 229, 239, 252, 260, 265, 284 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 133 gtcacttcca aaggcccctc agaacganca acagntgaaa cccgcggggc ggactccgtg 60 ttgaaccgng gacagcggca accacagcag cganacggac ctgtgctttc caccaagaac 120 agattccgca gcgggacagc agtcactttg cagtggtagt aatttattcc ccacacaaaa 180 cacnccagct aaatgccctt naacccggtc caaggaattc tggaagtgnt ctaaaagtna 240 aaatccaata tnaaccatan atttngtggt ttcaatcaaa cagnactctt ctaaatca 298 <210> SEQ ID NO 134 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2994210T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 66, 202, 286, 292, 359, 374, 381, 396, 435, 442-443 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 134 accgaggcat agttctgacc aggtactatg tctgcagggc ttttgaaatt aaagaaacag 60 tccagnaggg ctccagtcag acccagaatg acaccagcca cacttgtgac tggcagagat 120 aacctctttg atcttcagca attttaaaag ttcttcatcc taatttctga gtatcataaa 180 aagtaaaaag tactttcatt tnatttttcc tttgaaaatg tttttagtgg caaacaggac 240 tacttgtttt ccttacttca tttttataag catagtagtt atatgncaat tnacttaaaa 300 ttagagaggg aaaccccaga gacctgagtg gcactgccca tccactgaag gcccacatna 360 ataggtactc atgntcatgt natcacgtct acaaanagca ataaaatgat gtccgtaaat 420 cggaagtaca gcagnagcag tnnatacata tctgatatgc tttcacacca gga 473 <210> SEQ ID NO 135 <211> LENGTH: 435 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2996094F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 378 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 135 gtcacaaaga gcttcaacag gggagacagc caccctcttg tgcagggccg gccagccttt 60 gcccggcacc gcccttgcct ggtttcaaaa gcagcctgcc cagcctccca ggctcctcgt 120 ctacggtgca tccgttaggg cccctggcgt cccagacaga ttccgtggca gtgggtctgg 180 ggcagacttc actctcacta tcgacagact ggaccctgaa gattttgcga tgtatttttg 240 ttttcaatat gagtctttac ctcacacctt tggccagggg acaggctgga catcaaacga 300 actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 360 actgcctctg ttgtgtgnct gctgaataac ttctatcccc agagagggcc aaagtacagt 420 ggaaggtgga taacg 435 <210> SEQ ID NO 136 <211> LENGTH: 580 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3000067T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 217, 232, 287, 329, 344, 353, 366, 414, 443, 459, 466, 471, 479, 483, 485, 487, 495, 531, 535 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 136 taagacagag tgcactaaat ttaactttag aaaaaattag ccgttgttcc tgaattgttt 60 ttgttttgct tttcattcaa cgatatcaac ttgtaacttg tgtcacttga gttttaattc 120 agcagtaaat cacctccact ccatatctaa gcagcgttgt cccaaaaaca aaaggggctg 180 aggataattc agctaatgga tgtccaaggt tgtgctnggt ttatttcttc anttgattgg 240 gtcttatggc atttcatatc ctctatcttc aaccagaatt ttttttnttt ttacttaaag 300 taaatgtggc tttgttagtt tctaaagant gtacttttct tgtnttactt ttntaaaaag 360 tctttncatt tcaaaaaaaa agttttgcat ttgtctcaag agactcaaat aggnagatca 420 gttttcaagg cactcacatc aanttgaatg gcagtagana aactgnccta naaattatna 480 ttntntnttg tgctntatag gtgccaggta ttgtgaatgc cacgcttagc natantggac 540 actcaatctc agctgtcccc ttacagttta acccacctct 580 <210> SEQ ID NO 137 <211> LENGTH: 378 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3116117T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 80, 82, 130, 244, 263, 277, 291, 303, 318, 327, 343, 358, 372 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 137 tccatatttc aaatgcatta atgtggtcat gaaaaaagta atcagataga tgtttaatag 60 ttaagcattg tccatttgan tngcagagca ccccaccctt cattcattcc ttcaaccaac 120 tactcaagtn aagaacatgc ttacttgtta ctggttggtc ctgttgccaa gacatcggac 180 tgtaactttg gaaagaaccc ctgctcatat ttgccttgac caattttcat atcaagtaga 240 tgtnggtgga ttgcagtgtg atncattttc atcagtntct gctcaattga ntgggctgct 300 tcntttaaag tgctgcantt ctgatanata gatgtccgca agngggtgcc cttacgtnat 360 acagccttat cntatcaa 378 <210> SEQ ID NO 138 <211> LENGTH: 354 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3119119F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 49 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 138 gaaattctta acatcatcaa aaagttaaat ttgttttcaa taatttgtng gggggaaact 60 tagataaaat taactaacac cttgcattac agaattctca gtcatgcttt catggctcag 120 acctgaccag agactgtttc tgccaagttg agatctcccg cgagaaaaca tccaaaagtt 180 ttgtcattat ctacctattg ctcggaaatg gtttattctg cctgctaacc actcacaaac 240 tttgatatga taacaaagac taactgctgc ttacaaatgc tcgtttgata tttaacttgc 300 tattttctat tcagggcaaa ataactatct tgaaaatggt tgttaattct cagc 354 <210> SEQ ID NO 139 <211> LENGTH: 447 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3151807R6 <400> SEQUENCE: 139 gtgctcaccg tgagcggctg gtacctgtcc cctgggaact gcaagatgca caggaccttg 60 tgtacctgtt tgtgatcaca gccgaggacc agcgaggtag cattaccaca tccacacagg 120 gcttttacca taaccgcccc agtactggaa cgaggagctg cagatgatga gggacctacc 180 caacaagaac caacctgagc agctgcttca agaaaaagcc atgttcaagg tgcctgaatc 240 ccctggtaag tgagtgacag cctcacagcc tcaggcccac ctggctcctg ctggaaggtt 300 ttcttgtgct cgggagagaa gtgagggaag ccggcagtcc cagccctgtc aggtgccctg 360 aaggcccgtc aggtttgccc tgcaaggcct tctagcattc tgcttcctgg gagaccatcc 420 cccacctttc tccggcctct gagactt 447 <210> SEQ ID NO 140 <211> LENGTH: 195 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3208407H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 105, 110, 113, 119-120, 147 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 140 ctctggtatt catgccaaag acacaccagc cctcagtcac tgggagaaga acctctcata 60 ccctcggtgc tccagttccc cagctcactc agccacatac accangtgtn aanaggagnn 120 caccgcgctc gcgtgtgata aagggcnccg ggcccgtggc aaggcagggc ttcgcaggag 180 atgatgcccc ccggg 195 <210> SEQ ID NO 141 <211> LENGTH: 495 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3211415T6 <400> SEQUENCE: 141 tcccaaaccc ctccctgtga cttgcctctt ctcttgtgct actttggttg tcatcgtgtt 60 catcactaga ttttagatgt cctcggtgtt actgacggtt tttctgtcca cctcgtcctg 120 cagtctctct tctcctcaag tttgaaatgc ttcatctcat cgggttgggc cagaaaaatt 180 tggtccataa aaggtgcata atttctttcc attcactaca tggctgcaaa gtcaatctgt 240 acgtagagct gtctcactcc agcctgagta aaaatattat gtgtttggct taaaatccac 300 ctagcatcag catcaggtgc tactattaat ttcaaggtcc caacataaac gtcagaacat 360 aaagtccaga agtgctgttc ctgtaaactg taaactcctt gcaactgctg taccctctga 420 tagcactgag gcagactatt ttctaatagg ggaggagttc tctgcattaa tattccaaca 480 gattctctta aaaga 495 <210> SEQ ID NO 142 <211> LENGTH: 346 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3238201T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 20, 27, 34, 39, 61, 78, 82, 91, 98, 103, 109-110, 114, 138, 141, 149, 156-157, 165, 189, 233-234, 280-281, 285-286, 288, 291, 309, 319, 321-322, 328, 341 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 142 taataanaaa tataacagan ttgaaanatt taantacant cactacccac tccagtaatt 60 natttaagtc ataccaanta tngaatatga naaataantt canaagtgnn attnctttaa 120 aatacactac ttccactntt ntaagtatnt tacatnnatg tatanattct atagtggaag 180 cagacaatnc tctctaaaaa cattatctcc ttaaaatctt gcaggtgcat atnngagcca 240 caggcaatct ctgacatata aaattgcagt acaggccttn naaanntngc ntttcactgg 300 tacaatacna caaccaagnt nnataatnac tgtacagtgc ntagac 346 <210> SEQ ID NO 143 <211> LENGTH: 471 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3254006R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 396 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 143 gttgaagagg gggaagttag ctggagacac tgctgtcagg atcagcactg gggcagagag 60 gaagcagctg cgtttcggtg gtagaagtgg gaggggaagg aagaggggtc tgcaagggtt 120 ctgtacatcc tgcactgaca gaactcaaca gcccagccct gcctggctgg ccctggacaa 180 gatagaccct gggcagcaac tgggagaagg gaagaggaga aggggagctc ctggggccag 240 aatcattcag cagaggctgt ggtttcagtg catacctttg tgtgaaagga gtgcaccaaa 300 tcattgagtt gggctgtaat tccaagggct ataattataa ttccaattct tttttgtttg 360 taatatttca aattcttggt tcctagatat tgatcnagca aaaaattcct ccagatggca 420 atagcctctt ttctcctgca gctctctccc caaccttagc cttacaaagt a 471 <210> SEQ ID NO 144 <211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3255002T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9, 19, 26, 28, 41, 61, 71, 73, 80-81, 87, 95, 152, 157, 167, 169, 171-174, 179 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 144 ctttggaana agtgatttng aagcancngt gtatcctctt nttctgccct gggacattca 60 ntacggtaac nangaatctn nggctancgg tgctnttaac ttctgaacca cgacttaagt 120 caagagggag acagggtccc agcttctcaa gnggcanatg tgcaacntna nnnnctacnc 180 <210> SEQ ID NO 145 <211> LENGTH: 185 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3323143T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 44, 66, 69, 72, 90, 96, 102, 110, 120, 122, 129, 135-136, 142-143, 150, 162, 165, 168, 173-174 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 145 gagggggaac aattatatag aactttcgga gatgtanatt cttnggcctt cgacattctg 60 gagcanaanc gnctacaagc attttgaaan attctntgcc tncggcagan tttcgtgtgn 120 gntcactgng gactnnatcc anntgccttn ctgcttttaa tnttnctnct gcnngacctc 180 cttct 185 <210> SEQ ID NO 146 <211> LENGTH: 466 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3365533T6 <400> SEQUENCE: 146 ttccaaaatt cttcaggatg tttaatgttc aagtgtccat attcccagtc ccactggatg 60 cctggcagga tgcaaccatc tgaatgagtg gaagtataat gtttgcacca ggtattatat 120 taggagcctt gaacccagaa tatgtctgat taagtctttt agcccaataa tttgccactg 180 ctgccaagtc tggtaatttt gaaggagaaa gttcaaccat aacggggtga tacagggcac 240 ccccgtactc aaaaaacttt caaagtgctt tctaaacaag tttctctttc tccttgaata 300 caacgtcagt cacaactgat ggcagtacaa tcgatccatc catacactgc tctaagaaca 360 tcttgatggt ataatatgct gtcattcatg ctctacctgc tactagttta atttggtcaa 420 gtagctcttt ccctggagac tcaaatttct actagactca aattct 466 <210> SEQ ID NO 147 <211> LENGTH: 290 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3421032T6 <400> SEQUENCE: 147 caaaacaaaa caggcaattg ataaaggcgg cacaatgggg aaggagaggt gagggagaag 60 agagaaatgt ggcaggggtg aggggaacct gggtgcaggc caggctgcct cagcgatacc 120 ccagggaggc tagtgtggga aggaaggacc aggaatccct gaaaggacca ggaggcaacg 180 ggacctgagg gggtgttggg gaggcaagga ggggcggaga gcgaacaggt ctagaggaga 240 agggaaacca gggaagaggg gaaaggaggg cggcggcagc agccgggcgc 290 <210> SEQ ID NO 148 <211> LENGTH: 446 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3425501F6 <400> SEQUENCE: 148 gaaaagaaaa agataaggaa agaagagaga agagagacaa agatcactac agaccaaaac 60 agaagaagaa gaaaaaaaag aaaaagaaat ctaagcaaca tgactattca gactatgaag 120 acagttccct cgaatttttg gaaaggtgct cttctccact aactcgatct tctgggagtt 180 ctctggcttc acgaagcatg tttacggaga aaactacaac ctatcagtac ccaagggcaa 240 ttctatccgt tgatcttagt ggtgaaaact tatcagatgt agacttccta gatgattctt 300 caacggagag tttgcttctg agtggggatg aatacaatca ggactttgat tcaaccaatt 360 ttgaggaatc tcaggatgag gatgatgctc ttaatgaaat tgtgcgatgt atttgtgaga 420 tggatgagga gaatggcttc atgatc 446 <210> SEQ ID NO 149 <211> LENGTH: 444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3434684T6 <400> SEQUENCE: 149 aaaatgatgc attataaaac ttggaagcaa ctttatacaa attccaattt ttaaatatgg 60 ttgaacaggg tgccctgggg gttaggacac tggcaggaag tctgattagt tgctgggatg 120 gtcccatcca tgaagcactg gacacatgct gggaaccatc tgtgcataaa tcagaagagc 180 caacaagagt gggaacagga aaggtctgca aatacgcata tggacttgaa gatacaacac 240 cagctcaggt aatatacagc aggcggagga gaaatgaaac aggagaaaca ggacaaagga 300 gaattcatga catgatcaag aaaccccttc tcctaacccc ctatgtccta aaacccacaa 360 ccatacagaa agaaaaaatg gaaatgcaga caggttttta gttctatgct gtttaactgc 420 tgtaagtgag agtagtacca tggt 444 <210> SEQ ID NO 150 <211> LENGTH: 411 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3471751T6 <400> SEQUENCE: 150 acatgtacag tcattactgt gctacattgt tattagacac aaaatggtat gtgctgtact 60 ttggtgacta ttatttccat cagttttata catggtcttc cttatggttt aattattctt 120 actcaaaaca caaaaggcat ctcttttctc tctcttatgc accaagcaga gtatatagct 180 gatgtcttgt gagtgtggag aacagccagg gtactccaag acttgtcttc ctctttcttg 240 cctttcttcc agtgtggcca aatgaactcc ctgtttcctg tctcaggtga tttccatttg 300 accctgatgt tcccttttta ctatgtgctt tattccgtgc cccccagccc aatgtttccc 360 tgagcagccc ttctcttttc ctactcttcg tcggctggac cagttctaga t 411 <210> SEQ ID NO 151 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3475326T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 5, 7, 10, 14-16, 19-21, 25, 41, 46, 53, 56, 59, 64, 66, 68-69, 71, 73, 75, 81, 83-85, 93, 100, 116, 118-119, 128-129, 132, 140, 148-150, 180, 208, 307 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 151 taaancncan gacnnnttnn nacancgcaa aatgagacta nagggnatgt cantancgna 60 tttnangnnc ntntntttct ngnnnggatc ttnaaaaggn gagatagcag gatccncnna 120 tgacttcnng anagtaatan cagctttnnn aaccgcaggc atcgtggagc ctgcatgggn 180 acgcatccag gccacggcct tcctttcnag aagctcccat tcacacttca agtccttacc 240 aatgctgtgc agccagatca cggccaggat ggtggcccag cctgaggaat ccacaagctc 300 ggcaggntgt gcagccatta tttcttccaa actcatacct aggatcttgg ctagatcttc 360 attcagattc caggaaccat ttgcattttg 390 <210> SEQ ID NO 152 <211> LENGTH: 430 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3480489F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 216-218, 220 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 152 gactaaggga catttatggg acgtgtttaa caaggtggga aactagttcc cccaaccttt 60 ctatcgggtt cttgaccctt ttagggagac agcggacgag gttcgtaagc caggaaaact 120 agctccctgg actccctggc gagtgcgtgc gatgaggaga ggcccgagca ctttgggggt 180 gcacggtggt ggtgggggga atgagtaaaa gcgcannntn atcgtgaacc ccaccccaga 240 tgattacctc gccgttggtg atgttgatcg ccaaatagat gtccccgaag gagccagacc 300 cgatcttccg taccagttta tatttccctc cgacaatgaa ttcagccttg gagccgctgc 360 tactcgccat cctgagagac gaagatggag gctggggcca agccccggac acctctggga 420 agaggacgga 430 <210> SEQ ID NO 153 <211> LENGTH: 519 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3559834F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 14 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 153 gaagactgga agancacctg ggctgtcatt gagctctggt gccaggagga atggacaaga 60 tcttaggagc atcattttta gttctgtggc ttcaactatg ctgggtgagt ggccaacaga 120 aggagaaaag tgaccagcag caggtgaaac aaagtcctca atctttgata gtccagaaag 180 gagggattcc aattataaac tgtgcttatg agaacactgc gtttgactac tttccatggt 240 accaacaatt ccctgggaaa ggccctgcat tattgatagc catacgtcca gatgtgagtg 300 aaaagaaaga aggaagattc acaatctcct tcaataaaag tgccaagcag ttctcattgc 360 atatcatgga ttcccagcct ggagactcag ccacctactt ctgtgcagca agctcccaga 420 cgggaggagg aaacaaactc acctttggga caggcactca gctaaaagtg gaactcaata 480 ttccagaacc ctgacccctg ccgtgtacca gctgagaga 519 <210> SEQ ID NO 154 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3562407F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 59 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 154 aaaaatatct attaaaagta ttatattctt attggcttca tagtattctc ttgcaaggnt 60 gcaccattat ttagtctcct taatgttgtt tccaatctct tgttattgag gactgaatat 120 acttgcactc atatcatttc atatatgtgt aaatatatct gtaggataaa ttcctagaag 180 tggaagtcca aattatatat atattttaaa ttcttgtgga tatatcagtc catttacatt 240 cctcccaacc atcaataaaa ctgtaaaaac ctaaagttat ccaattagaa ttt 293 <210> SEQ ID NO 155 <211> LENGTH: 608 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3586531F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 528 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 155 gcgtttaaac ccaagccgca gccgctgctg tcgccgagct cccggagctg ggtgggggtg 60 ccccacgctg aaagagagtg atggagtgcc cagtgatgga aactggctca ctttttacct 120 caggaattaa gagacatttg aaagacaaaa gaatttcaaa gactactaag ttgaatgttt 180 ctcttgcttc aaaaataaaa acaaaaatac taaataattc ttctattttc aaaatatctt 240 taaagcacaa caacagggca ttagctcagg ctcttagtag agaaaaagag aattctcgaa 300 gaattacaac tgaaaagatg ctattgcaaa aagaagtaga gaaactgaat tttgagaaca 360 catttcttcg cctaaagcta aataacttga ataagaagct tatagacata gaagctctca 420 tgaacaataa cttgataact gcaattgaaa tgagcagtct ttctgagttc catcagagtt 480 cctttctact gtcagctagc aagaagaaac gaattagtaa acagtgcnag ttgatgcgtc 540 ttccatttgc aggggtccat taacttcaaa tgatgatgaa gatgaagata agagaaatgc 600 agtgtgac 608 <210> SEQ ID NO 156 <211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3685559T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 360, 520 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 156 tctctaagcc taaccaaatg ctttggtgaa tgatgcttgg aaaagctgga gttttaaaag 60 gcattcatcc atttatgaac tttcttccag cccaggatcc ctgcagagaa ccagaggtta 120 caaatctgcc ctcctttctc ccctaaaagg tggctgaggg gaggagaggt gcatgtagct 180 ccagctatag caaatcagtg ccctgactca ctggggagac ccagggggtt gggatgttgc 240 tgacacctca tgggccacct catcagccca tctttgtagc ttcaggttca gctctgggtg 300 ctgcaggcag ggacccctct gctccctgcc tgaatgcagg gccagtctcc aaggaactcn 360 gtctgcagag tagaaagagc tgtgggctgg gaatcagggg cctgagggag cccctgccac 420 tgcctgccca gaaccagtgc tcctcattct cctgctgaca gcatgcatgt gccttttggc 480 taacacacac tcttgtctaa tttccagcca ctttaacccn gggat 525 <210> SEQ ID NO 157 <211> LENGTH: 303 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3738958T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 249, 264, 268, 270, 281, 287 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 157 aagtttcttt gaaaaactcc aatatactat tattgcaatc actgtaacag gtagatggag 60 cattcccatt aacttggcta cttgacagta actcaataca ttattttctt aaccagaata 120 caaaataaaa cccacagtca cacagaataa atgccctcaa agaaagcaac ttaaacttgt 180 actgaacact gaaaaggtaa atctgtataa aaggttataa ctgcatttac agtgcaaact 240 cgtgtttcnt tctactctct tatnaacngn aaatgtcttc ngaaacnttg cctccccgca 300 ttt 303 <210> SEQ ID NO 158 <211> LENGTH: 338 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3809571F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 296 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 158 cccgtctgga agcctttata ctgaaacaca cgtgaccggc tgtctggaaa gtgagctggg 60 cgccgtcact gatgatgtct tttctgtggg acacagtcag gcacacccct tgcccttctg 120 agcctgggac gagacagagc tgacaggcgg agcccaaagg tgtgccgagc accagtgctg 180 ccaggggtga gagtcacatg cagctgtggc tgccgtggac gcctgctttt ttgccctctg 240 cagtttgcct aacccctgca gtttgcaggc agccctgggc ctctggacag agcagncctg 300 gttccctgtc aaggtgattg atccggaaga atctggca 338 <210> SEQ ID NO 159 <211> LENGTH: 366 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3817414T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 265, 276, 331, 343, 355 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 159 tggtaggaga aatgaatgag gtacttttag gtagttaaat agaaaaacaa atctagaaaa 60 tacctggtaa cttgtgttgg aacacatttt ccatgatacg tttaatttct agcctctgtt 120 ccaagttctc attgtgtaag ccaaattcct gtaccacttt gtcaatggca atgccaactg 180 catttatctg ggagggtgtt ggtgggggta acgtagtggg caactcttcc tcttgcttct 240 ccttaatgtt tttcttgtgc ctctnttcct tgatangctt atgggcaaat gcaatgggat 300 tcaattaaaa catcacagag tctgcaggtg nactttgctg tanggtagtt tcgtngtcgc 360 cttttt 366 <210> SEQ ID NO 160 <211> LENGTH: 483 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3875548T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2, 12 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 160 cntttttaca tnatcccttt tttccatatt ttttaaacat tagatacata atttgttaga 60 agttaaaagg gaaaaacatt tttttctgaa tcatatcaca ttatatttag cttaaagatt 120 attaactttt tgaatatcaa aaattgaagc tgctgggaat cacatttatt tgtaggtccc 180 aaaatagccc tgaggtctga ataggaaaat atcttttata aactataaca aaactctcac 240 ctcaaaataa aacactatga aatttacaca gttatatctg tactcagtat ctttacaata 300 tccagaaacc tactggatta ttagaaatga caatgcaaat aggtttacat tcagaaaaaa 360 agagagctta tactaagagg acctaacttg aaacctggca ccctgtgcag gaatctgttc 420 aatccttaga acggtcataa agtcatcttt gttaaaaaca caggtccttg gacaccccca 480 aat 483 <210> SEQ ID NO 161 <211> LENGTH: 376 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3992126R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 96-97, 99, 104, 106, 115-116, 121, 126, 144, 159, 164, 184, 188, 197, 204, 219, 223, 234, 244, 251, 284, 286, 334, 362, 365 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 161 aaaaataccc tgatttgaaa ccaacagcag atgttgcaaa ctttcatacc actgctggcc 60 atggaagcct cttaacaaca cactgtcatt taaggnngng gttntncttt atacnnagag 120 naagangtgg tcttaagggg atgnttccag gggggtgant tcangcctct cctgtatttt 180 ccancaantg gggtatntgt ggtngtttgt tttttatang ggntaataat cccnggattc 240 taancatatg ntcagctatt ttaaagaggg gattaaatat tatnanagaa atagtaaaga 300 taagttatcc tcacttaggc aaaagcacca ggtnctttcc atatcaagtt tagcctaccc 360 anggntgttt tttgtt 376 <210> SEQ ID NO 162 <211> LENGTH: 351 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 342907T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 344 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 162 tgacttggga tttgacaaat tcaaacttgg ttttaacaca ccatgtgcat ttcctgagcc 60 ccaggcgtac cagcagacac agggctgaaa gacccagggc ctacccgcag ggcttagagg 120 ctgaaccaaa ccgtttccca tttggctcaa gaccatggat gcaaaaatga ccatttttaa 180 aattttaaat tcaaatttat tttacttggg gataatcatc actgacactc actgagccat 240 tgctaggtca ttgtctatgg gcaggtccat gcataatgtt atttaatcct cactctggga 300 aatgttatcc tcacttacag aggaggtcac tgaaagctca gagnagtaaa g 351 <210> SEQ ID NO 163 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 462533R6 <400> SEQUENCE: 163 caaaattaca tttaaaacag tggattgttc tacaaatata tatgtgtata tatacatatg 60 cttctgaaat aaggatatat tatatgagtt tttatttgat ttgtggtctt tagtcatagg 120 taatcaaaaa taaagagatt tgaatgcaaa actttataca ttaatgtaca tttctaatga 180 tggtacaaat tgccacttta taataaaaaa gaaacaggtg ggaataataa tcaaagcacg 240 tgttccttca gtactttggt gatttttaat cccccttgtg atgcacagga aattattttt 300 tagttacaaa aagttatctt agaaatctat acttcccaat acagatttca tgttaagtca 360 tatcaaattg agaatttgtg gtgaaagaat aggaaaaggg atgctagatg ctgatctttc 420 tttttcaggg atttttcccg ggaggcccaa gttaaaaatt ccatacttaa atcc 474 <210> SEQ ID NO 164 <211> LENGTH: 335 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1554666T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 296 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 164 cagggctctg ttttaagccc tttttatctc tcacagtata gactctctca tggggtaaat 60 attgacatga cttcatttcc atctatctgc tcatcactca caaatctctc tctagtctag 120 acttctctct gagctccaga cacgcaactg tctcttcgag gccccatggc tatacctcaa 180 acacctgtcc taaacaaaac tccccatctt ctcccacaac tgctcttttt cttgaagtcc 240 acgcgtccaa ggcggcccat ccagtcccgg ggcagaaact ggcagacccc cttatnttca 300 catctgtgat aaccgacatg ttcactgttc tgctt 335 <210> SEQ ID NO 165 <211> LENGTH: 518 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1872410F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 47, 235 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 165 atctgaaagc atgcgtgtgt cacagaccat tcagaggggc tataganagc aaactccagc 60 tgaaagcatg cgtgtgtcac agaccattca gaagggctat acagagcaaa ctctagctaa 120 aagcatgcat gtgtcccaga ccgaaaacca gagagagcaa actccagctg aaagcatgcg 180 tgtgtcacag accattcaga agggctatag agagagtact ctagctgaaa gcgtngcatg 240 tgtcacagac cattcagagg ggctatagag tactctagct gaaagcatgc gtgtgtcaca 300 gaccgttcag aggggctaca gagagcaaac tccagctgaa agcatgcgtg tatcacagac 360 cgaaaaccag agagagcaaa ctctagctga aagcgtggcg tgtgtcacag accattcaga 420 atggctagtc catttttcct ctgggggttt ctctccccca ttatattgtt tgggaagcag 480 tttgtttact ttaaaatgac ctggattcca ccagtata 518 <210> SEQ ID NO 166 <211> LENGTH: 338 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1991934F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 71, 88, 109, 188, 268 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 166 aggtgaggca cctgagaagt tgtggcagcc tcttagggac aaagctgaat ttccctgaga 60 ctagaaacct nttcttccga aaactctnga tactttttgt actgggccna tctcttgtca 120 cttaggcaaa ttccttttca gttaatggga ccaaagagag atgtttttgc ctccccctaa 180 gctggacnta gttggcttaa agtggaagaa tcccgaggag gcggggacct ggtaaggccc 240 ccatcattca gctgccctct cacacctnaa gagccacttc tctgctccaa ctgtggctgg 300 ctttgtgttt tgttttaacc aggaaggtgt tccccgtg 338 <210> SEQ ID NO 167 <211> LENGTH: 533 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2264271T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 484 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 167 gacctttcag aacctctatt gccctctgtg ttaaatggca gcaataaaac ctcccaggat 60 tttcagggaa gggggtggat caaacaagtt acaacacatg tgaaagtgtg ttggaaagca 120 ccaagtattc taacagaaaa ggccaagaaa cagcatgcat gctgccactt ccctctcccg 180 tgcccaaggc agacatggct atctatctcg gcactgtctc accaagctat attgatcatt 240 cagaatccct ctcaacacat tccaggatag ttagggtgac atagcctcca tggggtgaag 300 agaagcagca atgcaaagca gggaatgccc agggaatggg ccaggtggcc tgtgccgtct 360 atgggctggg cctcatgctc agctgggctg tggctgggct tcaagaggcc tttgttccca 420 gcatcctggt tagcaacccc agttcctctt tcgtgcattg tggttccctg agaaaaacgt 480 taanccagcc cccagcacag tcaggccagc cctggggaag ggctcattca tga 533 <210> SEQ ID NO 168 <211> LENGTH: 511 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2374921T6 <400> SEQUENCE: 168 atcaaagctt gctgcagcct tgaactcctg ggctcaagca atcctcttac ctcagcaact 60 aggactacag gcacatgcca ccacgcttgg ccttctaatt tatttctgtg tcaacaaaat 120 aaaactcagg cctaggaata gcttggttca gaaatcacag agggacttag tattccatta 180 atacaaatgg aaacattaag ttcatcatca gatgataaaa ggaaaaaaaa aaacctgata 240 ctcatctcaa aagacgcaga aaagacattt gcataaatcc agtacctatt attatttcaa 300 atttaaaaac ttcttctttt ttaagagata gggtatcact atgttgccca ggctgatctt 360 gaactcttgg cctcagatga tcctcctgcc tcagcctccc acagtgctgg gactacgggc 420 atgagccacc acacccatca taaattaaaa cttctgaaca atctagtaac aaatggaaat 480 gcttttccat gatccagcac atctagcagg g 511 <210> SEQ ID NO 169 <211> LENGTH: 61 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2530696T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 41, 47-48, 50, 55 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 169 aatatattaa tcagaaaagn cacatactat aaatccagga naatacnngn atatnaatgt 60 c 61 <210> SEQ ID NO 170 <211> LENGTH: 185 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3092415T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 73, 135, 173 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 170 agaaaaaacc caacaatatt anacaagaag ctactgcact ggactacaga gctaaggtat 60 ggtgagatcc tantgacttc attattagac catcagtctt ccatttctct ctatcctcac 120 agcctgactt ccagngcaag tcataaatca atgttgtctt agactgctgc agnctcctca 180 cagtc 185 <210> SEQ ID NO 171 <211> LENGTH: 346 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3092627T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 56, 58, 72, 79, 145, 177-178, 193, 212, 226, 229, 266, 271, 295, 309, 320, 332 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 171 atgtgttttt aatgtgttcc cttctattac ccctccctct ctacctcccg gggaananaa 60 aaagtagaga angaaagtng acaattccct tgttccctca aggagtaaca gctcaccctg 120 caggcataca gcagggaact ctcanaccaa gggaggacgt aggaagggag tgggttnngg 180 gggatgccac cancaccagg agagctgtgg gnggctaggg caggangtng aataatttca 240 tttcacaggc tttccagagt gttaanggta naaagagccc gggagatttg aaganggttt 300 gcagagatng agaaactgan gcaaaatggg tngttacttg ctgaag 346 <210> SEQ ID NO 172 <211> LENGTH: 500 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3602715F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 47, 250, 305, 319-321, 323, 325, 473 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 172 ttatttcctt aatccacaag cagtggttac acttgctttg cattctngtc tggttcctaa 60 ctctagagcc cttctccctg gcttagccag taagctgagc ccctggctgc gttcagccgg 120 cccgcctgag agacactagg ggaaatagct tttgtgggca agcagggtgg ccggtggtgc 180 tcagcagtct ttccagtggc tgtgtccctc ctccaaatgt ggacaggcca tgacagagtc 240 ttagcccaan tcccacagat ccccaaaagt tctgttgatt gcttcagggg atcagtgaaa 300 attanggaat tttgtgtgnn ncnanataca ttttttctgg ggagatgagc ttctcattga 360 gatctgtgac tcagaatcga ctaagccacc ataagtctgg atttctcccc agctcccaag 420 gcccttttgg ggtccagaag acctgcatat ggggctgttt actcatgcaa atnaggtatc 480 tgaactgcag ctttcagtat 500 <210> SEQ ID NO 173 <211> LENGTH: 375 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1879094F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 237 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 173 caattctatg actgaaagtg actaaaaagc tggctttatg ccattaacac tctgtacttt 60 gcagccaatc agaactgacg cagtctgggt gctagctgct tcaaaagcaa cccacaccac 120 acttttacca tttccataca tcaactgctg agaatatgaa aatgcacagt gacaggtttt 180 aggatcctgc ttcaggattt ccttttcctg gtttggtcac tagagttggc tatttanctg 240 tttctaaaca atagctattt tatcgaatag tttagagacc actattaaat attgtgactg 300 atgaaggatc tgtgaatttt ttatatatgt tctaagagtt accattttga taccttttaa 360 aaaccagcag ctttc 375 <210> SEQ ID NO 174 <211> LENGTH: 451 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3735627T6 <400> SEQUENCE: 174 tgaggcagca tgggagtctt ggcttggaaa tcaggtctgc gttcttggtc ccttcagtca 60 ctgacctaat atgtgaactt agacaattca cttgcctctc tggaccttta aatgaaagag 120 ttaaactgta atggataatg tccctgggct ctttcacata atccatactt gagaaatcaa 180 tgaatcaatt tgaagaaact ctaattctaa gacataggta tcctggcacc tgtttgaaac 240 agctgaaagg aggtaaaggt caggttcctg tttattatac atttagctat aggaaaagaa 300 gcacatatat ctatggagac acagaacctg gcagccccta tacttgacta ataaaagcaa 360 attcctggaa gaagcagaga aataggccac aagtgagact ggcagtgtca aaaaaggtct 420 ataagttaag tgatccaagt agtaaaaaac a 451 <210> SEQ ID NO 175 <211> LENGTH: 244 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1958331F6 <400> SEQUENCE: 175 aaaaagaggt cttgccttta atgcagtgcc taaattacca catctttatt agaatttcat 60 aataatgctt tgagggttga taaaaatttt tctcaaaaga gaacttctta aaataggagt 120 ttggatattc agatattcca gagaacttgg ttgtttagtg ttttaaattc taagaatttt 180 tcggccagaa aatgatcctg cagagcatcc cttcccccca cctcaccact atttctcaac 240 tcct 244 <210> SEQ ID NO 176 <211> LENGTH: 271 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3234716T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 5, 19, 66, 80, 83, 94, 109, 124, 127, 131-132, 135, 143, 159, 171, 180, 183, 196, 207, 230, 235, 249, 254, 260 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 176 atctncttcc atcactggng cagagtccac tggtacttcc acggacgctg tcagcaactt 60 tctgancgcc ttcaaagaan ccnaggcagt catncgttct ggctcttcnt gggcgggttc 120 ttcntcntca nnggnccctc canactccag ctcttatgng catgtgcccg ngaatcgtgn 180 tcngtcctct cttgcnacag gattcancac ggggtcatcc actcttgaan taatnagctg 240 ctcagtggna tctnggggtn gggttgggcc a 271 <210> SEQ ID NO 177 <211> LENGTH: 269 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2707709T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 199, 214 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 177 taggtgattc agttttatta ggctgattag caataatttg caaaaactgt ttaaacaagt 60 catggaaaat aaaatgaaaa tttaattagc accagtgtca agggtaaaaa agcaattaat 120 attaaacact aatgtgaaga tactgttctt ttgtttttaa ttattcaata ccacactgag 180 cagattttga ttatttttnc tttctgagaa aatnaagggc ttttaaaatt atacttaata 240 tgagctgtac taactataaa tggtgaaac 269 <210> SEQ ID NO 178 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3111091F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 49, 128, 130-131, 133, 415 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 178 ccgccgtcct gagaggattg tngctgatgt gcagatctca gctggctgna tgcattcagg 60 ataccccatc atgtgccacc tggagtctgt gaaggagatc atcaatgaga tggacatgag 120 gagcaggngn ntncggggcc ccatccatga gctgggccac aaccaacagc ggcatggatg 180 ggagttcccc ccacacacta ctgaggccac ctgtaacctt tggtcagtct acgtgcatga 240 aacagtcctg gggatcccta gggctcaggc ccacgaggct ctgagccctc cagagcgaga 300 gaggagaatc aaggcccacc tgggaaaggg agcccccctg tgtgactgga atgtatggac 360 agccctggaa acatatctac aggtactgag ccagaaattc tgggagaagg ggatnaccag 420 accccttcag tcatgtagcg acctgggatc ccagtagctc t 461 <210> SEQ ID NO 179 <211> LENGTH: 274 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1352487T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 224 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 179 gtagaagtat gtgttggcaa tcgttttcgt aagagtcaga aaaattaggc cggtttcaca 60 atatagagtg tcctttctgg tcaacagtat tgcttcagga cagaagagca tttcacagat 120 ctttcctgta acttctagaa aagtcatcca gccagattta ggctcaagct tctttacaaa 180 gccattttcc tatgagagaa taaatttaat attttaaaaa tcantggaga ttaagtatgc 240 tggaataaaa agcaaaaata ttttcattta aata 274 <210> SEQ ID NO 180 <211> LENGTH: 111 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1361439T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 92, 107 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 180 ccccggacag cccttttagc cataaggaag tagcggtcca cgggggcgcc gagggccacg 60 ttgatagcgc gcacggtgtt gatgttgcgc anaccaacag catgggncgc g 111 <210> SEQ ID NO 181 <211> LENGTH: 556 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1214059T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 309, 318-319, 359, 408, 554 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 181 ataatattct ctggaaaatc taaaatcatt ctgttatcct aacattttta tactatcatc 60 attttagaaa ataaaaggcc tgcgttatat actagaaaaa tttcttcatt atatgcaaaa 120 tatttatctc ctctagtaaa ggagattaaa gaacaactgc aagaggaagg aaggtcctga 180 aagtgtttca tttggtatct acctacccca accccaagac ataaagacag ataaaggcac 240 taagatgcta gtatgtggct agtcctttca ataacccagt cagtccatac agataaccca 300 tgggatatnt tttttgcnna tctctttgag ccatcgatgg tcattatttg gttagttcnc 360 ccaaggtaag gccataccag ctgttaaaat gatgtagaga ttaatcanca gggctgccac 420 ttgcgaatcc cctccaagga tgctgtgcaa agggtctcat tggtcctgat gagtaatctt 480 gtgactgtac atattcctgg gtgcatgtcc acaaatactg aggtatagcc tgcatgccac 540 taaaaataac aaangg 556 <210> SEQ ID NO 182 <211> LENGTH: 263 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 182609R6 <400> SEQUENCE: 182 gtgagctgga ctaaaggtta tcttaggtcc ctttcaactc tgcactgtca acttgaattc 60 atacacacag ttgacacaga accctcgttt tctgaacaaa agcatataaa atcctgttgc 120 caatccttgt atgtcagttt cccatgggtc ttgaatgcaa atacaaatat cgtaaactaa 180 atatttgtgt tttctttcct agactctcca gaaagagcaa cagtaatgga gtacatgagc 240 actggaagtg acaattaagg aga 263 <210> SEQ ID NO 183 <211> LENGTH: 577 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1930329T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2, 545 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 183 cngggagacg gggtcctgcc cgccccaccc tgaggtggaa cccccagctg ctcctgggca 60 cagaatcatt tacaaaaata aatatgaaaa aagcagcaac tctttagtga tcatggaatt 120 aatctgacag caattaaatg tgtttaagca tctggcatat ctcctcaatt gcaccaaaag 180 aatttggaag cacttggttt ggtctcaaag gcaaaaggaa aggacaagga aggggccagg 240 cctcccgcca ggcccccgcc cccctcacat ttctgagtcc gcatacatcc cgttgattaa 300 gtagtccacc tgggtgtagt ccttcttctt gtagctctca taggcctgca gggcaaacaa 360 aaccaagact gtgatgaaaa gggtcacccc gagtaacagc accaccagaa ggagagtttt 420 gtctaccacg gcctgggtga ggggctcagt ggtgaccacc atgtactggc cttgggtgct 480 gggctggcac gagtccgtgg ctggcatctt agtgccccct gagctcctgg ggtgttggcc 540 cagtngaatc agtacctggg tgtggcttca gtctcta 577 <210> SEQ ID NO 184 <211> LENGTH: 408 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 927117R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 80, 116, 132, 136, 138, 142, 155, 159, 170, 176, 183, 185-186, 188, 190, 193, 209, 217, 221, 238, 292, 309-310, 318, 325-326, 348, 351 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 184 caatatgttt cttctggata tccttcactt caaaatagct tcataaagtc aggtccttct 60 gtacctccct tagtgaatcn acctctgcct acaacttttc aaccaggagc tcctcntggg 120 atccctccaa cnggangncc anccccagtg agggnccana tgcccctgan atcatnatat 180 atngnngnan ccnagccctt atataattna gctgtcnacc nagagggtat tacatcanat 240 accatctaac ggatctatgg tggtccacag tagttacgac gagattgaag gnggtggctt 300 attggcaann ccacagcnta ctaannagaa tcccaaaatg agccgcantg ntggatattc 360 atatccctcc ttaccacctg gttatcagaa cacaacacca cctggtgg 408 <210> SEQ ID NO 185 <211> LENGTH: 464 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2859369T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 208, 210, 214-215, 229, 237, 244, 248, 266, 273, 277, 281, 325, 340, 345, 373, 380, 383, 409, 425, 445 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 185 aactgctact gngaaacaac tggataccat aacattaaaa agaagtaaaa ataaaagaat 60 gagtgcacaa agaaacgaac agctaattaa taagatgaag atgctcagga ttggactgga 120 ggagagtatg accgcaacac tcagatacat aaccacacct gtaaccacac ctgtttacaa 180 ccacaggtcc ttgctctcaa aataaatntn ttgnncattt acaacagant gaatgcntta 240 tgantgcnag cttttctttt attgcnattc tantcantca ntcaaacaga ccaaaaggtc 300 atacttctaa aataagctac aagtnatctt tttctatgan aatgntgtga cttggtgcca 360 cagctaaact ttntctaatn gcngcatcat cagcccatgg cagcaaagna atgttaattt 420 ctggnatccc atgggctctt accgnagcaa caacttcata aagc 464 <210> SEQ ID NO 186 <211> LENGTH: 424 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1554387T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 224, 251-252, 328, 332 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 186 aatgcaggta caaaaagtga caatctacag aatatttaac aataatcact gcctatgcca 60 tttacgatga aacatgagac aaaagggata aagtgcctta caaatccaac accacaagga 120 ggagttagga cttaggaata gactgagtag actatgtgcc ttgctcagcc acaattcttg 180 cctgtaattc acacaaagaa cactgtcaca ccaattactg tgcnaatgca catgtacaaa 240 cagatgacac nnaggagctc tgttggagac actgtttctt cagccttgac atgtggcaaa 300 gccaaggtac tccttgtcat tgacaccngg antatggcca agagggaaag gaacctctgg 360 gatctcccag ggaatctgaa tctcgaaacc tccaggaagc ctcttaggag ggctgtgtag 420 tgat 424 <210> SEQ ID NO 187 <211> LENGTH: 227 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 503030T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 173 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 187 ttaaatgtga taaaagctta tttctttaga tataagcaat ttgaggtaac atggcttgta 60 cacaatgttg ggacccagtg gcccttctgt cttgttgctc tgccatacct gacatatgac 120 ctctgtccca tggttagaat ggcatcttca gctcctgcca tccagtgact ggngcatcaa 180 tatccagcaa atttttttcc tgtcgaagaa ttgatgcacc ctctgtt 227 <210> SEQ ID NO 188 <211> LENGTH: 454 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2058709T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 418, 426 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 188 ttttgtaaaa tataaataca aaggcagaga atttacttac aaagttaaaa cacagatttc 60 aaacataaac acacgattca gaaaatttta gttttatgta catttccaag caacctcaac 120 atattatgtt agttttcaat attttacagg gtacagaaaa aaatagctca aagtcttctt 180 taaataagag cataaaatgt ttaaacatat aaacaatccg gtttgatgcg tgaaaactaa 240 tttcacagct tttaaattag gatataaaag tttcatacaa ttagttgttg tgtgtggata 300 tggtttgaat ttatattaca cactactgga ttacatccaa tagcatttac ctggcccgag 360 caggtactct gtaaacaaaa caaagttata tcaccaagtg ccttccccga attcgctncc 420 tcaaancaac cacacagttc tgaccagtct acag 454 <210> SEQ ID NO 189 <211> LENGTH: 365 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3988515T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 276, 345 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 189 ttgttggttg attttaagta tgcatttatt tttgagtatg cgaaatatca gagttctgaa 60 agtcagagct ttacaacaag ctgtagtcag agaagtgtca ctttcccttc atcttggcac 120 tgcattccca ttccatctgt ctttccattc tttccacttc atgcccactt atcctccata 180 gatatccaat cttgttagtt tctagtttac ctttcttgga ctttttttca ttaatgagca 240 tatacatgta tattttctta ttcacatttt ccaacnaaaa gatcacatca cttagaaata 300 tgggagtctt tccctatcag ttcgtaggaa gatttctcaa ttctnttgac aggcatctac 360 tccat 365 <210> SEQ ID NO 190 <211> LENGTH: 583 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2888859T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 253, 410, 492 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 190 agacttgtgt tctgtatcca ggagtgtgtt agatactaac atagtgtttc atttacatgt 60 gtgtgaaacc tgggtgaaga gccagggttt ctctccccca cccgcctcag agtgcttgtc 120 ctggaatcag agtgtaaaac cccctcttga agcagacacc aaaactgaac ttccacccgg 180 tcatgggccc tgctcttcct gctgtcagcc tagtccaaag agcaatgagg gaactgctta 240 ggaggggtct ganggtgatg agggcctggg ggccacacag gggtgggtgc tgtcaggtac 300 aagcccatcc ctgcctgcaa ataaccttgc acagggtcct tcctcattct ttcctcttcc 360 tttttgttta tgagatgaat ggctcttctg ctgtggcttt aggggcagtn gggaggcagg 420 gagctatttg ggaacagcct ggaaagctga ccctgcagaa tctcccagaa gccttggtgt 480 ggctatgggt anccaggctg tagaaatccc agatggtcct cttccagacc tctccccaac 540 tccagctcac agtttcagct tcttggcact gaaaacacta cta 583 <210> SEQ ID NO 191 <211> LENGTH: 303 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3169474T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 277 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 191 atataaccag cgctgctagc ggggacggtg gggacacctc tggtctcaga tgagtgctgg 60 gaaggagggg acttgctccg agcgcaagtt tgtgcggaag cgcggctgga cctgggctct 120 gaatccgggg gtccggggtt ctgcacccag gcgtcagttc ctcatccgca gagtggcccc 180 cagaagcctc cgggtggtcg cgaggatgct ctaaatcccg ggggctaagg ccgagcccgg 240 cgtcccgcgc ccagcccgcg ggagctcttg gggatcngag cgcggccgac cttcgccagc 300 ctc 303 <210> SEQ ID NO 192 <211> LENGTH: 345 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1865880F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 184, 260, 327 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 192 caggagttca acctcagcgt tactttgaaa gggctgccga cttcattgac caggctttgg 60 ctcaaaagaa tggccgggtg ctcgtccact gccgggaagg ttatagccgc tccccaacgc 120 tagttatcgc ctacctcatg atgcggcaga agatggacgt caagtctgcc ctgagcatcg 180 tgangcagaa ccgtgagatc ggccccaacg atggcttcct ggcccagctc tgccagctca 240 atgacagact agccaaggan gggaagttga aaccctaggg cacccccacc ggcttctgtt 300 cgaaaaggct cgtctgtgtc ctgccantct gagttatcca gaaac 345 <210> SEQ ID NO 193 <211> LENGTH: 442 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1440669F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 382 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 193 caggcagttg tagccggggt ccgtgttctc acaccggtgc tctccattgt ggttgaagca 60 ggcatcaggc acttctttgc actatggagg aaataagagc gtgcatcatg tttagaagtc 120 actgccataa ggaagcgact gcacaggtta gctgctttcc tagatccaga aactcggagc 180 cccatcagtt cctcacctca tcaacatctg tgcactggat gccatttcca ctgtaaccag 240 ggggacaagc accacatttc cagctgccat cagggtagct agtacacttc acgccggcaa 300 agcagggatt ggacaggcat ccatctgaga caaggagaga gagacagtca cagtaaatgg 360 ttggtctaag ctgccatact gnccatgctg ggcattaaca cagtgtaaga tattataggg 420 tatagggaac cgataacttg tt 442 <210> SEQ ID NO 194 <211> LENGTH: 467 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2995031F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 89, 189, 206, 252, 272, 397, 411, 429 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 194 ctattctatc caaggtatgt agcccaggaa ataaccaact tgatgcgtgt tatgacccat 60 tttaagcctc ccatgatcac agtttttana atacaattaa ggactggtcc ttttctaggt 120 gacacaagaa aggtaatagc tagaacagaa gaaagagggg tccccaaaaa tgtaacctta 180 aaatttgana cttgtgccac tattgntagt aagcagcatg gatgaggatg tggttctcta 240 aattggaaaa anaagttaca cagtaaaaaa anataagtat atctgtcaag aatcatattt 300 atgtgagatg tgtcaatact ggtcttgcgt tatttcggct acttgaaaat aagttaaaaa 360 agatagtgtt tggttccaaa aaggaaaagt ccagccnctc ctgcatgagt ngggagctgc 420 aaccttttng aattgataaa tcacaaaccc ctcagaccca aagtgga 467 <210> SEQ ID NO 195 <211> LENGTH: 535 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 667705T6 <400> SEQUENCE: 195 aattaatcct cagtaagtca gcaaaccagt gacaagaaat tgacaaacac tccttctaca 60 gcttcctgag acagcaggct ggcttgtggc cccctgggtg gtaacatctt aaggaatcct 120 atcatgtttg tttatatatg ctaaactgta aaaacaaaca cttcatgcga caatcattct 180 taggtcaaac acaagaacga actattttga aatcaattcc tcacactttt tccctgaata 240 tgcagtactg tactactaac atctaattct gtagaaaata atgcatttgt tagtgacttt 300 gttagagctt gaaaagaccc ttttagaaat tatttaaatg atcactcttt aaaaattttt 360 tttaatctca gaatctacta atgtgacaga caaacggtat gcttaacaga gtcataaata 420 ctgtgtataa ttgcttgacc atttctgggc atttaaatga cctcccagaa tattacacaa 480 gccctgagac tagtgagcat cttactactg accttgtaca ataccaaagc ttcat 535 <210> SEQ ID NO 196 <211> LENGTH: 370 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2808826T6 <400> SEQUENCE: 196 tcttacattg gaacgatttt cttgttttta ttttctacaa aaaaaaaagc ggggggacgt 60 taaaattaag catagaaatg gtggaacttt gggatttcct gtccagtcac ctgcgagtca 120 ggttttattc caattgattc aacgtggcag attaaatgtg aaaagtaaaa tggtgggctc 180 ctttaggcag caagtcttgc ttctctcctg gttacctctg cctacataga tatttggtta 240 agcaagatgt ttataccccc acacgtattc tagatagttc tggtcatgaa gtaagtcaca 300 attttccata tctgcacgat ttttaaaaaa tggaactacc catctgcaca aaatctttgg 360 gagtgcaggg 370 <210> SEQ ID NO 197 <211> LENGTH: 155 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2841974T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 4, 26, 31, 66-67, 71, 89, 97, 103, 112, 114, 116, 124, 126, 130-131, 142, 144 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 197 aatnttcata tataaacaac tttaantgct ntcctccaat ttaaacatct aaagacttca 60 aaaatnnggc nttcaatatt tgaaaaaant acagatntac aanatgtgta tntncngtca 120 tgananctcn ncaccaacat tntncacttg gaaaa 155 <210> SEQ ID NO 198 <211> LENGTH: 504 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3175296T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 477 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 198 gacacacata cacacacata aagaagnaaa gtcaccagct gagagcgaag tttggggtgg 60 aagttttgag gtttgagaaa aaagaagtct gaaagtctaa cctctttttg aaatgtgcct 120 gtgatgaaga gtgacaatcg gcaaagcaaa tctaatagga tctctaaaga gccttttcct 180 gttgtttaca attgtggcta aagccctgca ctagaaaaca acaaatgcta agatcctccc 240 tgcatcccct acccccgacc ccctggggca cacacaaccc tcctccacca cgttctaaaa 300 agactggaag gacttggaaa aacattccta tgggatgaac tagaaggtgg caggactgct 360 atcatcagac ctcatttacc caccgcttcc agctgaaaac cagggatttc acaaaggaaa 420 aatcatgaga gtcatagttc tgtggttttc tcaaaaagga gaaggaaggg acgcttnttt 480 ccttcccacc cctgaggaac aggc 504 <210> SEQ ID NO 199 <211> LENGTH: 481 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 693452R6 <400> SEQUENCE: 199 gagaaaacaa atgaaccagt attcttacat tgatttcaag tttgaacaag gtgacataaa 60 aatagaaaag aggatgttct ttcttgaaaa taagcgacga cattgtaggt cctatgaccg 120 acgtgctctc cttccagctg tgcaacaaga gcaggagttc tatgagcaga aaatcaaaga 180 gatggcagag catgaagact ttttgcttgc cctacagatg aatgaagaac agtatcaaaa 240 ggatggccag ctgattgagt gtcgctgctg ctatggggaa tttccattcg aggagctgac 300 gcagtgcgca gatgctcact tgttctgcaa agagtgtctc atcagatatg cccaagaggc 360 agtctttgga tctggaaagt tggagctcag ctgcatggaa ggcagctgca cgtgttcgtt 420 cccaaccagt gagctggaga aggtgctccc ccagaaccat cctgtataag tactatgagc 480 g 481 <210> SEQ ID NO 200 <211> LENGTH: 375 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2203194T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 58, 69, 185, 198, 288, 330, 337, 361, 367 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 200 ctggagatct cacataaaaa tataagctta tcttgtcaag ccagaaaatt tggcagtngg 60 gtctgcatnc tggcgtggca tcatcagctg ggcctgagta gtgtgggagc tccctgggca 120 caggacaagg gctcaggagt gtgcccagtc cccaccactc ccatcgtctc acagtgggct 180 gcctnattcg cttgtgtnac ccgctaacct tgcttaaatc tcagctctgt ctctaataag 240 ctgtgggacc agctctggtt ttccctctct ctgaatgaga tgtgaatnac agcgggtaga 300 ggggaacaga ttctagaggc tcggtgcttn ggttcanaac cccagctctg tcgtttacaa 360 ngctgtntga cctta 375 <210> SEQ ID NO 201 <211> LENGTH: 596 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2231176T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 577 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 201 ggaacgagaa ggggctaggg ataagaatga ataaaagtgg aaaaactaaa acagaatgat 60 ttaaaatgtg caaatacact ttgcaacctc caccattcaa tttagggatt gatatgtatg 120 tacagtgaga tccatgtagg ctaaagtgag tttcactttg tagttgatgc tacttgtacc 180 agttctatca ttagtaagtc accgtttaat tctgccaaaa tcagacaagg atctttctgg 240 ttagtgcaaa caaggttttc catcctgggc tgcagtctga cccgccagtg ctcagtaggc 300 atgcttgtga tgaattcgca cactttccag ttccccacct ccaatggcgg ccagggtctc 360 cagcctgttt aagcgctcca agcttcttcc aagaacttct tctagccgac tgcgtaacac 420 ctgagcccct tccagttcca cctgcagagt tcggtctctc tcagagctct ctggatgggc 480 atggaacttc accagactgc tatagagctg tctctctgct tgtaaggcct cattgagccg 540 actccgttca tctactagtc cttctagcat cagcagnaac tgttggcctt cgggtt 596 <210> SEQ ID NO 202 <211> LENGTH: 534 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2370457T6 <400> SEQUENCE: 202 tacatagtca ctatgccaca agatgttaag aatagttttc tctagatagt ggccttacag 60 gcaattttta tttggggtgt gtgtgtttta ctcaataaat atttattact tttgtattca 120 gaaaaaacat taagagaatc ataggaaagt ttaactaaaa aagaaaatct ttaaaatatc 180 attaaattat ttaacatatc cttcaagtga gattgtttcc ttttgctaag ctatattttg 240 taatctccac aacaaacatg aaatagtaaa gttgacataa aaaaacttgc acagtaatag 300 gaagcagtgt ttacattttg ccacccctta cattttgaag agggaactca tattcttaac 360 caagactgtt tcttatcatt attcaaaggt acctactttt cctaaatatt gcaattaaat 420 tatttgtact taagaaagca gtgtattgta aaggaaccag ccagacctgg ggtaaattcc 480 taattttgcc attaactttg acataaccac ctaacccaat ccaaaaacga aagt 534 <210> SEQ ID NO 203 <211> LENGTH: 496 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2379695T6 <400> SEQUENCE: 203 ggagacactg ctacaaagca tgaccccaaa ggtgcagaaa tgcctgcatt aggctggaag 60 attccctgag gtggctcagg caggtaagaa acccacacag tcctgggtcc tccccaagcc 120 tcggacgtgc agctgctgct tcactggaat tcttctctcc tcctggaaac ttgctccagt 180 tgtgtcactg gaggaggaaa aggtgtgggg gagggggaag agggggctgg agctggcctc 240 ccccgaggcc tggctccaga actcgggctg tgtggggcgg ctgaggactg tgctctgtct 300 agagcttttg caggcaagga gtcgggatgc agcaaggact gagggctatc tgccgtgact 360 cttcaaagag gggcctgcca cacccaccaa gtcccatcct ggagtctaca agccaaggag 420 ctgcgacctc accgagggcg cctgttatta aatagcccat tggctgcgcg cggtggctca 480 tgctgcaatc cagcac 496 <210> SEQ ID NO 204 <211> LENGTH: 453 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2503204T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 394, 419, 441 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 204 attgatgttg gagtatgctg aaatgcagta tataattcca caggaacctc atcaccactc 60 tcagttgcac tggtatcacc atctgacata ttttcccttt tccggcgttg tagtagcact 120 gccctctctt tatccaaatt cctaggctga caacgttcac atagatatgt atcaggaata 180 tgctgcctat caatccccat gcagtcaata tgttgccaaa cgctgcattt gtcacaacag 240 atcatgtatc catcatcatg tgtaaaacca catatgcacc tggttacatc agtaccataa 300 cttccatcct cagatgtgct gattgtagta gcactggaag tttcatcaaa attaggagtg 360 gtaaatatgc ctacttcatt tttgctaata aggnctgatg gaggagggga agcccggang 420 tgtcggagga gggacgagca ncattaatta tgg 453 <210> SEQ ID NO 205 <211> LENGTH: 240 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1849962H1 <400> SEQUENCE: 205 cggttctttc cctgggttct tgagagagag aaagtcagtg tcttttgata caagttagag 60 cagagaggag ctgcatgaag acttgaaaaa gcaacactga taggcataag gaggctgaaa 120 ggagacttga gtaaattaaa tttattgcat ctccatatcc tgcagatcta tccaataaag 180 gagagaaaca accgcacacg cctggctctc atcatatgca atacagagtt tgaccatctg 240 <210> SEQ ID NO 206 <211> LENGTH: 396 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2078863F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 327, 340, 381, 384 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 206 ggggagaagc tgctgctgcc gccgttgccg ggagccgcgg agacaagtca ttacgttttc 60 atttctcaca actgggctga gcacaactga accatggggg aacacagtcc agacaacaac 120 atcatctact ttgaggcaga ggaagatgag ctgacccccg atgataaaat gctcaggttt 180 gtggataaaa acggactggt gccttcctca tctggaactg tttatgatag gaccactgtt 240 cttattgagc aggaccctgg cactttggag gatgaagatg acgacggaca gtgcgggaga 300 acacttgcct tttctagtag gggggtnaag aaggctttcn acctggatag atcatgaagc 360 aatgtcccca gggttatgtg nagnacattt atctca 396 <210> SEQ ID NO 207 <211> LENGTH: 277 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3218325H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 97, 107, 130 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 207 ccttgtgcaa taccagangg ctaaaaaaca ttagcaagca tctaacctcc tgaaactggc 60 catttcttga cctgttcctc ctgttcaagg cttcccnttc tggattngac caacaagttg 120 aaggatgacn ggggttttgg tgatgcccat gtgtaaagat cctctctggg gtttattaca 180 caggcttgta cagcgagatc ttttcatcat cctgctgacg attgacaggt acctggccat 240 cgtccacgcc gtgtttgcct tgcgggcacg gaccgtc 277 <210> SEQ ID NO 208 <211> LENGTH: 443 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2927175T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 29, 32, 62, 75, 97, 107, 110, 166, 210, 227, 230-231, 237-238, 243, 245-248, 251-253, 257, 260-262, 276-277, 283, 311, 317, 359, 434 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 208 aaaacaacat ttctatgata cantttggna anacaaactt taagaaaatc ttcaagattt 60 anaaaggttt aatanttagt acaatgcaaa aactganttt aaatacncan atgcacttga 120 caacatacaa ggtcacaatt atttcagttg gtaggatagc tctggntaaa ttcaatggtc 180 attttttgct acaaaatata atttaaaatn aagatcacag agattangan ntaactnntg 240 cancnnnnac nnngctntan nntattttgc agaganntct gancacttta ggaaaccaga 300 atgaggaaag nggacangag agatcatgtg actgcttcac cctgatcaac ctggggcana 360 agcaccccgc gtccctccca ccgcctgcca ctggtcagcc ctatgatcca catcaaccat 420 gtcctttgtc ctanaaactc cca 443 <210> SEQ ID NO 209 <211> LENGTH: 532 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1997874T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 335, 354, 407 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 209 gtttcataga aacaacttac atttgccaat ataaggcaaa tggtctatgt acagatacat 60 caggactgcc taactgacag tgagtgttgc tagccaggct ccaagctaat ggagctaata 120 cggtggagct ctctgctgaa tggactttcc cttcaggata cgtcggatct gttctcccac 180 agggccatcg ggaaccaaat gcactggctg ttcgttctcc aagttccgag tacttgggtc 240 tgctcccttc ctcatcaaca ggcggacagc atctaattgt gtcaaccgat actgcaggct 300 ggcagcaaca tggagggcag tgttgccatt gtaanccttt gcattcacaa aagncaggca 360 actgggcagc tccaaaaaga ggcgaatgag ttccagattt gcttctncag ctgccaaatg 420 cagggtgtgc ggccactttt gcgatccttc gcttccaccg ctgtcccatt tgaattaggc 480 acttaatggt atcaaccaga ctcttaattc ttcagtaaaa gctcctgaac tt 532 <210> SEQ ID NO 210 <211> LENGTH: 538 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2660871T6 <400> SEQUENCE: 210 gcactctaat tcaaagtctc ggcattaaca tatattttgt tgatctggtt gatgatttta 60 aaattatttt tcctttgtat tctttaccta cggctaaatt tctaatcttc aaaatgccta 120 cattcatttc atttacctta cattttatct tactcatttt taaagccttc aacatttttt 180 gagttttgaa ataattctca atttcttagt ctcttaattc ttaaatttaa aaaggttgtt 240 tcttaccttt taaaattttt aaaaataatt atgtcaagta atttttgaat atagtaacct 300 gattctacat ttctcatggg ataaattcta aggtaaaaaa aattgcaaat aaatcttaaa 360 ctttatttag taggtttatt attagcagca gatgtctagc cagggtagat tacttttatc 420 agaccaacct ctcaccaaca actactagaa gagctagaga gggagaaaag tctatttgaa 480 gacatcaagg atttgatgag ctaagattgc agagagaagg gaagtatggt gaaacagt 538 <210> SEQ ID NO 211 <211> LENGTH: 54 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2907049T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 34-36, 53 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 211 gggagctcaa tcttcagggn aacagctcaa agtnnnaagt attcatgtaa gtng 54 <210> SEQ ID NO 212 <211> LENGTH: 521 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3149004R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 499 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 212 aaagtcggca agcaaattta ttaacctgct gggctgctct acagaaatct gaggaggcag 60 acaccgggct tacaggctaa ggggtataag taggtctgca ggggttttgt gtgtgtgtgc 120 gggggtgtcg ggggggcaag gccatttgtg gagacttttc ctcccagtat ggccacatcc 180 tgcagtttgt cagtttttgc ccccgcctgg ctcagggtac caggatgtgg tttagcttag 240 gggtggttat agtggcacct aagttctggg aacttgcggt gggggcgacc ttttggacga 300 aaaataagct gcagggcagc taggggaggg ggcttgttat attcctctgg gggcagggtg 360 tccctaactg ggctcagtcg gaaggaactt gaccaaagtc tgggctcagt tgggcatcac 420 tgaggctaat ggtcgtgtgc tggatgccat cagagggaag taccaatggt aaagtggaaa 480 caatgtgcag ctttcaacng ggtggaggct gctattctgt g 521 <210> SEQ ID NO 213 <211> LENGTH: 246 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3269702H1 <400> SEQUENCE: 213 ggagtgggag ctcaagcagg attcttcccg agtccctggg taagacaacc ctgcttcttt 60 tcttggcttt agagggtctc cttgcttaat gggaagcgtg cagcacctag tgagtggatt 120 tgaagagcca ctttgtaagc aacttgggca tttatttcag ccccagttcc agtcttccct 180 gactcttttg gcatcaaggc atcctcagaa gcttcaactc tggaggcaat gggtcgaaag 240 gaagaa 246 <210> SEQ ID NO 214 <211> LENGTH: 264 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1929661T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 189, 196, 201, 206, 213 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 214 cacgtgtata aggcacaggg gcaaatggct ttggggtcct ggaactggaa atggagacag 60 gtgtgtctca ggtgtccctg cctccaccac cccctaagtg cacttgagac aggaccagtg 120 gtggtggttc cagcccaggg tcctgaaggg tcccactggc tctagaggag agccatgggg 180 acagctccnc aggctngaac ntctantctc canctaccca ggagggaccc tctcctccta 240 gggggcgagg ccagcttcca aagt 264 <210> SEQ ID NO 215 <211> LENGTH: 300 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2709044T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 16, 30, 58, 96, 105, 203, 211, 217-218, 249, 256, 296 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 215 caggtttgtt ttcttngggg ttctcttctn agtagattaa atgttcacag agactagngc 60 tcaggggact gtccattcaa aagctaatgc attttngcta acaanaagcc agtacaagta 120 gcaaaaatta tatttgaaga gatactcctt tgaatgacat gggttgcaag ttctctgtca 180 aataatgccc tactatcctg gtnatatgag nacacgnntt aagttgttta aaaggtcaaa 240 aaacatggna aaaccntaag atgtctaaga tactcaactt ttactctcaa caaggncact 300 <210> SEQ ID NO 216 <211> LENGTH: 534 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3254777T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 499 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 216 aaactacaca atgtaattca cgtaaccaca aaccagcaac tgcaaattaa gatttttgta 60 ggtcatgatt tctaaaaaat ccagccacgc aataacagcc tttctaaagc tgactttgtt 120 ttagtgaaac aaaactgtga tgacatccct aagcttcctc cagaagagct tcgacgtgga 180 gaaacggggt ggacgctcca cctaaccgca ccattgggaa aagaggaggc acctggagca 240 gaagcttctc tcccaagtgc acaacagagc atcagcgaag gcagtgagaa gagtagcaag 300 aaaaaggttt aaaatcatcg atgaaaatgg aaattaagct tgtcttatta caattaagac 360 aaactgacca tgtgcatttt ccccacattc ctgtggggaa tcccagctcg tttgaacaca 420 cgccacgaac tcctggtatc cgtaagtatc ccagctcgtt tgaacacacg ccacgaactc 480 cttcgtatcc ataagtatnc cagctcgttt gaaacacacg ccacgaactc ctcg 534 <210> SEQ ID NO 217 <211> LENGTH: 531 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1452827T6 <400> SEQUENCE: 217 ataacaaaat tcatacatac aagtaacaaa atacacaaaa tataggtgaa agcaatgtta 60 aagtgccaca caagttttaa taaattaatg actttttatt tgaagcagaa gaggatgaac 120 cgccctcccc ccaaaaagtc aaaagacttc agttatcctg gaaagaaagt tctagctttg 180 gagggaagac ccccccaagc ccttcatctc tgaagggcag gatcatagaa gacagtctag 240 aaggcccata gcatagccct gacagtcaca gctgacttat cacgaagggc cattcaatca 300 acctcctcaa tgatggggcc ggtgctgggg tccccctggt gggcttgagc gctacaactg 360 ctgcccccag ggacaccagg ccccccatag agcctggaga agatggggcg acagatttgc 420 tccagctcct cttctgatgt catactcctc ttctctgcca gctggttgtg tccagccagg 480 caaaggactt cctgacactt gtcttgcact ttgcgctgtc ctcttcggga a 531 <210> SEQ ID NO 218 <211> LENGTH: 441 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3325383T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 360 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 218 aacttacatt ttgttgacac taaatggcag gtttcataca aagactaatc ttttttatta 60 gggtaggaat aattattggt gactttctct gccaattttc caagtgttgg taatacatgt 120 tgttactttt taaatgtgtt tttgttactt ttaaaatgaa atgaaaaaga catataaatt 180 atagcataca tgtctacccc tacatttaaa acaatatatt cctatgataa ggcagaaaaa 240 ttaacctacc cttccctaac acaaacttcc ctttaatgcc tgtggccatc tgtagatcct 300 gtcctctgtt agcaaactcc actcatttgc tttttgaagt tgagttcaag atcctcccan 360 ctcctcacct gccccgtcac ccacatctct gcattactgt aggctcactg catgtgccct 420 tcatctgacc ttgaatctag g 441 <210> SEQ ID NO 219 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3220151T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 505 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 219 tggagacaag tcacttagca cctgaagtct ggtactgctg agcaataaaa tagatacagt 60 aattcccacc tccacctccc attaagcaac atgatgaggt taaacagaat aaaactctga 120 tgtactctaa gccattttga gagaaatctc tttgtgtatc ccaataaaag gacactccaa 180 attattttta tcatgtaatg ccacgataaa aggagcaagc tgcaaaatct ttaagaggca 240 actccattgc aaaaacaaaa acaaaaactt gggatctttt gtccaggggt gtcactctag 300 catctgcctg agtgacagca gcttcatcac tcagtctagc tgccgtctgc cctgtggatg 360 agcaagagcc tcaaatgcta ttataactct aattgctttc ggttatggtt gaactcactt 420 gaagaaagag tgataaaaaa cttcagtttc tccattatct gtatattcca tcacttaatt 480 gcaaaaatta atgatttgcc aatgnctaat cattaggggt caaccaatcc ggacgcgtgg 540 <210> SEQ ID NO 220 <211> LENGTH: 386 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3809026T6 <400> SEQUENCE: 220 ctagtttttg aaatagacat ctaatttaaa ctgcttaaat gtaaatctca tctcagcatt 60 ttaaggaata gcactaatat gagcaccaaa ttaaaacaaa caaacaagca aacaaaacac 120 aagcatttac cagaatggac ttttgttttg tgcttcttta aatttttaat atctgtgtaa 180 gaatttccac ataattcgca gataaatggt ctttctcctg aaaaacaaat tagaagttta 240 aatttcaata ttttaaaagc tgctagctaa gacaaaaata tcaatgttta tgaacacaag 300 gcaaaaatta ttatagtgtt taaatttggt ttcaaattgt cactttaatc acctggttat 360 aatatagtga aatgcaagat tctata 386 <210> SEQ ID NO 221 <211> LENGTH: 175 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 065498H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 122, 139 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 221 gaaagtagca ggtcagatgg aaaattcttt tccacagccc tgctctccgc ctccctccat 60 cttaggagcg cctgcctcaa ttcctcgtca actgctttgc tccactccat cccacaggtg 120 tnagtggggg aagtttttna ttaggaatac agtctgcgtg acatggagaa tggat 175 <210> SEQ ID NO 222 <211> LENGTH: 360 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1417323T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 79, 185 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 222 taaagaaatg ttacagtcca tgtaggaagt gctatgatag aagcagctgg agcaccttac 60 cgagctcagg agaccgggng gatggggggg cttgccagag ggcacagcat tgcaagcagg 120 gcaatgaccc agttctaaga cagactcgtc acatggcaag cagagtcggt cagactttgg 180 acaantttat tgacttcttt ggaacctcag ttttctcatt tgacaaaact agatggtcaa 240 gaagcgtcta ggattattgg gacacgtaaa ttacataatt ctgacacagc ccccccaact 300 ctgggttcct ggtatggggt aagtttttta gtaaatgtga agatgctgtg attagtactg 360 <210> SEQ ID NO 223 <211> LENGTH: 446 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2410888T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 3 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 223 gcnagtcagc aaatactacc taaggacatc tcagatcatg tgacacgcct gaaatggaaa 60 gctcaagagc agatggggga caagaggagg acaaacgtcc gcacgcgggg gtcccactca 120 tcatggttac actcctggac atgaccctac ctgatgggaa acttcccagg gagggtgttt 180 aggcagtgac aggtggcagg caggggctac gtgggtcacc ccacagggca cagcacacag 240 tgaagagaaa ggagagagtg ggacctagga agaaactggg gaggaagcaa aacacaagtt 300 ccaggggccg gccatctaac cagatccacc acacaaatgg cagccagatg ccagaggggg 360 agaggcacat cacgcacaat tctcaggaaa cagaaactgc cttacacacc tcaaacactg 420 caatttgaca tcaaaaagta tcttgc 446 <210> SEQ ID NO 224 <211> LENGTH: 79 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1552980T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 27, 55, 62, 69 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 224 ttacatcccg gcagggtaaa cagccantaa cttcacgaaa ccaaacatcc agtangtcag 60 antgccatng gaaaggtac 79 <210> SEQ ID NO 225 <211> LENGTH: 465 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2507526T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 76-77, 235, 262, 286, 288, 291-293, 403, 407, 433, 439, 441, 453 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 225 aaaaagatgt cacatatgaa ctggggaact ttagcaccaa aatcaagtct ctcctagtcc 60 atctagcttc cccttnntcc ccacttaaaa aaaagaaaaa attaaatcac aaagtcccac 120 ttaagtcaaa atcttcgtcc gctttttcag ccttccttcc tgcagaccta cacaaaccca 180 ggcaagatta gtcaacaggg gttcagatcg ggaagaaaaa ggttttgaat gtcangacag 240 gtttccccca aaaccctggt cnggcaacaa ctcttccaag gggccncngt nnnccccgcg 300 ggggcgggta caggtggaga ggtgccaccg ggaagagggg aggaggaata agtgtggcgg 360 gagactgaaa tgagggaagg tgcagttgtg tcgccagagc tancacntta aagttcaact 420 tttttactag tcnaatagnt ncttcaactc acnatatctc ccaca 465 <210> SEQ ID NO 226 <211> LENGTH: 150 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3258109R6 <400> SEQUENCE: 226 gcaaaatagg gtagataatg gtagttattt catagggttg tgtgcagctt aagggagatc 60 atgaatggac atttctaacc caatgtgaca atcagtgacc aatatgtttt ggctttttca 120 aaccaagaat ctagttgagt ccacagccac 150 <210> SEQ ID NO 227 <211> LENGTH: 359 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1306411F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 88, 200, 208, 223, 233, 266, 280, 285, 314, 345 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 227 gggcgggttt gaggaagtta agagaaggta cnatgttggc ctcacccgat gtccactttc 60 catctttatt gacatacgaa ctttcccnac acggaattct tgtaaatgtc tccccctaag 120 aaagaagccc tgaaaatgct gcggaatcca acagatgaag atgttccttg gcctggattc 180 attcttgggc agaccccagn ttcagtangg tactggtgtg ctnaccaagt cancgttcag 240 agggtccttg cagccaaaaa cattgntcca tgccaaaggn tctantctta tggctggctt 300 cttaaagctc ctgncaatgt ttatccatag ttgtcccagg aatgntttcc aggatactg 359 <210> SEQ ID NO 228 <211> LENGTH: 504 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 708018T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 286, 290, 294, 335, 357, 424, 433 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 228 atgtattgtt actagaacaa cttgtatagg gttttatggt ttgggganaa catttttaaa 60 aaatggactt atctctatta tacagagtta taatataaaa atgatttaaa ggctatattt 120 ttcagcatgt aggtagctac actgtaatcc tgttgaagaa actttcctat ttaagcttat 180 aggatgaaaa tatataatta aagtcttctg atcatagctt gagaccatca agggaatgtt 240 tagtttcctc cacaaagagc caccaggatt ttctcataat ctcctntggn ttcntcctgt 300 tgattcaaaa aaaggtatac ttaatgttag tcganaccat aattctctat ttttttntac 360 ttatagaaga attattttta gacttagctg tagatgagat tacacattac cattcactta 420 attnaacaat atntacaaca gataactgat tttttatcat tgcataaaaa agcaatagcc 480 ttcaagactg agattaccaa cttt 504 <210> SEQ ID NO 229 <211> LENGTH: 619 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1713038T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 219, 230, 294, 576, 589 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 229 ctttatagaa aaataaagaa aataaaaatc atcaataatt ttatcaccca gaaacaatca 60 cttttaatgt gctggtagag gttagtctat tttaacattt ctgaaatcat atagatttac 120 atgattgttc tcacgtaacc tgtaacataa gcatttccca agttgctatt atctgttaat 180 aacagtggtt tgattaattg gattggctgt gtggatgtng aacggaagan ccttgatgtc 240 aagaagtgct gaagcacaga aggtgcagtc ggtcatttgg gaccatattg tctntggctt 300 tcaggacagg gagcttcagg actcaggtag atgactctgg aagaaacctt ctcttggaac 360 tgcagcatct ccctgtcctc cccaagggga atttaggcca ggaaatacca gatcttccct 420 ctctgatttt cttctcaaat cccaatgcaa gacaatggag actaaatacg gttctggtca 480 tcaggctctt ccagagcatc cgggtgcatg agaagtgaat aggtgattgt gtctcagccc 540 caactttgtc agcctcatca gggattagtg ggattngctg ggttctcang gagggtctct 600 cccatttccc tgcactcag 619 <210> SEQ ID NO 230 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2226878T6 <400> SEQUENCE: 230 ggagtaagag gggtgggatg gaggacagca gcagggccga caggacccta cttctgctcc 60 cgcctccaga cgatgaccat gccgctggcg tcactggagg ccagtaggct ctcgtcgcag 120 ttgaagctga catcaagcac aggtgcactg tggccctgca gcttgttgac agcagccttg 180 gccgcccgct ccacatcaaa gaagtgcacg cacatgtcct cactgcccgt caccacgcag 240 gccccctggc ggaaggacat gaggggacag aagatgctgc gcacaggatg tgagctctgc 300 tcgatgggga agcttctctt cagctgcagg gtcccctcgt tgtctaccac cctgtagagc 360 agcaacttgt tgaggcaagc attgatgagc agtgagggat cccgggcctc gcggctgacc 420 caggaccggg ctgagatgct ggtcacaggg tcccctcatg c 461 <210> SEQ ID NO 231 <211> LENGTH: 86 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3483069T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 31, 37, 43, 74, 78-80, 84 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 231 caaatacaaa ttttctgtta agaacggnaa ngtgcanact agnagagtca atactggtaa 60 ccagaacgca ctantccnnn cacnta 86 <210> SEQ ID NO 232 <211> LENGTH: 574 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 405967T6 <400> SEQUENCE: 232 tgtcttttcc cacacatatt ccaaatcttt taggggagta aaagcagtga aaataacaaa 60 attatgttcc acatgcccaa gtcacaaaat gtattaaata tgataaagta gcggctgtac 120 aaaattggac aaattgacaa ataacaatgg gtcaggaaca ctgtatctgt ttgatacagg 180 agtgatattg aaaaagggtt ctgtttttac tttctcttat ttgtcatcaa aaaagaaaat 240 tgcatcttcc ataaacagat tccagaaaaa gaaatttatt gttacctctg cgaagttgtg 300 gatagcttct ggtggtaagg atggtattga acacgtttac gtctgtcccc tttctccttt 360 ctcctgcttc atacaaggcc tgtcaagaaa cacaaaagta aacacttcac tatctgctga 420 aatgatatct gcacaataat gttagacctt gtcaaagatt atataggcaa tcgctttgtg 480 cccaatacaa tcagagtagt caacaataag attgcaagtt ctttaaagat agggacctta 540 ttttgtttgt caaatatctt ccacagttct ctca 574 <210> SEQ ID NO 233 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2783681F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 416, 468, 480, 526 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 233 catcaagctt ggctcatggg atctgctgct gcattaaatc gggaaagaaa atgtgaagat 60 ttcatttgga atcacagaaa atgcccaaat gaggtcaaga tggcgagtgg gtgcgagtga 120 gaatgagtgg caaaatgtaa tgaaaacttt acatgaatgc ttatttaggt tgttcaaagt 180 aaaaagggct acaggtcaca gatcgtcagt gcctgagaaa gaacattgac ttactctata 240 tcaattgagg ggaaagtgca gtaccgtcat cttcaagcct tgtaagcata aaagagaata 300 ggctgcccat ataagtcaaa ggaaaatgag cccaggcctt gctatgaagc agtgtgtgaa 360 tggacaatgt tgaatgaatg tctggctcag tgatggagag ccaggttcat ctttgnaatc 420 tagggctctt cactcatgaa gcagactcct agtcctggag tgactgtnta cgagagcgtn 480 gttgtggtgc tgtatgtgaa cgcatgcaag ctttgattca ccttcngggg ggctgataac 540 cctagtaaat ca 552 <210> SEQ ID NO 234 <211> LENGTH: 599 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 345673T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 567 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 234 gtcggattaa cgttcaaagg actgagtccc aaacaaagag tcaagctacc ttttaagcat 60 ttcgtggggt ggggggagac ctttgtaggg ggagcatatt acagaagcaa gaaacaaaga 120 cagttattca actgagacat gcattacatc atttcttatt tttcaaggaa caacgtgttt 180 tatgatttga gatgatctgt ctagtgacct tgcagctgca cagctagaga aacagagtct 240 tcacaatgcg tgggaaaggg agagagaagg ctcactagcc acagaaaaac aggcagttaa 300 ttttaaagga ctccagctct ttctcttcct cagggggagt tgggttttct tacatacaac 360 tgagtttttg cttacacatt ctttaatttc ttttaattcc tgttccacaa ggtcatatta 420 acaatgataa gaataaataa ttgtgtggca gtttatgtag tgcattgtac atcagtggtt 480 tcattccatc tttataacaa cctcactact atccccattt tcacagatga gagaagactc 540 agaaattaag aggtttgaca cagaganggt acctggggca cagcaacagc cttctccaa 599 <210> SEQ ID NO 235 <211> LENGTH: 508 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2723202T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 497 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 235 tttgataatg aggatattat aaatcatact ttaagcaaaa atctatgcat gatatatgta 60 agcagtaaca ttttgaagaa aaaagccatg aaagcattta cctaaaattt agtaacatcg 120 aaaaacacta gtttgtgcat agtaatgttg aaagcttcat aatacactag aatactggta 180 agtcttcagg tattgtaaga aaaacctggt acaggaaaag actaaaatta gacacatcca 240 tatccttaga tgtgcacatc atctagaaat aaatcccaca atgtagcagt gcactaagta 300 tcctttgttt ggcacttaac aatacagaca aacgtgtatt tggtttaacg tgattttatt 360 attcttagat acattttagt tattttatat agataaaaat atacaatatt gcttttcaaa 420 cttttaattt tataactgta taactgattg tatcatattc atgattaaaa agcctatttt 480 ccactaaaca atttatncag taacatgt 508 <210> SEQ ID NO 236 <211> LENGTH: 435 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3091058T6 <400> SEQUENCE: 236 agaactcagc aagcaccccc acttcctcca aagagtagtc aagtcccaca gcacagcccg 60 gagcagtagc tgttaaaaga caagggctgg gctggatccg gccaacatta caaggacaac 120 caactggtct cattccttag tcttgtgctt ttaaagggca gacgatgtgc caactatttt 180 aaagctccaa cacactaatt ctgtaaacaa taatagctac agcctgcaca ctgcgcactg 240 gaatggattc ctcaacttgg cctcatcact tatgcagctg atgaaacaaa cactgacagc 300 ttttttgcat ttgtaaaggc cccacagcag ctgtggtgat cccaccatag agcaatgaat 360 taagcctgaa acccagctgg gtctgaacag aagccttttt tgcacaatac agcaagacta 420 tcattgttaa cctag 435 <210> SEQ ID NO 237 <211> LENGTH: 512 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2762254T6 <400> SEQUENCE: 237 agctggaaaa aagtagtccc aaaacctaaa ttcaaaataa aactatgcaa cataattttt 60 gagttgacaa ctaggcttga tttagagaaa gtaaacatat tttcacctct atcattattc 120 ttttgaattt cttatgagat cgagaatgaa aatgtataat ggtacaatat tcttcatgtt 180 ataaactctt tctctactgt acagaaatat atcttataac tatatgtcac tttacagtat 240 ttaaaaatag tttcacataa tctcctttga tatatgaaag cacaaaatat tagaaatgtt 300 ctagactaat caagcgatat aacatctatt tgccatgaaa tgcaagttag tattttatca 360 atagccaata tttagtatcc ttgcactcca cagtacaaca ataaagatta tatatttgta 420 aagattcagt aatattttta gctatttggg tcatgcttca ctgcattttt tataacagct 480 tctcaatgaa tttctgccaa gcatatcgta gt 512 <210> SEQ ID NO 238 <211> LENGTH: 203 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1501582T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 183 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 238 tacctgcagc acaaagcata cgtcttttct atacaaagcc aacaagcttc tgctcctttc 60 tgaagtcgtc tttgccaagc agggtgttgg gggcgggggt gaggataggg gtgaggggac 120 attttacccg gttatgctct tacgtactaa ccttcacctt gacaaagctt gtcaacgaaa 180 acnaaaccag tcagagcctt ttc 203 <210> SEQ ID NO 239 <211> LENGTH: 503 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3282967T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 275, 444, 446 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 239 ccttcatacg tggcatgcca caattccaaa gaaaaaaaaa gagggggata aagatcacat 60 ggagtatttc tggaaggatt cacaaggaag ttctcatcac tggctacact tttcaatttt 120 gagccatgtc agcctattac atatcttaaa aaactaaagg ccaacttcta agtagggagc 180 catggagggg cctcagctga gaagaatgaa gaggacatca ccgatgacct ggagctgctc 240 caagacgctg gccatactgg gggctgtgaa ctgangggcc gtggggggat gagctgtgag 300 tgaggctcat cctacccagg ccgggtgggg gcccagctcc acccagggat atagctggag 360 gggcaggatg ctggcactgc agccgaccag tatctcccat tcacagtgtg ctgctgggcc 420 atggcctgct tggccaggca cttnangatc tcggagcttt ccttctcgtg gttctcacca 480 aaaaacaagg ggagagagca caa 503 <210> SEQ ID NO 240 <211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1966576H1 <400> SEQUENCE: 240 gtctgaccct gcaccacttg gtggtggaga tcaaggggtt gcttggactg cagcacctgg 60 gccgagatca cagtgatggc atctgtttga atgtgctggt gaccgtggct tttcggagcc 120 cagggatcca ggatgaaccc ccaaaagttc ggggtgagaa cttctcttgg tggaaggtga 180 SEQ ID NO 241 <211> LENGTH: 561 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1859155T6 <400> SEQUENCE: 241 atgactcata ttacaataaa aaatgccatt caagaacttc caaatactat agtcacgaga 60 ataaaaaaga aactaaattt cttctaaatc atctttgtgc cactaccata tctgataata 120 tattccttct gtactcttga aacctatctc agaagtatct ttgacaaatt ataaatgtag 180 aagaatttaa gaagttaatt aaaattattt taatataatt tctcctttat tttaataaca 240 aaataccagg gaaaaagttc catttattta cctcagtaat tggctgccct tgatgtgtca 300 aatccagctc ttgagggcgt gttactttat caatatccaa agagtccatg ctggaggctg 360 cggaagtgat gctggaatgg gaggaattac taatagagtg tacttcagca tcactcactg 420 tgcctgctga cgcggttctt ctgtgctgat tagttactaa gggtttagta tcttctagta 480 cagattgctg agcagcctca tccatactca aagaggcctg ttctaactgt gcagtgacgt 540 cgtccaagga gtagctggca t 561 <210> SEQ ID NO 242 <211> LENGTH: 510 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2652949F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 47 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 242 atttggagta tctgtaattt gtaatcatgc tgacgcttct cctttanctt ttaaaatttg 60 cagtggctga gaggactact aactagtaga cagagtttta acatcatatt tggtgaatgc 120 ccatattgta gtaaggtaag caaattgtta atcacatctc ataaaatgtg cctagctttc 180 agtaatatgt tctagaagat agatctatat agtatatcag tttatctaaa acttttgaaa 240 ctcattctct gtatttctat ttttcaaatt ctctgatcaa aaacattaaa ctccttttct 300 agatttccta ggtgatctga aacttcagaa gtgttttcca aactgtacta tgacactatt 360 ctatgacact atttctagta caaagcaatt ttatttttta gagtgtccac aaactttgtt 420 aaaatatgtt ctctttttaa aggccaatta ccttaaaaat ggtctgggaa ggaaacactg 480 aaataagaat acaacattcg ggtgaagagc 510 <210> SEQ ID NO 243 <211> LENGTH: 642 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2589371T6 <400> SEQUENCE: 243 tctaaaatgg cagagatttc aggaaagtct aatcacactt gaccatgagt gttgagttgc 60 ttttccttcc tctgaggcca agagttactt atatccaaga ccgtgaagaa ctctttttga 120 cctgttggat atgatcttgt gactgggtcg aggaaaatga actcccaggg ttgttggagt 180 agagctgttt ccaccaaaag acagaactgt atgcagctaa taagagctcc agcacagtga 240 agatgagcat caccactagg acacctgtta aactgacact ggtcaggaga caatctttga 300 tttcatatat tggataatag tactccgaat aaggcaatga ggatagataa tccatttctg 360 agccacaatg ttgagaggca gtcctcaggg ctaccatgct gtcagcaagg aggaagaggc 420 ctgctcctgc agtaacagaa ctcactgcat ttgaggtcaa gctgctcagg tcaaagggct 480 tagttgattg ttttccagag ataattgaga gggatccagt aatgccaaaa cacagagctc 540 ctaaaaatgg gtacccagac atcaaagtgg tggaaattgc tggattgaag tgggaggggt 600 agggagcaaa aaccaagatg ggcccccaga cttgaaatca ac 642 <210> SEQ ID NO 244 <211> LENGTH: 558 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1714938T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 390, 435, 522, 546 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 244 taaagagttg tgctattcaa caaataaact tcctcttccg tttcttctct ctcctcatct 60 gtgagattca gttgaacatt attgaagcgg ggtcttggtt tgccgtctgg gccatatgcc 120 ggaggatatc tttttttgtt ataatgccaa ggagggccca ttgtgagtta caaggcactg 180 cctcagtccc agctttcgga aaatatccac cacgatctcc attggggtgt ggtctgtcac 240 tgtaaaaggg ctcatgtcaa gaatgcttcg aagcttcaat ggccgaggac tttctgctgg 300 aagagatggg gtgtgctgtg caaaacacac ccgagaactg ccaacgatac cttcttgttt 360 tttcctggca ctttctattg caattgtcan gtctcttctg agggcaaatc ccactaatct 420 ctgagattct tttgncatta tgacaggaaa tccattgtag ctggtttcat taatcatgtt 480 ttctatatca tccactggtc atattgtcct gtgtcaggac anctaatgga ggatcattcc 540 ttcgangtct cataacgt 558 <210> SEQ ID NO 245 <211> LENGTH: 480 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2641714T6 <400> SEQUENCE: 245 aatgtcatca acaagtaaat gggtaaatga attgtggtat atccatacaa gggaatattc 60 aacatttaaa agaatgaatt catacgagca tcaagatgga gacatatgaa tctcaaaata 120 attatgcaaa gtgaaagaag ccagacaaaa aaaaaagaca tactatatga ttccattcac 180 ataaaactac aaaatgcaaa atgaaagccg attggaggtt ttctggggag gagtcatcag 240 gaggagcatt gtgacacttt gagggatgat ggatatgttc actctcttaa ttgtagtatg 300 catgttctcc acaaggtgtg aaaacttatc aaatagtaca ctttaaatat gttcagttta 360 ttttatgtta attatatctc aataaagctt ttaacaaaag caaacatctc ttgcctacat 420 aaggatgaca cagctcttaa aaaaaaaaaa agattcctgc tagattgtgt gcagcaaaat 480 <210> SEQ ID NO 246 <211> LENGTH: 436 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2842285T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 22, 172, 401, 413, 423, 430 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 246 tataacattt ttggcttgtc anaccagtaa atcatgtttt tccactggac aaaggaagct 60 gaagaaacaa ctgttgaaca aactaaatgc tgtgacatga agcatctgac ttctaagtct 120 gagtatttag ttaaaatgat tggtgaacat ttaactgggc aaaaggaatg gnatccatca 180 tccaaacagg ctcacttccc ccagccccca aaatgaacag tagttttaat agcaaaagat 240 ataaaaagtt tttttctttt gattctttag agccaactgt gaaagaggtc agcaatacat 300 taacagcagc aatggacaag gaagagcaaa atagaggatt aaagtatctt gctggacgtt 360 tgttcatctt tttctgtatt agcctgaaaa ctgcaactgg nttatggaaa ttnccggtgc 420 atntgtctcn ttagat 436 <210> SEQ ID NO 247 <211> LENGTH: 319 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1376538T6 <400> SEQUENCE: 247 gaactgcaca ctacttcagt ggaaaaaagt tcaatattgt gcaattttct gcctcttaat 60 agttaaaaag tggcagcaat ccctgcattt gtgtttgaaa caaggatctg agaaacttta 120 tcaaaaaagg taatgaaggc aaaaattggc agacatccag catcttgttt ctttttaaaa 180 caatgtggat gataagtaat ttcatgatta aaaatgaatc ttttaaataa atacattgta 240 tctgacattt gcactgactg atttgataaa tctttaagta aacaacggct ttactacact 300 ccctgtagct caagccact 319 <210> SEQ ID NO 248 <211> LENGTH: 641 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 154741T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 224, 227, 229, 384, 611 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 248 catatgttat ttcctgtggt agtgcagcct cggggcaagg gcgcgttccc tatcgcagga 60 tcacttgcta tggtaagccg cccaccctgc gcgctcctcc gcgcggggaa gaacctgcgc 120 ggcaggacgt ggtgttggag ttggggcgcc cggagcgtgg agtggggaga cctgatgcag 180 agagtctgga gtcggagctg ggggtgctgc aggtaggagc aggntcngng cggagaggga 240 ggcccgaaga agaccccaca caggttggcg cacggggctt ggggaggctt cagcccagaa 300 gtggagaggg ttgacagacg cctgcctgat tagaaaaagc cgggagcttg ggaaggagac 360 gggattgaag aagccacccg gcanggaggc cgaacggccc agagctctcc gggtaaaacc 420 cgcctgcggt gatctgggaa gtgtgtctcc acctagccct gcgagcagcg gccttcctcc 480 cgcccgttag aagggcgctg tgctggagta cgaacccggc ccagagaagc cactcgccct 540 tctttgtcac ttaaaaccct gtcccgaacg cggatctcac gtctagaact ctgtctttaa 600 agcggatgta nagcgcgttc taaccgttcc ctaaccattg t 641 <210> SEQ ID NO 249 <211> LENGTH: 199 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1502915T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 161, 173, 185 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 249 tatcattttc aagcccttac ttgtctactt ccactgttgc ccataagtat cctgataaaa 60 ttcctggttg tcattattgt aaccatagtt accagaatag tcaccacctt gctgaagcgg 120 ctgctgagcg atgggttggg aaccccagtt ctgttggttg ntggtctgac gangcttgga 180 atcangctgg ttgtaccca 199 <210> SEQ ID NO 250 <211> LENGTH: 298 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1488759T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 76, 119, 126, 140, 146, 187, 194-195, 263, 282 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 250 ggggaacaca cagaaatgga tcggaacana atggagagag acggaggcgc tgtaactaca 60 gcaacctaca cgccangtat ctcggaggag caggctcctg cacacgcggg ctctgtgana 120 ccaganggtc tatttgttcn caatantgaa gggcatctag aattagctac agtaaggaat 180 cgaaagntgc ctgnngaatg ggcacagaac ggctgcgtcc gaaaatggcc tgtcacttgg 240 gagggtggag ctgctgggtc ttnctgttga ccactgtctt gnaaaaagtg cacagggg 298 <210> SEQ ID NO 251 <211> LENGTH: 597 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 393928T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 539 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 251 atgctgagca atatttacat ctccaaatat caggtcacaa tccctattat acgttgaagt 60 tagaatgata aattatcata tgctttgcat atcagagctg gtatcacctt tcccataggg 120 aatgctgcct gaaattaaca tattcccaaa ggtaaaatgc atattctctg aaatgcattt 180 tattatgaca atggcatgta tttactcata aaaacaataa acacagacaa ttctacacta 240 gctctcaatc tgtggattta aaatttcagg ttaaaatcag ccatccacct tgtataggga 300 gaagagttct gctagtgttt acaataaagt gattccttgg gattagaaat agtaatgctg 360 tttttttatt ttgaagtggg ttctacttat gattggtttt aattctggca tttcatcttg 420 ccaactacta tcctgtttaa gcaatgttgt cagctaaaag gaatttctga ttaaactaaa 480 gtggtccagt gataagtaca tacacaccct actttgaata atcccagcca attggagana 540 atgctaccac accttattaa ctaatgtaat aaatctccca ttcatggttc ttttgct 597 <210> SEQ ID NO 252 <211> LENGTH: 494 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2219992T6 <400> SEQUENCE: 252 atcataaaat agaacgggag tttcaaaact gtacaagcca caaggctctg ggctggtagg 60 aaagaagggt ggggtcgagg gtcccagggt gtcggggggt gggagatgca gagagagcta 120 gagggtcacc cggcatctgt gaggacggct gggtcaaggc cataagctgg gatctgtaca 180 agggaaacat tcatcagaat gtgacccacc tgaaacagga gggaggaaaa tctttaaaag 240 tcttacaggt aaggtcccct gccccgaaaa aaaaaaaccg tcaaaataat aagggggtaa 300 tgtacatttc tcacccagtc ttggcaccaa ttttgtgctt taaaaaatat actccactgt 360 aagatttact taaaaaaagg tactctacag cagctgttta aaacataatt cttacagaca 420 aatatatata tatgtatgta tatatattaa acattttaaa caaataaagt catctattgt 480 acctgtgcag aaat 494 <210> SEQ ID NO 253 <211> LENGTH: 521 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2816984T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 421, 497 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 253 actgatcaca gctattaaat aacaatgcac caaagtttta caatatttga acatctgcaa 60 atgtagagct ttctggtatg acacaaattt gaatacaaat ggaagttcat tgaatattag 120 gtttatcagt aagctagggg aaacaaatta catacattgt ataggtagta acctatgaaa 180 aaagtggaga ttaggtaaaa attattaagt gaaattattc atatgctttc agtttcatct 240 ttctcctggg aaagccccaa aacaggcctc tggaaaacca atttcataca tgtacaaaat 300 ggcatctgct ctcaaataga tatagctttc cttcaatggt agataagtca cagacgtatc 360 tcagacattc atttcatgca taaggatttt tgagacatct attccactga aatattataa 420 nggagtctac aaccactcta ggaaaaaggc acttcactgt gaaagttgga tttaattacg 480 tcaagtgtga gctaggntag actcaaaatt cagtattcat t 521 <210> SEQ ID NO 254 <211> LENGTH: 468 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 452209T7 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 178 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 254 ccatagaaga atggtaatgt tgtatcagtg catgttctat ggaaaattca tatctcaagt 60 aactagccta gaaatcagag acagcactat gtcaagctag tatacaaggt caaagacaca 120 atgctgccaa tgcaattagt atatagaaat aatacgcagc tgttagaaaa agtctgtngc 180 caagtggata aaacagtagc agtgcactgc actgacatcc agaacagaaa atagggaagg 240 accagagaat gcacttcctg caaaaaaaaa gtccagtaga tcacaagcac aaagagttcc 300 caactgtctc accagctctc taactcatgt gtacctgcac cttcctcttg aaatctgaac 360 attataatac cacaagccac tttcagcctc cagtgggaag gctccagcca cacgccgata 420 tttcgtcctg cttcccgtca tctcatatct aaaagtcatg gcttaagt 468 <210> SEQ ID NO 255 <211> LENGTH: 261 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 638749H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 169, 195, 199, 231, 248 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 255 atccgatttg cagtctggag cagtggctgg atttaagttg ctctggatcc ttctgttggc 60 cacccttgtg gggctgctgc tccagcggct tgcagctaga ctgggagtgg ttactgggct 120 gcatcttgct gaagtatgtc accgtcagta tcccaaggtc ccacgagtna tcctgtggct 180 gatggtggag ttggntatna tcggctcaga catgcaagaa gtcattggct nagccattgc 240 tatcaatntt ctgtctgtag g 261 <210> SEQ ID NO 256 <211> LENGTH: 634 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 640841T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 117 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 256 ttcttttcac attaaacatt gtttaccaca atcagctaac agaaattact gtaacattgg 60 tcacgatgac ttcataaaac taaagataaa tgttatgagg aaacttcatt taacgtnaat 120 ggtaatgtta gatactgtat ttttccatgg taaaatacaa cttatcttga agagaaagca 180 aatagttcag atcagggaga catgctgagg ttttaataaa gaaaagcttg gccttgtcca 240 gaacacttaa caaagttcag gacaatttag gtaaaagaga tgagtgagac accagcgtta 300 ggcagggaca taggctcatc attcaggctt tatgtacatt actggatcta tgcagctctc 360 acctttagat aagtgagcta tatttttggc agagggatct tcaaaagtag ccttggatat 420 gaggaatcgt attttaacca ccaggcagtc caaggaatta tttttaaagg gacagctgag 480 tatttcacgt atatactatt aaggcatcta aatttttggt gttttcagta tataatttta 540 ctgctacttt ttattctttt ttttcatatt gtacaactat gatattaggt ttaagcgacg 600 taattctttc tctactagtg gaccagttta tttc 634 <210> SEQ ID NO 257 <211> LENGTH: 454 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 740878T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 211, 214, 218, 292-294, 299 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 257 aagtacacag aaccaggcac ttctgggaaa cttgtcttct catccctttg ccctcccttc 60 ctcccccttt agtaaagctg gttgggcaca tttgctagga tctgtgggtt tcatcacttc 120 aagccttact gcttaaaaaa atgaggtaag aaatttctat cggaaaagtg aaactgacac 180 ataaaccaaa ccaaggtctt ccctggctgc ngcngcancg ttattgctct aagttggagt 240 gttctgtttg cttttattat gtattcggag tccttattgc cattctggct gnnntcgtng 300 ttggccaagg agaaatgatg gggaaggagc tcggtcgcct gctcccagct gctcagtccc 360 aactttctgc ccgcatgcgg cccgtcctac ccttgctggg agccagctct ggttctgggg 420 ccccagggcg gctctaacac tgggagaggt ggtg 454 <210> SEQ ID NO 258 <211> LENGTH: 519 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 779073T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 158, 315, 439, 506 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 258 gcagaaaata attttgtaaa ctgtcacttc gcgggcaggg aggatcgatg ccacgtgggc 60 cccagctcac ccgggtggag gctgggagct gaaaccgaac ccaggcagga gatgggcgac 120 ggcggaggtg caaggcaggg cacggcgcac aagacgangg cggccgggcg gggtggatta 180 gaggtcactc tcgccgtaca gcgccgtgga gaaggacatg tagtccagag cacctggcac 240 ggagtcgggg ccggtgtagg gggccatccg cgcgatgcag tactcagcct ggtcgggtgg 300 cagctcgcgg cgcantcgtc catggtaatg tagttcttgt ccccagccag gatcttgaag 360 gaagccatga cttggtctgc tgtatctgtg tcggctgtct cgcgggacat gaagtcaatg 420 aaggcctgga atgtcatanc ccccaggcgg ttggggtcca aatgctcatg atgcgggcaa 480 attctgcttc tcctgggggt cttgcnatat cataaccca 519 <210> SEQ ID NO 259 <211> LENGTH: 464 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1445310F6 <400> SEQUENCE: 259 gagaagaagt ccctcaacca gagcctggcc gagtggaagc tcttcatcta caacccgacc 60 accggagaat tcctggggcg caccgccaag agctggggtt tgatcttgct cttctaccta 120 gttttttatg ggttcctggc tgcactcttc tcattcacga tgtgggttat gcttcagact 180 ctcaacgatg aggttccaaa ataccgtgac cagattccta gcccaggact catggttttt 240 ccaaaaccag tgaccgcatt ggaatataca ttcagtaggt ctgatccaac ttcgtatgca 300 gggtacattg aagaccttaa gaagtttcta aaaccatata ctttagaaga acagaagaac 360 tcacagtctg tcctgatgga gcactttttg aacagaaggg tccagtttat gttgcatgtc 420 agtttcctat ttcattactt caagcatgca gtggtatgaa tgat 464 <210> SEQ ID NO 260 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1806435T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 487, 502 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 260 ggaggtgcag ggcagcgctc aggccttgct cagtttcttc ttgatgaagt agctcaccag 60 ccgctgcggc ctctgctggt actcgctgag cacattgcga gggctgctga tctggtcccc 120 ttccaggcgg ttcaggaggg tgacacacac cacggccgct tggaggccgc agggctgcac 180 atggcggcaa acaccgagga ctccatctcg atattgcgga cgccggctgc ataggctgcc 240 tccagatacg cctgcttgtc cttctccgtg taggagcaga gagccccatc cagacggcct 300 tgcccttcat agaagtccaa ggtgcacatg gtgttcccaa ccactgtggt gaactcgctc 360 agctctgcag aacacagcaa cagctcctgc accagcttct tgttaaggtc cgttttccgg 420 atgacccgct tccccaggac aatctgctca aactctgcct tgaagcaggt atccactgcc 480 tgctctntta tgaacaaagt gnggggctca aga 513 <210> SEQ ID NO 261 <211> LENGTH: 487 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1859340T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 263 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 261 caatatacaa tttctgttaa atacaactgt taagggattc tgagaacaat tataagatta 60 ttataatata tacaaactaa cttctgaaat gacatggttg tttccttccc accctcctac 120 cctctcaaag agtttttgca tttgctgttc ctggttgcaa aaggcaaaag aaaatctaaa 180 aatagtctgt gtgtgtccac gacatgctcg ctcctttgag aatctcaaac agccagaacc 240 atcccgtccc acggactgcc agncgccagg acggcttccc ggtgcctctt tctcgaccat 300 tttcacttaa aagcactgtg agtagaatta gctgtgccgt tgctgccaca agggaggcag 360 cctggtcaag aggcgtggtt tgggatgcaa taaggccact gcttcttggc cactttcctg 420 gacattttca atcctgcctt tcctgggtcc tcggagcagc tggtcaggat gggcttccca 480 ctcagtc 487 <210> SEQ ID NO 262 <211> LENGTH: 426 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1889671T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 376 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 262 caaataaaaa ttaagctaca atatatagcc tgaataaaaa tgactagaac aaatacaaca 60 caggacttgc tttcttgcat tagtcacaaa gcatgtgaca atctagaaaa cttcaaaatc 120 aattacattt ctttgaaaaa ggggtaacag cagttactga tacatcacaa ctaataaact 180 tataatacaa gtttcctgac atgcatttcc tgagtgaacc caaatgatca ttttttaaaa 240 caaggaagtt tcgacagttg aagtaaaata aaataattca tggcttctaa gcaacaagtt 300 ttgtttttta aaaaccaaaa gaaaattcag aacagttttg taataggata aattaaaggt 360 atgctaccac atatanaact ttgctacagt cagttaagta ttatacaact tttcaaacta 420 aaggaa 426 <210> SEQ ID NO 263 <211> LENGTH: 421 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1908860T6 <400> SEQUENCE: 263 ttcaatttct cccacgtcaa gagaaaagcc aacatgcttt tcctccaatg cataaaagga 60 acttccatag ggctggcagg agtcaggctg ttcaagacaa ctggaaggag ttgaataaca 120 tctatccagt gagtcctgca agacttcagg ctctactacc tccagcagct ccctgctgag 180 cctggggcat ggtgggcctt ggtcttcttc ctcttcttgg tcctttttaa ttctgtccac 240 gtcaagagcc aagccaaggt actgttcctc caatgagtaa acagcactgc tgtagggctg 300 gcctaagtca ggcagttcaa gataacctga aggagtcgaa taacatctac ccagtgagtc 360 ctgcaagact tcaaggctct ttctcatcca gcagctccct gctgaagcct ggggcatgat 420 g 421 <210> SEQ ID NO 264 <211> LENGTH: 224 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2447337F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 87 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 264 ctcgcctggg ctgtttcccg gcttcatttc tcccgactca gcttcccacc ctgggctttc 60 cgaggtgctt tcgccgctgt ccccacnact gcagccatga tctcctttaa cggacacgca 120 gaaaattgga atgggattaa caggatttgg agtgtttttc ctgttctttg gaaatgattc 180 tcttttttga acaaagcact aactgggcta ttggaaatgg tttt 224 <210> SEQ ID NO 265 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2452210T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 465, 503, 515 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 265 aaccaaactt atcaagcctg tgcttaaaca ccttaggaaa aaagacgtcc cactttctgc 60 accagggcct ctacagcacc agaactgcct ttcccccagc tgaggcctaa ggggcagtag 120 cccttctgca cagggcctag gggaaggttc tcagcaggag gtgggtcagt ccatatgccc 180 cagggagcag aagcagctcc gtcgggcagg aagggtgatg gtgagcagat aggacaggac 240 gcagttccag aagtgctcag gggcaaggca ggggaatgtg gtccctcctc tgcccagacc 300 ctctgacctc tgagcagggc ctgtcatgcc tctgggtgct agagcagaga cccaggcagc 360 agcagcatgg ggtggccaat ggggcgggtt ccacaggatg ggagataggg cctcccgtgc 420 cctgactccc tgagggtctg gtcagtcgcg atgggtaaac tggtngccga actgccggtc 480 atcgtaaatg ctgtagcgct ttnacgtgga tgcgngcgga cacggtcccg cagtttcaaa 540 ggtctcctca tc 552 <210> SEQ ID NO 266 <211> LENGTH: 375 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2497145T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 235, 257, 327 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 266 tgctaattag gcaacctgtt taagcagcta ccaaaaatga aaggcaagaa atgaaaggag 60 gacaaattat tggtttaaag ctatgatagt cttttgaaac gatgagtaag ttctctgagt 120 catggcagca tgatttaagg ttgaatttag aatcaatgaa ggaggagtcg atccactttc 180 cagtctggtc ttccatcagc attgtccttt ttaagaaata aggtggctgg aaggncctcc 240 agaagattct tcttccntct ttgttcaggt atataggacc atggcttccc acacttgtgt 300 aaacttctct ttgctgacag tgttgangat aatgtgattt gatcatactg tgtgcccctt 360 taaatgtcta aaact 375 <210> SEQ ID NO 267 <211> LENGTH: 518 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2612839T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 97, 103 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 267 caaagtttta tgacccagaa tgaaacaaaa caaaacattg gtgttattga gggaattaaa 60 tctaacattg agagaaattt ggatttaaga aatatgntat ttnaaaagta tgttacagta 120 ttaacatctg gcaatatata atctattcag tcctttctag ccatttgttg gcaagaaata 180 ataattaaat tttttattaa aacaaaactt tttacattgg gagttattaa gagcgcctcc 240 ttttggtgta ttcgtttaca aataaaaatg aaatatttat ttgcattttt attgtgcttt 300 atgttgtttg ctttatgttg ttctcttggg cttacttccg agttggagat gggaaagtgc 360 ccaatgaaag aaatataaaa gaatactaat tggaagctga acaattattt tgctttataa 420 gggaagtcct gcaaagtttg tcatacagtt acgtcactat aaacccaaat acaatccatt 480 tcacttttcc atttgaagac ttggaatgta tcatcatc 518 <210> SEQ ID NO 268 <211> LENGTH: 318 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 508735T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 116, 313 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 268 tttatttcat tacaggattg actttagcta ttaatgtaag cataccaggt gagggtgggg 60 ggtagaggga cttgcccatt ttactaggac aggaatgctc tttaagcagc atgganggaa 120 cattaactga cgtttgtgtt gtgcgtagga agatcattct gttcactttc gtgtcctctt 180 tttagcctcc actgagcttc agcaagtcat cctgatctcc gtgggaacat tttcgttgct 240 gtcggtgctg gcaggagcct gtttcttcct ggtccaaagg atgacgtctg ggactctgtg 300 tccattatct cgnttccg 318 <210> SEQ ID NO 269 <211> LENGTH: 566 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1737578T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 299 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 269 tcagtagcag gtgccgtcca cctccgccat gacaacagac acattgacat gggtgggttt 60 acccgccaag cggtcgatgg tcttctgtgt gaaggccagc ggcagggcct cgtggcccac 120 catgcaggag aaggtgtccc ccttcttcca gtcctcggct gccacgcgca gtatgctggt 180 cacagcgaag gtggtggtgc cctggctggg ctcctgccgg gatgcccaag tcaggtactt 240 ctcgcggggc agctcctgtg acccctgcag ccagcgaacc agcacgtcct tggggctgna 300 gccgcgtgcc aggcacgtca gcgtcaccag ctcgttcagg gccagctcct ccgacggcgg 360 cggcagcagg tggacctcgg gccggaatgt gtttccggat tttgagaggg tggcggttag 420 cggggtcttg gactcggggt aggcagcagt gcaagtgaag gtcttcccat ggttccatgg 480 ctcggcacag cccggcagga cactggacac gctgtagcag ccacagaggt cacgctcagg 540 tggtcttgaa cagcgctctt cccact 566 <210> SEQ ID NO 270 <211> LENGTH: 453 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1865070T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 274, 447 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 270 tgctcatttg atataaacat ctaattccaa gagagaccag tgctcaaata tagttttttc 60 agctaccatt tgatacggcc ataaatttgg atggtccatg ttacaatcct tccacaattc 120 tccacttaaa gacatcattt ttctatgttt ttaatgacta ttgccatcta acaattctac 180 aattcgcctc tttgcctgta aaaaggccaa ctctacgtcc acctgtgtct catattgcta 240 tcttttattt atctctgctt aagattgcaa aagnttttga ttttattatt cacctgaaca 300 atgtattgca attccaatac acccccatct cttgctgtta tctacagctt gtgacaaaat 360 gaacaccttg tagaaatatc ctactggttg ggttcccaag tctatgacac tatgagagaa 420 gcattgctga tggattgacg aggagancac cag 453 <210> SEQ ID NO 271 <211> LENGTH: 331 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2238605T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2-3, 6, 8, 19, 34, 131, 171, 192, 212, 214, 220, 304, 314 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 271 annggngnca gcagtgggnt gaaaccccca gaanggcata gaggcagctg ggcagccccc 60 caggcccttg agggtaggag cagggagaag cagcagaagg aggtgatgcc cctgccgctc 120 ctcccaaggc nagccccgtc cccacgctcc catgccaggg aggggtcagg ngccagaaaa 180 ggccctacat cnttgagtgg ggcccgagtg tncnggcaan ctgtctgtca tcccaaggcc 240 tggactctgg cagaggcgct tttcccacct ggtggctccc agggccgatt gcttggtcaa 300 gganccagat atantcttaa gacatgatgt g 331 <210> SEQ ID NO 272 <211> LENGTH: 410 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2448222T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 33, 229, 350 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 272 atttactttg ttttactgta atttacacaa ganactggca agtaaactag gtattttaca 60 ttcaccacac attccctcaa atctccacag ttgttagaaa aacattaaaa tccatgcgcc 120 gggctctcat ttccatgtgc gcctaagctc ccaatgatac tacagatgcc agcgagagtt 180 aagttcatta aaaggagagg gctagactct ttatttcaca aaattagcna taatcttcct 240 cgcaccaaac actttgcaga caatgattat gctctgacaa aacctatctt acaacagtgc 300 ccagagagta aacatcagtc tttatcctga gtacacaaag gatgtatgan atgtgggttt 360 tgttgctgag gataacaggg tattgcaatg cagtagtgat cctacacatc 410 <210> SEQ ID NO 273 <211> LENGTH: 229 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2453340H1 <400> SEQUENCE: 273 gttgtcgtcc ctgctagtac tccgggctgt gggggtcggt gcggatattc agtcatgaaa 60 tcagggtagg gacttctccc gcagcgacgc ggctggcaag actgtttgtg ttgcgggggc 120 cggacttcaa ggtgatttta caacgagatg ctgctctcca tagggatgct catgctgtca 180 gccacacaag tctacaccat cttgactgtc cagctctttg cattcttaa 229 <210> SEQ ID NO 274 <211> LENGTH: 567 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2474214T6 <400> SEQUENCE: 274 ttctcacaaa acatattaca aatgacagca tgaaaaaaaa atcttgcaca gtaactcaaa 60 gttcggctct acaatgtacc cttaaactgg caggacattt ttgaaatcac aaatttgcac 120 ataaagaatg tcacgaacag ccatgtatcc atatacagca atcaaataag gaacttatga 180 cctaaagcaa aggtaaactt tcttgaaact taacattcta taccaactag gcaacctctg 240 cccaggatga gagttggatt tttcaaaaac ctctaattta atagtgcagc atttcgtttt 300 ccctgatggc ctgtgtttca cagcagtttt taaagactgc ttgttcaact atagctgcag 360 cctatatccc agctatggaa aaaaaagtaa atcttagttc aatttttgcc agttgtttct 420 gtatttaaat ttaaaaaaaa acacacttcc gctgggcagg tttagaggtt attatcagtc 480 tgtgcataac taaaagttca aagcaaattc aattttgctt aagggaacat tgtaaagtaa 540 caattcttgg gattacatgc ctcgtat 567 <210> SEQ ID NO 275 <211> LENGTH: 280 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2645695T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 20, 139, 218 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 275 atttgcaaat gacagagagn gagaaaggct tcagacgcaa aggactttta ataagttacc 60 ttttgaagat gagacaagac aggttctaag ctaatcagac gtgtccacca ggtggacctg 120 cgctcttttc acaggtagng gttcctgatg tactctcggt acatggagga gtcctctttt 180 cctaggggct gcatgatacc ttggctggcc tggatgtngg cttggaagat ctctgtagat 240 tttctgtcta ctctttgggg ctgaacttca tagatgttat 280 <210> SEQ ID NO 276 <211> LENGTH: 569 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2716582T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 276 ggacatacaa cacgcccnga cacacagcat agcagggcct cgataatgag ataatttccc 60 cccacgtctt gagaagaaga atactatgta tttctttatg aacactatta aaaaaaataa 120 acccctcaca acattctgca ggacctagag cccaagagaa cccactgaag atccatcatc 180 tgtgggatgg cggaggcagt ctctggggag caggagggaa tgtgcacagc caggggaggc 240 tgcagcagcc ttgcctctgc cgtgaatgtc aggcagtgac aagcagcaat aagggaacag 300 agggggtggc agcagtgttt ggcagctctt cagcaatctt aatcataaat tcgggtagga 360 tccagttggt ggcattgccg ggggggcaca gaggtggtag cagctttcac ctccttgggg 420 gtgggagagt tccctctgtt tggagaggga gaagaggggc aatgcagagg aaggagcgag 480 ggagcacagg ctgtcttaca atcttgcaga tctcagctgg accacagccg cagcgtcatg 540 agcagattaa acccgggcac tttcaggag 569 <210> SEQ ID NO 277 <211> LENGTH: 260 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3141568T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 161, 185, 199-200, 215, 217, 226, 230, 242, 246-248, 253 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 277 cagtgcattt ttgcaaacaa taacaattca ctgagagtaa taacattcac atatgtaatt 60 agagtttaaa aatgtaaaaa acttagggta acaaacactt taaacttatt ttttagacat 120 tcaataagcc cattctccca caaactgttt gattacaaag nagcacaatg ggttaactgt 180 ggcanaacat aagaaatann gcaggggagg cagananaga cttganaacn taaggctatc 240 cnaacnnntt tgncaatatc 260 <210> SEQ ID NO 278 <211> LENGTH: 330 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 510540T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 220-221, 227, 229, 236, 260, 265, 268, 272, 293-294, 310, 317, 325 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 278 atttgaatct aatagatcat tatttaggnt tatactctgt gaatatatat atgatattgt 60 atttaattaa tatctgagta atctcaatta ccattttcta ggaaggatag agtgtaagag 120 ctaaacattt catgtagaaa tattaacttt caaaagttat aataccagag ttttagagtg 180 aaggagtatt taaaatgtgt ctttctttgg gagagaatcn ntttgtncnt tactgncaat 240 aatttgaaaa ttggtaattn aatanctngt gnatatggcc aatattatgg tanngattag 300 cttctaggan aagttangtg tagcntgatt 330 <210> SEQ ID NO 279 <211> LENGTH: 62 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1285830H1 <400> SEQUENCE: 279 cccaattgga acctgggatc aagtggccga ggtcctgagc tggcagttct cctccaccac 60 ca 62 <210> SEQ ID NO 280 <211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1532801T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 193 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 280 cttcactgcc ccggctggtc ccaagggtca ggaagatgga ttcatacctg ctgatgtggg 60 gactgctcac gttcatcatg gtgcctggct gccaggcaga gctctgtgac gatgacccgc 120 cagagatccc acacgccaca ttcaaagcca tggcctacaa ggaaggaacc atgttgaact 180 gtgaatgcaa ganaggtttc cgcagaataa aaagcgggtc atctatatgc tctgtacagg 240 aaactctagc cactcgtcct ggggacaacc aatgtcaatg cacaagctct gccactcgga 300 acacaaacga aacaagtgac a 321 <210> SEQ ID NO 281 <211> LENGTH: 282 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1747756T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 225-226, 241 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 281 tataaatatt cagtgtacag gagtggtcct caccccaccc agtgaggatt ggatgaacta 60 ggctaaaagg aagggataac tggccaagaa agggacatct atgtgaaagt gaaactgaga 120 cagtgctggt cacaggtcat gctgcagaat aatacattcc caggcactgt cacgtggggg 180 acccaaaagg ccccaagagt gacctataac ctctccagaa gaccnntctg tgtggcatca 240 nagtccacca cagtttaagg aaatatttag gacttaacaa tc 282 <210> SEQ ID NO 282 <211> LENGTH: 256 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 032467H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 211 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 282 aaagaaactg tctaacgcac caaggnctct aaagaaacgt agttctatta cagagccaga 60 gggtcctaat gggccaaata ttcagaagct tttatatcag aggaccacca tagcggccat 120 ggagaccatc tctgtcccat catacccatc caagtcagct tctgtgactg ccagctcaga 180 aagcccagta gaaatccaga atccatattt ncatgtggag cccgaaaagg aggtggtctc 240 tctggttcct gaatca 256 <210> SEQ ID NO 283 <211> LENGTH: 371 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 511038T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 349 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 283 acactgaagt gtgcaaggat taaccagacg tggtgaggtg ttgcacagaa attcctacac 60 caccatggac agcaagactt ctgtcccctt tcatttcaga ctggactttg gcatggtctg 120 ggtttggtcg ttaaggtctg gttcaagatg aggcctcaca gagagcagat caaatcaaac 180 caaccatctg gtcaatctgt cgcatgtaga tgctctttaa gggcagggag tacctcctct 240 catcaggtac acgattgcag ttggagctgg agttgatgac ttttaactca tgaggtttcg 300 gcctgtgcac agactttccc ccttggtcct gccctccctc ttcagagang aattccttcc 360 atgggcaaat t 371 <210> SEQ ID NO 284 <211> LENGTH: 577 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1383823T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 548, 550 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 284 gctggggtgc tggagtggga aggggaatcc aaggagcaaa ccaagaaggt cctagggcca 60 gcctaggcct ccacggcccg gccgttgatg acgcggatgt ggcggatgac gtcctggatg 120 gcttcagatg ttgtgccctg gcccccgatg tccggagtgt gcatattctc attgtccatg 180 gatgccagga cagccttacg gatggaggtg gcataggagt gcagcttgag gtggtccagc 240 atcatgcagc tggccagcag ggtggccgtg gggttggcga tgttcttatt ggcgatactc 300 ttgccggtgt tcctcgtagc tgtttcaaac accgcgtaca catggccata gttggcccca 360 gccacaaggc ctgggccccc gaccagtccc gcgcagacat tgttgacgat gttgccatag 420 agattgggca tcaccatgac atcaaactgc tggggccggg acaccagctg catggtggtg 480 ttatccacaa tcatgttctc gaaggtgatc tgaaggtagc gggctgccac ctccctgcaa 540 cactggangn aaaagccatc gcccagtttc atgatgt 577 <210> SEQ ID NO 285 <211> LENGTH: 365 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1517291F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 297 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 285 ggcatgacca cgtccagtga agacatttga ggcagcacat ctcaggaccc aggcaataga 60 ctggccccaa ctcaggctgg actaaggtgt gattaattct ttgttttttg tgtggaacag 120 ctcaccttgt cagacagcct cagggcatct ctgagacaca ggggcagaaa atgacattca 180 tcttttgagt cctcatccat ggagtgctgt gtttgggggg ctgcatctgc tgaagcgaga 240 accccattct gccaccccac caggatgccc attctccagg attctccaac ttactantag 300 actaaaccag aacaagcaac aaactgtatt tatgcaagca aaattgatga gaaaattata 360 ttcaa 365 <210> SEQ ID NO 286 <211> LENGTH: 206 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1862017H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 110 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 286 ggaaggaatg attgcatcat cgataaaatt cgaagaaaaa actgcccagc atgccgctat 60 cgaaaatgtc ttcaggctgg aatgaacctg gaagctcgaa aaacaaagan aaaaataaaa 120 ggaattcagc aggccactac aggagtctca caagaaacct ctgaaaatcc tggtaacaaa 180 acaatagttc ctgcaacgtt accaca 206 <210> SEQ ID NO 287 <211> LENGTH: 429 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1922735T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 387 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 287 tttggaccca gcatgtcctt aggttttacc cattcgtcaa actgctctgc tgtgagatag 60 ccaagttcga tagcagtttc ctttaaggtt gatccatttt tgtgtgctgt cttagcaatc 120 tttgctgcct tgtcataccc tatatgagga ttgagagctg tcaccaacat tagagactca 180 ttcatcagct tgttgatcct ttctgtattg gcctggattc ccaccacgca gttttctgta 240 aaggaaactg aagcatcccc cagcagcctg gctgagtgta acacattttt aatcatcatt 300 ggcttgaaaa cattcaactc aaaatgtcca ttgctgcctc cgacagtgac agcaacatgg 360 ttccccatga cttgggctgc aaccatngtc atgcttccca ctgagtaggg ttcaccttgc 420 ctggcatga 429 <210> SEQ ID NO 288 <211> LENGTH: 467 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2116322T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 43, 122, 125-126, 130, 162-164, 169, 200, 240, 373 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 288 ctgaaacttc catttacacc atggcctcat ctatcaagaa gangaagaaa aggctctgcc 60 ttataccata aaaatcaagt actcatgtac ttgttagagg tggcaggata tttgtttctc 120 cnggnntttn gctctaagaa attacacttt cagtaccagt gnnntgacng aaccactggc 180 aaactgttgg aaatgtcttn tggattagtc agtgtaccat ttcataaagt gcttctggan 240 ttaaaatctg ccaagctgtc aaaagtgtcc acacttttgc aacaaaggat aaaagatccc 300 agtgggtatc accgagtcct tcccagctgg gtctcattat tggcactgct gctttaacct 360 ccaagccgct ggncctcacc ccaggcgaac tcctggccgt tcctcaggta gtggattgta 420 atttggatcc tcatctggtg tatcaaaaat agctttcaaa atagatg 467 <210> SEQ ID NO 289 <211> LENGTH: 310 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2366633F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 160, 172, 213, 254, 305 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 289 gaaaatagag aaagtcaaac ctcctccntc ccccaccact gaaggcccca gcttgcagcc 60 tgacttagcc cctgaagagg ctgccggaac ccagcggccc aagaatctga tgcagaccct 120 catggaagac tatgagacac acaaatctaa aaggcacgan agaatggatg anagtagtgt 180 cctcgaggcc acacgggtta atcgaagaaa gancgcactg gctttgcgct gggaagcagg 240 gatctatgcc aacnaggagg aagaagacaa cgagtaaact tccttcaacc caggaagcgt 300 ctttngtgct 310 <210> SEQ ID NO 290 <211> LENGTH: 519 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3271754T6 <400> SEQUENCE: 290 gtaaaaattt ttatcagcac tcattccagg agttgtgtca attacaaaca atgcattgtc 60 acatgacaga cttcctgtgt ctccacttaa tgactccctt tggccactat tttcaacaaa 120 acataaagta tcctcttcat tctcactgtt ttcagactgt tggctttcat cactgctgag 180 aactagtaag acagaattat ctttaccctg agatgtgttg ggcgcagacg tgtatagttt 240 ggtatcacat tcaaaatcta cattcccttc actgttcatg tcttcactga cacttataac 300 tgtggactct tcttcatcat cactaccacc acaatcacca aactttgtca agtcacttgc 360 ttttatgggg ctctttttgt tgttattcca tctgcctact tccacagttg caaatgtttg 420 agttaatgat ttcattacag cctcagagtt cagattagag tgcactgata cagcattttt 480 attttggggg gttgatgtct ctgagaaact aactgttga 519 <210> SEQ ID NO 291 <211> LENGTH: 535 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 161115T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 292-293 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 291 attataaaat ttgccaaata aacatgtcaa aaacaaactt aaaaacaaag tgtagctgat 60 atccagaaat tgcagcactg tattgataaa gggctctttt cattaccagg gaaagaattt 120 aatgtccttc cttcctcccc aaaagcttcc ttggtgcaat ccagtacaga aaacgccacc 180 actttctgat gccaggagaa aagcaaaata aaaaaactgc ttgcacacat tagcactgat 240 aaaacaatga caatttcact aaaagaatgt ttaaagacta ccggatgctg gnncaaacca 300 acttcatgac tgcattaaca taagctaagt tacatacact tcaaatgcag tatagaatta 360 acactgcata tctaaatggc tcatatataa aatgtgtaat taaaacccaa acatacacac 420 tatgtttatt acattcccct acattgaaag tactgagaac aatttaactc tgaacacaaa 480 agtttagtga atttgctact gttccattac aggacaatta aaaatgagac tatat 535 <210> SEQ ID NO 292 <211> LENGTH: 415 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 308581T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 393, 408 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 292 tcactctttt cttcatcggg ctctttcata tctaagggtt cattttgagt gtctactgta 60 cttggacctg tcgcttcctg acagttgccc tcagttcctg ctggagaacc aggaacttct 120 gtcttgattg gtttctcgtc ccttaatcct gtttcttcac cctcttcttc gttgtgatcc 180 ctacctactt ctgtactgtg cgctggaacc tccttgggct cagctgcttc ctggttggtg 240 aattctttct ctaaactatg ccctgtgctt gtctctaact cttgggggac ctctaccata 300 catttgtcat catgataaac tgtgtcatca ctatgcccta aaggacacga ggccactgtg 360 cctgcctgct cttcaacctg agtcactgct gcntctccca cattctcngt gtggt 415 <210> SEQ ID NO 293 <211> LENGTH: 461 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 394087T6 <400> SEQUENCE: 293 ttctttccat agaagaatgg taatgttgta tcagtgcata ttctatggaa aattcatatc 60 tcaagtaact agcctagaaa tcagagacag cactatgtca agctagtata caaggtcaaa 120 gacacaatgc tgccaatgca attagtatat agaaataata cgcagctgtt agaaaaagtc 180 tgtggccaag tggataaaac agtagcagtg cactgcactg acatccagaa cagaaaatag 240 ggaaggacca gagaatgcac ttcctgcaaa aaaaagtcca gtagatcaca agcacaaaga 300 gttcccaact gtctcaccag ctctctaact catgtgtacc tgcaccttcc tcttgaaatc 360 tgaacattat aataccacaa gccactttca gctccagtgg gaaggtccag cacacgccga 420 tatttcgtcc tgttcccgtc atctcatatc taaaagtcat g 461 <210> SEQ ID NO 294 <211> LENGTH: 559 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 511300T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 527 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 294 ccattaacaa aacaattctg gtactacaga ccagtggtgt cagaataggc ttagtgcctc 60 cttgtttgtg tttgttttgt tttaattgca tgagcactct agatggtaaa gttttcagag 120 ttcattttat gcagggccat tctcagtcct caatgtactc ccacagatct ttttcatagc 180 cttcatgcac atgctgtaac aaaacccttc gtcgactctc acagtatctg tacttgtctt 240 gtactttctg ctttatatcc tgcagagaat cttgggaaat atctcgttca aggtagcccg 300 agagcacctc tgtggcattc tctagatctg cttggttatt ctcaaagata atggactggt 360 tattcttttt gaggtagaaa gcgaagacat aagtgtacat gagtgtggca cgacactggc 420 agaggacatc aactgccttc ttcaggaact gcacctcaat ccaggacatg ttgtgctgct 480 gcatctcctc cattttctgt ttcacctgag catatagttt gtgctcnaag cgcaggctct 540 gcatgtggtt catatagcg 559 <210> SEQ ID NO 295 <211> LENGTH: 472 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 604978R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 143, 145, 150, 156, 361-362, 402 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 295 gcgggcgcag gcggcctgac ccttccgcag gcctccgagg agctgctgcg tgagcactac 60 gccgagctgc gtgaacgccc gttctacggc cgccttgtca agtatatggc ctccgggccg 120 gtggtggcca tggtgagtat ccngnaagcn ggcggncggc tccgggaccc ccacccccgc 180 gtgataccgc gcccgttcct ccgcacaggt ttggcagggg ctggacgtgg tgcgcacctc 240 gcgggcgctc atcggagcca cgaacccggc cgacgccccg cccggcacca tccgcgggga 300 tttctgcatc gaggaacctg attcacggca gcgactcggt ggagagtgcc cgccgcgaga 360 nncgctctct ggttccgcgc agacgagctc ctctgctggg angacagcgg ttggggaact 420 gggctgtaat gagttagccc ggcagattgc gcgttaacag agggttttca aa 472 <210> SEQ ID NO 296 <211> LENGTH: 550 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1218053T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25, 56, 363, 404, 448, 452, 473, 477, 522 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 296 tttgtcattg cagaacaaac aatangaaat ccaaaattta tggcttcgtg agacanaatg 60 tttacaactt tacacattgc ttttacatca ctctttgtta cacttgcagt tccacaaatg 120 tgggtggtta agatactaaa tatttatata taagtctgcc ttttccaaag aaaataataa 180 atggtatgtt catatttata ttctgtatca aatataattt tactgaaagt tctcagaaat 240 aagcagtaaa aataggattc atcctctatt cagaaccaca aagatagtac agactgaagc 300 ttttaaaatt ttattaccct attaacatca gtaactcact tattttaaaa taacttcctt 360 aancttaaca ttctggcaaa agtttaattc cccatgtatc agtnacaaat caagaggccc 420 tttgtggttt tatgagacct aggctggntc cnttatgatt aagacacaaa gcncaanatt 480 gcatagggta cgaagtccac attactcacc gagatatgga angctcgcac tgtgcctatg 540 ctccatctgc 550 <210> SEQ ID NO 297 <211> LENGTH: 509 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2191256T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 41, 64, 72, 77, 79, 83, 91, 95, 106, 112, 117, 141, 177-178, 181, 200, 213-215, 473 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 297 gccagtggac cagtgagggg tgagggcacg tcctccgaag ncgaggggtg gcatccctgc 60 ccangggcct tngcctnant gcnctaaggg ntggnccctc agacangctc angggangtc 120 cgcccacaag ggctttgggc ncctccctca tgaagacgcc acccctgcca tggggtnngt 180 ngcccttcac tgtcacatcn gccttggttg atnnnaggga ggttgatctc tctcagggag 240 aactgtgggg tggggatgta gccttgggag ggcccttcag gaagtaggag tggggggttg 300 gggagtgtgg tagacccaga aacttctggg gacgtcagtc atagttacta atatttggag 360 gcagtaggag atgctggccc caaggttgag gtatcagtta gagcagaaca attggaccta 420 gagctggttt ttcctttggg tttaggtgta agtgaactat tatcattgga gtngagaact 480 ggagagaaag ggttgtcact gtccagcac 509 <210> SEQ ID NO 298 <211> LENGTH: 589 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1287267T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 398-399, 426 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 298 cacagcctga acatcacatc ttcagagaaa gttactttta tgccattgta tttactattt 60 accacacagg cattgaacat tctcattaac atgataagac aatttgctgg taaacattta 120 aacacacaga cattagtttc agtatctcaa catatttttg gtcataacca aggaaataca 180 tcaaaataat gacaacattg gctaatattt tacaagcaaa tatttaactc tgcatagttt 240 atacaatagg ctgtggcaat aaataatgtc accaatctca tcaactatta actggccaca 300 agaagcctaa cattcatttt aattatgata tgaaatgctc tattggtgta gtttcaacat 360 atccttaaat gtttgggtgt ttaaccttga atacacgnna agaaaaagta ctaaactgga 420 ctaagnaggt gtgtttggtt aactacaaat atgtcatgtt cacatagtac attcctaaca 480 tgaaggccaa tatttaaata gacaaactag cagtccaaaa aatgtgaatg tgcaaattgt 540 gagtaaacat tgctttaaat ttgcactcat ttgcaagtac agtactagc 589 <210> SEQ ID NO 299 <211> LENGTH: 150 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1288342H1 <400> SEQUENCE: 299 ggaaaaaaga aaatctctac ggacaactgg tttctattca ggattttcag aagtggcaga 60 aaaaaggatt aaacttttaa ataactctga tgaaagactt caaaacagca gggccaaaga 120 tcgaaaagat gtctggtcaa gtattcaggg 150 <210> SEQ ID NO 300 <211> LENGTH: 319 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1306707F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 88, 121, 198, 218, 281, 316 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 300 gggacgctct cagctctcgg cgcacggccc agcttccttc aaaatgtcta ctgttcacga 60 aatcctgtgc aagctcagct tggagggnga tcactctaca cccccaagtg catatgggtc 120 ngtcaaagcc tatactaact ttgatgctga gcgggatgct ttgaacattg aaacagccat 180 caagaccaaa ggtgtggntg aggtcaccat tgtcaacntt ttgaccaacc gcagcaatgc 240 acagagacag gatattgcct tcgcctacca gagaaggacc naaaaggaac ttgcatcagc 300 actgaagtca gccttnatc 319 <210> SEQ ID NO 301 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1394439H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 16, 91, 110, 152, 178, 221, 238, 257 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 301 cttcactctg cttctnctct ccatcgtcat tctgtactgc agaatctact ccttggtcag 60 gactcggagc cgccgcctga cgttccgcaa naacatttcc aaggccagcn gcagctctga 120 gaagtcgctg gcgctgctca agaccgtaat tntcgtcctg agcgtcttca tcgcctgntg 180 ggcaccgctc ttcatcctgc tcctgctgga tgtgggctgc naggtgaaga cctgtgcntc 240 ctcttcagag cggagtnct 259 <210> SEQ ID NO 302 <211> LENGTH: 512 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1454705T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 409, 461, 496, 499 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 302 gtaaaatgtg aacatttaat tacctttaaa tcatatatga aataatttac atgctataca 60 cttccaaaca cactgaacat aaattcaact ttataagaca tatacacagt ctgcttttgc 120 caacatatac cctgtaggtc acttaagatg taactgattt ctcagtccac ctgtgagcat 180 ataaacacac aaatatatgt ctgaagttga agattaagat aataaaccag agttgaatac 240 aagaagtcag ccacagaaga ttctaaaacc acaatcagtg actggaacac caaggcacaa 300 aaacttccct ttgtagtcac agagattaag tttccattcc cagtgcttaa atatggaagc 360 aggattggtt aatcacatac tatattttat agtgcatttc tgttgctgnt taaaaaggaa 420 tattttttaa attacataat gtattacagg aaagcattgg naaaataaac aggggtaaga 480 taaagctccc catacnatna aagttttttt tg 512 <210> SEQ ID NO 303 <211> LENGTH: 326 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1477962T6 <400> SEQUENCE: 303 caaagtacaa tttgactcaa acctgtccaa ccagcatcaa cagctactga aagaattcaa 60 acatacagaa gatgtggggg tggggtgaag ggtgggacac ttaggtccca tctctgccaa 120 tgtggcaaaa aaaaaaaaaa aaggaaaaga caaaatgact gacacagcca ggttcattct 180 tgtcttggag ctgaggcagc agccctagct cctgctacag acggaatact ggaggacggg 240 ctccctaggc gtaggtatgg tgggtcgggg gcacccaacc tagcagagtg atgcacagag 300 gaaggccagc cctgaccctc ctcctt 326 <210> SEQ ID NO 304 <211> LENGTH: 254 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1503230H1 <400> SEQUENCE: 304 tacatgccct ccgtcctgct ggtcgccatg tcctgggtct ccttctggat cagccaggcg 60 gcggtgcccg ccagggtgtc tctaggcatc accacggtgc tgacgatgac cacgctcatg 120 gtcagtgccc gctcctccct gccacgggca tcagccatca aggcactgga cgtctacttc 180 tggatctgct atgtcttcgt gtttgccgcc ctggtggagt acgcctttgc tcatttcaac 240 gccgactaca ggaa 254 <210> SEQ ID NO 305 <211> LENGTH: 495 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1509884T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 333, 398, 404, 422 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 305 tatatttgga attagccagc ttgactcagt ttaggtgatc ccaattttgg tggcaacaac 60 caaagcatcg tagtcaggag ccagtcgaac atatgccttc ctctctccat cagactgaat 120 cagagtgttg actttggcca catcaatgtc acaaacttct tcacagcctg tttgatctgg 180 tgcttgttgg ctttaacatc cacagtgaac acaagtaggc tgttgttttc tatcttcttc 240 acagcctact cagtggtcag cggaaacttg atgataacat ggtggtcaag cttatttctc 300 ctgggggtgc tcttccaagg atatttgggc tgnctccgga gtcacagtgt cttgggccgc 360 cggaaggtgg gtgacatgtg gatcttgttt tttttgtngc tgtngacatc tttcaacact 420 gncttcttgg ccttgcaaag ccttcgcttt ggcttcggct ttaggagggg caggagcttc 480 cttcttcgtt cttgg 495 <210> SEQ ID NO 306 <211> LENGTH: 429 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1633262T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 290, 337, 347, 379 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 306 actttacaaa tagacaaata ataaaaggct cagtggctaa aatagatggt aagcatcatt 60 gaaagaaatc aacaccatca cggtatctca gttggcttac acgtgtaaaa agaaattttc 120 aaagagcaat ttcacagaaa tgaagccagt ttttttctta taaacaaatc accaattctt 180 ggttcaaaac tgacatctgt tatgaaaatt accatatcac atatttgtaa gatgacaagg 240 agtaactcat cttcaaagtg caagtaagtc tatttacaac cacaaaaaan gcaatgatga 300 ggagaaaagg atttttaaaa aatatacaaa gattaanaac atttggngtg caaaattaaa 360 caattttttg ggtagaggnt taaagaggaa aagtgattga attacaggtt tcagctatac 420 ctactatat 429 <210> SEQ ID NO 307 <211> LENGTH: 496 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1669006T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 342 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 307 cacagctcat aagtcacaaa accatattat aactcaaagt caaatatgta ttcgtttgcc 60 agatatattc gtcggaatat aagagctgcc aatgccaaag tcaggatgac aatcagtaca 120 gctgacccac catgatcagt gtggttgtct cttggctggt ggccctggat tacatctggt 180 gaagtagaca accttctctg actctgctgc tgggcccggc gctgtcgagg gctcatggag 240 gtattcttag ctacaggttg ggtaggttga tgaaaggatg ctgctgagga attctggagt 300 ccgtacgatg tactggccgt agcaccctgg aatgttgtag gnatatcatc ttgtaaatca 360 gttagtgaaa aagagtggtt taagtctgac tcagagatag tctttccaga tgaattgact 420 tctgcctata aacaagatag acccaagagc agtgtgacaa caggaacaac agggaacata 480 cacaatctac aacctg 496 <210> SEQ ID NO 308 <211> LENGTH: 493 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1706162T6 <400> SEQUENCE: 308 ggtacagggt gagtacagat gcacaggagg ccatagggtt taggcaaagg ggagcacaaa 60 agttgaagat gaggcgctgc catcaatgct gggacttcag gccaagggca ggaactgagg 120 aagccacaag ggaggacatt ttctgcagtt gctgaaccag tagcaactag gtcctgagaa 180 agccctctct cgtggaagaa taacagccag gcgggaaagc ttttcatcct gcaaagctgg 240 ggcagaagat tcttccttaa attgtcatct gcacttcagc tcaggaatcc tgttggctga 300 agtccagagt gtcctttctg attcctgaag tagatgaaca gcccggcccc aaggaagagc 360 aggcccagca caaagccccc gactccactc agcatcttgc tctgtgcaga ttcagaccgt 420 gctctccatt ccactgtgag agcgctcgtt acgcttgggt gctccacttg gcaagtgtaa 480 acctctccca ctc 493 <210> SEQ ID NO 309 <211> LENGTH: 505 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1706278T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32-34, 190, 235, 237, 239-241, 243, 248, 253, 255, 259, 266, 274, 313, 349, 406, 494 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 309 gcttataact ctgcagcccc tatgggtagc tnnnggtggg ggaagatagt atcaaaaaac 60 ggtgaagaga gctgatgagg ctgtggggac tggctggaag ctgctggcag ggtggagtgg 120 gctggggccc cggcagattc agatcgaggt acagcagcgt taataatact cttggagcgt 180 taatactctn gggaggggca ggcacttggg gggccctagg gcatgaaggc acttngngnn 240 ngngatgnga cangngatnt actgcnggac tggncggggc caggccctgg ggtttggcag 300 gcactttggg gantgctggg gttgggcagg ttgggccccg acagcccana aggctttggt 360 agtggcacgc acagtctctg ggccgggtct gcattaaata gaagangctt ctttagtgct 420 catctcgaag ctctgaaggc agaaacttgt actgctgctt ccggatctgg gccagtttct 480 tccgcgcctc ttcnagctct cgttc 505 <210> SEQ ID NO 310 <211> LENGTH: 82 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1729325T6 <400> SEQUENCE: 310 aatcttcttg tgccatgaga ctccatcagg cagtctacaa agaccactgg gaggctgagg 60 atcacttgag cccagaagtt tt 82 <210> SEQ ID NO 311 <211> LENGTH: 508 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1750447T6 <400> SEQUENCE: 311 aatagaattg tgcttctttt gcagactggg gacaatgaaa tgtttagcta caattttccc 60 atacaaacat gaaacaatat tcatatagaa taaacaccct cacaaataac tgatgggtga 120 tgaacacaca ccaagttcga ccaaagcaaa aaataaactg aaaattgttg ggtggggtta 180 ttcatatttt aaattcaaca tgcttgctct atttaaaaat acctgtagaa gctcataata 240 aatagcttct attttcagac atagcagaga aggcatattc cattgttaac tgtaaaagca 300 actcttaaat ttaaaattac tgctatacca cctattaaaa taactttaga taaaatgcct 360 tcttttagca acctgctggt ttatttaaaa aattgtttta gaattatagt gatcaatatg 420 catttttaaa atacaatatt aattccatca tagccaatgg aaaattaaga cggttccata 480 tttctcagtt aaagggtttt cttcactg 508 <210> SEQ ID NO 312 <211> LENGTH: 445 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1813891T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 312 atacaacaac aaaaaaaatt taatcaagtg aaacgtnaat aaactgaaca ataaacactc 60 aaaacatttt ccattggaaa catgtaaaga caatatgagg ttttgttacc atcttactgc 120 aattttctta tgtgttacta gtctacatac cccatgtttt ctgtaatcat gcagatgtga 180 atggaagttt gaatgattaa ataaatgaaa agtccgttta ctgcagggaa tcatttcaca 240 aggcagccaa accgggttta gagaacaaaa ctattcaaga aattctccac gtatttaggt 300 tcattttaga atccatgaac cttaagctgt tcctccttta caatgccaac ctccaagaga 360 aactgggcag atgttttttc tttggtcacc ttgaagctga ataacctctc cgtattcagg 420 atgttcaatc acagtaccat tacag 445 <210> SEQ ID NO 313 <211> LENGTH: 387 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1825132T6 <400> SEQUENCE: 313 ataattcaga caggtcaaca tatatgattt gatgggagaa tagttagggt tccatttcct 60 ttaagtttct attccaatca atttccactg gtgatgtcta actcagatcc cgtctcagtg 120 tacagatgca acctcgctac atccccagca tgatcgtata gactctgtca accagaatcc 180 caacagctgc cccaggggga gcagcgtgtt ccagacacac atggtttctt agacaaggta 240 gggtgcggct gcagcggaca ggcacttctg gctaggtcag gcttcaagct agttaatatt 300 gaatcttcct cttagctttc ctcagttcaa tgctcttctt aagtagtcaa gaatttcctc 360 aatcttatgt aggtaaaact ggaattc 387 <210> SEQ ID NO 314 <211> LENGTH: 383 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1849154T6 <400> SEQUENCE: 314 gaaaggaggg aagaaggtag tggcactaac caaagtcaca aagcccaggt tggaacaaca 60 acaaatcact ttggttccta gagccaagcc tgaaggggaa acaggcagaa gggaagacaa 120 aatgggaaga agtctacagt caatgggaat ctttttctat ctcaatgatt tagttataaa 180 tagagattat tagtcttctc tctatacatg taacaaatgc cgaacttact accacgaaat 240 ttctaaaact gactttttca catttgttaa aaaaggtaaa aatcacatac ttttcttccc 300 ttccttcagg tcaagttctg aactaaaata ttacatgtaa caacagctgg tcctaacttt 360 tatacaaagt gaaactatat aga 383 <210> SEQ ID NO 315 <211> LENGTH: 443 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1980941T6 <400> SEQUENCE: 315 tagttacagt aatactttgc ctgtgtctta ccaacatgta gctgacagtc aaaattttgc 60 aatatagata taatatatag ggatatataa gaactacaag aaaatcccca aaacccataa 120 agttcaaatg tgaaaacaga aaagttttaa cactggagaa ttcgctatgg tgagcctaag 180 caatatatag aaaagagtct acaaaaaggc ttaggtgtta aataaatttt gacttcctct 240 tgctcagaaa atgtcggagt gctataaagt tccgtgaagt tccttaatgt gactcgctca 300 gcccttcata gctagtgcca atcctggcca agccagattt cttgtgtgtc tgcaaacaat 360 atgtgagccg aacatcacca atgcctcctg aaaatgggct ctgactcact tccttttttt 420 gccaagatag ggtttgcttt gtt 443 <210> SEQ ID NO 316 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1988078T6 <400> SEQUENCE: 316 taagttccca gctaagtgca cagatagaag cgaggtattt ctgggttaat gcaggagcca 60 gtgggttaca tgggtctggg cactgtggcc aaggggcgag taccaaggtt tctgagtcag 120 acccggccag agaccctgcg ctgaaggtgg actaatgtcc taacactgcc agctgctttc 180 tcctcacagc tggccacacc gcaaggcatc tcttcgacag taaatcattt cagcgatgtt 240 aagggaacag acgttaaag 259 <210> SEQ ID NO 317 <211> LENGTH: 468 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2132606T6 <400> SEQUENCE: 317 cacagtggcc acagctaaca tcattgcagc acctttactc cttcggctgt gatccaatct 60 ccagctcact tctttttgcc agcaccaaca ttggcctttg cagtccccct gactttcttc 120 attctgttct tgcgttcctt tcgttgcttt cttgaggtct ttttcttctc atacaggcca 180 tgtcttgcaa gtctatgttt gggttcattt ttctttgcat aatccaggga atcataaatc 240 atgccaaagc cagttgtctt gccaccacca aaatgagttc tgaatccaaa tacaaagatg 300 acatccggtg tggtcttgta cattttggct agtttttccc gaatttctgt cttaggcact 360 gtcgccttcc cggggtgaag gacatcaatg accatttgtt tcctctgaag tagtcggttg 420 gtcatgaact ttctagtgcg gatagttacg gtgtcgttca tgatggcg 468 <210> SEQ ID NO 318 <211> LENGTH: 383 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2137446T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 266, 274, 280, 283, 319, 352 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 318 gggtttttga atagtatcac ctggtatgaa aagttttccc aagaaaccac aaacgattgt 60 tcattttttc tccttttttg ttaacttttt gccacactca agtcagttta agtcctagca 120 aaaagacggt agttaggata ccactgtggc tgtagatgat gtgacactgg ttgaatttgt 180 gctggcgttt gtgtaacttc cctcgctgtt tgtgtttgat tcgttagggg gcacctgggc 240 ttgaattggc tcgaaggatt gctccngctg ccantgcaan gtngccgcgg ccctggttct 300 ggtgtgtagg taaaggtang gctggtggaa taaatgattc catcatttcg gnccaaagtt 360 actggaacct ggactgggtt gcc 383 <210> SEQ ID NO 319 <211> LENGTH: 309 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2180426T6 <400> SEQUENCE: 319 cagttgttta tacaacaatg aataaggaca agatatcaaa ctgaaaattc aaaaataaac 60 agaagaaatg taaacagttc taaaatatca gtatttataa atgttgctta gaggaaggct 120 attcaaagca tggtccatta actatttgtg agctgtccag aatgaaagag gcttgtgcca 180 gaatgaaaat caattacatc actaatcata ctggctcagt tgactttttt taaataacaa 240 gacttctttg ataaaggaag caatgtgttg atttatattc tggcacaagt accttattac 300 tgactagag 309 <210> SEQ ID NO 320 <211> LENGTH: 533 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2201912T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 450, 486, 507, 513, 521 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 320 caatttacaa gtaaacaaat tattacttct tgaggagggt gggggttgaa aagcagaagt 60 ctcttcatga ttcctggcgt tgaaaatttc ttgaggggag aagtggaggc aggtgttgga 120 acattcacag tttaatgcaa aagcacaaat gaatgaaatt ctgtagttgc tttcaggcag 180 ttttgcgcat agaaaaaaag aaatgtttag aaaataaaat gtttattttg tctttcaggt 240 tgtggccaag ccagtccatt ttccacctta acaggtgaaa atttaaatcc caaattaatc 300 tgatttgtgg cagtaaaggt ccttaagtgc ttttagctcc tcaatcaatg tcttgttttg 360 attttcaagc actgccactc tgttttctaa acatttcaca tattctttct tctttctacg 420 acactctcga gctgcttccc tgttcttcan tagacggacc tctctctttc gtggctgctt 480 cttcancagg ctgtgtagga agtgctnggg gangatgcca naacaactcc agg 533 <210> SEQ ID NO 321 <211> LENGTH: 385 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2203287T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 84, 89, 171, 179, 201, 231-232, 244, 255, 313, 315, 365, 371 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 321 accctagact ccaagtcatg tagaatctct tctaattcct gctttttagc agcaagtctt 60 gccctcatct cttctgcttc agcnaaganc tcagtctctg cttgtagttg ttctgcaagg 120 atattcttct cttctaaaag ctgctggtgc ttccgctcca tctcctccag ntctccttnc 180 aaattcggct gccctctccc ntcaccttca acagctcttc atctttggcc nnaagttctt 240 cctnctggcg agtcncttgt agaagcggct tcacctttgt gaagactcgc caccactgcc 300 agtgccgtaa ttncnggtac gcggcaaagt tccggctgca agacccttta aggcacttag 360 ttgcngctgc ntcttggcaa aggcc 385 <210> SEQ ID NO 322 <211> LENGTH: 481 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2236363T6 <400> SEQUENCE: 322 gtgctgggct tcaccccatt tgccttaggt cttttaaaca aagcaaacct acttttcctc 60 cttcctctat cgccatttgg gagagaccca ttatacctga tgggggaaaa aaagtatagg 120 tgatctcttg caagaactgc acaattataa aacaaatgtt tgactttgcc ttgcagaatc 180 aattcccaat taattatcta ttaacacatt ataattattt aaaattcctt tgagcaactg 240 ttgatctcca taccaggtgc cagtgtgtga aacaaaatga gattcttttt ctggcttcat 300 tccaagtcac agagaacctt ttggattata cacagattcg tgttatctct atttttttcc 360 ttccctcttt tatggaagat aattaagagc tgattaatgg catgtctgac tccttatgac 420 tcatctgttt tttttaaggt gaactggttg catgtggcta atacaacctt aaaactcgag 480 g 481 <210> SEQ ID NO 323 <211> LENGTH: 407 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2291484T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 15, 26 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 323 catcattcat tnggnggaga ttagcnggga agtagctgta tatttttagt gagatcactg 60 atggcaatgg atctctggat cgtgctgctg cttatggtta aatcatatct aatgtgaaat 120 ttcgaattac atccagagct ccagtatcaa agccgcacat atccaacatg cctctatcat 180 ctgggtctgc aatggtgaaa ccatttgatg tcattccaca aacaatcaat ttagctggaa 240 tatccatttt ctttcgatac tccctcagag caatagcagg atggacacct ccagcaaagg 300 tctcattatc agtgaataca atgaagacat cagcaggtgt gtttgtcttc tgagcccaga 360 tcattggaag agagcaatca gttccacctg ctgggatctg actcata 407 <210> SEQ ID NO 324 <211> LENGTH: 213 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2375549H1 <400> SEQUENCE: 324 ctcctttact tcatcatgac ttgaagactc agaatatctt attggacaat gaatttcatg 60 ttaagattgc agattttggt ttatcaaagt ggcgcatgat gtccctctca cagtcacgaa 120 gtagcaaatc tgcaccagaa ggagggacaa ttatctatat gccacctgaa aactatggaa 180 cctggaccaa aaatcaaggg cccagtatca agc 213 <210> SEQ ID NO 325 <211> LENGTH: 222 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2423808T6 <400> SEQUENCE: 325 ccaccagttt tgagagtctc tccatttact gccctgttca ttttactcaa gggtctgtca 60 gcatcttgtt tatctttctg gtatacctgt gtaggtgttt ctttctcctg aagttctgtg 120 tcttgttttt ctcctatctc tgacctctgt gttacaacct ttgctctgtg gctctcaaga 180 gacttttctt catttggaag ctggggaaga gttcgtctcc tt 222 <210> SEQ ID NO 326 <211> LENGTH: 186 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2446704T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 326 tnctaggagt atatttcaag attattacat tttaagccag cacaccatgg atgtacatga 60 agggccactc agtgtccctc gctgggacag gttgtgtgac ctgcccaagg ggctccggct 120 catttgccaa agtcaagacg acgaccaggt cttctgactg ctcagcccaa ccaataatga 180 aaaaag 186 <210> SEQ ID NO 327 <211> LENGTH: 367 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2452667F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 47, 84, 256, 301, 306, 309, 312, 350 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 327 gtgttgcgcg actggccttg agggagagct ggggcctgct cccgganaga tacggctatg 60 tcgatcgaaa tcgaatcttc ggangtgatc cgccttatta tgcagtactt gaaggagaac 120 agtttacatc gggcgttagc accttgcagg aggagactac tgtgtctctg aatactgtgg 180 acagcattga gagttttgtg gctgacatta acagtggcca ttgggatact gtgttgcagg 240 ctatacagtc tctganattg ccagacaaaa ccctcattga cctctatgaa caggttgttc 300 nggaantgnt anagctccgt gaattgggtg ctgccaggtc acttttgagn cagactgatc 360 ccatgat 367 <210> SEQ ID NO 328 <211> LENGTH: 551 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2503017T6 <400> SEQUENCE: 328 gcacattgat gagtttaaat cactatagtc cttatacatt gaaacagaac accagtagtg 60 aaatgacatt tattaattcc attaagacac aactacatat tttattctta taatggccat 120 gttaataagt tcaaggcata cttcaaggtt aggatcaaaa tttggccagg gcttcttaag 180 atagacctta aaacattgca cgttgatgtt cttttgaaca agtttgtctc caggaccagt 240 aaatatgaca ctttggattt taagctgatt aaagagaaca ggttttatta ataaagactg 300 atctcaaaat gctgggattg ataaaagaat taaagtttca acatatcaat tttaagaagc 360 aaagtgtttc aacaactgag aggtaagaaa atcttgttat ttgcatgtat ttttatataa 420 tcaatcaggt tgcagattct aaaattgctc atatccagca tgatggtgct tgagaccaat 480 aaaataagcc agcaacacta gaataagtac tcctgccaag gcagctccca ccgctatggg 540 cacaaggaag t 551 <210> SEQ ID NO 329 <211> LENGTH: 479 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2677105T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 16, 164, 187, 296-298, 308, 317 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 329 actgaataaa aaccangggg caatataact gctactggtt gagtcataca gtgatgtgta 60 gtttggaaaa gaagacgaat gatagatatt gagccccttt aggaaatgtt gccagtattt 120 gaatttggct ttcatagtta tctcttgcac acgaagtaga gtancatggc tgataacaag 180 aggtcanatg tacaagttgc tctaatatgg cctcaatgag gcaccagctt caaaacccgc 240 ttgctgataa ttcaggtatt catggagggt caagacttca aagtcatgta cttccnnngc 300 ccagtagngc atctggngtt gcttaaggga gtctgtcagt gtagggtgca tagaattgtt 360 ctctggctat atcccattct aggaatcact ggatatccat ctggagtgga gggctgttaa 420 tctaggttca cttgacacca tcttcagcaa atgatcattc cctggggtca aagacatgc 479 <210> SEQ ID NO 330 <211> LENGTH: 247 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2702380T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 22, 27, 52, 60, 81, 115, 126, 170, 177, 195, 232, 236 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 330 agctagcagg ataacagntg anttaanggg cctcagacta catccaaggg antgtttatn 60 gggcgatccc aattacacca naagccaaac gacttccagc gtttcctgtc tttgnacttt 120 cttcanttcc acctttgccc aagtcatctg ctttttcatg gaccaccagn gtgcggncaa 180 tgatgcaatg gtctnctgag agtgagatca cagaatcttc aatagacaca tnggcnacac 240 catcttt 247 <210> SEQ ID NO 331 <211> LENGTH: 434 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2744270T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 356, 395, 400, 417, 422 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 331 ttaaaaggga attcatgata aaaatagaag atacttgagg aaagatgtgg gaaatggact 60 ctgcacacac actaaactaa caatgcctct aaaactaatg attatagcaa aaaatgtctt 120 cacattaaaa ttctgctttt tatgtttttt tccatttttt acacaattac aaaagaaaaa 180 ataaaagccc taaaatcttg attatttttc ctttttttgg accaaatact cattttcctc 240 taagtttatt gacctgtgaa actttttata caataaaatc tttcaagtga aagattaggg 300 ttaaaaagaa aaagatggat atcttaaagg gtacagcgaa tgctcagaac aaaggntgat 360 gggaaaatgg tttcagtcac tgattatttc attanccttn gattcactcg ccctttnatc 420 cntccccaac ccca 434 <210> SEQ ID NO 332 <211> LENGTH: 170 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2748823F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 88, 119, 136, 141, 146, 150, 155, 161 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 332 caaataagga ggcactggct aagacggaag tgtctctcac cctgaccaac aagttcgacg 60 tgcctggaga tgagaatgca gaaatggntg ctcgaaccat cttactgaat acaaaacgnt 120 taattgtgga tgtcanccgg ntccanccan gaganacctt nactgaaatc 170 SEQ ID NO 333 <211> LENGTH: 324 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2749472T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 173 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 333 gaggtgcagg gcagcgctca ggccttgctc agtttcttct tgatgaagta gctcaccagc 60 cgctgcggcc tctgctggta ctcgctgagc acattgcgag ggctgctgat ctggtcccct 120 tccaggcggt tcaggagggt gacacacacc acggccgctt ggaggccgca ggnctggcac 180 atggcggcaa acaccgagga ctccatctcg atattgcgga cgccggctgc ataggctgcc 240 tccagatacg cctgcttgtc cttctccgtg taggagcaga gagccccatc cagacggcct 300 tgcccttaat agaagtccaa ggtg 324 <210> SEQ ID NO 334 <211> LENGTH: 445 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2824491T6 <400> SEQUENCE: 334 aaagttgttt ttaacattag actttctttg ccagttggca acttagaatt tttgcagagg 60 tgattattaa tacttctttg cagctaattt tagctttaat ttttctctct catctaaaaa 120 catatcaatt gcacattgtt cctttgactt aataactgca ttcttgaaac agaggttagc 180 tatttcactg tatccagaaa cgtggtagaa attctgaccc atcattcttt tatctcagtg 240 acaacaccag cagctattgt agaaccaccg taacgtagca tgaacctccc cagctcttta 300 aagtctttat atagctcaag agctattggt ctttgtgtct gtagctctac caatgcattc 360 tggcctttag tcaaaaactt aggctttttc tttgtgactt cacccgtgct tttgtttaag 420 acactaaatc aatcgtttaa taacg 445 <210> SEQ ID NO 335 <211> LENGTH: 515 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2873229T7 <400> SEQUENCE: 335 gacatacaac acgcccagat acacagcata gcagggcctc gataatgaga taatttcccc 60 ccacgtcttg agaagaagaa tactatgtat ttctttatga acactattaa aaaaaaataa 120 acccctcaca acattctcca ggacctagag cccaagagaa cccactgaag atccatcatc 180 tgtgggatgg cggaggcagt ctctggggag caggagggaa tgtgcacagc caggggaggc 240 tgcagcagcc ttgcctctgc cgtgaatgtc aggcagtgac aagcagcaat aagggaacag 300 agggggtggc agcagtgttt ggcagctctt cagcaatctt aatcataaat tcgggtagga 360 tccagttggt ggcattgccg ggggggcaca gaggtggtag cagctttcac ctccttgggg 420 gtaggagagt tccctctgtt tggagaggga gaagaggggc aatgcagaag gaaggagcga 480 gggagcacag gctgtcttac aatcttgcaa aatct 515 <210> SEQ ID NO 336 <211> LENGTH: 201 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2890054T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 133, 183 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 336 atcaagtaat catggccagc nattattgat caaaatcaaa aggtaatgca catcctcatt 60 cactaagcca tgccatgccc aggagactgg tttcccggtg acacatccat tgctggcaat 120 gagtgtgcca ganttattag tgccaagttt ttcagaaagt ttgaagcacc atggtgtgtc 180 atnctcactt ttgggaaagc c 201 <210> SEQ ID NO 337 <211> LENGTH: 480 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2958621F6 <400> SEQUENCE: 337 caaatgatag acaaatggca tatactcaaa tatttatagc tgtttaatgg cattttatag 60 acatttattt gggttttgtt cttatttttg tttttaatta agggagtagt ggggtagatg 120 tgagttcatt gtggcattca gcttatattt gcttggcttt ttcatggtcg gtgacaccct 180 aattcctagc atgataaata gtaacccttt gtgcttgatt ttgtttaact tatttgagtt 240 gttttcaaaa tacattcttt ttaatttaaa aaatcagcta agcttgtgta tggttaagtt 300 tttgttttgt tttgtgtttg atttgttctt ttagggaaaa aatcctataa aatggctatt 360 aaatttttag ccaatgacaa tgagattttc ttaatattac tttgaattct ttacctctta 420 attcttagag tatgtggttt tgttgttctg tagtgtctac taaaatattc atttttttac 480 <210> SEQ ID NO 338 <211> LENGTH: 279 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3034495H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 162, 210, 233, 253, 255 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 338 gattgaccac gttttaaaag tactctgggc actggtgctg tgttttcttc ccctccctaa 60 atttgaagaa ctatggagaa atggtacttg atgacagtag tggttttaat aggactaaca 120 gtacgatgga cagtgtctct taattcttat tcaggtgctg gnaaaccgcc tatgtttggt 180 gattatgaag ctcagagaca ctggcaagan ataactttta atttaccggt canacaatgg 240 tattttaaca gcngnggtaa cgattacagt attggggat 279 <210> SEQ ID NO 339 <211> LENGTH: 364 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3297413T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 203-204, 211, 216 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 339 atgtaccata ctgcattatt gcaaaaattc actggtacaa aacactttgc agctggtgag 60 aaggcaataa aaagttgatt tttaaactca ttactataaa ttattcttac agtactttgc 120 aaattcagaa tttcaaactg catgttcttt ttctaaattg cccacagtac tcgaggttcc 180 tgaagctaag gcagctgttt cannacaccc ngggangagg tagcagatgt caagggattt 240 ccatttctct ttcgatgccg acatacttca gggcatcagc ctggctgtat ctgtaatcaa 300 aaaacagctc ttcgccagtc tggatggctc tcttgggcaa aaatacctat cctgtgatca 360 ccgt 364 <210> SEQ ID NO 340 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3326096T7 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 456 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 340 ttgacacatt gcctcatttg cttttttaaa atctattatc tgacttaaac ctattcagca 60 aaaatgccaa taaattatat taatcatact ttgggtcttt ttaaaactag gaacataata 120 tgttttatga taaacaataa tactaaatct gagttgtatg aactgttaac ttgaaatttg 180 ttttagatgt ttagcttaaa acaaaaagaa aaccaatcac attaatacac tgttgcaaaa 240 gtttctccgg aatgccctcc acatcactgt gtgtcagcat ccttcggctt cttcactgag 300 gtatggaatg cagccatatg taggtgtcaa ggcactcatt ctaagctgtc ctatcctgca 360 catcttagca atcacattag atggagggct gatgatatgc actaactccc aacccaggct 420 atcttgcttt taaataaact aatttcttta aaaganaatc atcaactaag gactcaaatg 480 ctgaatttag aaattaataa ttccaattca atacacattc aatcaaatgg gttagtactt 540 <210> SEQ ID NO 341 <211> LENGTH: 249 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3728208T6 <400> SEQUENCE: 341 ttaaaaagaa aatgttatat tgtagataat gtgtactagg taggtagccg tatggtggtt 60 gtgtctgtac tgaatatgta cagttgtttt ttcttgtcat acttccctaa atacaatata 120 acagttgtct tcatagcatt tacaatgcat taggtattat aagtaatcta gagatgattt 180 aaagtataca ggattgccta gttataggca aatacacttt tctataaagc acttgagcaa 240 aatgtatat 249 <210> SEQ ID NO 342 <211> LENGTH: 229 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 023582H1 <400> SEQUENCE: 342 atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtgcc 60 aaatgtgaca tccagatgac ccagtctcct tccaccctgt ctgcatctgt aggagacaga 120 gtcaccatca cttgccgggc cagtcagagt attagtagct ggttggcctg gtatcagcag 180 aaaccaggga aagcccctaa gctcctgatc tataaggcgt ctagtttat 229 <210> SEQ ID NO 343 <211> LENGTH: 197 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 089562H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 71, 76, 114, 130 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 343 cggtgttaga agcgctggta ggcttggaga ggcgggttag gaagacgcag ggccccttgg 60 cctagcttcg ntcgtncgaa ttcagagcac gtccttccga ggtgaaggaa cgcnaaactc 120 cacccatccn attgctgttc ggctgcgggc gggtcctttg gtcgggctga ccctgggtga 180 gcggcccgga gccaaga 197 <210> SEQ ID NO 344 <211> LENGTH: 543 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 108485T6 <400> SEQUENCE: 344 gcctcttcaa tagattgatg tttgtcagtt aaacgagctt tggttacttt gtgttcattt 60 acctcttgtt ctaaccgttg ttgtaatgat ttaagtttgt agtttaaatc tatctctaaa 120 ttattctttt ccttttctga gtgattaagc atgtcttgag cctcttttct ttctccttcc 180 actttttcga gattatgttt gagatgcttc acctcctctt gtaaagatgt aattcgagct 240 tgaaggtctc caatcatctc agaatcatga cctctgtctc ttcgttcagc ttctaatata 300 gcttgcagct ggtaataatc tttgtctgtt tgtgacttag aattctctaa aattcgattt 360 ctctcttgca actctctgtt cagggactct aactgactaa ttgacttgct catctctgtg 420 tgactcttcc tcaatcttac agctgtgtcc gattctgtcc taagtaagtc attggcttct 480 tctagctgct ttgtaactgg gacagcttct cattagcaag ctgtgaatct gactgacttc 540 ctt 543 <210> SEQ ID NO 345 <211> LENGTH: 425 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 169295R6 <400> SEQUENCE: 345 gcctcggagg cgttcagctg cttcaagatg aagctgaaca tctccttccc agccactggc 60 tgccagaaac tcattgaagt ggacgatgaa cgcaaacttc gtactttcta tgagaagcgt 120 atggccacag aagttgctgc tgacgctctg ggtgaagaat ggaagggtta tgtggtccga 180 atcagtggtg ggaacgacaa acaaggtttc cccatgaagc agggtgtctt gacccatggc 240 cgtgtccgcc tgctactgag taaggggcat tcctgttaca gaccaaggag aactggagaa 300 agaaagagaa aatcagttcg tggttgcatt gtggatgcaa atctgagcgt tctcaacttg 360 gttattgtaa aaaaaggaga gaaggatatt cctggactga ctgatactac agtgcctcgc 420 cgcct 425 <210> SEQ ID NO 346 <211> LENGTH: 522 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 261205F1 <400> SEQUENCE: 346 aggaaacaaa ggatatttta ttcctttttt ctgttgttgt tgaggataga tcacgataca 60 gagaacagca atgggtcaca gcgcacggtt tggttggttt ccgcgggaac acagaggaca 120 ggaggggcgg gatctgggtt gagttcccac tctcgttatg accttcaacc tctcactgtt 180 cccaagggct gcacggagcc tgctgagtct ccaacccacc tcgctcaccg ctctgaccac 240 tgacaggcag agcaaaggat gcgggagttg cctctgctgc ccatctaagg ggacgtaggc 300 agagaagcaa aggcctctgc tctccctcca tccatcccgg tgtgctggcc ccaacggaac 360 aggagtcctt caactattgc ctgccagaga cccaattgca gggactgtag tctgcatctg 420 gatgagctgg gctgtagatt gaagtctcag aagcagggaa ggttggaagg ggtagggtcc 480 cagagcccat gggagttatt gctgaggaag gatatgcagg gg 522 <210> SEQ ID NO 347 <211> LENGTH: 452 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 450739T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 367 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 347 taaaaccctt gtgttcatgg ggaggggttc agttcagtcc taagtgtttg tccattgacc 60 aaggctgatt gatctcgtgt tggcaacaga ggcaggagga cggttcattt gctcggctat 120 aacttgctat gggtaccctg cagcatgcgt taatgtgcac tggtatctgg aacctcggtt 180 tttcccatca atgagcagaa gtggcatttt cctgaagtag tcaataatat ctgacacaga 240 cagaaagtcc tctttccctc ggagtccagt tcccaacaag taaacttgac tttccttctg 300 ataacggatc tggatgttgt aaactttatc tttgtacaac accatgagga catatggatt 360 ggttgtngtt tttttagagc tgtctctgac cagaaatgtg ccatcctggt ttatctttct 420 aagagcagct tctgcctctg gtcgggtaat at 452 <210> SEQ ID NO 348 <211> LENGTH: 452 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 502311T6 <400> SEQUENCE: 348 gtaaacataa tcctgaatta cagtattttc cataggacaa aacacagcaa gacattttct 60 atttagacag gcaacttttt gatatagagc ttatttatac tgaagaatct ggaacaaaac 120 acaggacaca gtactaatct gtcaaatata ctatgaaatg catagtctcc acttaaaatg 180 ctgaatgaca cacacgtttt gcaagcatta ctgctttcca caaaaactgc tgaataggag 240 ttccgtccct gccaagatca gtgtttaaga gatactttat gatgctgata agtattattg 300 gtggtggtgg tgttcagaaa gtttgtcact catgcagatg tctgaaatct tgttccgaat 360 ccatggaaca cagggtggag gccagctccc ccttttttag atgatcacat agttctgagc 420 agagatgtgg tcctcaccct gcagttcctg ca 452 <210> SEQ ID NO 349 <211> LENGTH: 260 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 511666R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 32, 51 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 349 tctgcgcatt gatgaatagg cagcatttta cnaattaact gatgtgttgc ngtatatcat 60 ctctttgatg attgctcctc ttctttgtat cctgtcttat aatttcaaca catttgcgat 120 actcaatgtc tattctaaat taaccatgtt ttgtaccaca aactcattgc ccatggatct 180 gttgctgaaa caaggaagtc ttaaacaaga agtggaatct ttctgttatc agattgtgtc 240 tgaatcaaat gatcagaagg 260 <210> SEQ ID NO 350 <211> LENGTH: 435 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 567649T6 <400> SEQUENCE: 350 ataaggggtg ggtgttattt aaaacaaatg accatatcag atacatattt gtcacaattc 60 ctaagttcaa tattcataag ggctagctgg agaagaccac tttgggcagg aaattagtct 120 gcatttattt tatagcacaa ggagcaggac tagatgagcc agagtcatgg caggaggtta 180 attctccacc tccaaccctc ttttttcatg cttcaaataa gaatgtgcag aacccttcag 240 gcaatcctat tggttagtat ccttagcctg ttcttgaccc tagggagaat cagattcctt 300 tggtctatga cagtaataga agttatttct ttagataaat tttgtttaag gctttaaatt 360 aattctatct tggcattgtg tggttctaaa ttcattcatt catttaacaa aacttacttg 420 agtatccgct ctctg 435 <210> SEQ ID NO 351 <211> LENGTH: 474 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 701644T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 62, 64, 98, 102, 108, 202, 227, 300, 409, 426 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 351 tgctataaca tttctgancc aaaggcagag ggtatccatt aacttcattg ttgccttaat 60 tnangggtgg gtggcaatgc caagggtggg aacacaanga anaaaganat attaacgtca 120 gctaagaaat caacatgtta tcaggctata ctgtagttgg ttgcttctgt gttactggac 180 atgacaaatg atctggtaaa tnatgttaaa ttggcttgaa acaaganagt ctcccaattg 240 ttagccacgg tttcagtcag ccctggatga aagatggaaa aatttgacat atatctcatn 300 aagggaattt gttgcttcca tggagattat agatggaggt tactgaggaa ttaggtagct 360 gggtggctta ctccaggcat cccttagtag gtaacacttg agaaaagana aaaatcagga 420 agtcanggaa ataattcaaa ggcatttgtg agcctgagca gatatagcaa ttta 474 <210> SEQ ID NO 352 <211> LENGTH: 541 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1237113T6 <400> SEQUENCE: 352 ttgtagcagc tgtgtaggta ggctaccagc tccttacttc cagtaagtgg atgtctccat 60 taatttccag cgtgtcaata ctgctgagct ctttaaatct gtgtttgtac tccaggctgt 120 gtacgccatt tactgcaacc ttgaattctc taacatcaca gtaaattatc atctcaaagt 180 acatcccagg actaaatggg aaagaggtaa tatttctctc ttcttctccc caggactcct 240 gaagaaaaga atttcttaca aatgctttaa tattcaggcg tgggttcaag tgtagagcaa 300 tatcctttga ttttcctgct agtaggtcaa cattaaagct tttggcattt gcattcactt 360 ctcctttaac gacgacagtt cgtccagggc ccatgggggt gttcaacctt gcagcgaatg 420 gcaggctctt gaaaagaagc cacagtcagg accaagaggc ctgcagaaag cgatctccag 480 ggaaaactcg tgtccaaaga acactacaga atgtttcaga gccatgaccc tgtaaatccc 540 a 541 <210> SEQ ID NO 353 <211> LENGTH: 75 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1271372H1 <400> SEQUENCE: 353 acccaaatga attctaaacc aatcaaatgt ctgggaagcc ctccaagaaa aaaaatagaa 60 aagcacttga agaat 75 <210> SEQ ID NO 354 <211> LENGTH: 256 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1272733H1 <400> SEQUENCE: 354 ttcctgatcg tccagcaggc attggagtat attcagctat atggcagtta tgcctggcac 60 tcatatttaa aatcataatg acagtattca cttttggcat caaggttcca tcaggcttgt 120 tcatccccag catggccatt ggagcgatcg caggaaggat tgtggggatt gcggtggagc 180 agcttgccta ctatcaccac gactggttta tctttaagga gtggtgtgag gtcggggctg 240 attgcattac acctgg 256 <210> SEQ ID NO 355 <211> LENGTH: 220 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1297406T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 90, 125, 174, 196, 214, 216 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 355 gaattactat acagtaaaaa ttcaatactg tatatgaccg acacgtatta agcatacata 60 caaaatgaac ggattgaatg ttcaaaaacn aaggtaaaaa taaatagcaa tgataaaact 120 ttggnaaaaa taatgcacat tttagttgtg gaaaatatgg gtcttatata tacntagttt 180 atacttaata gaaagncatc tccttaaaat tgcncnaaac 220 <210> SEQ ID NO 356 <211> LENGTH: 552 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1297646T6 <400> SEQUENCE: 356 gctctgtccc agagagacag ggccatccct catgtctgtt attgggttgt agataaacaa 60 aagtataaat caaacaaact gcaaattact ctgtctcttt tcctaatcaa tacagcaaca 120 gtcctcagtg gtactgcacc actctggaaa aaatgccttc aggttccttc ccatccccca 180 aggcagcagc aaatccttcg tgtcgcctcc tactggccaa ggcagccaaa gatttgaaag 240 tctttggctc gtagatggcc agatccgcta ggactttcct gttgagctcc acctggcact 300 taactaaatt cccaatgagc gctggatact tcagtccatg ttcctggcta gcagctgtaa 360 ttcgattaat ccagagggtc ctcatgttct ttttcttcag gtatcgggct ttggtgcatt 420 tcacaaaggc tcgaatcacg gttctgaccg ccaacctgta gcagcgattt ttccttcccc 480 ggaagtgctg gcgtgcttca gaactcctgg atccgaaagt agcggtcggt gacgcgattc 540 cgcagccaga gc 552 <210> SEQ ID NO 357 <211> LENGTH: 303 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1369303R7 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 11, 23, 70, 117-118, 172, 195, 220, 247, 259, 270, 279 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 357 ctttgacaga ngtgaaggct ganacccggg ctgaggaggc cccagagaag aagagggaga 60 agcccaagtn tcttcgcacc acagcaccca gtcatgccaa gttccgttcc actggannag 120 agctggagac accatccttg gtgcctgtga agaagaatgc cagcacagtg gnggtttctg 180 acaagtacaa ccttnaaccc atccccctca aacgtcagan caacgtagct gctccaggag 240 atgccantcc ccctgcagng aagaaatacn agccactcna cacaacacct aatgccacca 300 aag 303 <210> SEQ ID NO 358 <211> LENGTH: 330 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1395739T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 66, 68, 76, 127, 152, 168, 177, 185, 192, 306 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 358 aaaatcccat catgaccctg gaagccttta gaacagtttt atcctttnaa acacaggaca 60 catttntncc agtgcncaga atttcaagtt tacgtggttc agcttaagaa gtgtatgttt 120 cacgttnctt agaggacaac agacccaagt tntcactatg agaaaggnac agctgtncca 180 gcttnaatgg gntaatccaa caccaccagc tacctgtaca acagtaagat ggtcaatccc 240 tgtctgttac ccacagggac agcatgacaa ggagagagcc cccatctgac ttaatagcaa 300 accaanccct ttattcttat ctctgctgct 330 <210> SEQ ID NO 359 <211> LENGTH: 469 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1430425T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 368, 374, 417 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 359 agatatattc caggatatag gaagaatggc aaatatcggc ttttctcaga tatctttgaa 60 attattttaa tgcgtacaaa acatgtagaa gatgcctctc gagatggctt taaaatgccc 120 agtattaaag ggggacaggt gcatggcagc taaatgcctc aacaagatca tgcagagagg 180 ggcatccatt ccctcccaag atcctaagaa aaggtacctt gctccagcct ggctgaaagt 240 ggagcaaaga tatgcatttt ctattggatt tagggtccta gggtctgtcc tggggcacag 300 acacctaaga ccatggcacc ttctccccag aggacagcct gagggtaaag tataaattgc 360 tctgggangg aganacggag agaacagctg tgtctgcagt tcattgttgt gtgagtntaa 420 gcagctctct tcctctctct gtgcttcatt agagggataa atactggta 469 <210> SEQ ID NO 360 <211> LENGTH: 257 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1443824T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 21, 81, 162, 165, 196, 211, 231 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 360 gcaagttttt cacggataga natatggaac tgagcagatt ctttttttct acaaaattat 60 ggtataaact tgctcaattt nctatcttat tgctaataaa ccttacaggc gcacagtttg 120 taaaataaac cccttaagga ctgaatgcgt agagcatgct cnccngtacg agaaataagc 180 taaaaatgag catatngaac ctacatctgg nccaacacag tactgaatgc nggcaaacat 240 gtatcacaac acagggg 257 <210> SEQ ID NO 361 <211> LENGTH: 335 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1482416T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 322 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 361 aaattttttt ctcacctgtt ttagacaaca gcttgtaata gttttgaatc cattaagatg 60 ttgctttcaa tttgaaatat tttgtgtata catgtatata aaaaataacc caatgtatga 120 ctcatctgac cgatgtttaa gatcaataac ggcttatttt tcaacatgca gttaggaaga 180 gagggaagca agccaacctc tctacagtat ctttttgctg gcttgttttt gtagtggtat 240 caatagtggt ttttggaggg aaccatgtgc cttcagccta tctagtcaag atcagatacc 300 acgatcaaca agagcggtag angagatggg gaaag 335 <210> SEQ ID NO 362 <211> LENGTH: 380 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1518133F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 10, 176, 359 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 362 gttgcttttn tctgccaaaa ggagcctaca tttataatgc acttattgaa ttcattagga 60 gcgaatatag gaaaagagga ttccaggagg tagtcacccc aaacatcttc aacagccgac 120 tctggatgac ctcgggccac tggcagcact acagcgagaa catgttctcc tttgangtgg 180 agaaggagct gtttgccctg aaacccatga actgcccagg acactgcctt atgtttgatc 240 atcggccaag gtcctggcga gaactgcctc tgcggctagc tgattttggg gtacttcata 300 ggaacgagct gtctggagca ctcacaggac tcacccgggg tacgaagatt ccaacaggnt 360 gatgctccac atattctgtg 380 <210> SEQ ID NO 363 <211> LENGTH: 261 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1556430F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 36, 106, 109, 134, 145 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 363 cgcgctcaag cccatcctgc aggcgtggct cgaggnggcc gagggcgccc agcgcgagaa 60 aatgaacaag cctgagctct tcaacggcgg cgagaagaag cgcaanggna cttccatcgc 120 cgcgcccgag aagngctccc tcgangctat tcgccgtgca gccccggccc tcgtccgaga 180 agatcgccgc catcgccgag aaaatggact caaaaaagaa cgtggtgcgg gtgtggtttt 240 gcaaccagag acagaagcag a 261 <210> SEQ ID NO 364 <211> LENGTH: 483 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1569648T6 <400> SEQUENCE: 364 gatgtcacgt tagattttgt cacaactgga tttagtggaa gcaggggaat caagttcact 60 attttctgaa acacacaaaa aagggatggg aacaatgact tacaactaag attgctcata 120 aaagaccatc agaaagatcc ctaaacaaaa gctaaatagt tacagttaat ggtaactggc 180 aagggattta atgcatttgc tggtattaag tttcttatgg aatgaatgaa tgaacccagc 240 agcattttat gacacagctg ccagaacatc ccatagaaaa acaattttgt aggaacgtga 300 tggcaacaat cagcagccaa tattctcaag agttcctaat taccaaaagc atatacaatt 360 ttagtctaga aaaataagtc aattttataa aattaagttt ttagatcgaa aagcaccccc 420 tttaacaggt acagagatac tgaaaaatag tcctaaaaat ctcactaaat agtttacgga 480 gag 483 <210> SEQ ID NO 365 <211> LENGTH: 226 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1642853F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 45, 191, 212, 218 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 365 tgacctctga catttttttt gacaacttta tcatttgtgc tgatngaaga atagttgatg 60 attgggccaa tgatggatgg ggcctgaaga aagctgctga tggggctgct gagccaggcg 120 ttgtggggca gatgatcgag gcagctgaag agcgcccgtg gctgtgggta gtctatattc 180 taactgtagc ncttcctgtg ttcctggtta tnctcttntg ctgttc 226 <210> SEQ ID NO 366 <211> LENGTH: 273 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1663769T6 <400> SEQUENCE: 366 gcatagtaaa gacaaaaaaa ggaaatgcat acataagaaa gggacactta gaaaggacct 60 gagataccta aatgtctgtt ctaaggaaca ctggaaggag ggaatgcaga tgcaggcagc 120 aggcctgggt ctggcttctg gcctgggttt ggagcctgca gaagctgctg gcatgctagc 180 tctacccagg gaacagctcc aagagggagt gttgggatga aggatcacac ttgggatagg 240 tgctgctggt accaaatgtg attttagctc cat 273 <210> SEQ ID NO 367 <211> LENGTH: 212 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1666209H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 59, 83, 91 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 367 gtcatgactg anctgaaggc aaagggtccc cgggctcccc acgtggcggg cggcccgcnc 60 tcccccgagg tcggatcccc acngctgtgt ngcccagccg caggtccgtt cccggggagc 120 cagacctcgg acaccttgcc tgaagtttcg gccataccta tctccctgga cgggctactc 180 ttccctcggc cctgccaggg acaggacccc tc 212 <210> SEQ ID NO 368 <211> LENGTH: 610 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1697901T6 <400> SEQUENCE: 368 tgacaaagca gcagtgaacc tctaaaccaa ttaataaaag tcctctactt acaatccaaa 60 ccagtaacct catcattgtc cttatcccag gcaaggcaca gggttagaca gcagacagag 120 aaaacagaga acacagtcag aaagggcatc aacaggacag tgtcagacag cagtgcagga 180 aattttgcaa atctgattcc aggttgtaga cggactgctc tcccccaccc cttcgttatt 240 aaacagggct cattacatgt ggacccagtt gtgggccatc cctgagattc aatgttcgct 300 gcttctccac atggaggatg tctggtaact caactcagca gcaggctgtg gcaatctccc 360 aagtaaggat aactttgttt acagagtaat cgtttcctcc tcctttgtca acgcaagtcg 420 ctgtgtgctg caggggaaga cacgcttgct tcctcctgca tcggtaccat tctcctttat 480 tgttcaatat ctatgagtga tttctagatg ttgtggctta cccttaaaca attcatgcta 540 aaaatgaatt aaaatacaag acatttatac atgtacaaac aaatgttaag atgcaccatt 600 tctatgtatt 610 <210> SEQ ID NO 369 <211> LENGTH: 157 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1830604H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 28, 45 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 369 gtgaggtgtt tgagggcata tgtttganag agggagcatc accanaggaa tcctttctgt 60 gaggtggaaa cagtggtcct gaatcattgt gctcacacct aacttgaaat ctggtcttac 120 tttcatgctg ttatgatttc acctggtgaa tcagtgt 157 <210> SEQ ID NO 370 <211> LENGTH: 569 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1867862T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 499 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 370 ggattgagca taaacccctc caaaaacaat ttttaaaaaa cccaaaaagt acacaaaaaa 60 cccctgaata caaaatctaa ccttttcccc cagcctccct aagggtaagt tactgacttt 120 aaggcagcta ttaatagatt gccccacaat tccaggtttc aatttagcca atataggaca 180 tatcaccaag tgagctaatt cacagcaatg cacacaagac tcctcaaggt caggcacaga 240 gtggggggtg gtggccaggg ggaattgagg gaggctctaa gctaggggca ctgcatggtg 300 ggacaggatg gccccttgag gactgaaccc tggggagaag acaaacagta ataataaaaa 360 caaataacaa gtactttaag aatggattgt atgacctata gtgacagatg acatcactaa 420 tactgaaagc ttcttatatt aataattttg gcaaaatgtc attttgtaat atagtatatg 480 ctttccaggt gtgggggtng taaagtaatg agggccaaaa tcatcctgcc ccaagactaa 540 tatcttctaa tggtgcatta gcaaggaag 569 <210> SEQ ID NO 371 <211> LENGTH: 489 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1890182T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 435, 449, 473 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 371 ggatttttta cgtttttttt caatgctttt ctttttctgt cctttttttg gtgaaaatac 60 ttgaccatct tcagatgttg tctctatgtt acccctctct attccaacat catcctcttt 120 ctttttctta attggtttct tttgaattct tgctttcttc ttgttttcat catgagctcg 180 atcagatgtc tctcgatctt cagactggtg gtgtcctata atgtcctgtg cacgcattct 240 tgagctttcc aggatttctg tctgttctct ctgtttatct acagaagaaa ctttctcctt 300 gagttcctgt tcttcgtagc gccttgaact ctctttcctt tctggtttac gatcctcctc 360 tttccatcta ccctgtctgt cttctgtgag gtgcgaggga ctaagagaac gagattcttg 420 aggtcgtaca acttngctca agagtctgng gttttcattt ttaacatctc cantgttgta 480 ggcaacact 489 <210> SEQ ID NO 372 <211> LENGTH: 340 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2072691T6 <400> SEQUENCE: 372 gagaggataa gtttctttct cagagtgtgc tgcagccaga cataatattt ctccttggca 60 gaaactctgc tgttccaatc atacatgtag ccattgagtt caatgtgaag atccaggagt 120 gggcgttttc tttcttgtct cagtttctgg gagaggcact gcaggtacag ggacggtgag 180 ctgtgagact gctccagcag ggacatgtcc gcagtacaca ggctccagaa gaagtcagct 240 tctcggtgaa ctgtgcacag ccctcgcttc tgagccttga attccacatt cttcatcgct 300 gggcccatcc acctccaaga aggctgctgt cctccagctg 340 <210> SEQ ID NO 373 <211> LENGTH: 364 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2176527T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 153, 177, 188, 224, 261, 276, 315, 346, 362 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 373 cacattcaat atggaaactc aaagaatact ttccacctga aacaattaaa ctagattcta 60 ctagcatata atgcttaaca cattacagca ataaagatgg taatccattg tcttctatac 120 ctactaaagc caagatggta aagccaattt ggntgcaata gtgtcataag ggtaggntat 180 taccatcnaa aaataaaaca aaatcagcaa ataacagtaa tggnagatga atatttttac 240 tctgtttcac tgaaaagagg ncaaaatgtt aaaacnccac agtactgcag gtgaacaatc 300 cccatgtaaa cttcnccata tgatgtttta atgttttatt cctggnatgt aaagactgga 360 gnct 364 <210> SEQ ID NO 374 <211> LENGTH: 548 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2204560T6 <400> SEQUENCE: 374 gaaaagtcct caacgtcctg acgggactcc cctgaagcca aggcagtttg agtccattca 60 ttattctgtc ttggatctta ggcaaagccc cgggcccctt ggagcagcac cagggttccc 120 gacaccccca ccgacagggt cgaacgtgca caggctggga ccacgccgga gttcattgag 180 ccctcgtggg ggagggcagt tccagggacc aggaagggat tcccgtccag tgtcaggtta 240 tccacctcgg gcagctcgtc aggctgcggc gccctgttca gtctgttgca gctgagatcg 300 agcactctga gcttggctgg cagtccttta ggcacctgtt ccagcccagc gaacgacaga 360 ttgagggagt tcagggcgct ggaccacatg catctcggag cgctagggtt tacggtggcg 420 cgcagaagtt tgtggctgag gtctaggctg tggggctgca cacctgccgc cgccagtgcg 480 gggcacacgc ctgtgggcgt ctccattcct gtgttgcgca cgctagattt ctggatgggc 540 cgggaact 548 <210> SEQ ID NO 375 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2233159T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 193, 209, 240, 257, 270-271, 362, 382, 496 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 375 cagaaatata gttgcgagta tacaaatgtt ccaatagaag caaaatatct ttttaatatt 60 taacaagtta tcacagatag ctaaaaacat agatgcaaat gaaattcccc cagagaacaa 120 actgaaaata tctggtatca gtgctctgaa atcccaacta tgaaagccat atacacaaaa 180 atgtaaccct tanatcattg caggacaang gaagaaggca gttcagtggt cgatcagtgn 240 gctcaagcaa ataacantaa ctaaaaattn naaatggcag aatggtagct aaaccacttg 300 agaacaggtt aatgaaatta ttggtactat acttaaaaca ttaagtaaaa gaagtgaatg 360 anactcattt aaagttgtca anaaattagc aactacttgg agcttatcaa ttaaaaggca 420 acaaggtaag cagacacatt cattagatca aaagaaatta gatcaagttc actggaatca 480 gtctgtaact actcangtca caatgacttc agt 513 <210> SEQ ID NO 376 <211> LENGTH: 246 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2242627H1 <400> SEQUENCE: 376 accagcaaca acattcacag gtctttgtgc atcatgatgc agctagttct gtggtgatag 60 tctttgacac agataaccgg atatttggtt tgccaaggga gcttgtggta actgtatcag 120 gtgctactat gtcggcattg atcctaacag cttgcattat ttggtgcatc tgctcaatca 180 agtctaatag acacaaggat ggctttcatc ggctcaggca gcatcatgat gagtatgaag 240 atgaaa 246 <210> SEQ ID NO 377 <211> LENGTH: 369 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2326810T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 367 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 377 aagatataga catttgaatg ccaatgtctt attctggaga gacactggag ctgaagttca 60 acaatgatca cacttattac ctggcaataa aaacacaacc atctttccag tcaggtcaaa 120 atatcctact ttttgccttt ctaccaattc ccaaacattc acagtttttc aaggaccact 180 aataaaatac aggaagcttt taaagacagt aagagaacac ctagtgtaag ttaggtgaat 240 taaagatggc aaaggagatt acatcctcaa cactgacagc ttccaagact tagaaaagag 300 attgttcctt gcttctaaaa ttgtctattt tccctgtagg aaatgaaagt ttttccttac 360 aattatnaa 369 <210> SEQ ID NO 378 <211> LENGTH: 541 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2383611T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 535 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 378 tgcttggttt atactacata attataagta agcaaaatag tatgacttct tttgactaat 60 ctactcctaa agccttgagt tgccgttcaa tctcttcatc tgagattgta gcctttgaag 120 tagaggcaga tggtaagctt cgagcagctg atggagcttt ggccatcttt ccagaaattt 180 caattccaat ttcatcaaga acttgattca caatatcctg gctttcttct tcgtcatcag 240 aaccgtcaaa gatgtcatca agtgtatcat tgatcatttc ttcagtcatt tccattttca 300 tgttttcctt ctggaaattc tgcattgttt gtaatgtctt ttgtggatcc atcttcttgt 360 taactgcctg cattgttttt gctgtggtag acattgctcc agccatcttc atttgggaat 420 tcatcacttt tgtttgtgta gacatagaag taacttttga acttacagca aaagttctcg 480 tcttctgttt ccgtagatgc acaagttgtt tggctaaaaa ctttgcaagc ttccntatta 540 c 541 <210> SEQ ID NO 379 <211> LENGTH: 504 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2478839T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 234, 468, 473, 483 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 379 caaagcttct ccgatacaaa atatttggtc atgtattcat aatttgcttg acatttccag 60 caaagcgaag atggcaataa caaaaggaac ttcttacaag agaagagaaa gacccacgga 120 gctccagagt ttctgttgga acaagactct tctgttttgc ttatatacag ttaagttcgt 180 ttagtgtctg atccagtgtc tgatgtaagc ccacgttctc ttctttggcc tggncaagtt 240 tctcttccag gtcatcaatt gtcttttcca gttttgcaac cgttctctct gcaaattcag 300 cacgggtctc agcctctttc agtttgtcag acagaagttt aatttcttct tcatatttgt 360 cctccttttc agaatacttt tcagatgcag ctccagagat ttcagattgt tagtaacatt 420 cttgaggtct tcttccaggt caccacattt tagttcagac acctccgnaa ggntcctctg 480 ccntctccag ctcaccctcc agga 504 <210> SEQ ID NO 380 <211> LENGTH: 487 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2498039T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 243, 390 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 380 acaaatgcag acaggctagg acatggtact gggtggagga cggctagctc tttggaaagt 60 gaaaggtttg ggtggcgtgg gcctcatgcc acactgattg gtcagtagac agggggcaca 120 tgccaaacac cacagggcat cagatgctgc tctgtgtgct cacaagtgtt ccctgtctta 180 tctgggcctt cgaagggagc acacccagaa gcgagcaact gaagcgaagg ggcttcctaa 240 ggngcccctt ccaggcttgt ctctgaagtc acagcaacac tgttttaagc agtatgttta 300 attggatgat ttccacaaac tatccacgaa gtttctaacc atcacaattc agtgaagtac 360 aaaacactga gttacaggct gtgggaagan aaggcagcac caatggtggc accttctaat 420 actggttgtt ctaggggcag ggacagggaa aggtcttttt ttaaaaccaa gcccctcatt 480 tcaatgt 487 <210> SEQ ID NO 381 <211> LENGTH: 415 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2553130T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 223, 274, 326, 380-381 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 381 caaaataaaa aagggatcaa tcaacatata tcttagaagt ccttccaaga gtcttggtat 60 gcaacagcca tggaggctgt gacctttttc cttcttttct cagcctgcag ttcatttaag 120 gatcaccgga gatgactcgt gctctagttc ttaaaatcaa acttgttctg ccaaatccaa 180 gaccctgaat ttgtccaaat tgtagaaaca tgcttttacc acncgtccac caaaatacct 240 cccattcaag tcaacaaccg ctttaattgc tgantcaact ctctcaaatt ctaaaaatat 300 ccgtactgct tcatcatcag gggcancagg aatttcaaat atcacacatt ttccaacttt 360 gccatatttt tcacattctn ncttgggttc aacttccaag tcttcatcca cctct 415 <210> SEQ ID NO 382 <211> LENGTH: 536 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2652321T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 444 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 382 ctatttcgta cttgggggtt gggagctcaa tcttcaggga aacagaaaaa agagagaagt 60 attcatgtaa gtaggagatg agaagcagag tgagaatcac ttttaggaac acagattggg 120 agcaggtaca ggagaatcct gggtgaggat gaagaatgac ctgggatggt tttggagcta 180 gcctctggaa tcctttctct tgaccatggc catcagcacg agggcactga ccagcacggc 240 atacaaggtg gccttcccta gcaagatctc atagaggatg gtggcagaca ggaccccttg 300 ctggtaagac tcggaggtga agccacagtc tgctctaccc caggcctcgg cgctgacgat 360 ctgggtgaca ggtttggccc tatcctgggt ccactcgtca ttctccgaga gccgtagaac 420 tggacttgac agcggaagtg gttncggggg ttctgccaga aggtggccga aaaccctcag 480 gcggcttctc aggcagtatc tggagtcatt gagggcgggc tgctccttga ggggct 536 <210> SEQ ID NO 383 <211> LENGTH: 122 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2729382T6 <400> SEQUENCE: 383 cattaaaaaa actgaaaaaa ttaaacttaa tatatataaa atatatttaa tttgcaaaaa 60 tgtgaaaaat ctgcctcatc cagtaaacag tcactgaaat tttaattaag agtgccctcg 120 ag 122 <210> SEQ ID NO 384 <211> LENGTH: 445 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2766696T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 393 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 384 aacatatcaa tttgctttgc agagcaattt acataaaaat tcatgatgta taccaacgac 60 agcatagcat tatctacctc agtttgtgaa gcatcctttc ctacagatct cagcaaaacg 120 cagagccagt aggggaaatt caagctttca tttgggggcc tctggggtcc tacctgctgg 180 cagttctttc agcagaaagt ggggtacggg ggatgctgaa gagggggaag tggaccccat 240 tgcctgttaa gtcccatctg tctcagtttg aagcaacacg ggaatttcca ttggaggagg 300 gttggcctgc cggcctggcc cttctctcac gccccctcta cttcagctac atttcttatg 360 catgttcctc aaagctgtga aaatcaatac aanaaaaact gacctttact tcattcctgt 420 aacaggctat caggatctca aggag 445 <210> SEQ ID NO 385 <211> LENGTH: 543 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2783918F6 <400> SEQUENCE: 385 cttctatgta ctcatttcac ttttacccaa ggattatttt taagttattt ttgtcgtttt 60 cacacttcaa acataaagac aaaaactatc aaaaatatat actgtgtttt acatatgtgt 120 ctattttcac acatatatgt atgtatgttt atatgtatgg aaactacaga agcacatgtc 180 gccaataaga gctctgagac acctttgacc acttaccctt atcagatgcg atttgccaaa 240 tgagttgtgg aaacaagttt tttaaactga atttctgagc tttgtgaatt tagaaatgca 300 aaggaaagtt tgtggacatt tacagggatc atggttttat tgtcctttaa actcttcgat 360 actttaccat tgtcttacta taaatccaaa atcctaacgc cacccacgag gctttcaata 420 cctggcttct tgtgatttct ccaggctaac cttttaccct ccttcccctc agcctctctg 480 ctttagtgaa ctttctccta gttttttgaa gaagttcatc aattcaagct tttgtacatg 540 gga 543 <210> SEQ ID NO 386 <211> LENGTH: 471 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2822377T6 <400> SEQUENCE: 386 ctgaaaagat tatttcttgc tttaatccta atatgctaag aaaagttcat tggcacaaat 60 atccagaggt attttacagt ttcatttacc tttggtggca aagagtattt tgctaaccgt 120 atggatacag tcacatagtt tccaatgcac agctttatgc taaagagaat tcaaatgtgt 180 ctcttttttt tgctaaaaaa gggatgtaaa aagtccaata tgaaacagaa cgagtgcaac 240 acgaaataca aaatatgcct atcatgtagg cttttgaaca gttaatagct ctacgtgtta 300 tctataaaca ttttttacta gtaacatcac tattgtataa atattaaaaa caaaaatgac 360 attaaaaaat agcatatgaa ctttacaaaa atggctactt ttagtcttcc taaactaaaa 420 tcggattcaa atacgcaaac aaatctacac taactaatca aaacacacca a 471 <210> SEQ ID NO 387 <211> LENGTH: 641 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2835582T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 212, 218, 226, 571 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 387 aggacataca acacgcccag atacacagca tagcagggcc tcgataatga gataatttcc 60 ccccacgtct tgagaagaag aatactatgt atttctttat gaacactatt aaaaaaaaat 120 aaacccctca caacattctg caggacctag agcccaagag aacccactga agatccatca 180 tctgtgggat ggcggaggca gtctctgggg ancaggangg aatgtncaca gccaggggag 240 gctgcagcag ccttgcctct gccgtgaatg tcaggcagtg acaagcagca ataagggaac 300 agagggggtg gcagcagtgt ttggcagctc ttcagcaatc ttaatcataa attcgggtag 360 gatccagttg gtggcattgc cgggggggca cagaggtggt agcagctttc acctccttgg 420 gggtgggaga gttccctctg tttggagagg gagaagaggg gcaatgcaga ggaaggagcg 480 agggagcaca ggctgtctta caatcttgca gatctcagct ggaccacagc cgcagcgtca 540 tgagcagatt aaacccggcc actttcagga ngagattcgg aacccaatca ctgacaggtt 600 ttgaaagttt aggttcgtaa ctgtttcaaa gctttctcga c 641 <210> SEQ ID NO 388 <211> LENGTH: 305 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2837720F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 240, 255, 277 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 388 tgtatccaga gaccaacaaa accaaaaata aaggtgttta tagcagcaca aatgagctta 60 caactgattc cactccaaag aaaacacagg ctcacacaca gcaaaatatg gtagaaaaat 120 tttctcagtt accattcaaa gtggaagcta aaccatgtac ctcaaattgt agaattaata 180 ctttcagaac agtgccaata gaacagaaac atgaagtctg gggttcaaac cagaactacn 240 tttgtaacac agacnctgga aactgatggc ctttcanctt ctgttgcctc tccaagtccc 300 aaaga 305 <210> SEQ ID NO 389 <211> LENGTH: 512 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2935837T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 48, 61, 231, 314, 390, 400 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 389 aaaaaatgct cagcacatta actcaaactg gaatgacaaa cgttaggntg acagttttgg 60 ncaaaggctg tgccttgctt ttttaaaaaa tgggtacatc aatgctcatt ttaacaactg 120 gcataaaatc ccactaattg gctaataaaa acagatacaa atacagaaca tttaaagtaa 180 taacaattca agtgctgggc tttttacaac aagggggtga taaggaaaga natgaaaatt 240 cactgcaaac cagtctgctg aacgcatctg ttaaggttta ctgtttaaaa aaagaaaaga 300 agaaaacaga aganaaaata aactgaaata gggctgccaa ttgctaccaa cagagtgggt 360 ttggctatta catttattta gctctactgn acaccttacn agggcggaga agccactatg 420 tgttacaggc aattcacaga gaagccactt accagacaag ctgtctcaga aaaagaaggc 480 ttctttttat ggtcattatt tcaaactttt cc 512 <210> SEQ ID NO 390 <211> LENGTH: 592 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3137077T6 <400> SEQUENCE: 390 tttggtcaag ttgtttccat taaaaagtac tgattttaaa aactaataac ttaaaactgc 60 cacacgcaaa aaagaaaacc aaagtggtcc acaaaacatt ctcctttcct tctgaaggtt 120 ttacgatgca ttgttatcat taaccagtct tttactacta aacttaaatg gccaattgaa 180 acaaacagtt ctgagaccgt tcttccacca ctgattaaga gtggggtggc aggtattagg 240 gataatattc atttagcctt ctgagctttc tgggcagact tggtgacctt gccagctcca 300 gcagccttct tgtccactgc tttgatgaca cccaccgcaa ctgtctgtct catatcacga 360 acagcaaagc gacccaaagg tggatagtct gagaagctct caacacacat gggcttgcca 420 ggaaccatat caacaatggc agcatcacca gacttcaaga atttagggcc atcttccagc 480 tttttaccag aacggcgatc aatcttttcc ttcagctcag caaatttgca tgcaatgtga 540 gccgtgtggc aatccaatac aggggcatag cggcgcttat ttggcctgga tg 592 <210> SEQ ID NO 391 <211> LENGTH: 336 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3142624T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 324, 331 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 391 aaaataatta ccaacaatac attatgtaca ccatttacag gagggtaaca caaaccttga 60 caggtagtaa cttttcaccc cacatcactg aacgcttaac actcctggct gttacatgtc 120 acaggatacc actggggtca gtcactcgaa gcacaataaa tataaaatgt ggtccttcca 180 tgaaattttt gataaccttc tccaaaaacc ccacaaaggt gaggtttaaa agaagttttc 240 tcagaatttc aatgatcttt ctcgtcccct acaaaaagtt cacaaaagca acaaaatgag 300 ggctgatcct accacaataa gacnttttgg nccagg 336 <210> SEQ ID NO 392 <211> LENGTH: 564 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3294993T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 519 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 392 aggctttgga cactttagta gaacggaacc agggggtaag gtttccagag aagtcctaga 60 ggtatatttg tcttgctggt cctcatagat actatcgttt tgactaaaac tgtcaacagg 120 taggtcttga gtcccccggc cttctggagt gctaggggag ttggagttag aatttacaat 180 ctgaggagga tgtgagatgg gcagataggt tgaaggcagc ggtggagggg tggggatggc 240 agcagccgca gggggcagtg ggaggcctgc agccgatttt tcactggtgg gattcaaatg 300 accatttagt gttggtggta ctctgttcgt caggtgagat attcgggctt ttttattcat 360 taaaggatca ataaactctg aatccaaaag ccgtttctga ggagaagata cagcatctct 420 actagaacat acaggagatt ctgaacggct ggtgcctgta gcattctgag acggatttag 480 ttttctagag agcactgact ccaatgaccg tctgtctant tcactgtatc caggccagtc 540 tctttgaagc tctttaaaaa cata 564 <210> SEQ ID NO 393 <211> LENGTH: 379 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3820893T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 57 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 393 tgtgacttgg gcaacgtggt ccaggagggc ctgagactaa cacatccacc tcggcanaag 60 gacatcaaat atctcttaca gtcggaaaaa acagcctttt gtgtatttcc ttagtttacg 120 aaatatactc gaaatgctat tattagctga atttgtggtt tccttttgag tttctgagtt 180 attcttattt atttttccca ttttgttttt gcaccaagga gaccggagtc aaataatact 240 cagcgactga tttcctctct ttggactgaa aaattaaaca gatactaaat gatgacagtg 300 aatttagaga gggctccaag ggcttgaaag aacatgtctg ggataatatg gtgcttctaa 360 gagtattgca atcacatcg 379 <210> SEQ ID NO 394 <211> LENGTH: 462 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1403970F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 426, 453 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 394 tggccctcag ccttctctcc ctgaagtctg tggccagcaa aaatctggac tttacttcac 60 tctgatgctg aacacccccc tcccccacct cttccccaat atctcagatc ccaagcctcc 120 ctggtttgct tctaggaagc tcagcaattc cctgaaaaga atgcagctca agtgactgct 180 ccactttttc accttggcct ttgcggaagg ctgtggctgg gctaccctat gcatcgatca 240 atgaggtcat atttacccag tgcttggcct agaggcccaa gacagggtca gcagtgcttg 300 ctttggctct agtttgggcg ttggttttgc agcctcagca tcagcacagg caggccctct 360 tctccagcag tgctctggct gatatttctt ctttttccca cagccaatcc cactaatcct 420 gatgangctg acaaagttgg ggctgagaac acnatcacta tt 462 <210> SEQ ID NO 395 <211> LENGTH: 361 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2749575T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 221, 243, 258, 281, 301, 324 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 395 catctccaaa aaaatagttt tcatctaaca attatgaaac aaatttgaaa ggcaggatga 60 ttcacaatat agacccagta gaggcttata cttcatataa atgaaaaata tcagttctac 120 aatttaaatg tttactttgg attttattat agaagaaaat atcattgtaa ttataaaagc 180 cataaaaatt ggaactgtat tgtgaaatta catcaaggta ncagatttta tataaatgaa 240 cantaaaatt caattttnat ttatttaaac gtagttaaac nttggaagac aatctccccc 300 ntggggaaga aaaaaaaaaa aaanccttga ataataaagc cccaaaagcc acaccacaaa 360 a 361 <210> SEQ ID NO 396 <211> LENGTH: 329 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2753531T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 166 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 396 cgatgccacg tgggccccag ctcacccggg tggaggctgg gagctgaaac cgaacccagg 60 caggagatgg gcgacggcgg aggtgcaagg cagggcacgg cgcacaagac gagggcggcc 120 gggcggggtg gattagaggt cactctcgcc gtacagcgcc gtgganaagg acatgtagtc 180 cagagcacct ggcacggagt cggggccggt gtagggggcc atccgcgcga tgcagtactc 240 agcatggtcg ggtggcagct cgcggcgcac tcgtccatgg taatgtagtt ctgcgaggag 300 agagtggtca agaaggccgc aaagtccag 329 <210> SEQ ID NO 397 <211> LENGTH: 217 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2875779F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 214 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 397 cgggggccgg acgaggacga agaggaaacg gcggcggcgc ccgggagtcg ttgaagccct 60 ccgcgctggg ggccgccagg aaccattctc cccaagccca gaggcaggac ttcgcagcag 120 gatggggtgg agagcccgcg ggagtgaccc ccacgagagt gaacgcccct cacactccca 180 ccatcgccgg ctggccccgg agcgggaggc ccgnagc 217 <210> SEQ ID NO 398 <211> LENGTH: 131 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 042222H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 12, 22, 45, 50, 60, 77, 104, 106, 110, 117, 126 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 398 ctgaataaac anggagggat gnttctaacc cgtgcaatgt ctggnaacan taaacttggn 60 ggacaggact tcaatcngag attgcttcag tacttatgta aacngntctn tcaaacntat 120 ggcttngtgc c 131 <210> SEQ ID NO 399 <211> LENGTH: 285 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 088219H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 112, 117, 133, 240, 260 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 399 gtttctcaca gatcccaaat tggccatgga agtttatttt ggcccttgta gtccctacca 60 gtttaggctg gtgggccagg gcagtggcca ggagccagaa atgccatact gncccantgg 120 gaccggtcgt tgnaacccat gcagacacga gtggtcggga gacttcagaa gccttgcttc 180 tttttccatt ggctgaagct ctttgcaatt cctattctgt taatcgctgt tttccttgtn 240 ttgacctaat catcattttn tctaggattt ctgaaagtta ctgac 285 <210> SEQ ID NO 400 <211> LENGTH: 512 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 149812T6 <400> SEQUENCE: 400 tgaataccct tatcatattg ctttaaatga cagaaagatt aaagctggca tcctctatag 60 tatactaagc atgaatgtaa agtatgagaa taaataggag actttcctaa atgtcaaatt 120 acaaaaccgc tcaaaacttt gtaattgtga ctcatgcaaa taccttgtta ggtcaactta 180 atattacaaa tactgcatca gctcggtacc tttatatccc ttttcataaa aaagaaattc 240 tcactccact cctgaagcca gcaaacagct ctggaggaat tacctgtaca cccaagtgcc 300 acggtcactc tggaatttta atacacacac acacacaccc ttactcatga acatacacat 360 tttacaaaca cacaatggtg tacacacaca cacacacaca tccacacaca ccccatcttt 420 aggatttgta gctgattcca agcctgcact tatttctatt ctatattttt ctttgtatca 480 tcctgaaaca cactggttgc tcagcaaaaa ta 512 <210> SEQ ID NO 401 <211> LENGTH: 592 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 182514T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 320, 352, 426, 428 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 401 tattaaggtt ccttaaaaaa ataacttatc tttaaagccc tttctctctt gccctctttg 60 atatttaagg tatacaggat ggtgaggggt gtgccaggac agtaaggcag ggggctacag 120 tgggcagagt agctagggga gtcaggcgga caagggtttc agtcctgctt ctacagggca 180 agctatttat cctctctgaa ggtttctgta cctgagaaat gggcacttcc atgcccacct 240 ctcaaggata ctgtgaggag ccttgcccag agcctggtca tggtaggagc atgtcagttc 300 atccgcctaa agaaacagan tccagggcct taggctggct caaggggcag angaaaagac 360 aatggcaata agaacctctg gagcttaaac caaaccactg atgccaggga gccagccagc 420 cacccntncc tgctgcagtg tgtgacggga cacacagatg cccctgcgcc cggctcctct 480 ctatggaggt ttaagcatct cttgagcagt tacacatcac ttgccccttc ctctcacctt 540 cccccatctg tgggatattg gtgcaggatt gtggcatctg tgcacgtgaa tc 592 <210> SEQ ID NO 402 <211> LENGTH: 550 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 492443T6 <400> SEQUENCE: 402 attattgata gatggaacaa aattcatgtc ccttgcttga atcttttagc gagctattca 60 gagattctat atccccattt actcatggtt ttttcaaggt gaatgaaaca acataccctg 120 ctttcaatat tttctccaaa tgcaaagcaa aaacagaaca aaaaactttg aaactttaaa 180 tcttctttca aacaatccaa tcacatttac agaagtgtcc aaaaagagat gatggataat 240 atcagtgcca gcactatgtc atacagcaac ttcctcatat tctttgacgg tttgtaaata 300 attttccata tcaccaaaag ttacaaaagg ttccacagtt tcctttagca agctgaagct 360 tactcttcat ttgtcaatgt gcataaaagc tgcttatagc atagcatggc gtaagtattt 420 tttaagcaat aaatggtttg agtcatctat tttgtcctga aatgctatct gtagttaact 480 gcactgctta taaatggtca tagtaaattc agcatgaaag tggatattac agaaaagacc 540 agcaagcaga 550 <210> SEQ ID NO 403 <211> LENGTH: 439 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 516262T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 29, 49, 75, 81, 85, 96, 115-116, 143, 154-155, 195, 330, 355, 365, 400, 426 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 403 acaacacgcc cagacacaca gcatagcang gcctcgataa tgagataant tccccccacg 60 tcttgagaag aagantacta ngtcnttctt tatgancact attaaaaaaa aatanncccc 120 tcacaacatt ctccgggacc tanagcccaa gagnncccac tgaagatcca tcatctgtgg 180 gatggcggag gcagnctctg gggagcagga gggaatgtgc acagccagcg gaggctgcag 240 cagccttgcc tctgccgtga atgtcaggca gtgacaagca gcaataaggg aacagagggg 300 gtggcagcag tgtttggcag ctcttcagcn atcttaatca taaattcggg taggntccag 360 ttggnggcat tgccgggggg gcacagaggt tgtagcagcn ttcacctcct tgggggtagg 420 agactnccct ctgtttgga 439 <210> SEQ ID NO 404 <211> LENGTH: 505 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 567292T6 <400> SEQUENCE: 404 tgatgaaaag aagttttata taccatataa acaagatttg tcagatttga aagtgaaagt 60 taaagtaatt tacagttagc ttttaaccct ctcgggacat ttagatacat cctgataatc 120 catcttgtat tagtgtgtgt caattttaca atacactggg gaaaactcag ctattgtatt 180 taacggtaca gtttcattta tcaagtgttt cccattaatt ccattattag tgacagctaa 240 caagtgaccc catcaaatga agtgaatgac attagactgt ggcagagtaa accacatctg 300 gattgctttc tataattcac cagtttgcag gaagtaaaca ttctttgatt tgttcataat 360 atactgaagt tacctataac actggtgcag taacacagct agttcctctg tattgttatg 420 gtagaacggg attttgtaat ataaagttaa cagggaaaaa atgctcacac attatgtggg 480 tgaactttat ctcaccaaaa gagct 505 <210> SEQ ID NO 405 <211> LENGTH: 511 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 927392T6 <400> SEQUENCE: 405 caccaactag gtcacaggga atgttaatta aggcaagata ggtagaagga aaggagggta 60 tgtacagcaa ttgctcctct ttacggagaa gagaacctgc cacagaacaa gatgcagttg 120 gttttgtggt gcctgatgaa gaaaagaaaa gggtggtctg cacagaatct tggctccatt 180 ctgctgcacc gggaattcct gaccacagca gtggctgcgg cagcctctgt gccttcctca 240 ttgacctcca cgaagcactt gtgggcaacc ttggacagag gcacattctt ctcagttgac 300 attccagaaa agtctgcctt ggcttcgtca aaagcatcga tcattcctaa tcttcgaagg 360 aaaggctcca agtcataact ctcctccagc tttaatctgg gaaggaaaac ttgaacctta 420 ctttttgtca acttttctga atttgtccag gctttgaatt tctcatatgt aagtgctttt 480 tccaccacgg cgaaggtccg tgttgtcatc g 511 <210> SEQ ID NO 406 <211> LENGTH: 335 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 936419T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 144-145 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 406 ataaaggaaa acaaaaaaca aaaaaacaaa aacaaaacaa aaaaaactta aggtatgttt 60 cctgcaagca aaatggagaa aaaggtatta ttgttgttac tatgattatt aagccacaga 120 cacataaaat ccacaaaatg gatnnccggc tttagaaatg caataccgta tcaaaggtgc 180 agactgtttc aaatgttctc tacatattgg gctgaaacaa gaaccaaacc aaacttcaac 240 cccatcagcg acgcaatgct cctgtgacct tggtgaaaac atcgtcgtga ccagctagat 300 ccaggaatcc ttctctagag acacgtggaa acgtc 335 <210> SEQ ID NO 407 <211> LENGTH: 347 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1268604T6 <400> SEQUENCE: 407 atggtctcat cccttctttt catagttcct tcctcttcct catcctctgc attgatcacc 60 atggtgccca gttgtgatgg caacgtgtca tcgtgctcaa tcatagtatt ggctccatca 120 gtcatggtgc tggctactcg gacagtgccc atctcatcac ccactgctcg aaccatcgtg 180 ccagaatcca tttcatcctc ttctgagttt tcttcatcgt cctggtccac ttcccgctgc 240 tgggattcct ggcgtttcag tttcacatcc atggcttcat taattaagtc tcgcagtatt 300 gacactcctt tggcactcct gacaaatggg tgctgcagga gctgagt 347 <210> SEQ ID NO 408 <211> LENGTH: 227 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1290504F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 101 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 408 ggcttcggga gcgcccgggc tgatccgagc cgagcgggcc gtatctcctt gtcggcgccg 60 ctgattcccg gctctgcgga ggcctctagg cagccgcgca nttccgtgtt tgctgcgccc 120 gcactgcgat ttacaaccct gaagaatctc cctatcccta ttttgtcccc ctgcagtaat 180 aaatcccatt atggagatct cgaaacttta taaagggata tagtttg 227 <210> SEQ ID NO 409 <211> LENGTH: 336 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1314775F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 23, 77, 144, 155, 157, 164-165, 177, 184, 297, 304, 315 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 409 ccgcagcccc tttctcttcc ggntctaggc gcttcgggag ccgcggctta tggtgcagac 60 atggccaagt ccaagancca caccacacac aaccagtccc gaaaatggca cagaaatggt 120 atcaagaaac cccgatcaca aagntacgaa tctcntnagg gggnngaccc caagttnctg 180 aggnacatgc gctttgccaa gaagcacaac aaaaagggcc taaagaagat tcaggccaac 240 aatgccaagg ccatgagtgc acgtgccgag gctatcaagg ccctcgtaaa gcccaangag 300 gttnagccca agatnccaaa gggtgtcagc cgcaag 336 <210> SEQ ID NO 410 <211> LENGTH: 438 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1347582T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 360, 410 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 410 atagtacccc cacgattaca cagctttgaa caagtgaaac tatggttacc aaacagctat 60 ttttattata gcatctacag tgtctggaaa aggatgtaac aataaataac tgtagacgca 120 tcacgagaca tccatttact taatcacaga agtggatctt gctacatagt tttctcaatg 180 tcttcattct tcagattctc caggcttacg aatgtcatca atcttcaaaa tcattctaac 240 catttgtgtt gcaagagata tctgttgctt tttgccaatc aaggtttcta tgacatgctg 300 ttgcttcata tcatttgtcc ccttgtgcaa acagtcgatg ccaagagcag ggttcatctn 360 cttcacctgt ctggctcgga cttcggtcat agtctggatg gggattcatn gccactggtt 420 ttcagagaag ggccatgg 438 <210> SEQ ID NO 411 <211> LENGTH: 162 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1395143T6 <400> SEQUENCE: 411 gctggggcct aatgttctca cataacagta gaaaaccaaa atttgttgtc atctcttcaa 60 agaatcgaga attgcgtaca aaaaaacctt acataaatta agaatgaata catttacagg 120 cgtaaatgca aaccgcttcc aactcaaagc aagtaacagc cc 162 <210> SEQ ID NO 412 <211> LENGTH: 349 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1507333T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 295 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 412 aaaattgctg ggtttagctc tcagcagccc gctcctgagc tctgaggaag cttgccttct 60 tttgagctac ccgatccttc ttctgagcaa gggacatttt gggacggttc cacctcttct 120 ttttaacttc tttcttgggc ttcttttcat agactggatt ctctcgtata gcagcatgag 180 ctttcttata catctcctcc atcatgtctg gagttacgct gttctttatg tattgagaga 240 actgtttctt gtaagcatct tcatcttctt ccattaagta gcgcatgtaa tctgnaacat 300 tctgggccat gatgtgcttc cgatgtactt ctgcattaaa ttccttgct 349 <210> SEQ ID NO 413 <211> LENGTH: 524 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1517479T6 <400> SEQUENCE: 413 gtaataaaat aaatttaagt ggcacctaat ttaacattta aaatagttca ttaaaagata 60 atctacaaaa caatgttatg cctaattgtc aaaataacac cttttttttt tcaagaaagg 120 agaaataaag gcataatcaa aattatggct aacaacgtgg gttcattttg acacttacag 180 atgattctgt aggcatatcg gcaggcacga tgttgaaaac caatccacta gatttaaaat 240 taatggtaag ataaaaaaga aaagatacac atttcagagg taatgtttga aattaaagaa 300 aaatatccac catatattac aacagatctt ttaatgacta tttttaacat aaagattgtt 360 gttttgggaa acatctattc tctttgaaca tttcactaaa ttttcaatgt attaaataac 420 tgacagaaat aagttctgtg ttctgtacaa attaaaggtc ccatggaata cataaccccc 480 tcccagcccc accaaagctc aattttgcat ggtttcagca gaaa 524 <210> SEQ ID NO 414 <211> LENGTH: 302 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1701950T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 98-189, 240, 246, 263, 279 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 414 aaagataagg aagttgggtg tgatgtttac ttctctatga tgatgcttct caaactttca 60 tgtgcataca actcctttgg atctcatcaa aatgtccnnn nnnnnnnnnn nnnnnnnnnn 120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180 nnnnnnnnnt ggagtacaac acaaagaggg ttcaccctgg cctttcctgg gtcatgagan 240 gccttnttca gcgttatctg gcntctccca agcacaatnc ccaagcaaaa aggtttcgat 300 gc 302 <210> SEQ ID NO 415 <211> LENGTH: 559 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1730294T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 522 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 415 gcagggaagg gtcatggctg gagggtaggt ccaggtggtc cgggctctgt gtctggtggt 60 agggtgggct ctggaggtgc agacccgggg gctgcctagt gttcgggaac gcagcttccc 120 gtctgcaggg gcgtgaaaat gtcctcctcc gagagtccct tgcgctgcac caatttctta 180 aattcttcca gggcctcccg gttggtatca gaattcctac ccacaagctt tcccatgtgg 240 agcaggcccc catggtgctg gtctttgcag taaaagatgt agtggtccct cctgggcagc 300 tcctgcaggt acatgagctt cctgccccca taggcgctgt atttgccagg ctcctccgtc 360 ttccgcatca ggattttctt ctggatgcac cgatcctccc tcatgaaggt gaacgtggct 420 tccaacttcc caccgcccag ggctgtcacc ttcactgggg acaccttcct gggcctcctg 480 tcctccggaa agtccttatc gaccaccatg gccttcacgt ancaggtcct gtgatatcct 540 cctcctccaa gggtgaagg 559 <210> SEQ ID NO 416 <211> LENGTH: 529 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1730609T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 97, 244 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 416 ataaaatgta ttctttcagt ctttccgggt gttccttttt tacaaaaaca aaaaggcaca 60 taaaaacctt ccccgctgtc atttccacag atggganggg ttttcaggca gccctccccc 120 ctccccccat agagctacat gcttcattcc aggacgtctt gcttccccac atgctgcggt 180 gctttcctac cagggtagag ttccaaactc caagactgaa gtacacaaag agggggtggg 240 tgtnggatgc agagtgtgtg gcctgatgct ccacggcgtg caggacgggg ggctaatagt 300 aggtttcctt ctccacccag ccgccagggc gtcgcctgat gatgagtttt ctgacttcgt 360 catatacgaa gatgagaaga gagtagggga aggcacagaa ccaccaggta ggtttgaggg 420 gatacatcct aagagcaaca cccattccag ggcagtagga aaggaaagca gccaggggtg 480 tctcttcaaa gaggccaaat attcaagatc ttgttcttca tcccctgct 529 <210> SEQ ID NO 417 <211> LENGTH: 504 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1752762T6 <400> SEQUENCE: 417 tacagtagaa atgcagacca ctttggatag ctatggctcg atacttctgg gtgccctcct 60 cctaagacat cctcttctta cattccactg aacagaaaac catcccttct actggcatga 120 acttctgccc aatgaggcat ttgctgcagc aagagcacag aaagcactct gtggatgcat 180 gccagctgaa attgttatag gtcacccgct gcacttctgg gtcgatggca ttgtggcatc 240 cttgacacac cacagcgtga ttcttcacat agcagggctt gcacacgggc ttgtcattga 300 ccatcacgta tatctcccca gctagaatgc tatcacagtc aaagcagcag aagtgtttca 360 ggtgccaatt ctggttttct gcctgggtat actcattgct gaatatcagc tcgtcacagc 420 cagcacatcg ggggttctcg ctggtcacag taatgtctgc cacagtatag ttctcattct 480 tccaaaaata aatcatgtca aacc 504 <210> SEQ ID NO 418 <211> LENGTH: 557 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1760583T6 <400> SEQUENCE: 418 tataatacat tggtcgtcaa tttttatttc cacatggtta cacaggctga atgactagct 60 cacaatccca ggaggtatta taagttttgc tcttcaaaaa atggtgttac tgttgtaagg 120 ggaaaagtcc tcaatgacaa agaaatgaca ctaatgaaaa caaaatcaag aacgatccac 180 tggtactgca ggttacagag aagctgtcag tgagcagttc cccacctctc gcaagcaaag 240 gggatcaagg gctaaaaata ccttagaaaa atcaaacagc acctgcaaca catgcttata 300 taaaggccaa acttgcaaat tcttccttct cgtccatgct gcccaaatgt gaaggaatta 360 catataaggc taaaatctgg cgaatcttct cacttcttcc tcttctttgt ggaatataat 420 ttttctgcga gtgggactgg gacaatccct tcacattctt ttagttcctg ggtcagaggg 480 tgtttgacaa tattcccctc taatcacatc tatatctcga gacaaggtgc tccaccatgc 540 tttcaacagc tgcggtg 557 <210> SEQ ID NO 419 <211> LENGTH: 587 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1888251T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 415, 542 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 419 agagtttaaa taagtcctgg gtgtctggtg ccaaggtgag ggaagggttg ggcagagaga 60 tgaggggcag catcagtgca gctggcaggc agaacccaaa ttctgcaggc ccaggacagt 120 gggctcccct ttctctgggg aacagggagg gcctgtgtct ggccaggctg aggttccaga 180 tctgttgcca tcatggcccc ttcagggtcc tgggaaattc ctggcttctc ctaaatcagg 240 gtgaactggg cctccaggat caggtctgga gcaggcccaa atatagtcct ggatctgcct 300 ggattaggtg ccaatgtctg agtctgggtt ccagatcaac tccagacccc aggctggatc 360 tggccccatt tgagttctga ttccccttgg agctgggctc tgggccctgg gccancatct 420 atccttgtgt ggcatctgtc ctgagctggt cctggggcac catgcatagt tagtgttctt 480 tgttggccca ccagggtggg gctgtccaga actgccaggt cttaactccc caagttccag 540 gntcttaact gggggcttct tttggatctc tggcaaggct gaggaca 587 <210> SEQ ID NO 420 <211> LENGTH: 62 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2061030T6 <400> SEQUENCE: 420 aatggcagcg gtcttcatag gacagaggag tgagttctgt caacagacag gcggccccta 60 ct 62 <210> SEQ ID NO 421 <211> LENGTH: 287 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2070387T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 234 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 421 aggactttct gcttaaaata tttaaaattt acatgtgcac acaaacaaac acaggttccc 60 ccacccatgg ggaagggcga gatgactctg aataaaggat ggaggagaag aagagggtgt 120 agacggaggg cccttgaccc ctacaggggc agcaggataa ggaatagaat ggggcagaag 180 gtgggttatt aagaagcatc ttgcttactg acatgaagcc acgtgcccag cganagcaca 240 gatgaggcct cattggcgta gaggaggccc ttggaagggc aggcaca 287 SEQ ID NO 422 <211> LENGTH: 604 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2107288T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 578, 584 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 422 ttacaaaaga gcattacatt ctgcacactg ctctgaacag atgccaggga catgtggact 60 attgttactt ttcctccctg tcccaccccc caaatgttac agtgaccaca aagcaaggtg 120 ttcacaataa ttacatgggg ggaatttttt aaaccaccaa caataacgaa aaataaaatc 180 cactcactct gctgctgttt caaaatttca atgttagttt ttgcacgccc ttcccccccc 240 caaccctgtt tgtaaggaac taaaacatta catctggtga acagcaaaga tttcactaca 300 cctcaaatgc agaacaccta tgaagcagag gaatgttggc tttttaaaca gaagcagata 360 aaaaaaaaaa gatgcaggac tccttcagtt cttcactagt cttagaaaaa ctttccagaa 420 tactgcttca cactgttctg cagcaaatac tgtgcattct gtatctggtc ctgtgttcct 480 gtaatggtaa tgatccgatc ttcggatcct tctaaaggct catcaatttt gatcgaagct 540 cccgactcat gacgggattt gtttaatccg ctgaccanct ttgncaataa tagatccagc 600 caaa 604 <210> SEQ ID NO 423 <211> LENGTH: 458 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2176305F6 <400> SEQUENCE: 423 tctaagatgg cgactgtcga accggaaacc acccctactc ctaatccccc gactacagaa 60 gaggagaaaa cggaatctaa tcaggaggtt gctaacccag aacactatat taaacatccc 120 ctacagaaca gatgggcact ctggtttttt aaaaatgata aaagcaaaac ttggcaagca 180 aacctgcggc tgatctccaa gtttgatact gttgaagact tttgggctct gtacaaccat 240 atccagttgt ctagtaattt aatgcctggc tgtgactact cactttttaa ggatggtatt 300 gagcctatgt gggaagatga ggaaaaacaa acggggagga cgatggctaa ttacattgaa 360 caaacagcag agacgaatga tctcgatcgc ttttggctag agacacttct gtgccttatt 420 gggagaatct ttttgatgac tacagtgatg atgtatgt 458 <210> SEQ ID NO 424 <211> LENGTH: 585 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2198796T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 561 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 424 attaacatgt aaactcacat gtacaatttt actttttgtc atatatttaa atattttctt 60 atctgcagag ctatctcagg atatgaaatc ataacatgct agcaactagt aatttaacat 120 taaaacactt ccctaaatta ttccatggaa aagtgcattt acaatataaa catgtcatat 180 atgaagctac aaatcataat ctcactggag tggatataaa atttcaaatt cagtccaaat 240 gagtcaaaga aaaaagtgct aacagagcaa atctgaaaca agttcatggg gattgggtaa 300 tgagtcatcg aaacgaaatc ttttggaaac catgctgcta tcctctggga tattctcttt 360 gtcttctcta tcaccacagg ttccattaca ggaggattta gaagtcttgt cttcagagga 420 ccttacagaa tgatcctgag tttgagagga actggaagtt tcttcagggt gaaacaagtt 480 ttcaaagtcc cactgctgta gccaagaatg agaaaggcat atctctgctg ttgggtcttt 540 tctctgggat tttttactaa naggctctga ataaagtctg tgggg 585 <210> SEQ ID NO 425 <211> LENGTH: 347 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2345762T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 120, 305, 331 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 425 acaaaaaagc caggaacacc ctacccaacc cagcccagtg taacaggtta gccattaaca 60 cagaataaag aaggtcccag ccacacacgt cattactcgg cagagggtgt ccagcctggn 120 cggccgacgt cacagtggat ggccctgcgt ggctgggaca cagacaggga gcaggcatgg 180 caacctgcgc cacgcagaag cagcaaggct gagcatgacc actggaaata aataaacatg 240 gtgccgacag catctttaaa ttagtaagac gttagcacaa aaacaaaaaa gcacaacgac 300 tgaanatgca cttgcttgtt gtggtgggtt ntgcttgaaa acacctg 347 <210> SEQ ID NO 426 <211> LENGTH: 538 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2447063T6 <400> SEQUENCE: 426 ctttacaaac tatgtttttg caatatattt gttacaacac acatttcctt atgaatgtat 60 ttgttaaatc tttttgcaga ggaagtaggg aaaagtgagg ggagaagagg aggaataaga 120 ttttagaact aatcgtcagc aatgggccta ggtatttggc aattatttcc tttacaaaaa 180 aattacaggt ttgtaacttc aaacatcaaa agtgtagtgc atcaatttaa ctaaaaaatc 240 agtagtgcct aatatattat ctgggcatca aatttctttt tttaaatata tccagattca 300 catattttta ctcttattaa ataatggttt taaataataa tcatcacaat gtttagctac 360 ataatcccag atctggatta aatcatggtg atatcgatat ttttaaattc caatttattt 420 gttaatcagt aaaatgtaat aggtgatagt gtgtccagag atgagcctcc tatgtgtgga 480 agacgtagtc ttattacacc tgctatcaat taggtcttta catagctgct aatgtatc 538 <210> SEQ ID NO 427 <211> LENGTH: 365 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2492212T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9, 87, 328, 330 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 427 ccccaaatnt gatgaaaaca aagttttata taccatataa acaagatttg tcagatttga 60 aagtgaaagt taaagtaatt tacagtnagc ttttaaccct ctcgggacat ttagatacat 120 cctgataatc catcttgtat tagtgtgtgt caattttaca atacactggg gaaaactcag 180 ctattgtatt taacggtaca gtttcattta tcaagtgttt cccattaatt ccattattag 240 tgacagctaa caagtgaccc catcaaatga agtgaatgac attagactgt ggcagagtaa 300 accacatctg gattgctttc tataattnan cagtttgcag gaagtaaaca ttctttgatt 360 tgttc 365 <210> SEQ ID NO 428 <211> LENGTH: 305 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2542309T6 <400> SEQUENCE: 428 ttatgaaaaa atttttagtg cttaaaattt tacgatccat accatatctg ccatagtaaa 60 aattcatttt taacacagct aagatgataa ctcatagata ccacagtaac ttttttgtag 120 gtatttaaga aaaccatttc ttccttcttt ctccagccta atttctatga aaatattagt 180 gtctaatatt ttacatgacc cagcacacct tagtaaatgt aaacattcta aatgatttaa 240 tagcaagctt tgaaagttca gattttaaag tgctcatgaa attctcaagt ggttttgtaa 300 aagtt 305 <210> SEQ ID NO 429 <211> LENGTH: 389 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2807227T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 25-26, 68, 100, 107, 194-195, 200, 248, 278, 326, 347, 356, 363, 376-377, 379, 384 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 429 gcaaatcacc gcgatcccag attannccag ccggccgggt gcctccctcc cgtccgcctg 60 ggcagttnag gccaatcagc agtttaggcg cacaggtgcn ggctcanaaa gcagcagcaa 120 tctccggtgt gttctggaat cagaagttta ggtccacgtc tgattagttc ccttcgtttc 180 attagacttg gctnnatgtn tgccagtccc actagagctt cgatttcaga cttcctatga 240 caggtttntt cacagaaaac tctggccacc aggatgcncg ctccaacacc ttgctttcct 300 gcaggacagc gccccagagg tttttntaga gctcgccgtc ggtctgncaa tcggtnagtc 360 canaacaaag tcacgnngng cgtnacgtc 389 <210> SEQ ID NO 430 <211> LENGTH: 521 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2878786F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 259, 507 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 430 gcttcatatg atgttgtgag gaatgacata gatttcttta gaaatattaa atttaactac 60 tgcattcttg atgaaggcca tgtcatcaaa aatggaaaaa caaagttgtc aaaagcagta 120 aaacaactga ctgctaatta taggattatt ctttctggaa caccaatcca gaacaacgtt 180 ttggagctgt ggtcattatt tgatttcctc atgccaggat ttttgggtac tgaacgccag 240 tttgctgctc gatatggtna acctatatta gcaagtaagg atgctcgaag ctccagtcga 300 gagcaagaag caggtgttct tgctatggat gcgctgcacc gccaagtact accgtttctt 360 ttgagaagaa tgaaagaaga tgttttgcag gatcttccac ctaaaattat tcaagactat 420 tattggactc ttagtcctct ccagggtcag ctcttatgaa gattttgcta agtctcgtgg 480 ccagtgtgat gttgatggaa cagttcntca gctacacttt c 521 <210> SEQ ID NO 431 <211> LENGTH: 242 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2926914H1 <400> SEQUENCE: 431 ggccgtacca ctggcatcgt gatggactcc ggtgacgggg tcacccacac tgtgcccatc 60 tacgaggggt atgccctccc ccatgccatc ctgcgtctgg acctggctgg ccgggacctg 120 actgactacc tcatgaagat ctcaccgagc gcggctacag ttcaccacca cggccgagcg 180 ggaaatcgtg cgtgacatta aggagaagct gtgtacgtcg ccctggattc gagcaagaga 240 tg 242 <210> SEQ ID NO 432 <211> LENGTH: 338 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3141751T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 140, 180, 190, 289, 292, 320 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 432 tcaacattaa tcaagaaatt cctccatctg caaaagtcag cctatgccat taaatacagc 60 caagatcata aaatacaaat gtcattaggt ctactgaatc ttgagattca ttcactagaa 120 tacacaggga aaaggaaaan gtttgccctt gtgaaaggtg tgtatcattt tttagaagan 180 cttctgaaan tctcaaacat ctgtgagtgt gctaagagcc gttacaaagg tattttatac 240 aatctatgct gagtcagcta ggagttagca ggaggctgga tgcagatgnt anaacatacc 300 cctgcagatc tgttgttatn aagggatgac ctttggaa 338 <210> SEQ ID NO 433 <211> LENGTH: 320 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3537363T6 <400> SEQUENCE: 433 catcctccag tttcttgatc ttggcctcag ccgtgacctt ctcaagttgc agcttctgcc 60 tggcagcttc ctcctcctcc agctgttctt caaggtccag catctgctgg gccatcttct 120 tcctttcagc ctgtagctgc tggcccctgt cttcctcctc ctccaggcgg gcctccatct 180 catgcagtat ctcctccagc tcctgcttct tggccgccag ccgcacccgc atctcctcag 240 cctctgcata cagctctgtc tctgcctgca gctgttcctg tagcaggttc ttctcctcgg 300 gtcagctgcg agtgcttctg 320 <210> SEQ ID NO 434 <211> LENGTH: 386 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3967402T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 111-112, 185, 193, 196, 251-252, 257, 278-279, 283, 307, 338, 363 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 434 ccacagttca atcccctagc ctatacgatg ctctttcccc tggccatcat ctttccctcc 60 ctgtcaccta cacagtcaac ctgtcccaaa ccttggccca cttcatcctg nncttctgcg 120 gtcacagctg cctgctgggt gggagtccgg gggaatggta tgtgtggtca ccagagggca 180 ctgantgggc ttnagnggca tgtgaatcct ggcagagtct cggatccccg atggggagag 240 gagaaagcag nngccangac aacgagtggg ggaagganng ccnggctaag tgacgggtgg 300 ggggtcnggg ttgtaactcc agtgtacaca ttgacagnct ctatattggc ttcaccagcg 360 ctnctctgtt tgtctcgtcc ctggat 386 <210> SEQ ID NO 435 <211> LENGTH: 419 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1218810R6 <400> SEQUENCE: 435 cgcttgggag aaggccggaa gcttaccagc cgagaaggaa ttcctagcta gcttcagagc 60 cgggtaggtt tgcctgggac cttgtaggcc ggctgtgggg gactccccgg gtcgcacagc 120 cccattgttt gcatattgcc cgagcaggcc acggtggcct gcgcgcccca ggactcgcaa 180 gcagctccga tcggttggaa ctcggggcgg cggcagcagc gctgagccgg cctggatgag 240 gagatgcagc ttcctgcagg ggccaaggaa ggatctgggg acaaactgtc cggaactctg 300 ggccagggag gcgagaagga gagagagagg aagagccgag gcagatggag gactttggcc 360 acaactgcca tgtactcaag agtagaaccg agtgggtaat gggtcgcttt gctttttgt 419 <210> SEQ ID NO 436 <211> LENGTH: 514 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2747633T6 <400> SEQUENCE: 436 tacagcagat aaaatcagtg ttactgctct cagatgttaa ggttagcaac ctttctggca 60 tatgctaatt catcatgaac tcccaatagc tgaactgaat ggcttttaag tacagctata 120 aggtctcatg gtataattcc ttttgttgat gccagtgaca ggattttaaa agctacattc 180 cattaaaaat taaaaataca gcagcttttc caggggaact agatcccaaa attgtaccca 240 gaactcttgt ctaagatatt aagttaaata tcttgcatgt atatatcatt atagtaaatc 300 agtattcttg acaaccacag tgtaagaaat taaactttgg ctaattgttt tccccatcat 360 gaaatcagtc ttttgctgtc ttcataaata aattatgacc aaacattaca aatactttat 420 acatgtttac tgatttacag agaatattta ataatcagaa ctcaccagtt tcatagtatt 480 gtacattaaa ttataagcat ataaccactg ctac 514 <210> SEQ ID NO 437 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3119391T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 401, 409-410, 415, 425-426, 434, 448, 450 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 437 tcagaggctc tgggtaatag cattcctgag attgatgaca tccattacct cactagtcca 60 acttctccag actaacgcag acttttctct tcccttggcc tttcctctcc tcgccattgg 120 gccaattcct tcgatttctc atttcccttg aagttagggc cattcacagt ttcatggtca 180 aagccagttc caggttcaat agtctgtgat ttatccaggc tctgaggtat gcaccgcttc 240 tgttttgctc gttcctccaa gagctagttt ggccagaaag gggatgcttt ataccataga 300 acacatccac cttctagaac ctgctctaga aggccaggcc ctcagattcc acatggttgg 360 agttctggcc aagtctggag ctttcttcac actcggctct nagagctcnn ggttnagaaa 420 aaacnnagca tggngagaga agacagtntn agaccgaggc ccctggagga cct 473 <210> SEQ ID NO 438 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2052083T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 17, 28, 30, 233-235 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 438 attcagcagt acgaaanccc tccctggncn ctcccaccct ctcatggtcc acaactggta 60 gaaaggtcca gaaatccttg agctctggaa aggtccctgg tcagtccttg gggagctcag 120 atagctatat tggaagaacc tgctcaagta cggttcttga tgtctgggga atcctttcgg 180 ggaagatcac ttcaaactca ataatgaggt ccccacgttt ctcgggtgtt ttnnngaggg 240 ggaggccttc tccaggaact tttcgccgca tgccaggcct gataacatct ttgaatacga 300 cgggtatcgt cctgccgtcc agagtgggga cgttcactgt gcagccacac agagcctccc 360 ggaggctgat cctggcagga taaatgacat cagagccatc tctcttaaag atattgtggg 420 gcttgtcctt taaaacaaag acgatatcag ctggaatgtt gttggaggtc tggtctcctt 480 ccttggggaa agtgattttg gttcttcttt ccaacccttc ttcacttcga tggtcaatat 540 <210> SEQ ID NO 439 <211> LENGTH: 141 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2701222H1 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 14, 124 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 439 ggctattgta aatnatggtg ctatgtacaa atatctatat tattgtattt acaagtataa 60 tgctgtaatg tacacacatc tttttgagat cctaccttca gttcttttga gtatatagcc 120 agangtggta ttactaaatc t 141 <210> SEQ ID NO 440 <211> LENGTH: 444 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 708939T7 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 2, 189, 358 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 440 gngcagcatg aaacaccaag agccccactg ctttctgctt tagaagcagc tttggtgcag 60 aaaagattcc cgtttcccca ccgagttctg ttgtctctgt acacacaaga agccagaaga 120 tatttttttt tcagtgaact ttctcctgga agcaaaggag aagctatggg agatccaggc 180 atggttttng cttctggagg ctgttttttg gttactgggg tctcttcaaa gcaaaacggg 240 atcaggatga agagggggaa aggcatgggc cataaataaa taaggaaatt tgccccgatt 300 ctacaaatgc atctgatgga atgaggaggg tcaggctgtg agggattggg ggtagctnca 360 ggctgctgtt agggacacac ttgagctggt tcattccctg gagtgccccg caactgcgtc 420 tagggagagg caggcccaag caca 444 <210> SEQ ID NO 441 <211> LENGTH: 502 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1964291T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 305, 396, 402, 417, 487 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 441 catattggct ctattaaaaa ctcaggtaat aaagcactaa gcttgatttt tgtattgcta 60 cagtctcttt cttctaaggg gaagaaaatc tccccaagaa taggatgcta cctgaggaat 120 tatgccgaat aaagaaaagg aatggatggt cggcagtgaa attttcttcg ggcatcaaca 180 tgcagaaagt tgcgatgcct gctgtggcag ctgccgcctc tgttccctct tcattcactt 240 ccacaaatga cttgtggaca atttttgata taaaaatatc tctggctcct gacatgccag 300 acagntcagc cttgctactg ttaaagagat cctgcacacc taggcgggcg aggtcggagt 360 tgagagtgta actctcttcc agtttgaacc tgggcnagct gncattaact tcaatgnaat 420 cgagattctc aggttagtcc actcatgcaa ctttttccaa agtcaactgt tcctcaatct 480 tcttcangcc cgtggactcg tc 502 <210> SEQ ID NO 442 <211> LENGTH: 579 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2455118T6 <400> SEQUENCE: 442 ccctttaatc agaaagtctg attaaattca atagtaactc aaactcttaa aaaatttctg 60 gaaaagtcaa caggatacat acatcacaga aaagcaggca gctgctgaca gttctttggt 120 ggaaaagtaa gttgcgtact tacccaagct gcccaaatga ttatcaagcc aagtttgttt 180 ttcaaaaata ggttttaaga tacaccaaag aaactataca atacaaaaat ttaacaatga 240 agttaaagta tatagcaaaa gccaaatatg acaacacaca tgtataatgt agaaaagaat 300 cctttcagtc ctagaaaact aaaatgggga gaacttactg aagggtaaca tacataaaat 360 gagtactaat agcaaggaat aatcctaaac attttcccaa taaactgact aagcctcaaa 420 aggacagctt aggaaaatga ttaacatgca gtttttcttt tttcctagcc aattcagttc 480 tacttagata aatctggttg ccaatcaata catatataaa ttaatttttt tctgctccaa 540 ttactaccat tttttctttt caccttttcc ctaattttc 579 <210> SEQ ID NO 443 <211> LENGTH: 378 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2839121F6 <400> SEQUENCE: 443 gtttttaaaa ctataaatgt tgtctttttt atatttttat gaaaaagcag tagaaaatta 60 cttttgaaga aaacaggcta tttaaatatt gaaatatatg tatgttgtga gtttaaggag 120 cctgtaattg tcagttttac aaaaccatct gtgttcaatg gttgtaaata aattctcaaa 180 acatcatttc aaaggctgcc tacagaatat tatcacttga cagatagagt taataaatta 240 ccaatcaggc acattttata atgtttgtct ctgtaaaggt aatattagca gttaaagaac 300 acggatgaga aaagaatgtg ttacataggt tgcatcactt gcagttaaat aaaactcaca 360 atttgtgctc acaagctt 378 <210> SEQ ID NO 444 <211> LENGTH: 569 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 356774T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 481 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 444 gaaaaatata taaagccaaa agctcataat aaaattaaat catgatacaa ccaccacagg 60 caattaccat caaatacatt cccatgattt acaaatgtat cgcttataca gaggaagttg 120 caaaatcact gccagtacag acacatccag tctaattaac tatcgtctat tcatacaaca 180 gcaacaactg cagctcctga gaccacagaa ggacacagtg agcagctggt gactgagcca 240 gggtagcctc cgatcaataa ctgatcagag taatgagact tcgagaggaa tgcctataag 300 aaatctcaaa aggtatttgt ttgggtgcag aaacaaatgc accctccaca tttggatttt 360 ctctagaaga atctgtggcc aaatctctta tccaatggag gtactgagtg gctggatcag 420 ttaccatgca agctcacgat gaatgagatt gaatttggtt ctgtgtgcac actgggctct 480 ngggagggag gacacccctg tgtgttgctg ctgcttccgt gctgtctact gtatccttca 540 tgtgtctcca aatgggacat gccccatgg 569 <210> SEQ ID NO 445 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 414523T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 19, 53, 73, 77, 139, 141-144, 322 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 445 tgcttaatgt gattctgana agttctttga cattctcata aaaacagcac atncccaccc 60 acccttcaaa gancaanacc cagtttgtca agaaaaattg cgtgccagtc ttttctggtg 120 ctgaatatgt atgttctgng nnnnttcctg gacactgctg gtaaatttag aaactcgttt 180 agaaaagcac ttctctcgta ttcaacagcc tataggctca tggcgcagaa tctaagggaa 240 aatggctaaa tccagcttgt gaattcgcgg gctgtgatga ttctttccaa gtaaataaaa 300 accctcggtt cgccccgacg anccacataa tctgttcaaa tccaacaagg aaccagattt 360 tggacgcaaa gaaggatacg ttctactcgc 390 <210> SEQ ID NO 446 <211> LENGTH: 429 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1359550F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 26, 66, 186, 216-217, 241, 267, 310, 318, 387 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 446 cgccaccttt ctgctgtgtc gctccntccg aaatcacaac acctacctcc acctgcacct 60 ctgcgngtgt ctcctcttgg cgaagactct cttcctcgcc ggttatacac aagactgaca 120 acaagatggg ctgcgccatc atcgcgggct tcctgcacta ccttttcctt gcctgcttct 180 tctggntgct ggtggaggct gtgatactgt tcttgnnggt cagaaacctg aaggtggtga 240 nttacttcag ctctcgcaac atcaagntgc tgcacatctg tgcctttggt tatgggctgc 300 cgatgctggn ggtggtgntc tctgccagtg tgcagccaca gggctatgga atgcataatc 360 gctgctggct gaatacagag acagggntca tctggagttt cttgggggca gtttgcacag 420 ttatagtga 429 <210> SEQ ID NO 447 <211> LENGTH: 390 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1521513T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 15, 66, 181, 183, 215, 221, 235, 255, 262, 271, 286, 289, 294, 302, 327, 333, 361 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 447 taacaaatac ttatnaagtc ctttgaagtt cagcgcacaa atttctcgtg tggggcggtg 60 ggtgtngcca tgttcttgct cttccttctt tacacatttg agttgtgcct tctgttctta 120 aagagatttt cctttgttca aaggatttat tcctaccatt tcacaaatcc gaaaataatt 180 nangaaacag gttacatcat tccaattttg ccttngggtt naagagtctc tcatngtggc 240 acagtcctcc agggnaacta tnttgttggg ntcccctaca tcccanaanc tcanagactt 300 tntcaaaagt gtgccgttca cccattncca ctnaccctcg acaacctggt ctgacagtcc 360 nataaaaaac tctctcattt taggtttctt 390 <210> SEQ ID NO 448 <211> LENGTH: 449 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1667912T6 <400> SEQUENCE: 448 aaaattccat agttatatac agtaacatca atttcaacaa cagcagtaca aagcacacat 60 ttgacttaca ggagcactga ttgccaaaga ataccaaagt gtttcacctt gatgatccat 120 gggaggaccc cacaacacta cagacaggta ggagggagaa caatgacatt ttgccgtgaa 180 cttagttgag ctcacaggaa aacaaaaaca aaaaacacat caccaggatt ttgcatttta 240 cattcactag gatgtatgac agatagagtt aaaacatcaa caacttaaat ataattaaat 300 actttttaag aaatattatg ctttaaatta tttaaaaata atctctttgt ggatgttata 360 ataaaataat gtcacactgc acctggggga ggttggggaa aataaataag cttttcttca 420 agctctgact ctcagtccat gtatgaagg 449 <210> SEQ ID NO 449 <211> LENGTH: 204 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1694490H1 <400> SEQUENCE: 449 gtctggaggt gtccaggctg tggggaccac attgctccaa gccagatatg gtacaggact 60 gtcaacgaaa cctggcacgg ctcttgcttc cggtgttcag aatgccagga ttccctcacc 120 aactggtact atgagaagga tgggaagctc tactgcccca aggactactg ggggaagttt 180 ggggagttct gtcatgggtg ctcc 204 <210> SEQ ID NO 450 <211> LENGTH: 521 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1818802T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 445 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 450 acatagagag caagtccatc cattcatccg tgataaaatt ttagaaatat tttctataaa 60 atgtttagta tttaattgga aatgaatcca gtataacatg acttccacag atacagcatt 120 cccatcctca ctcccattcc tattttgaga aattttaaaa atacagaaaa gtacaaaaaa 180 taagacaaga tatccctata ccacaatcca gaatcaatca gtatcttctt atatttactt 240 gaagtctttt gaaagagaag tggatgttta tataaaaagc tgaagtcccc tttaaccaat 300 acccatccca cctcccacac tcattatttt cccttctcca ctcttcacag gtgaccacta 360 tcaagagttt ggtctgtatc ttccaatccg gttcaaaaac atgtacatac atatatgcat 420 ccattaccaa tagatagtac tgagntttat gaggaacttt taattccaat ttacaaaaaa 480 gtcattgtac tatctgtatc attctgcaac ttgattcccc c 521 <210> SEQ ID NO 451 <211> LENGTH: 75 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1855389F6 <400> SEQUENCE: 451 ctcctgaagc cagcgagacc acaagcccac tgggaggaac gaacaactcc aggcgcgcaa 60 tgaacaactc caggc 75 <210> SEQ ID NO 452 <211> LENGTH: 442 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1905291F6 <400> SEQUENCE: 452 agcctgcata taatttttta ccttgtggca taatcagtaa ttggtctgtt attcaggctt 60 catagcttgt aaccaaatat aaataaaagg cataatttag gtattctata gttgcttaga 120 attttgttaa tataaatctc tgtgaaaaat caaggagttt taatattttc agaagtgcat 180 ccacctttca gggctttaag ttagtattac tcaagattat gaacaaatag cacttaggtt 240 acctgaaaga gttactacaa ccccaaagag ttgtgttcta agtagtatct tggtaattca 300 gagagatact catcctacct gaatataaac tgagataaat ccagtaaaga aagtgtagta 360 aattctacat aagagtctat ccattgattt ctttttgtgg taaaaatctt aggtccatgt 420 ggaaggaaat ttccatggtg ga 442 <210> SEQ ID NO 453 <211> LENGTH: 606 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1968621T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 504, 598 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 453 gcactcagca ggatggctct agagatccgg cctcccccag tctctaaact gcttttcagt 60 taattttctg tctctttgcc tgctgtatat gagtaatgag actgtttttc ttggtaggtt 120 ctcgcatact ctccaggatg tttgggtttt tagagacacc tggtcctcag ctggggacaa 180 tggccatggc tcattacctg gccttcaggg ttcaagcagg ggacatatac ccctaaataa 240 cctaaagggg atccatcaca ctacaaccac cacctccacc gccatcatca agaagccact 300 ggctgactga gatacacttc caggaggaca agacagagtg gatgctggaa agacagggca 360 ggggaccatc accagggaaa gacttcattc ttggaaggac atcgaaccgg gggcaggtcg 420 gtagtggagc cgctgtttct tctgctgtat ccaaaagttc taactcttcg gctttctgca 480 ttttcagctc tttcttttcc tggncttctc attgctggtt cctgcacacc tcccctctat 540 tcctcccccc aatatattcg ttagtctaaa ggaaatttct tcttcctatt ccccacantc 600 tccagt 606 <210> SEQ ID NO 454 <211> LENGTH: 169 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 522294T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 109, 122 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 454 ttattttact gtgtacgccc aggatccagg caatctttcc agacacatct acttcccagt 60 aatatttccc cgaagagaaa tattggcagc cgaagacacc aaaagcagna aaatcacatg 120 gntttgaatt cttaaatgtg caggtgcgta cagtttcact gtctctgat 169 <210> SEQ ID NO 455 <211> LENGTH: 323 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2469208T6 <400> SEQUENCE: 455 atatactgtt ttaatggata caaaaataaa tattcattca gcatattaaa gatatgtgct 60 ttgacattca tttgaattgg agattcaagc ctattgttat cttatgaaca cttcagcaaa 120 caggactgcc attcttaaaa atataatgct ttgttggaca aaagggacaa gccacgtccc 180 ctggtcctct cctctattcg cctgtgaact ccatccacac gtaaaggacc tctgggtctg 240 actgtcccct ccacaggcat ggtgctggga aaaggaaaca ggcatatctg gctttcagat 300 tttaaaccgg aaactctcac agt 323 <210> SEQ ID NO 456 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2642654F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 445 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 456 tttttctgcc tccaaaaggc tgggaatggg aaggagagtg gatagttgat cctgaaagaa 60 gcttgctgac tgaggcagat gcaggtcaca cggagttcac tgatgaagtc tatcagaacg 120 agagccgcta ccccgggggc gactggaagc cggccgagga cacctacacg gatgcgaacg 180 gcgataaagc agcatcaccc agcgagttga cttgtcctcc aggttgggaa tgggaagatg 240 atgcatggtc ttatgacata aatcgagcgg tggatgagaa aggctgggaa tatggaatca 300 ccattcctcc tgatcataag cccaaatcct gggttgcagc agagaaaatg taccacactc 360 atagacggcg aaggctggtc cgaaaacgca agaaagattt aacacagact gcttcaagca 420 ccgcaagggc catggaggaa ttgcnagacc aagagggctg ggatatgctt ctc 473 <210> SEQ ID NO 457 <211> LENGTH: 605 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2651610T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 7, 310, 314, 405 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 457 gaaagtntcc cttccaaatc acagctgtaa ctaaaatcca accattccag gaaatagaaa 60 tatcaacttg ggggcttcct gagaatgtca gattgtggat tgcaagagtc aaaaagagat 120 tttccagtcc aacctaccca ctggacagat gaggaaactg tggctgaagc gagggtgggt 180 gtctgggagt aggaaggggg tgtgggccct ggcggatggt gctggagcca ccttgcagcc 240 accacctggg caccccctgg ccctgccctg gtcctcccta tcatggctgc tgttggtact 300 ggctctctgn gccngttaga agtcatccag cacactctgg atgtattcga aggtcggccg 360 ctcctccgga cggtttttcc agcagcgcat catgatgttg taganctcct ctgggcagtt 420 ctctgggcga ggcatccggt atccacgctc cagagctcgg atcacttcag ggtttgacat 480 ccctgggtaa gggatccggc cgtaggtgac gatctccatc agcaggatac caaaggacca 540 gacgtctgac ttgatggtga aggagccaaa gttgatggct tcaggagctg tccacttgat 600 gggga 605 <210> SEQ ID NO 458 <211> LENGTH: 400 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3558108T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 133, 182-183, 374 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 458 ctccgacagg acgcacacac acggcactca tgctcctaaa acactgggtt tgtgaaggga 60 cattataaaa atgaggaaat aagctgtgat gttcagcatg tgtcagtttc taggaataca 120 gagaagggga ganctgcaag gtggagcgat tctgagggct gaaaatccct ttcccagtac 180 gnngacagca tccttcaatc ccgccagctc atgtgcatct gagggtgggg ctctgtcttc 240 atgctagaaa ccaaactgct ctcacagctt cctgctaaat caccacggct aacggataag 300 cagagacgga ctatccagtc tgactactgg gcactcaagt cgtcagtcca gtggctaccc 360 gggaacgggg gcanacagtg tgcgtgcacg tctacggggc 400 <210> SEQ ID NO 459 <211> LENGTH: 416 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3810351T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 145, 266, 331, 352, 355-356, 376 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 459 ttaaaacaat gagaagtgtt attgtcatta tactgccatt ctataaactc actgatacaa 60 tctgcccggg attcctgttc tttggccaat cgaactctct tgatcatcgc ctcaatttca 120 tctctagcct gcatcacatc tctgntaatt cccaaaacct taatcaaagg tctcttatgg 180 tccagggaaa tgtaatattt aacttcttct gcagctcatt caactcctga tactcctttt 240 catcaaagtc tttgatgcac tcatcntcac tggtgtaagg acactgttct ttttcaatca 300 ggtcttgtag ccaggagata gcgtattcca nacacgtgac atttttacca gncanncgaa 360 aagttgctga ttctgngttc ttttccaaaa ccaaatgatt ctttttttgg ggagat 416 <210> SEQ ID NO 460 <211> LENGTH: 443 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2075438T6 <400> SEQUENCE: 460 gtccagcagg aaacccctta tagaaaaccc aaatcctcat cttggagttt ctccttcagc 60 cagggcagca cttgaaagag gttgatgtga aagtctcggg cgtgagcagg tacctgcttt 120 tgccgcttct ggtttttgca gacatccact actccccagc tgattacacc aacttgaatg 180 aaacgacttc tcttgtgaac tatcaagggg ccgccagaat cacctctgca agtattgggg 240 tcagcatagg gactcactcc tccagtacaa aggaaccgag gggtgaccac ctctgagatg 300 tccttgactt tgtcatagcc tggggcatat tgagcatctc tctcacagct gcctttctta 360 tccccattct tgatgtagac ctccttccga gtcagttttt ctcctcctca gacacaaaca 420 gagctttgat atcctgtgca ggg 443 <210> SEQ ID NO 461 <211> LENGTH: 430 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1929583F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 215, 282, 297, 328, 357-358, 377, 380-382, 402, 410 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 461 gagacatgag cctccaactg tgtggttggg ctcggtagca catcgtggga cttgggtgtg 60 cgcccacaga tggtttggcc ctgcagtgac cagagcagcc caagccgcca ccatggtgaa 120 attgctagtg gccaaaatcc tgtgcatggt gggcgtgttc ttcttcatgc tgctcggctc 180 cctgctcccc gtgaagatca tcgagacaga ttttnagaag gcccatcgct cgaaaaagat 240 cctctctctc tgcaacacct ttggaggagg ggtgtttctg gncacgtgct tcaacgntct 300 gctgcccgct gtgagggaaa agctccanaa ggtcctgagc ctcggccaca tcagcannga 360 gtacccgctg gccgaanccn nnctcctgct gggctttctt cntgaccggn ttcctggagc 420 agtgatcctg 430 <210> SEQ ID NO 462 <211> LENGTH: 465 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1870501F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 394 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 462 ttggagtgaa aggatttgtt aaagattcca taacaggatc tgggttagag aatgcaacca 60 tctcagtggc tggtattaat cataatatca caacaggcag atttggtgat ttctaccgat 120 tacttgttcc tggaacttac aaccttacag tagttttaac tgggtatatg ccattgactg 180 ttactaatgt agtggtgaaa gaaggaccag ccacagaggt ggatttttct cttaggccaa 240 ctgtaacttc agtaatccct gacacgacag aggctgtatc aactgctagc acagttgcta 300 tacctaatat tctttctgga acatcatcct cctaccagcc aattcagcca aaggactttc 360 accaccacca tttccctgat atggaaatct tctngagaag gtttgccaat gaatatccta 420 acattacccg gctttattcc ttggggaaat cagtagagtc aagag 465 <210> SEQ ID NO 463 <211> LENGTH: 531 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1873942T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 53, 97, 329, 413 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 463 tcctttattt gtcccaactg aggggtgggt gtggggtgtt aaataagatt tgnaataggt 60 ggggacgctg tacagggggt ccgggaaggg ggctggnggc aggcagcagg tcagtgcacc 120 tgaggctggg ggtgcccgtg gcagagccct cctggtggct cagggggtgg gcccagcttc 180 tctgcctcct gctccactga ctggctcccg tacgcactgt cttccttcac ctctgtgctg 240 ggcagcttgt ctcgggtttc tggacccctc agcagcctca ctccctcctc taggcccatg 300 tcagacaggg cctccagtag acctgccang tccccgccag ccagctcgta gctgcgcagg 360 aggctgccac tgggtgaggt tgtctgtcgg tacgtgtcta ccaggctgcg cancccagac 420 gctctgccag ctctgcccag ctgccctggg cttctggccc gtctagcagc tgctccaggt 480 tctgcagagc tgtatcacca agtgacagtc ccggccctgc tgggctgggc g 531 <210> SEQ ID NO 464 <211> LENGTH: 498 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1865713F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 16 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 464 aagatgtttg gcgtanagag ttaaatctca aataggctat taataaagtc tacaacatag 60 cagatctgtt ttgtggtttg gaatattaaa aaacttcatg taattttatt ttaaaatttc 120 atagctgtac ttcttgaata taaaaaatca tgccagtatt tttaaaggca ttagagtcaa 180 ctacacaaag caggcttgcc cagtacattt aaattttttg gcacttgcca ttccaaaata 240 ttatgcccca ccaaggctga gacagtgaat ttgggctgct gtagcctatt tttttagatt 300 gagaaatgtg tagctgcaaa aataatcatg aaccaatctg gatgcctcat tatgtcaacc 360 aggtccagat gtgctataat ctgtttttac gtatgtaggc ccagtcgtca tcagatgctt 420 gcggcaaaag gaaagctgtg tttatatgga agaaagtaag gtgcttggag tttacctggc 480 ttatttaata tgcttata 498 <210> SEQ ID NO 465 <211> LENGTH: 558 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1726703T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 515, 536, 539, 554 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 465 ataagaacag ataatttaca attaacatta cagtatgtac attgcaataa atacatggtt 60 gtaaacagac aaacaagact gtattacagg taaggtcatt tggtgagaaa aaaaatgcat 120 ggcacaaaaa ataaataatg cattcaaaaa ttatcataaa gctttctgta aaatccattt 180 cattcaagtt ttttctttcc ttgtctgtaa tttgttctat ctacattatt gtgaatttta 240 actgatataa aacaaaatta aaacagcatt attgtgttca gtaacttgca agctgaaatg 300 cactggtttt atacaaactt ggacattttt ttccccatac agtacccaga tattgcattt 360 tcttatggca ttttaggaaa tgtaaagcca cttgtaaaag gatattcttt tattcttttt 420 taaagcagta tatatttctg aagcacactt tgggcaagag agaagggcaa ggataagccg 480 ttgtacagtg cattagtccc tggtctcttg gatantgagc cttttctggc aatttngant 540 ggtcccatta agtngggg 558 <210> SEQ ID NO 466 <211> LENGTH: 437 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1738538T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 196, 206, 229-230, 239, 243, 252, 255, 265, 267, 299, 302, 306, 318, 346, 350, 391, 394, 422 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 466 cattttatta ttcccaaaga atcaagccca tcatgagtag cccacatggt tgctgttcaa 60 aggtactgaa aagggaggca tttggtcacc attacccatc aaggaactct ttacaaggat 120 aggttccaag tccttcgtgc tgctcttggt cattcagtga ctgcagtttt ggcccagaag 180 ccatccaaga tgagcnagtg ctgagncatc cttaactcat acctagatnn aacaacttnc 240 gcngaaacgc tngtnctccc cagtnanccc ttagcatcat attccaatac aggaaaggna 300 tnaggncagc tttcatgnga tacatggaaa ggcgctcttt gctttnatcn aaggggaagg 360 tttctagcgg tctgctttgt agtcaaactc ngcnagaatc acacggttgt agccggtcac 420 cngtggacat gatgtgt 437 <210> SEQ ID NO 467 <211> LENGTH: 276 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1742602H1 <400> SEQUENCE: 467 gacagagttt gacagggaga tagaccgggg atccctcaac cctggaaaac agctgtttga 60 gaagatggtc agtggcatgt acttgggaga gctggttcga ctgatcctag tcaagatggc 120 caaggagggc ctcttatttg aagggcggat caccccggag ctgctcaccc gagggaagtt 180 taacaccagt gatgtgtcag ccatcgaaaa gaataaggaa ggcctccaca atgccaaaga 240 aatccaacta atggtatata ttgtagggta cagaat 276 <210> SEQ ID NO 468 <211> LENGTH: 424 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1822751F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 381, 386 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 468 cttcggcagg gtcagccttg cgggtgcttg tggagtgggt ggctatggca gccggagcct 60 ctacaacctg gggggctcca agaggatatc catcagcact agtggtggca gcttcaggaa 120 ccggtttggt gctggtgctg gaggcggcta tggctttgga ggtggtgccg gtagtggatt 180 tggtttcggc ggtggagctg gtggtggctt tgggctcggt ggcggactgg ctttggaggt 240 ggcttcggtg gccctggctt tcctgtctgc cctcctggag gtatccaaga ggtcactgtc 300 aaccagagtc tcctgactcc cctcaacctg caaatcgacc ccagcatcca gagggtgagg 360 accgaggagc gcgaacagat naagancctc aacaataagt ttgcctcctt catcgacaaa 420 gtgc 424 <210> SEQ ID NO 469 <211> LENGTH: 508 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1823789T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 472 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 469 tatacacata gtaaaaatta aagccatgta tattatttaa aaatctaaag tgtttaaata 60 attctaccag ttgttttatc actggacaag aaatgtatta ggtttgatat ttacaaagat 120 gtttatgttg tctgctattt tctattatag gtttattcaa agagaatatc acctatagca 180 taaataatta aatttttcaa taaaaacaaa ctaaaaaaac cctagaaaca tttgacatca 240 ccaaattcaa cagctctcac tagaaatcca agcaataaac ttagatattt gaaataaaca 300 taaattatga ttatataact ctaagtcaca tacataattt tgaattatag taatagcact 360 gtaaacatga atacaaagga ttacagtttt atacagaatt ttttttgttt ttcttctttt 420 agggcttatt tctccttgga aagaacagaa tgatctttta aaaaataaga gntatatagt 480 aaatccagaa aaaaattcca atagctgt 508 <210> SEQ ID NO 470 <211> LENGTH: 448 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3214119F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 181, 259, 374, 392, 417 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 470 gtgaggtccc aggccccaca cccatggaac tggaggccga gcagctgctt gagccacacg 60 tgcaagcgcc cagcctggag ccctcggtgt ccccacagga tgaaacagag ccacaggcag 120 ccttaagcct ggtccccata cacagcgctg aagtggcagt tccagcggct gtccctgcgg 180 nagaggctga ggccgaggtg acgctgcggg agctccagga agccctggag gaggaggtgc 240 tcacccggca gagcctganc cgggagatgg aggccatccg cacggacaac cagaacttcg 300 ccagtcaact acgcgaggca gaggctcgga accgggacct agaggcacac gtccggcagt 360 tgcaggagcg gatngagttg ctgcaggcag anggagccac aggtccctag gcctggncta 420 tcggaggcgc tttccctgct cctgttcg 448 <210> SEQ ID NO 471 <211> LENGTH: 422 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3230628T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 42, 47, 58, 130, 288, 307, 317, 361, 405 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 471 cattgaatgt ttacacatac aaatacatct taaagataag gntctcnaaa ggtttttnga 60 cattccatca cccctgtact tggtggtcta tcacagttgt gtgtactctt gacttgacta 120 ggtgtgagan gatcgtatgc catcttgtac tctttatcaa aagcatctat atcaatgttt 180 tctcttccca gtgccacaag tgagagaaat agtatttctc tgtataaact cctctgtctt 240 ttaaaatgtg gacacttatt cagtgtctct aaaatctgac tcattggncc atagacatca 300 ttcattntaa tgctttntac catacttttc aacagttcct ggttaaatga gttatcactt 360 ntttgcaata aatggaccat tggataattc tgggtgcgag cactncagag aatgcacaag 420 gg 422 <210> SEQ ID NO 472 <211> LENGTH: 257 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2697170T6 <400> SEQUENCE: 472 tatataaaat agctattata aatgcacata gtgtattcta tagctgccag gtttactttt 60 ttttttttta aaggaaactg taagttacac tgtggttaag acttgtatct tcacccttga 120 aaaagcccac attctatcac agtgatgtat ggtcagactt aacagcccca attgttaaac 180 acttggatca agtcataacc agttttattg caaaaggacc ctgtacacat ttatcaactc 240 tagtacctta atagcta 257 <210> SEQ ID NO 473 <211> LENGTH: 257 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2605603T6 <400> SEQUENCE: 473 acatctaaat ggaaatcaca atacaaggaa agatttaaac caaagcctca gattttcata 60 caaacgacac gaccaaactt ctaaagtatt ggtattacat cttaaaattg tcccgtatcc 120 ttaaaaaaaa aaaaagtgta cactcacgtg ccttacagga tattaaacca aaaagctaga 180 attaacaaac atgccaaatg ttttcacttt gaatcgtaga cacagctcct atatttgagt 240 tttacagaaa aggcatg 257 <210> SEQ ID NO 474 <211> LENGTH: 518 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2618045T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 484, 496 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 474 atgtacattt ctttccacag cagcacttca ttcatctcta aaaaatttaa caaaattaag 60 gctaaatcag agcgagctga taggaagggg tattctatgt ggtggtcttc ttaaagaatg 120 ttctcataaa tataggatgt tctgcagaca agaaataaaa ataaaacatg ctgaacaaga 180 taccaaaaat gggaaatgca gtagaaaatg agcccctttc taccaatcta ctaagaatcc 240 caactcccct gggaagtttc agatgggatg tgagttcttt taatgaatgt ttatgatctg 300 atgctaagac tttctaaaat taaaattcca cagtactagg ccattttata aactaaaacc 360 aagggcagtt gagtctccaa tataatccct ctagaatttt ttaagttaaa gtggacaata 420 tttgaaagta ctaattttat ctgaagctgt ggtgcttgaa aggacaatcc ctccatttgt 480 ggcncttctc cctaanccca tgttattaaa ataaatga 518 <210> SEQ ID NO 475 <211> LENGTH: 576 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2633001F6 <400> SEQUENCE: 475 cctcgggtcc ccaagccgct gggagatgtc ccatgctggg ggtccgcacg tggctggagg 60 aggtggtctt ccatccgctc tgaaatcatg tttcttagag aaatgcctcg gatgccgccg 120 acgcggtgct gctgccgccg ctttcgggtt tggcccctca gaacccctcc ttttctgagc 180 gcttccctct taggcctcag ggcagtttga tctgtgggga gaaagagcag ccatcgctga 240 gcctgccttt taaaatatat gtgtatttcc ttagccccac tctaagaaat ctatgttcct 300 gagtttgccc tctgccctcc cactccttcc ccttctcccc tctaaacctt ctcccatctc 360 tttcaaaatc ttttcccaga aaggcaggct tcaaccagcc acttccagct ttgtgtcttc 420 tctcaattac atagcaattt ctccttccca ccatcatggg gaagctggct ctgcttttgc 480 cctttgtcat caccaacaca acagatagaa attaaatata agtataatgg gtgtgcgtgt 540 gtatgtatgt ggtatgtata tgcatgcatg tgtata 576 <210> SEQ ID NO 476 <211> LENGTH: 568 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2506614T6 <400> SEQUENCE: 476 gtactcaaag ttgtccagtt aaaatctact tcctcttgaa aaacaaaaat acactgaagg 60 aagatgcaaa gagctaaaag tggtatcatg attccacagc agtgattgta agacagtgag 120 ccacagggaa atgggaaaac gtgaaaagaa acaagtatca ggaccaaatt agagaagata 180 tgagtagggc catcactaga ggtgaaaatg gagaaaccta agaaaaccag tgttggcatg 240 aattatgcaa gtggaaaata catctgtaga gggacgagat agaaggacct agatctaact 300 ccaagtgctt gattggagaa gagagggaga aagagaattt atagaattaa ctgtatagaa 360 gcctaaaaaa taagattatc agcctagtca tgtaaagtct agaagttcct ttatttgctc 420 atcacctttc ctttttctat aagactatta agcagaaggt cagtaacaga aaatttaccc 480 tttcctctcc tctcttggtt taaattttat aaggaatctg aagaggctat ggatcagttg 540 gcttacagtg ggaagagctt attgaagc 568 <210> SEQ ID NO 477 <211> LENGTH: 504 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2972510T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 432, 469 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 477 tttaagattt acagcaatgg caattaacaa tatagaccaa aagcttcgaa tttagctgca 60 tacttttaaa aaatggtaag aagtaaaaga tgctttaaaa gctatccatc tcagttctta 120 aatggcatct aaaccttaga agtcaaatgt tacagcaaat atttgtaaaa gcaactgtaa 180 ataaaaccga acgcaaccac agcataatat aaccatgtag ccatagatat atgataaata 240 taaacaacag cttaatatta ggaccattag tcacagtggc aaaagttctt agatattgaa 300 aagaagatgt gttaggtcaa ctgctaagat ggtccacagt gatccctgcc tcctgatatt 360 cacaatctat catcaagata gcaggccatc ccaggacagc agtcaaggga aaatagttga 420 tgaccaactg gngcatcaga gctcaccatc ttggtcttca gctgttttnc ctggactgag 480 gtggtcactc ccatggagct ggtg 504 <210> SEQ ID NO 478 <211> LENGTH: 430 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2205246T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 138, 152, 158, 175, 185, 213, 223, 243, 258, 266, 288, 299, 306, 308, 316, 320-321, 328, 335-336, 343, 346, 371, 381, 392, 407, 420 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 478 tgaaatattg tataatatga caccaataaa ctgtgcaaag gtctttgagg tagagcctta 60 tttaaattct gcactcaaat acatatactt tacataaata tgatcttctc agagttataa 120 acaaagttta gaaatatngt aaaatctcta gnattatnag aggtaattta gaggnaaagt 180 ggccngcctg ttcagtaact gatatttcag canaaggtca tancttcttc tattgattca 240 tanagtgggg ttagcccntg gatagncatt tgtactaaca tacactgntt acattcatnc 300 tacagnanca tatgtnagan nccagagnat aatcnnaatc ttncancctc tgcatacact 360 cctatttggg nacttagcat nccactgcat tnactcttga tgaagtngtt ttcccaacgn 420 gattttaaag 430 <210> SEQ ID NO 479 <211> LENGTH: 230 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1902366T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 52, 113, 130, 195, 216, 223 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 479 aactctatag gtctagcctt tggaccaaaa agagaccctg gagcagtgag antctcacca 60 aggtcattcc caaatccaac agccgcagga ggcaggaggc agggaggaga cancacagcc 120 cccaccacan tttctgcaca caatgaggcc tgctgggaga agagaacatg aatgggaagc 180 tacagaagta ttganggaca gaagaacagg aaaatnggca ggngaggaaa 230 <210> SEQ ID NO 480 <211> LENGTH: 548 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1686561T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 383, 400, 450, 486 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 480 gtttggtctg aggatacaca agcatctggc taactcataa aagtagcctg aagtgattga 60 taggagagtg tttgtagtca tttccatttg ctgccacatc ccttacatta tctacttgct 120 aagcactgag aggcccagaa tggacacatc aaactgtcag gaggaacata tgggacactg 180 gcacctgcaa tggttttttt aaaagcagag aatgcagagc agtcacagac tccacttcaa 240 agccagggtg tgtggaggtc tccggggaag agctctgcac aacaggtttc ctgggggcca 300 gagggcctct cggggaggaa cagaaaaaaa ccagccagga gtgctaccga ccagcctcag 360 ccagaatgct gtcagaacaa ggncccaaac atggcctggn ctcagtgatc tggggatgaa 420 cggtgtcaca agggaaccac ctgaaaggtn ggcagaggcc cccgtggagg agccacatac 480 tcttcntctc tcagcagccg cagcaggatg ttttttttat cttgggccag ctgtagacat 540 gagtgttc 548 <210> SEQ ID NO 481 <211> LENGTH: 505 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1846209T6 <400> SEQUENCE: 481 cttaagagta tacttggaac cctcggagtc ctccatggac aagaacaggg tggcccatgg 60 acttccagcc aaaggctcca ctgtggggct gctttgggga gagactcaca gctggacttc 120 tctatccgac catgcaatgt tagccagcac caattaccca caatgctttg cccataagag 180 atagaaataa tggaactcac aggaagaaac agtattgata acatacacag gcttacagag 240 gccaggccca gtaattacca tgagacagaa gcctacaggt ggcggtgctt tgactgggct 300 gggattattg atacattact gatacatcac ttcttttata agcatatgta aaacgagtgc 360 tactgaaagt cgaaggacag cttccggggg agtcatgaac tctttcacta tctcatccgt 420 gacctccttg cgccgggcct ggtgctctgc gatcaagggc tgcagaacct ctatgagtgc 480 ctttcttgag ctcacccggt gaagc 505 <210> SEQ ID NO 482 <211> LENGTH: 533 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2472702T6 <400> SEQUENCE: 482 gagggcagag tgctccagag gagacccaga tacatcaacc aaggacttcc ctgagatttg 60 gctttgctct tccaggcctg cacatgctgc gtgatgaaat gaggcctgcc tagacatctg 120 tgagggcctc gagggctgct gcctcgactt tctccctagc taagtccacc cgtccaggga 180 cacagccagg gcactgctct gtgctgactt ccactgcagc caagggtcaa aatgaagcat 240 ctgcggaggc caggactcct tggcatcgga cacagtcagg ggaaaagcca ccctgactct 300 gcaggacaga gggtctaggg tcatttggca ggagaacact ggtgtgccaa gggaagcgag 360 catgatttct ggagtggact acatgcatgg tctggagttc agtaaactgg aaagtttcac 420 ccccaagtct taatttaatc aaaattgctg aactctgttc aatcttcatt gttaaaagca 480 gctttaaagc tgggtgattt cttagtcaaa tgtataacga agcttttact tat 533 <210> SEQ ID NO 483 <211> LENGTH: 361 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2746232T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 275 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 483 ctaggacttt tgacacataa gacaaagtct acatatacta ggtaaacaca agagcattat 60 taaatgggtc aaaaatgtca aaaaaaatcc catattctct tctggggaaa ctcagaaaga 120 tttcaagtat gagtgttaag aattagaaaa gactatcata agctttaaca ttctaaataa 180 taagtaattg aattatttca gtttagttac acagcatctt ttaaagtcca tctttgcaaa 240 ttatacgttg ctataaatac attgtgtatt tggcnttatg tgaatttgtt taatccagtg 300 tcaattgtct aatggtctaa agtgtcccat tgaagttata atctggatga actgaacaat 360 a 361 <210> SEQ ID NO 484 <211> LENGTH: 582 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 452968T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 417, 484 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 484 ttgcaagcat taaaccaagc ataggctttg attctgtgag cccaaattca catattgaag 60 aagatcaaag caaactgtga tccatgtaca tggatgaaaa ctaaaggctc gagttaatca 120 cattgtagtt tttaaatttc tacagcctag agctcactag tcacaggtct tttaggtcct 180 tctggatgtc ccacagggta tctgcacttt tcttgagctg agcaacctca tcatccttta 240 gcttctggtt gataacgctg gttaatcccc gggcattgag gatacatgga aggctcagga 300 agacttcatt ctcaatgcca tacatccccc tttaccattg ttgacacggg atgaatcctg 360 gatagatttt tcaacatgga ttcaataaga tcagccacac ttaatccaat agcccanttg 420 gtatatcctt ttagcttgat gacttcatag gcactttcaa ccaccatctt atgcacttcc 480 ttcnaatttt cactatcatt gtcagttccc atttctggat tcaattcctg gagagaaaca 540 cctgccacat tcacaccact ccacacagcc acacttgagt gc 582 <210> SEQ ID NO 485 <211> LENGTH: 470 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1491088T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 9 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 485 gcacaacang ggaactttgt ggggtgtctg tggcttgcta cagtgacatc tggcaggact 60 aactgggtca tcagagccac agaataagga ctgggaaggt ggccacaact gcaaggactg 120 gggccatgtg gggggaggac tctgagactg accacttggc tggtaacttg gctgtccagt 180 gtatgggaat ctcagtgagt tcctggcctg aagtcagact ctgtctctga cgcagacgtg 240 agaggtcgga gtggcaggaa ctgctcagct gctcatccgg gaacttgtcc tccaaggggc 300 tttgccattt gttttcttcc tgtacttgcc ggccccatca taatctccac caatcccgat 360 gaacttggat ccaatgacag ccttgatgtg gtcgaagtga tctgccacag tggacacatt 420 ggctgatggg ttgcactgta ttactcccat gatgtctgat acagacaatt 470 <210> SEQ ID NO 486 <211> LENGTH: 242 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1294238H1 <400> SEQUENCE: 486 ctcggctttg tttcctttca gggtggcttt gcaaaatgtt acgagatgac agatttgaca 60 aataacaaag tctacgccgc aaaaattatc cctcacagca gagtagctaa acctcatcaa 120 agggaaaaga ttgacaaaga aatagagctt cacagaattc ttcatcataa gcatgtagtg 180 cagttttacc actacttcga ggacaaagaa aacatttaca ttctcttgga atactgcagt 240 ag 242 <210> SEQ ID NO 487 <211> LENGTH: 431 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 884512T6 <400> SEQUENCE: 487 caacatctaa atttgcatca atttgataca tcgttgctca ttttgcagaa cataacagtt 60 gcacattgca agagtcaact tgcttcgggt cttttcatgc tcatggcggt ccacccctgc 120 cttccctctc cctgacctgc atcctgtcct ccacagtctg ccctgcctcc tgtcgccaca 180 ggttgaagac ccaagccctg aggagaacct gctgccaggg ggctggctgg ctgcgagcca 240 ggagggccag gcagttagcc ctgccacagg gaggggcagg caagggatcg tttctcctct 300 tcctgggctg agcccatgcc aggccagcca cagagtgccc tagtcagccc atgtggctcc 360 aggaagcctg ctgttgttct tctccatccc atttcacccg cagctagtgg ctaaactctg 420 gatactctga g 431 <210> SEQ ID NO 488 <211> LENGTH: 434 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 933140T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 303, 318, 344, 403 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 488 ttactaaaag ctcagttgta accactccta acaccactag cagaacctca agggagccaa 60 gagctcttcc cttttcccct gttaatttcc agtataatgt agcagcacaa ttatttcatg 120 tcacatttaa gaagaacaag aaccaattta tataaagtac aattgtatat ccttaaacat 180 tccacataaa cacactgtca aaactcactg gatatgctgg aattggagga cttaaatttc 240 tacatattat ttattgcacc cagagtactg gttaaaatgc actttctgtg aagatcaaat 300 gcnataacgt atgagggnat ttttaacact gtgaagtaca cacntaatat tataaaatgc 360 catttaattg gaaggagttt ctatcattgc aagtcataaa tgnaactttt taaagatact 420 agcagctttt acct 434 <210> SEQ ID NO 489 <211> LENGTH: 491 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1557811T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 436, 442 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 489 gatcctataa tgcatttatg catttaaaag cacagagaca caagtcctca tatatgaagt 60 tgttatggtt acagaaagaa aataaatatt tgtgcacaca gagatagcat gaaatcattc 120 tacagtgaaa ataatagcct ctggaaaaag ctttgaaaat cagagatggt gccatcacca 180 gacaacacaa gtgctggggt acagggcagc cctccatgca tctcatagca tttgcatggt 240 ttgtgagccc catttaatga cataaaatga gggcactgag ggaggaaaag tgaacagaca 300 cacaacccga gagcacattg ttatttgttt attttgtaca agtgatgtca taagcaagga 360 ttttgcctgt gttctagatt atctccaata aataaataac tatgtacaaa tattttgagt 420 ttacaaaata gaaganggaa anctttgtct taccaaagtt acatttctat gatacattta 480 tttccataca c 491 <210> SEQ ID NO 490 <211> LENGTH: 498 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1747645T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 451, 472 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 490 cttcaaataa gctgacacta tctggaaaac tcatctgtcc ctaaagccca caatgcgtcc 60 actgcttcgt cctcccatgg aacctgagcc tgacgtgaag gagtcagacg tgtgacagag 120 gaagagtctg agaagagaag acacctttac agaatgtaca gcgagagagc cggcctggcc 180 cccgggttac agtaagatgc acgggtcctt tcagtctcac ggactccaga cggccacgca 240 ggctgctcag atggacgtct ccttcctatc cctgctgggc gatggctttg ccggctcctt 300 gcctgccttt ggctgctctt tagctgcttt tggctcaagg acgccgtctc tgggcggctg 360 gacggcaccc ccgcgccact caggtcctcg tcctcctgcg cctgctgctc ggccttggct 420 cggtgcatct ggagaagccg cagctgcacg ngcagtcgat gatggcctcg antcctcatg 480 aattgttgat tcaaatga 498 <210> SEQ ID NO 491 <211> LENGTH: 357 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1862007F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 294 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 491 gcttagcaga cttgcgctgc accagcgaat ctgcctgggc tgctcctgtc ccacccaccc 60 tcactaagat ccatgtaagg ggctcctctt cccacctgga acttgtgagt ggggacccat 120 gatgtatggg tctcacctga cttgaggtga attttggagt gaagggccct gaggtcagct 180 cccaggtcgg tcgtgctggg ccaggcctgg ttttcacagg ggctgaagga tcccagtcca 240 cctgtgtgca tgtcagggct cggccgggaa gaagccagca aagtcccccg tgtnccttgc 300 tgagtattct gtcacagaca agctccatta aagccacagc agtgctaacc aacaaca 357 <210> SEQ ID NO 492 <211> LENGTH: 403 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1968661R6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 128 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 492 atcaattaat tcaataattg acccttgggt ctttgccatc cttaggcctc ctgttctgag 60 actaatgcgt tcagtcctct gttgtcggat ttcattaaga acacaagatg caacacaaac 120 ttcctgtnct acacagtcag atgccagtaa acaggctgac ctttgaggtc agtagtttaa 180 aagttcttag ttatatagca tctggaagat cattttgaaa ttgttccctg gagaaatgaa 240 aacagtgtgt aaacaaaatg aagctgccct aataaaaagg agtatacaaa catttaagct 300 gtggtcaagg ctacagatgt gctgacaagg cacttcatgt aaagtgtcag aaggagctac 360 aaaacctacc ctcaatgagc atggtacttg ggcctttgga gga 403 <210> SEQ ID NO 493 <211> LENGTH: 660 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2207534T6 <400> SEQUENCE: 493 gaattccaac tgattaccat ttacagtgat cacaatgaaa ctgctcagag ttatcactga 60 acttcagtaa gaaaatacaa cagagtgcca tcaggacagg ggagagggca ggagactgct 120 ccatcgctct gctcatgtcc acactgccaa ggtccccacc acgggggtcc ccagtgcacc 180 ccagctccgg ggcagaagag gcagcctgca gatctctgct gccgggaaag agctcctgaa 240 gttgtggggt ctggactctg ctggggacgg ggccttccgc gagtctccca cctctcgggg 300 gactgcaggg agaggcgtct ccagtgggca gccttgggtc acttccatag ctcccccagc 360 ggcttctctg tggcagtgcg gatggcgtcc tcagagagca cgcggatgtc ctcatggaca 420 gcttcgatgc ttttggaagc atccaccatc ttccagttca aagtcgtgtc tttcatgagc 480 tggtggaaac acggagcgcc cgctcctgga aagccccgtt ctcatagcgc tcatggccaa 540 acgctccccg cttggcagca tccgccagct gtaactggag gaacaggacc aggtcgggtt 600 tgggaaaggc ccacgtctgg ctgtttacac caatctaggg aaaaattctg ccaagaaaga 660 <210> SEQ ID NO 494 <211> LENGTH: 249 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2326622T6 <400> SEQUENCE: 494 taatgtttat tttaaatcta attgaaattt atctgaaaca acttatttca agtaacttat 60 tgtacagtcc attgtccatt taaaaatatt ttcttccaaa aaactgcatt gaaagacaaa 120 aaaattcttt tatacggcat atacgcgaga tgcaaacttc tgatgtaaat ttgtttcact 180 gtcaactccg atgataaaga tgagaggcac aagggttcac agttcagtta aatgatgcaa 240 acaaaaagc 249 SEQ ID NO 495 <211> LENGTH: 494 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2452694T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 37, 123, 139 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 495 tgggttgagg gtggaggtgg gggacacagg tgcgcantgc acagagtcag cagcagcagc 60 ctgctccccg cactgaggac tcggcctgga ctgcagtgcc tccaaatcaa cacgcagcaa 120 gangggagtg cagggaggnc cctgaacacc aagcctctga aaggctaagg gacacagctc 180 cagctgtccc aggaaaacca gcaataataa aagtgaggca cggccccacc cacacatatc 240 atctagtcac ccatcttcac tctggaggtc tgaagaattg cgacgatgac cccaaagagg 300 ccaatggcgc tgccaaagat ctccacgatg agaatcttta caaagaggct ggggttctga 360 gcatcggcca gggcagcccc actgcccacg atgcccacgc agactccaca gaagaggtta 420 gacaggccta cggtgaggcc agccccaaac atggagtagc ctgcatggta gttccgatgg 480 ccgatggctt gggg 494 <210> SEQ ID NO 496 <211> LENGTH: 199 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3441613F6 <400> SEQUENCE: 496 ctcacttcac ttagccgaca ttccatgccc tgaccaatcc tactgctttt cctaaaaaca 60 gaataatttg gtgtgcattc tttcagactt tttcctatac attttatatg tagaaatgta 120 gcaatgtatt tgtatagatg tgatcattcc tatattgtta ttgatttttt tcacttaata 180 aaaattcacc ttattcctt 199 <210> SEQ ID NO 497 <211> LENGTH: 500 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3518439T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 297, 348, 350, 352 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 497 atcaatacag tactctttta taatgaaacc atacttttgt tggagtcatg ttactttagt 60 gataattttc actccaaaaa tatttaagta ccaaatcaaa acactggttt ttaatggtgg 120 tttatagcat agtaaggtat tttacacaaa atatatttta aaactacaca atttctcctt 180 ttaagtgagc tcccttgtgc aagctgctga agtgtacagc agcagggcaa tgggcgtcta 240 taggaggtgg ctctgctctg ttctggggtt ggtccaaagt caggtggagt tccattntat 300 gaaaagcttg aaaaatctac cttaaggaga ctgaatatca ataccagnan cntctagagt 360 tcttgttgaa ttttcacaga aatactggaa ccctcaaaat cagatagtaa tttcaaacaa 420 cattaatttc agatgatccc ttttatttag aggccctgca tctgttttga tcaagtcaca 480 tagccttaca ccaacttatc 500 <210> SEQ ID NO 498 <211> LENGTH: 451 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3876090T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 18, 423, 433 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 498 attcaataaa cacaagtntt atgagtacct tgaagctcca gaatgtgctg gggaaagggg 60 ttgtgatggc caggaggagg atacccttca aaacgggctg ttccctaacc acatagaaat 120 gggaaaggga aaaaattggc agagaaagtc tagactctct ggcctaccat ggagcctagg 180 cccaggcccc caagatccca ccttccccaa cccccatggg actggagatt tttgtagctt 240 ccattggacc atgaggggca tgatgggagg cctgagttag ggtgaccttt tttgtgagcg 300 tctcatttga attttatctt cactgggtca tagatgtagc agcccacatc gccaatgttc 360 acacctttgg ggccaaacag gtagccgtag caggggacgt ggcagtaggg gactccatca 420 tgntcagcat gantcccagc agtcagggtc t 451 <210> SEQ ID NO 499 <211> LENGTH: 471 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 452336T7 <400> SEQUENCE: 499 atgtcaaaaa cgtatagcat ttccattgct tagcttccat ctttaaactt aaagctagtt 60 aaaaacaaca ggaacaaaag taaactcatt tgattctctc aaaaaacaag ctgtaactta 120 cctttgcaaa taattaagtt ctctcacttt aaatatcgta attcactggt cttcataata 180 aataattata ataatatata aaaggagaca gtggcctgaa ttattttgca gagaacattt 240 cacacatctt ttaaaaaaat cactaaacta ccacaactta aaacttgtaa gaataattag 300 gtaagagtta ttgtaatatt gaattaatat agcacctaga aatttgaaat ttgtaatatt 360 tcagatgata tgatttactg agaaaaagag taatgatttt cttcagtgaa ttttcagggg 420 ttttcaacat aggtctcttt taaaaggggt taaaaaattt atgcatacta g 471 <210> SEQ ID NO 500 <211> LENGTH: 347 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 961630T6 <400> SEQUENCE: 500 agagtttaag atcccatttt ttaaaaagta caatacagtt gattttttaa aatgaggttc 60 tacaaacact tttggacagt ctaacataca tataagctgt ccctttcaac taggatatgg 120 ggaaaagaag tcaacccagt gtttccactt tccatgaagg acttctcaag ggcaaggtaa 180 taagcaggaa taaagcttcc aaaaacctgg aaggactctt tcaggtggac taataagcat 240 catcatcacc tgccttaaac tacagtaaag ccaagattgt taataatata gttccttgct 300 tttagctagt atagaaaata aaattgaatc acattgttga tggtaat 347 <210> SEQ ID NO 501 <211> LENGTH: 209 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 041795H1 <400> SEQUENCE: 501 aagattttgc attagccaga tgctaggttg ttgaaggcat ttcagtgttg ataatagcct 60 gagcagactt ctttacaaat gggatctgtt tctatatgtg tatatgccca cttaccattc 120 agagagactg gtctttctct ttgtcttcct tcacattgct gtgtcagttc tacacctagt 180 cttttcagca cttagcaaat tcaaatttt 209 <210> SEQ ID NO 502 <211> LENGTH: 513 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1406908T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 486 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 502 tctgcccagt tacaacaacg aaatgggaaa ccacaattaa aattcacaaa ccatggcatg 60 aaaaacaaca cgcaccccat caggaattac accaaacccc ttttcctttt tattcattca 120 aaagagagtc caatacacaa gtgtcaaata tgagcactgt catttttttt ttcttagaag 180 ggggaaaaac atttattttg gcagtgcttt gacaattcca ggaagtggtt ttgatactac 240 aagttgcagg aatagaaacc ctaacaaact tggagggcat ttgtttgaga ggcaagggac 300 gccttgctta gaaaacattc ctcttgtgct tagtgaatca cctatcgcct cggtgggctg 360 ctgtgtcttt ccaggtgctg aaagagaaaa cggaatttct tgcatagaca gctgaagagt 420 cctgtagagc agagtgattt ttgtatctcc aaccctcctc cccaacttga aacaaattct 480 caagcntctc tggagcatct tttggtcaca tga 513 <210> SEQ ID NO 503 <211> LENGTH: 430 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1430933F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 245, 389 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 503 gcctgccaga cttcaacgcc ggcgccatgg agaactgggg actggtgacc taccgggaga 60 actccctgct gttcgacccc ctgtcctcct ccagcagcaa caaggagcgg gtggtcactg 120 tgattgctca tgagctggcc caccagtggt tcgggaacct ggtgaccata gagtggtgga 180 atgacctgtg gctgaacgag ggcttcgcct cctacgtgga gtacctgggt gctgactatg 240 cgganccacc tggaacttga aagacctcat ggtgctgaat gatgtgtacc gcgtgatggc 300 agtggatgca ctggcctcct cccaaccgct gtccacaacc gcctcggaga tcaacacgcc 360 ggccccagat cagtgagctg tttgacgcna tctcctaaca gcaaaggcgc ctcagtctca 420 ggatgtctcc 430 <210> SEQ ID NO 504 <211> LENGTH: 195 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1468353F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 63, 124, 148, 164 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 504 gccggacaca gcctggagtg attgagcccc tcatcaagtt ccaggtggga tgaagaagct 60 gancttgcat gaggaggagc atgtcctgct catggccatc tgcatcgtct cccccagatc 120 gtcntggggt gcaggacgcc gcgctgantg aagccatcca ggancgcctg tccaacacat 180 gcagacgtac aatcc 195 <210> SEQ ID NO 505 <211> LENGTH: 235 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1500367F6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 52, 75, 97, 102, 119, 138, 141, 223 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 505 ctaattttga agtagggtgc atggagaggg agaagtggtg acagaacttg gnaactagct 60 ggctggggga acgangggaa ggaaggagac tgctgtntcc angctgaggt cagggtggng 120 ttggcaagag cgcaaaantc nagggaagcc aggctggagc tgctgtgtat agactgccaa 180 atgtgaagta tttatattgt attcactaaa ctatacttaa gantgttcaa acaaa 235 <210> SEQ ID NO 506 <211> LENGTH: 203 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1561504H1 <400> SEQUENCE: 506 gacgcttttg atgctgggga gcggccctcc tttgacagag acacagatgt gcacactgtg 60 gcttccctgt taaagctcta cctccgagac ctcccagagc ccgtggttcc ctggagccaa 120 tacgaagggt tcctgctctg tgggcagctc acgaatgcgg atgaggcaaa ggctcagcag 180 gagttgatga agcagctctc cat 203 <210> SEQ ID NO 507 <211> LENGTH: 132 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1709659T6 <400> SEQUENCE: 507 agatggaggt tactgaggaa ttaggtagcc gggtggctta ccccaggcat gtctgtgtag 60 gtaacatttg agaaaagaaa aaaaaaatca ggaggtcagg gaaagaatgt aaaggcattt 120 gtgagctctg ag 132 <210> SEQ ID NO 508 <211> LENGTH: 425 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1817550T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 140, 153, 247, 419 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 508 cacaaagttc tgttcttctt cctggcagct tcggacgaaa ttacacaggc atctcccatg 60 cccaccaccc gttaggaatg tccattcctg ggctgcgtgc gcaggtccag cagccagtct 120 gtgcaggctc ctggtccggn cagggagatt gangcagacc cccacaagcc ctgaacccca 180 gtctcaagtt ttctgcacga cctgtacttc agtcaccaga cactcctcca ggccggcttt 240 gcccgcntcc cagaccacca gcttgtcgtt ttggaagctg tcaccgatgg ggtctttcat 300 gtgagggatg cggggaaaga gtctctgcat caccagatac cttctgcaga tcacgaagac 360 acagaccagg gccagcagcg tccccagcgc gatcagcagc gacgtccgcc aggcacgtnt 420 gtttg 425 <210> SEQ ID NO 509 <211> LENGTH: 495 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1852712T6 <400> SEQUENCE: 509 ccaaacagct cgatggagac accctgcact gcttatggtg atgctgcagg aatggcggca 60 gcgatgcccg ctacactcca tggcctgctg cacatgtgac aggacagtta tttcatctat 120 gcttacacct gcaggtccct taccctagaa acactctata tcttcttagg tacttccctt 180 gaaacaggat gagttctaga ggaaataaaa ctgctgcact tacaaaccta gaaatattca 240 gggaccaaga ttagttgttc agtgacctag gaaaccttag aatcctgtag gttcctcagg 300 agaggtgctt ccaagtactt gagaatccac aggcagagat gcttcccttt ccatggtgga 360 tgtgtatgtc actccaggac aaactgcgga gtcacggagt gtgggaacac atctggttgt 420 gtacagtaca ctatcccaga ggaaaatcac caaagcaaca caactctgca gcaaaaaact 480 agtcccaaag tcaga 495 <210> SEQ ID NO 510 <211> LENGTH: 106 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1861724T6 <400> SEQUENCE: 510 agggccagat tgcactgtgc tatataaaga ggttaaaggt gagaaaagtc aacctgaaat 60 gatgtttcct gcaattatta accgatattt aaaaatactg gcctga 106 <210> SEQ ID NO 511 <211> LENGTH: 494 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2449112T6 <400> SEQUENCE: 511 atatacagat ctgctgccct gttgattcct cagatttagg gtctttaggg aaaggtgaaa 60 gagggtacag ggcggccccc agcaaggccg ttcattgtcc atcgagagct tctgctcatc 120 tggccctgga gctgggcttc cctgagatca gccccagggc actgggcgac aggtgccatg 180 ccaggcctag ggcggggttg gcatgagggg caggggctgg gaggtgctca ggcagcctgg 240 gtcatcagga actagactgg ctcacaggca gagagaacgt gggctggaga ctttgtcctt 300 gaggggagga cactggtgcc tcgggctcca ggaatggagg ccctgcacca gccgctggga 360 tggacacatg tgggcacctt gcatcggggc cgggtgactt caagggctgg ggactatttg 420 ctgttttctg tgaaccactg gagcaccacc tccttgttct ccttcaccca cttgatgttg 480 gctttcgtct tctc 494 <210> SEQ ID NO 512 <211> LENGTH: 502 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2769161T6 <400> SEQUENCE: 512 ttgcaaccag aatccccggt cacgtgggga agggattgga gctagggatg aggcaggaca 60 catctggtcc ctgacaggac actccccgtc caggatgcaa agccaaaggc ccggaacagc 120 ctgctcagtg gctgagccct gtggccagct gtgccctgtc tcttcccctg cccccagtca 180 gggcatccaa cggggcagag gcagaaggga cgtgaaaagg ggggtcggtt tcagcaaagc 240 cttcacccag ggacctgaag gaagaaggag tattgtgatg gggtccaggt gccccaagat 300 gctcagggcg cctgggctga cttcaggatg tgtccatgtg gttatcagag gaaagcgatg 360 gggcctgccc tgcccacgtg gagagggagg gagaggggaa acacggctca gaaggagaat 420 cactggccag cgaccataca ggtgggattt gggaccctga ctccgccgcc agggccgggt 480 ccacacccca ctcctggctg gg 502 <210> SEQ ID NO 513 <211> LENGTH: 320 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 2855766T6 <400> SEQUENCE: 513 catgtattgt tactagaaca acttgtatag ggttttatgg tttggggaaa acatttttaa 60 aaaatggact tatctctatt atacagagtt ataatataaa aatgatttaa aggctatatt 120 tttcagcatg taggtagcta cactgtaatc ctgttgaaga aactttccta tttaagctta 180 taggatgaaa atatataatt aaagtcttct gatcatagct tgagaccatc aagggaatgt 240 ttagtttcct ccacaaagag ccaccaggat tttctcataa tctcctttgg tttcatccag 300 gatggcttgc aaagggagat 320 <210> SEQ ID NO 514 <211> LENGTH: 107 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3034487T6 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 36 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 514 cctcacttca aatatagcat ttcattaaat acatantctc cacggtgctc attacaaact 60 ccagacacta cttttaaaaa cccggtagtc acacataaac agcatga 107 <210> SEQ ID NO 515 <211> LENGTH: 304 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 3334413F7 <400> SEQUENCE: 515 acctcacccg cctcatcgac atcctcaatg tcttcttcca gagggatccc tctttgctgc 60 tgcataagct gctcctaggg accagtggag agggcaaggc ggagggggaa agctccccgc 120 ccatggcgcg gtccaccccc agccaggaac tgctccgggc cacccagctc catcagtatg 180 tggagggctt tctgttgcat gggctcttgc cagctcatgt cattcggttg ctgcttaagc 240 ctcatgtcca ggcccagcag gacttgcagc tgttgctgga gctgctggag aagatgggat 300 ctgt 304 <210> SEQ ID NO 516 <211> LENGTH: 452 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: misc_feature <223> OTHER INFORMATION: Incyte ID No: 1266985T7 <220> FEATURE: <221> NAME/KEY: unsure <222> LOCATION: 442 <223> OTHER INFORMATION: a, t, c, g, or other <400> SEQUENCE: 516 taccccagag acagacccag ggctggctac gtgcacagga agtaacgctt gccacatgca 60 taaatacgtg aaggtgcaca ttacatcagc acagattcac aaaacacctc gccttggcaa 120 gaaaactgta gctaggcagc tcccgtcctc agggactcct gccacagacg tcatggagac 180 agcatgagcc tccccagaac agtccccacg gcctagactc cccagagcag gaggagcagc 240 ccaggctctg ttgcgagaca gccatcactt cctgttcttt gcaggtgcct aaggtaggtt 300 acctggccaa ggttttggtg gaaaaaatga gttttttcaa tgttgcaggt cttttaatag 360 ttcatctgta ggaagtgcat ttgcaaagtc accaacctgc agcttccatc tgtagaccag 420 gaagggtgat tctctgggtg ancacagcgg gg 452 

What is claimed is:
 1. A composition comprising a plurality of polynucleotides whose expression is modulated by cytokines, wherein the polynucleotides comprise SEQ ID NOs:1-516 or a complement thereof.
 2. A substantially purified polynucleotide whose expression is modulated by cytokines comprising at least a fragment of a gene selected from SEQ ID NOs:1-243 or a complement thereof.
 3. The polynucleotide of claim 2 whose expression is modulated by pro-inflammatory and anti-inflammatory cytokines, wherein the polynucleotide is selected from SEQ ID NOs:1-172 or a complement thereof.
 4. The polynucleotide of claim 2 whose expression is modulated by pro-inflammatory cytokines, wherein the polynucleotide is selected from SEQ ID NOs:173-218 or a complement thereof.
 5. The polynucleotide of claim 2 whose expression is modulated by anti-inflammatory cytokines, wherein the polynucleotide is selected from SEQ ID NOs:219-243 or a complement thereof.
 6. The composition of claim 1, wherein the polynucleotides are immobilized on a substrate.
 7. A high throughput method for detecting a polynucleotide in a sample, the method comprising: (a) hybridizing the composition of claim 1 with the sample, thereby forming hybridization complex; and (b) detecting the hybridization complex, wherein the presence of the hybridization complex indicates the presence of the polynucleotide in the sample.
 8. A high throughput method of screening a library of molecules or compounds to identify a ligand, the method comprising: (a) combining the composition of claim 1 with a library of molecules or compounds under conditions to allow specific binding; and (b) detecting specific binding, thereby identifying a ligand.
 9. The method of claim 8 wherein the library is selected from DNA molecules, RNA molecules, peptide nucleic acids, mimetics, peptides, and proteins.
 10. A method of purifying ligands, the method comprising: a) combining the polynucleotide of claim 2 with a sample under conditions which allow specific binding; b) recovering the bound polynucleotide, and c) separating the polynucleotide from the ligand, thereby obtaining purified ligand.
 11. An expression vector containing the polynucleotide of claim
 2. 12. A host cell containing the expression vector of claim
 11. 13. A method for producing a protein, the method comprising the steps of: (a) culturing the host cell of claim 11 under conditions for the expression of protein; and (b) recovering the protein from the host cell culture.
 14. A protein or a portion thereof produced by the method of claim
 13. 15. A method for screening a library of molecules or compounds to identify at least one ligand which specifically binds a protein, the method comprising: (a) combining the protein or a portion thereof of claim 14 with the library of molecules or compounds under conditions to allow specific binding; and (b) detecting specific binding, thereby identifying a ligand which specifically binds the protein.
 16. The method of claim 15 wherein the library is selected from DNA molecules, RNA molecules, PNAs, mimetics, peptides, proteins, agonists, antagonists, antibodies or their fragments, immunoglobulins, inhibitors, drug compounds, and pharmaceutical agents.
 17. A method of purifying a ligand, the method comprising: a) combining the protein or a portion thereof of claim 14 with a sample under conditions to allow specific binding; b) recovering the bound protein; and c) separating the protein from the ligand, thereby obtaining purified ligand.
 18. A method of screening a sample from a patient for an immune response, disorder, condition, or disease, the method comprising: a) contacting the sample with the composition of claim 1 immobilized on a substrate under conditions to allow formation of a hybridization complex; b) detecting and quantifying complex formation; and c) comparing complex formation with a standard, wherein a change complex formation indicates the presence of the immune disorder, condition, or disease.
 19. The method of claim 18, wherein the immune disorder, condition, or disease is a pro-inflammatory disorder selected from viral infections, rheumatoid arthritis, insulin-dependent diabetes mellitus, multiple sclerosis, encephalomyelitis, inflammatory bowel disease, psoriasis, and pemphigus vulgaris.
 20. The method of claim 18, wherein the immune system disorder, condition, or disease is an anti-inflammatory disorder selected from bacterial and parasitic infections, allergies and other atopic disorders, chronic graft versus host disease, scleroderma, and systemic lupus erythematosus. 